阅读说明：本技术 一种局部用抗炎组合物 (Topical anti-inflammatory composition ) 是由 陈宁刚 叶静静 张恋 钱伟 徐豪亮 叶姝 胡致恺 王慧 鲁晏武 于 2020-07-22 设计创作，主要内容包括：本发明涉及一种局部用抗炎中药组合物,其中制备中药组合物的原料药包括1-5重量份的生石膏、1-5重量份的白鲜皮、1-5重量份的苦参、1-5重量份的千里光和1-5重量份的生地榆。本发明的中药组合物对于面部皮炎的治疗效果显著,鲜有不良反应发生,具有广阔的临床应用前景。(The invention relates to a local anti-inflammatory traditional Chinese medicine composition, wherein raw material medicines for preparing the traditional Chinese medicine composition comprise 1-5 parts by weight of gypsum, 1-5 parts by weight of cortex dictamni, 1-5 parts by weight of radix sophorae flavescentis, 1-5 parts by weight of groundsel and 1-5 parts by weight of raw sanguisorba officinalis. The traditional Chinese medicine composition has obvious treatment effect on the facial dermatitis, has few adverse reactions and has wide clinical application prospect.)

1. The anti-inflammatory traditional Chinese medicine composition for local use is characterized in that raw material medicines for preparing the traditional Chinese medicine composition comprise 1-5 parts by weight of gypsum, 1-5 parts by weight of cortex dictamni, 1-5 parts by weight of radix sophorae flavescentis, 1-5 parts by weight of groundsel and 1-5 parts by weight of raw sanguisorba officinalis.

2. The traditional Chinese medicine composition as claimed in claim 1, wherein the raw materials for preparing the traditional Chinese medicine composition comprise 1-3 parts by weight of gypsum, 1-3 parts by weight of cortex dictamni, 1-3 parts by weight of radix sophorae flavescentis, 1-3 parts by weight of groundsel and 1-3 parts by weight of raw sanguisorba officinalis.

3. The traditional Chinese medicine composition as claimed in claim 2, wherein the raw materials for preparing the traditional Chinese medicine composition comprise 2 parts by weight of gypsum, 1 part by weight of cortex dictamni, 1 part by weight of radix sophorae flavescentis, 1 part by weight of groundsel and 1 part by weight of raw sanguisorba officinalis.

4. The traditional Chinese medicine composition of claim 3, wherein the raw materials for preparing the traditional Chinese medicine composition further comprise 1-5 parts by weight of radix paeoniae rubra, 1-5 parts by weight of mint, 1-5 parts by weight of cortex moutan, 1-5 parts by weight of purslane and 1-5 parts by weight of giant knotweed.

5. The traditional Chinese medicine composition of claim 4, wherein the raw materials for preparing the traditional Chinese medicine composition further comprise 1-3 parts by weight of radix paeoniae rubra, 1-3 parts by weight of mint, 1-3 parts by weight of cortex moutan, 1-3 parts by weight of purslane and 1-3 parts by weight of giant knotweed.

6. The Chinese medicinal composition according to claim 5, wherein the raw material medicines for preparing the Chinese medicinal composition further comprise 1 part by weight of radix paeoniae rubra, 1 part by weight of mint, 1 part by weight of cortex moutan, 1 part by weight of purslane and 1 part by weight of giant knotweed.

7. The traditional Chinese medicine composition of claim 6, wherein the raw materials for preparing the traditional Chinese medicine composition comprise 2 parts by weight of gypsum, 1 part by weight of cortex dictamni, 1 part by weight of radix sophorae flavescentis, 1 part by weight of groundsel, 1 part by weight of raw sanguisorba officinalis, 1 part by weight of radix paeoniae rubra, 1 part by weight of mint, 1 part by weight of cortex moutan, 1 part by weight of purslane and 1 part by weight of giant knotweed.

8. The Chinese medicinal composition according to any one of claims 1 to 7, wherein the dosage form of the Chinese medicinal composition is a decoction.

9. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 8, wherein the preparation is obtained by weighing the prescribed amounts of raw gypsum, cortex dictamni, radix sophorae flavescentis, senecio scandens, raw sanguisorba officinalis, radix paeoniae rubra, mint, cortex moutan, purslane and polygonum cuspidatum, adding 1-10 parts by weight of water, decocting and concentrating to 2-5 parts by weight of water, and filtering the filtrate.

10. Use of the Chinese medicinal composition of any one of claims 1-8 in the preparation of a medicament for treating facial dermatitis.

Technical Field

The invention relates to the field of medicines, and in particular relates to a topical anti-inflammatory composition.

Background

Facial dermatitis generally refers to various kinds of dermatitis occurring on the face, including allergic dermatitis, seborrheic dermatitis, acne rosacea, hormone-dependent dermatitis, and the like. The clinical manifestations are mild to moderate erythema, little scale, unclear margin, and long-term attack which can cause the symptoms of facial telangiectasia, mild edema of face, etc., and the symptoms are mild and moderate pruritus, burning, tightness, stabbing pain, etc. The disease is common in spring and autumn, is usually seen in 2O-4O-year-old women, can disappear by themselves, but can recur, and is stubborn and difficult to cure.

According to the diagnosis and the cause of the facial dermatitis, the facial dermatitis can be divided into four main categories: (1) localized facial dermatitis: dermatitis occurring on the face is defined and includes allergic dermatitis vulgaris, seborrheic dermatitis, rosacea, hormone-dependent dermatitis, etc., excluding other diseases such as acne, rosacea, herpes simplex, systemic lupus erythematosus and facial involvement caused by simplex-light sensitivity. (2) Facial contact dermatitis: contact dermatitis is diagnosed by history and clinical manifestations, including allergic contact dermatitis and irritant contact dermatitis. (3) Seasonal facial dermatitis: the course of facial dermatitis was defined as more than 2 years, seasonal attacks, and cosmetic allergic contact dermatitis was excluded. (4) Facial dermatitis with unknown cause: other facial dermatitis that cannot be attributed to contact dermatitis and seasonal facial dermatitis was defined.

With the improvement of living standard of people, although the wide application of various functional cosmetics and medical and American technologies are rapidly popularized, the incidence rate of facial dermatitis is obviously increased due to various improper treatments. At present, the treatment of the diseases is limited to the application of hormone medicines in the acute stage, calcineurin inhibitors are mainly used in the subacute stage, various skin barrier repair skin care products are mainly used in the chronic stage, but the use time and side effects of hormones cause anxiety, and tacrolimus and other medicine dependence increasingly arouses the attention of people. The traditional Chinese medicine has long use history, definite curative effect, safety and no drug dependence.

Gypsum, a mineral medicine, mainly contains hydrous calcium sulfate, has the effects of clearing heat and purging fire, relieving restlessness and quenching thirst, astringing and promoting granulation, and is mainly used for treating apoplexy, fever, heart-down adverse qi and convulsion, dry mouth and tongue, indigestion, abdominal pain, eliminating ghost evil and bedsore. It is considered that the exterior application of gypsum for clearing heat and toxic materials, relieving swelling and alleviating pain by taking its cold and qi property.

Cortex Dictamni Radicis, also known as caulis et folium Paeoniae suffruticosae and herba Dictamni Radicis, is root bark of perennial herb Dictamni and Dictamni angustifolia of Rutaceae, and has effects of clearing heat, eliminating dampness, dispelling pathogenic wind, relieving itching, and removing toxic substance. Mainly treats rubella, eczema, mange, jaundice and damp-heat arthralgia caused by wind-heat and damp toxin.

Radix Sophorae Flavescentis, the dry root of Sophora flavescens ait of Leguminosae, is bitter in taste and cold in nature. Has the functions of clearing heat, drying dampness, killing parasites and promoting urination. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonal vaginitis.

Groundsel belongs to perennial climbing herbaceous plants, and belongs to the family of Compositae, and is used as a medicine by using whole herbs. Bitter, pungent and cold in nature. Has the functions of clearing away heat and toxic material, improving eyesight, eliminating nebula, killing parasite and relieving itching. Can be used for treating influenza, upper respiratory infection, pneumonia, acute tonsillitis, acute enteritis, bacillary dysentery, icteric hepatitis, gallbladder eczema, acute urinary tract infection, conjunctival congestion, swelling, pain, nebula, carbuncle, furuncle, erysipelas, eczema, tinea, trichomonal vaginitis, and burn.

The raw sanguisorba officinalis is a herb, belongs to the Rosaceae, and has the effects of cooling blood, stopping bleeding, clearing heat, detoxifying, reducing swelling and healing sore. In clinic, it is used for bacteriostasis, anti-inflammation, hemostasis, and can be used to treat various blood diseases, leukorrhagia, eczema, pruritus vulvae, etc.

Radix Paeoniae Rubra is dried root of Ranunculaceae plant radix Paeoniae Rubra or radix Paeoniae Rubra. Bitter in property and slightly cold in nature. It enters liver meridian. Radix Paeoniae Rubra has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis. It is mainly used for treating heat entering nutrient-blood, warm-toxin macula, hematemesis and epistaxis, conjunctival congestion and swelling and pain, liver depression and hypochondriac pain, amenorrhea and dysmenorrhea, addiction and abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Mint, named Yindancao in the name of Labiatae, is a common Chinese medicine, is used as a dish for young stem tips, is pungent and cool in nature, can relieve exterior syndrome by sweating, and is mainly used for treating symptoms such as cold, fever, laryngalgia, headache, conjunctival congestion, muscle pain, rubella of skin, pruritus, measles imperviousness and the like, and is also effective on carbuncle, gangrene, scabies, tinea and dermatitis.

Cortex moutan, a dry root bark of Paeonia suffruticosa of Ranunculaceae, is bitter, pungent and slightly cold in taste, and has the effects of clearing heat and cooling blood, promoting blood circulation to remove blood stasis, and relieving deficiency heat. It is mainly used for treating warm diseases with syndrome of heat entering blood system, macula, epistaxis, fever due to yin deficiency, hectic fever due to yin deficiency, blood stagnation, amenorrhea, dysmenorrhea, carbuncle, sore, traumatic injury, and arthralgia due to wind-damp-heat.

Purslane is an annual herb, the whole plant has no hair, and is sour in taste and cold in nature. Purslane has the functions of clearing away heat and toxic materials, cooling blood and stopping bleeding, inducing diuresis and treating stranguria, and stopping dysentery. Can be used for treating sore and carbuncle, swelling and pain due to toxic heat, blood heat, metrorrhagia, hematochezia, hemorrhoid, dysentery, damp-heat stranguria, leukorrhagia, etc.

Rhizoma Polygoni Cuspidati is dried rhizome and root of Polygonum cuspidatum of Polygonaceae. Rhizoma Polygoni Cuspidati has effects of promoting diuresis, eliminating jaundice, clearing heat and detoxicating, removing blood stasis, relieving pain, relieving cough and eliminating phlegm. Can be used for treating jaundice due to damp-heat pathogen, stranguria with turbid discharge, leukorrhagia, rheumatalgia, carbuncle, swelling, sore, scald due to water and fire, amenorrhea, abdominal mass, contusion injury, and cough due to lung heat.

According to the traditional Chinese medicine, the face belongs to yangming meridians, and the flush and scorching of the face are caused by yangming blood heat and body fluid deficiency and burn the face; the retention of damp-heat can cause erythema, blisters and papular dermatitis on the surface of the muscles. The gypsum, the raw sanguisorba, the cortex moutan and the red paeony root selected by the traditional Chinese medicine composition can clear heat and purge fire, nourish yin and promote the production of body fluid, and have the functions of diminishing inflammation and removing redness by local external application; radix Sophorae Flavescentis, herba Portulacae, herba Senecionis Scandentis, and rhizoma Polygoni Cuspidati can clear heat and eliminate dampness, and can relieve swelling and itching when topically applied.

At present, few documents report the use of traditional Chinese medicine external preparations capable of effectively treating facial dermatitis.

Disclosure of Invention

The invention aims to provide a topical anti-inflammatory traditional Chinese medicine composition.

In order to achieve the purpose, the invention adopts the following technical scheme:

the first aspect of the invention provides a topical anti-inflammatory traditional Chinese medicine composition, which comprises 1-5 parts by weight of gypsum, 1-5 parts by weight of cortex dictamni, 1-5 parts by weight of radix sophorae flavescentis, 1-5 parts by weight of groundsel and 1-5 parts by weight of raw sanguisorba officinalis.

Preferably, the raw material medicines of the topical anti-inflammatory traditional Chinese medicine composition comprise 1-3 parts by weight of gypsum, 1-3 parts by weight of cortex dictamni, 1-3 parts by weight of radix sophorae flavescentis, 1-3 parts by weight of groundsel and 1-3 parts by weight of raw sanguisorba officinalis.

More preferably, the raw material medicines of the topical anti-inflammatory traditional Chinese medicine composition comprise 2 parts by weight of gypsum, 1 part by weight of cortex dictamni, 1 part by weight of radix sophorae flavescentis, 1 part by weight of groundsel and 1 part by weight of raw sanguisorba officinalis.

Preferably, the raw material medicines of the topical anti-inflammatory traditional Chinese medicine composition further comprise 1-5 parts by weight of red paeony root, 1-5 parts by weight of mint, 1-5 parts by weight of cortex moutan, 1-5 parts by weight of purslane and 1-5 parts by weight of giant knotweed rhizome.

More preferably, the raw material medicines of the topical anti-inflammatory traditional Chinese medicine composition further comprise 1-3 parts by weight of red paeony root, 1-3 parts by weight of mint, 1-3 parts by weight of cortex moutan, 1-3 parts by weight of purslane and 1-3 parts by weight of giant knotweed rhizome.

More preferably, the raw material medicines of the topical anti-inflammatory traditional Chinese medicine composition further comprise 1 part by weight of red peony root, 1 part by weight of mint, 1 part by weight of cortex moutan, 1 part by weight of purslane and 1 part by weight of giant knotweed rhizome.

Most preferably, the raw materials of the topical anti-inflammatory traditional Chinese medicine composition comprise 2 parts by weight of gypsum, 1 part by weight of cortex dictamni, 1 part by weight of radix sophorae flavescentis, 1 part by weight of groundsel, 1 part by weight of raw sanguisorba officinalis, 1 part by weight of red peony root, 1 part by weight of mint, 1 part by weight of cortex moutan, 1 part by weight of purslane and 1 part by weight of giant knotweed rhizome.

Preferably, the dosage form of the topical anti-inflammatory Chinese medicinal composition is a decoction.

The invention also provides a preparation method of the local anti-inflammatory traditional Chinese medicine composition, which comprises the steps of weighing the formula amount of gypsum, cortex dictamni, radix sophorae flavescentis, groundsel, raw sanguisorba officinalis, red paeony root, mint, cortex moutan, purslane and polygonum cuspidatum, adding 1-10 times of water by weight, decocting and concentrating to 2-5 times of water by weight, and filtering the filtrate.

Preferably, the preparation method of the topical anti-inflammatory Chinese medicinal composition comprises adding 5 weight parts of water, decocting and concentrating to 2 weight parts of water.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating facial dermatitis.

Preferably, the facial dermatitis is selected from seborrheic dermatitis, hormone-dependent dermatitis, acne rosacea, allergic dermatitis, facial recurrent dermatitis, acute/subacute eczema, solar dermatitis, and facial cosmetic dermatitis.

More preferably, the hormone-dependent dermatitis is recurrent facial hormone-dependent dermatitis.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for reducing the expression of the IL-4 content in blood plasma.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for reducing the expression of the IL-13 content in blood plasma.

The invention has the positive and beneficial effects that:

repeated experiments show that the combination of gypsum, cortex dictamni, radix sophorae flavescentis, groundsel and raw sanguisorba root according to a specific proportion has an excellent effect on preventing and treating facial dermatitis, particularly hormone-dependent dermatitis, and the effect of the combination of gypsum, cortex dictamni, radix sophorae flavescentis, groundsel and raw sanguisorba root is better when the combination is matched with radix paeoniae rubra, mint, cortex moutan, purslane and polygonum cuspidatum. In long-term clinical tests, the traditional Chinese medicine composition has an obvious treatment effect on the facial dermatitis, has few adverse reactions and has a wide clinical application prospect.

Detailed Description

The present invention will be further described with reference to the following examples, but the embodiments of the present invention are not limited thereto. The experimental procedures used in the following examples are all conventional procedures unless otherwise specified.