阅读说明：本技术 一种治疗高血压病的药物 (Medicine for treating hypertension ) 是由 闫伟 闫家旭 于 2019-04-17 设计创作，主要内容包括：本发明公开了一种治疗高血压病的药物,系循环系统疾病类非处方药药品,主治原发性高血压,可使血压下降到或接近正常范围。本发明由绞股蓝、丹参等7味中药组成。加工制作薄膜衣片剂、胶囊剂或颗粒剂,供口服。其药性平和,无毒副作用,较严重的肝阳上亢或阴虚阳亢型患者,可及时、平稳、适度降压,头痛、失眠、项强、心悸、耳鸣、便秘、肢体麻木等症状尽快消失,安全、特效、低成本,疗效明显优于西药。在降压的同时,又能防止心、脑、肾、视网膜等靶器官的损害,消除危险因素。而且对高血压并发的器官损伤、血脂、血糖、血黏度等功能代谢异常可有多靶点调治作用。解决了治疗高血压病没有特效药的问题。(The invention discloses a medicine for treating hypertension, which is an over-the-counter medicine for treating circulatory system diseases, mainly treats primary hypertension and can reduce the blood pressure to or close to a normal range. The invention consists of 7 traditional Chinese medicines such as gynostemma pentaphylla, salvia miltiorrhiza and the like. Processing into film coated tablet, capsule or granule for oral administration. The traditional Chinese medicine composition has mild medicine property and no toxic or side effect, can be used for treating patients with severe hyperactivity of liver-yang or hyperactivity of yin-deficiency and yang, can reduce blood pressure timely, stably and moderately, can eliminate symptoms such as headache, insomnia, stiff neck, palpitation, tinnitus, constipation and limb numbness as soon as possible, is safe, special in effect and low in cost, and has a curative effect obviously superior to that of western medicines. Can prevent target organs such as heart, brain, kidney, retina and the like from being damaged and eliminate dangerous factors while reducing blood pressure. And has multi-target regulation and treatment effects on functional metabolic abnormalities such as organ injury, blood fat, blood sugar, blood viscosity and the like complicated by hypertension. Solves the problem that no specific medicine is available for treating hypertension.)

1. A medicine for treating hypertension is characterized by comprising 16 g of gynostemma pentaphylla, 9 g of wolfberry fruit, 6 g of chrysanthemum, 10 g of fried cassia seed, 8 g of uncaria, 6 g of scutellaria baicalensis and 10 g of salvia miltiorrhiza.

2. Pharmaceutical according to claim 1, characterized in that it is a film-coated tablet, capsule or granule.

The invention relates to an oral medicine for treating hypertension, in particular to a medicine for treating hypertension, which is prepared by taking pure traditional Chinese medicines as raw materials.

Hypertension refers to a complex syndrome with continuous elevation of systolic and 1 or diastolic blood pressure in the systemic circulation as its primary clinical manifestations, with or without various cardiovascular risk factors. In the absence of antihypertensive agents, systolic pressure is greater than or equal to 140 mm Hg and/or diastolic pressure is greater than or equal to 90 mm Hg, and persists, often referred to simply as "hypertension", which is classified into classes 1, 2, and 3 according to blood pressure level.

Hypertension seriously harms people's health and life. It is not only an independent disease, but also an important risk factor for cardiovascular and cerebrovascular diseases, resulting in the change and damage of the structure and function of heart, brain, kidney, blood vessel and eyeground. The mortality rate of cardiovascular and cerebrovascular diseases caused by hypertension has been ranked first among all disease mortality rates. Hypertension is also the disease with the highest sudden mortality. Hypertension is not only harmful in that it can cause symptoms such as dizziness, headache, etc., but more importantly it can cause stroke, heart disease, kidney damage and limb vessel blockage or rupture, directly endangering life.

Hypertension is related to genetic factors, mental and environmental factors, living habits, medicines, age, and the like. Hypertension can be divided into two main categories, one is primary hypertension mainly caused by atherosclerosis or unknown-cause hypertension, and the prevalence rate is high and accounts for 80-90%. The other is secondary hypertension, also called symptomatic hypertension, which is caused by other diseases, such as hypertension caused by kidney diseases, i.e. renal hypertension.

Hypertension belongs to the category of diseases such as vertigo, headache, apoplexy and the like in the traditional Chinese medicine. Hypertension patients are mostly warm constitutions. Clinically, it is marked by hyperactivity of yang due to yin deficiency, and more frequent deficiency of both yin and yang. The key to the treatment of this disease lies in the regulation of liver and kidney. Nourishing yin and suppressing yang is the major method for treating the disease, and in the later stage, the liver and kidney are nourished and yin and yang are nourished.

If patients with hypertension can be treated early and regularly, the incidence rate of serious complications such as myocardial infarction, stroke and the like can be reduced, but no good prescription for treating hypertension exists at present. The western medicine is taken for a long time to reduce blood pressure, the dependence is higher and higher, the blood pressure is more and more difficult to reduce, the more the medicine is taken, and the danger is higher and higher.

The invention aims to provide a medicine for treating hypertension, which has the effects of nourishing yin, suppressing yang, reducing phlegm, reducing pathogenic fire, regulating liver and kidney, delaying senility and the like; the oral preparation has the advantages of quick response, short treatment course, treatment of both principal and secondary aspect of disease, and no toxic or side effect. The medicine mainly aims at reducing blood pressure, reducing the damage of target organs such as heart, brain, kidney, eyes and the like, and eliminating risk factors; and has regulating effect on functional metabolism disorder such as blood lipid, blood sugar, blood viscosity, etc. The medicine can timely and moderately reduce blood pressure of patients with hypertension, maintain treatment, improve the general condition of organisms, prevent complications, delay aging and improve the quality of life.

The technical scheme of the invention is realized in the following mode:

a medicine for treating hypertension is an oral medicine prepared by processing or refining a traditional Chinese medicine prescription, and the prescription is as follows: 16 g of gynostemma pentaphylla, 9 g of medlar, 6 g of chrysanthemum, 10 g of fried cassia seed, 8 g of uncaria, 6 g of scutellaria baicalensis and 10 g of salvia miltiorrhiza.

The prescription consists of 7 traditional Chinese medicines according to a proportion, the weight of the traditional Chinese medicines is 65 g, most of the 7 traditional Chinese medicines are exquisite products for delaying senility or being used as both medicine and food, and no toxic or side effect is generated when the traditional Chinese medicines are taken orally.

According to the proportion of the medicines of the formula and the proportion of the medicines, namely the relative dosage, the medicines are processed or refined to prepare film coating tablets, capsules or granules for oral administration.

The prescription is an agent for treating both the incidental and fundamental aspects. Symptoms such as dizziness, headache, amnesia, insomnia, palpitation, short breath, apoplexy and the like caused by hypertension are the symptoms; yin deficiency of liver and kidney, hyperactivity of liver-yang and disharmony of yin and yang are the causes of the disease. Therefore, nourishing yin and suppressing yang, resolving phlegm and lowering fire, and regulating liver and kidney are the therapeutic principles of the disease, and the specific therapeutic method is to moderately lower blood pressure in time and reduce the damage of target organs such as heart, brain, kidney, eyes and the like. In the formula, the gynostemma pentaphylla has the effects of clearing away heat and toxic materials, tonifying qi and soothing the nerves, relieving cough and reducing sputum and delaying aging. The product also has effects in regulating blood pressure and blood sugar, reducing blood lipid, resisting cerebral ischemia and atherosclerosis, and promoting urinary acid excretion. Is the main medicine for treating hypertension. Wolfberry fruit and white chrysanthemum are used as auxiliary main drugs for nourishing yin, reducing fire, calming liver and improving vision, and treating wind, headache and vision, reducing blood pressure and blood fat. Semen Cassiae, ramulus Uncariae cum uncis and Scutellariae radix have effects of suppressing hyperactive liver and subsiding yang, lowering blood pressure and reducing blood lipid, and can be used for treating hypertension. The red sage root can promote blood circulation to disperse blood clots and lower blood pressure. Preventing and treating complications of target organs such as heart, brain, kidney, retina, etc. caused by hypertension.

The invention has the positive effects that:

pure traditional Chinese medicine, low cost, wide source of medicinal materials, mild medicine property, no toxic or side effect, quick blood pressure reduction by oral administration and short treatment course. Most of the 7 traditional Chinese medicines in the formula are fine products for delaying senility or being used as medicine and food, can regulate the immunologic function and enhance the body resistance. Treating the secondary symptoms in case of emergency, calming the liver, suppressing yang hyperactivity, reducing pathogenic fire, and eliminating phlegm; it can treat root cause, nourish liver and kidney, and fill genuine yuan. The invention can reduce the blood pressure of patients with primary hypertension and renal hypertension to an ideal level of less than 135/82 mmHg. The blood pressure is reduced, the whole blood viscosity and the plasma viscosity can be reduced, the platelet aggregation and the thrombosis are inhibited, the microcirculation is improved, the atherosclerosis is resisted, the target organ damage is reversed, the cardiovascular events are reduced, the death rate is reduced, the service life is prolonged, the life quality is improved, and the problem that no specific medicine is used for treating the hypertension and the complications thereof is solved.

The properties and functions of the 7 Chinese medicinal herbs in the prescription are further explained as follows:

gynostemma pentaphylla is bitter and slightly sweet in taste and cool in nature. It enters lung, spleen and kidney meridians. Clear heat and remove toxicity, relieve cough and reduce sputum, benefit qi and tranquilize mind. Gynostemma pentaphylla is a medicine for nourishing and strengthening body and delaying senility, and is mainly used for treating palpitation, shortness of breath, hypertension, hyperlipidemia and other diseases.

Wolfberry fruit, fructus Lycii, sweet in taste and neutral in nature. It enters liver, kidney and lung meridians. Nourishing liver, invigorating kidney, moistening lung, and nourishing yin. Mainly used for treating waist soreness, dizziness, yin deficiency and fever caused by kidney deficiency and essence and blood deficiency for old people, and has the functions of reducing blood fat and blood pressure; reducing blood sugar, etc. Is a Chinese medicine for delaying senility.

Chrysanthemum is bitter, pungent and slightly cold. Disperse wind-heat, calm liver, improve vision, clear heat and remove toxicity. The white chrysanthemum flower has the effects of calming the liver and benefiting yin, and is used for treating headache, dizziness, conjunctival congestion, swelling and pain, hypertension and the like. It is a dual-purpose herb used as both medicine and food.

Cassia seed, semen Cassiae, sweet, bitter and slightly cold. It enters liver and large intestine meridians. Clear liver and improve vision, moisten intestines and relax bowels. It can be used for treating acute conjunctivitis, hypertension, hyperlipidemia, hepatitis, and liver cirrhosis. It is a dual-purpose herb used as both medicine and food.

Dan Shen is bitter and cold. It enters heart and liver meridians. Promoting blood circulation, removing blood stasis, cooling blood, relieving pain, nourishing blood, and tranquilizing mind. Mainly treats irregular menstruation, amenorrhea due to blood stagnation, sore, carbuncle and gall, palpitation, severe palpitation, insomnia and the like, and has certain curative effect on cerebral arteriosclerosis, cerebral arterial thrombosis, cerebral thrombosis, hypertension, coronary heart disease and the like. Salvia miltiorrhiza is a traditional Chinese medicine for delaying senility of old people.

Huang Qin is bitter and cold. It enters lung, heart, liver, gallbladder and large intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity, stop blood and prevent abortion. It can be used for treating damp-warm syndrome, damp-heat syndrome, distention and fullness, hyperpyrexia, polydipsia, hyperlipidemia, and hypertension due to hyperactivity of liver-yang.

Uncaria rhynchophylla is sweet and slightly cold. It enters liver and heart meridians. Clearing heat, calming liver, calming endogenous wind and arresting convulsion. It can be used for treating infantile convulsion, night cry, excessive heat, dizziness due to liver-yang, and headache due to liver fire. Uncaria rhynchophylla is an essential herb for generating wind due to liver heat, because it can extinguish wind and stop spasm, and clear heat from heart and pericardium.

The function and indication of the medicine for treating hypertension according to the present invention will be described below.

[ function ] pacify liver and subdue yang, resolve phlegm and lower fire, extinguish wind and stop convulsion.

The traditional Chinese medicine composition is mainly used for treating patients with hypertension of liver-yang hyperactivity type or yin-deficiency and yang hyperactivity type with symptoms of dizziness, headache, neck rigidity, insomnia, palpitation, tinnitus, constipation, limb numbness and the like.

[ medicinal composition ] 7 Chinese medicinal materials of gynostemma pentaphyllum, red sage and the like.

[ formulation type ] film-coated tablets, capsules or granules.

[ Properties ] this product is brown and fragrant. Slightly bitter and sweet in taste.

[ action class ] this product is an over-the-counter drug for circulatory diseases.

[ dosage by application ] 2-5 g of the crude drug is orally taken three times a day. Or following the medical advice. Two months is a treatment course, and the dosage can be reduced when the blood pressure is reduced to normal; for patients with hypertension and insomnia, 5-8 g can be taken one hour before sleeping.

[ Note ] pregnant women and children are prohibited to take the medicine. It should be used with cautions for patients with deficiency-cold. Patients should stop smoking and drinking wine as much as possible, limit salt and eat little animal fat.

Embodiments of the present invention are clinical applications, and are described as follows:

[ case one ] Qiu somewhere, woman, the age of 42 years old, Shanghai county tower bridgetown, Henan province, who is the mother of the present patent applicant, suffered from essential hypertension for five years, and had a blood pressure of 170-95 mm Hg. And persists. Indapamide is usually orally taken, the blood pressure reducing effect is still good, in 2017, in 4 months, the fact that nothing can be seen in the right eye is suddenly found, the retina is damaged through diagnosis of a doctor, and blindness can be avoided only by performing surgical treatment in Zhengzhou ophthalmology hospitals. During the spring festival of 2018, the western medicines have no obvious blood pressure reducing effect due to the fact that the western medicines are too much eaten, are fat, sweet and thick, cause blood pressure to rise, and cause symptoms such as headache and insomnia, and are orally taken three times a day by 5 g each time. After taking the medicine for two weeks, the blood pressure is normal and stable, and the blood pressure is reduced after the administration of the medicine for two months. No side effect is found during the administration.

[ case 2] Zhao somebody, male, 52 years old, Shancai county tower bridgetown. The blood pressure of the patient with primary hypertension is still higher than 150-90 mm Hg during taking western medicine antihypertensives for 6 years. Meanwhile, the medicine has various diseases such as hyperlipidemia, hyperglycemia, liver disease and the like, and is frequently treated by infusion and hospitalization. The product is taken during the spring festival of 2018, and is taken for more than one year, the blood pressure is stabilized at 110-70 mm Hg, and various complications disappear.