阅读说明：本技术 一种小鼠实验装置 (Mouse experimental device ) 是由 张雨寒 王梦羽 蒋雨彤 顾习 于 2020-07-29 设计创作，主要内容包括：本发明涉及一种小鼠实验装置,其包括前挡板、后挡板、左侧板、右侧板,顶板、底板和阻隔挡板,所述后挡板、顶板、底板和阻隔挡板围成的区域为麻醉区,所述前挡板、顶板、底板、左侧板、右侧板和阻隔挡板围成的区域为活动区,麻醉区与活动区沿实验装置长度方向前后设置,阻隔挡板位于麻醉区和活动区之间；麻醉区内设置有麻醉剂,所述阻隔挡板为多孔结构,使得麻醉剂挥发后,能通过阻隔挡板进入活动区,麻醉小鼠。本发明结构能快速麻醉小鼠,且避免了实验人员因害怕小鼠而导致的实验失误或事故。(The invention relates to a mouse experimental device which comprises a front baffle, a rear baffle, a left side plate, a right side plate, a top plate, a bottom plate and a blocking baffle, wherein the area surrounded by the rear baffle, the top plate, the bottom plate and the blocking baffle is an anesthesia area; the anesthetic zone is internally provided with anesthetic, the separation baffle is of a porous structure, so that the anesthetic can enter the moving zone through the separation baffle after being volatilized, and mice are anesthetized. The structure of the invention can rapidly anaesthetize the mouse and avoid experimental errors or accidents caused by fear of the mouse for experimenters.)

1. A mouse experimental device is characterized by comprising a front baffle, a rear baffle, a left side plate, a right side plate, a top plate, a bottom plate and a blocking baffle, wherein the area surrounded by the rear baffle, the top plate, the bottom plate and the blocking baffle is an anesthesia area; the anesthetic zone is internally provided with anesthetic, the separation baffle is of a porous structure, so that the anesthetic can enter the moving zone through the separation baffle after being volatilized, and mice are anesthetized.

2. The mouse experimental device according to claim 1, wherein the active area is provided with a cross bar along the width direction of the experimental device, the length of the active area is a, the distance from the blocking baffle to the cross bar is b, the average length of the existing experimental mouse is c, the distance from the nose to the forelimb of the mouse is d, and the position of the cross bar satisfies b/a ═ (0.8-1.2) d/c.

3. The mouse experiment device according to claim 1, wherein the blocking baffle can move back and forth along the length direction of the mouse experiment device.

4. The mouse experiment device as claimed in claim 1, wherein the rear baffle can move back and forth along the length direction of the mouse experiment device.

5. The device according to claim 1, wherein the diameter of the cross bar is 2-5 cm.

Technical Field

The invention relates to a medical experimental device, in particular to a mouse experimental device.

Background

Mouse experimental apparatus is the conventional device of medical experiment, experimental apparatus is including the cavity that holds the mouse, the cavity height is moderate, after putting into the mouse, the laboratory staff puts into the anesthesia composition immediately, volatilize along with the anesthesia composition, the mouse gets into deep sleep state, laboratory staff can operate the mouse outward with experimental apparatus, but present mouse experimental apparatus all puts into the narcotic drug after putting into the mouse again, the mouse gets into the anesthesia state slowly, before the mouse gets into the anesthesia state, the mouse can originally "resist", influence experimental apparatus's steady, some laboratory staff in addition has the fear psychology to the mouse, then improve the experiment error, handle improper possibility that leads to the experimental accident.

Therefore, it is necessary to provide a mouse experimental device which is simple to operate, safe and reliable.

Disclosure of Invention

In order to solve the problem that the mouse anesthesia of the existing mouse experimental device is slow, and the experimenter can not experiment due to fear of psychology. The invention provides a safe and effective mouse experimental device with a simple structure.

The invention provides a mouse experimental device, which comprises a front baffle, a rear baffle, a left side plate, a right side plate, a top plate, a bottom plate and a blocking baffle, wherein the area surrounded by the rear baffle, the top plate, the bottom plate and the blocking baffle is an anesthesia area; the anesthetic zone is internally provided with anesthetic, the separation baffle is of a porous structure, so that the anesthetic can enter the moving zone through the separation baffle after being volatilized, and mice are anesthetized.

The active area is provided with a cross bar along the width direction of the experimental device, the length of the active area is a, the distance from the blocking baffle to the cross bar is b, the average length of the existing experimental mouse is c, the distance from the nose to the forelimb of the mouse is d, and the position of the cross bar meets the requirement that b/a is (0.8-1.2) d/c, so that the forelimb can actively grab the cross bar due to instinct after the mouse enters the active area, when the setting position of the cross bar meets the relation, the nose of the mouse closely contacts the blocking baffle, so that the mouse can enter an anesthesia state in the shortest time, and preferably, b/a is (0.9-1.1) d/c.

As a preferable scheme, the blocking baffle can move back and forth along the length direction of the mouse experimental device, so that the length from the cross rod to the blocking baffle is adjusted, and the distance from the cross rod to the blocking baffle just meets the distance from the nose to the forelimb of the mouse.

As a preferable scheme, the rear baffle can move back and forth along the length direction of the mouse experimental device, so that the length from the cross rod to the rear baffle is adjusted, and the distance from the cross rod to the blocking baffle just meets the distance from the forelimbs to the tail of the mouse;

further preferably, the moving structure of the tailgate is provided with a locking structure, and after the tailgate moves to the set position, the locking structure can fix the tailgate and prohibit the tailgate from moving continuously.

Preferably, the cross bar has a diameter of 2-5cm, and the forelimb of the mouse can hold 2/3 of the cross bar.

The cross bar can rotate around the central shaft, when the front limbs of the mouse grasp the cross bar, the front limbs can grasp the cross bar, and the running can be carried out on the cross bar.

Preferably, the aperture of the porous partition board is 2-3mm, the setting area of the holes can be set as a whole board, or can be a part of area right opposite to the mouth and the nose of the mouse, as an implementation mode, the area of the holes accounts for more than 60% of the total area of the porous partition board, preferably 70-80%, the anesthetic can be volatilized from the anesthetic area to enter the active area at the first time, and the mouse can inhale the anesthetic as much as possible.

As an embodiment of the invention, the rear baffle is provided with a fan which is used for blowing air into the anesthesia area, and the anesthetic in the anesthesia area is easier to volatilize due to the negative pressure effect.

As another embodiment of the invention, the anesthesia area is provided with an upper plate and a lower plate, a closed structure is formed between the upper plate and the lower plate and between the upper plate and the left side plate and the right side plate, and the gaseous anesthetic enters the anesthesia area through the air inlet device and then enters the active area through the holes on the porous partition plate.

The two methods are not easy to control the dosage of the anesthetic, and because the laboratory technician faces the experimental device, the residual anesthetic can enter the air after a small amount of the volatilized anesthetic is absorbed by the mice, and even is inhaled by the laboratory technician, so that the resource waste, the environmental pollution, the harm to the human health and the experimental accident are caused.

As another embodiment of the invention, a common baffle plate is used for replacing a porous baffle plate, an air outlet is arranged on the baffle plate, an air inlet is arranged on the rear baffle plate, the air inlet is connected with the air outlet through a Venturi tube, a narrow-diameter section of the Venturi tube is provided with a through hole and is connected with an anesthesia area, a liquid volatile anesthetic is placed at the bottom of the anesthesia area, the volatile anesthetic is volatilized to form steam to fill the entire anesthesia area, when air is introduced into an air inlet pipe, negative pressure is generated at the through hole where the Venturi tube is connected with the anesthesia area, anesthetic steam generated in the anesthesia area is sucked into the Venturi tube by the negative pressure and enters into an active area along with air or other corresponding carrier gases, and by adopting the mode, escape of the anesthetic steam is most moderate, and the anesthetic steam occupies less volume due to the action of the carrier gases.

Preferably, the air outlet is over against the nasal cavity of the mouse, the air outlet speed of the air outlet is less than 3m/s, and when the wind speed is less than 3m/s, the mouse does not feel uncomfortable, is not easy to be irritated and is easier to be anesthetized.

Preferably, the air inlet, the air outlet and the through hole for connecting the venturi tube with the anesthesia area are all provided with control valves, the control valves are connected through a controller, the controller can select any known form, when the controller controls all the valves to be closed, the anesthesia area is in a completely closed state, and steam in the anesthesia area cannot overflow.

In the actual operation process, the laboratory technician puts into mouse experimental apparatus earlier the mouse, and after the mouse got into the active area, can instinctively grasp the horizontal pole with the forelimb, can step on even and run on the horizontal pole, when the mouse was concentrated on the horizontal pole, the anesthetic that blows off from the anesthesia district can be absorbed by the mouse better, especially runs the in-process at the mouse, along with the increase of respiratory capacity, the volume of the anesthetic of mouse unit time internal suction further increases, and anesthetic effect obtains further improvement.

Preferably, the bottom plate with left side board, right side board, preceding baffle, backplate are detachable construction for after the mouse anaesthetizes, lie prone on the bottom plate, can take out the bottom plate from the upper portion space, convenient operation.

Further preferred, be hollow out construction in the bottom plate, hollow out construction is provided with the balancing weight, and the bottom plate is provided with after the mating mass, even the mouse runs in experimental apparatus, struggles, also can keep better stationarity, can not take place to turn over the equal accident, influences experimental security.

The invention has no special requirements on materials of various substances, can use any metal material, such as iron and stainless steel, can also use plastic material, adopts plastic material, and has the advantages of more compact structure, convenient disassembly, lighter overall experimental device, inconvenient cleaning and larger weight of metal material, and is inconvenient to disassemble particularly for girls, but the metal material has high surface energy and convenient cleaning.

The anesthetic of the present invention is not particularly limited, and any known drug that is volatile and has an anesthetic effect on mice can be used in the present invention, such as enflurane. The anesthetic should be liquid or solid at normal temperature and pressure, which makes feeding of anesthetic more convenient.

As a second invention of the present invention, a laboratory table is provided, which includes the above-described mouse experiment apparatus, a lifting table, an air inlet device, an air outlet device, and a table top, wherein the air inlet device is connected to an air inlet of the mouse experiment apparatus through a conveying pipeline, the air outlet device is connected to an air outlet of the mouse experiment apparatus through a conveying pipeline (not shown), and the lifting device is disposed on the laboratory table, so that an experimenter can flexibly adjust the height of the mouse experiment apparatus according to his own height and operation conditions, thereby meeting the experiment operation requirements.

Drawings

FIG. 1-Structure of one embodiment of the present application;

FIG. 2-bottom view of the base plate of the present application;

FIG. 3-a block diagram of another embodiment of the present application;

FIG. 4-a schematic view of the venturi of the present application;

FIG. 5-a laboratory table carrying a mouse laboratory apparatus according to the present invention;

in the figure, 1-left side panel; 2-right side plate; 3-front baffle; 4-a rear baffle; 5-a top plate; 6-a bottom plate; 7-a cross bar; 8-a fan; 9-blocking baffle plates; 10-a balancing weight; 11-a through hole; 12-an air inlet; 13-air outlet; 14-a venturi tube; 100-mouse experimental setup; 200-a lifting device; 300-an air intake device; 400-air outlet device; 500-tabletop.

Detailed Description