Detection chip and detection device
阅读说明:本技术 检测芯片以及检测装置 (Detection chip and detection device ) 是由 金范埈 高间信行 于 2018-05-25 设计创作,主要内容包括:本发明的检测芯片包括:基板,所述基板具有流入孔、与流入孔连接的微流路以及与微流路连接的反应室;多孔质的微针,所述多孔质的微针由生物降解性材料形成,设置于与流入孔重叠的位置;传感器,所述传感器配置于反应室;以及毛细管泵部,所述毛细管泵部具有小径流路,并且所述毛细管泵部设置于基板并与反应室连接。(The detection chip of the invention comprises: a substrate having an inflow hole, a microchannel connected to the inflow hole, and a reaction chamber connected to the microchannel; a porous microneedle made of a biodegradable material and provided at a position overlapping the inlet hole; a sensor disposed in the reaction chamber; and a capillary pump section having a small-diameter channel, the capillary pump section being provided on the substrate and connected to the reaction chamber.)
1. A detection chip, wherein,
the method comprises the following steps: a substrate having an inflow hole, a microchannel connected to the inflow hole, and a reaction chamber connected to the microchannel;
a porous microneedle made of a biodegradable material and provided at a position overlapping the inflow hole;
a sensor disposed in the reaction chamber; and
and a capillary pump section having a small-diameter channel and provided on the substrate and connected to the reaction chamber.
2. The detection chip according to claim 1,
the microneedle has:
a body formed of the biodegradable material having a plurality of voids; and
a coating covering at least the tip portion of the body and forming a tip portion capable of penetrating the skin.
3. The detection chip according to claim 2,
the coating is formed of a material that dissolves in the skin.
4. The detection chip according to claim 2,
in the body, the size of the pores is 30 to 60 μm, and the porosity is 60 to 80%.
5. The detection chip according to claim 1,
the biodegradable material includes at least one of polylactic acid, polyglycolic acid, and poly (lactide-co-glycolide) copolymer.
6. A detection device, wherein,
the detection chip according to any one of claims 1 to 5.
Technical Field
The present invention relates to a detection chip, and more particularly, to a detection chip having microneedles and a detection device having the detection chip.
This application is based on and claims priority from a provisional application with application number 62/643761 filed in 2018, 3, 16, and the contents of this application are incorporated herein by reference.
Background
In order to manage blood glucose levels, diabetics need to self-test their blood glucose many times a day. A self-measuring blood glucose apparatus currently on the market punctures a capillary vessel such as a finger with a needle and measures blood glucose by bringing blood oozing from a wound into contact with a sensor. Since this self-test blood glucose meter causes pain during measurement, it is a heavy burden for a diabetic who performs measurement frequently.
As a minimally invasive blood collection method without accompanying pain, a blood collection microneedle is known. Generally, the blood sampling microneedle is a hollow microneedle having a length of about 1mm, an outer diameter of 100 to 300 μm and an inner diameter of about 60 to 100 μm, and metals such as nickel and photoresists are proposed as materials.
Disclosure of Invention
Problems to be solved by the invention
The blood sampling microneedles are difficult to manufacture due to their structure and size. In addition, if the strength of the microneedle is insufficient, the microneedle may break off in vivo and remain in the skin.
In addition, it is important to continuously monitor blood glucose in order to more accurately grasp the condition of a diabetic patient, but the blood monitoring system described in
Due to the above circumstances, there currently exists no minimally invasive device that enables a patient to perform continuous blood glucose monitoring on his or her own.
An object of the present invention is to provide a detection chip capable of continuously obtaining blood and performing detection in a minimally invasive manner.
Another object of the present invention is to provide a detection device capable of continuously monitoring a substance in blood in a minimally invasive manner.
Means for solving the problems
A first embodiment of the present invention is a detection chip including: a substrate having an inflow hole, a microchannel connected to the inflow hole, and a reaction chamber connected to the microchannel; a porous microneedle made of a biodegradable material and provided at a position overlapping the inlet hole; a sensor disposed in the reaction chamber; and a capillary pump section having a small-diameter channel, the capillary pump section being provided on the substrate and connected to the reaction chamber.
The second embodiment of the present invention is a detection device having the detection chip of the present invention.
ADVANTAGEOUS EFFECTS OF INVENTION
According to the present invention, blood can be continuously obtained in a minimally invasive manner, and various kinds of detection and monitoring can be performed.
Drawings
Fig. 1 is a perspective view of a detection chip according to an embodiment of the present invention.
Fig. 2 is a plan view schematically showing the substrate of the same detection chip.
Fig. 3 is a sectional view taken along line I-I of fig. 2.
Fig. 4 is a sectional view schematically showing microneedles of the same detection chip.
Fig. 5 is a diagram showing a process of the method for manufacturing the same microneedle.
Fig. 6 is a diagram showing a process of the method for manufacturing the same microneedle.
Fig. 7 is a diagram showing a process of the method for manufacturing the same microneedle.
Fig. 8 is a diagram showing a process of the method for manufacturing the same microneedle.
Fig. 9 is a diagram showing a process of the method for manufacturing the same microneedle.
FIG. 10 is a diagram showing an example of a detection apparatus to which the same detection chip is applied.
Fig. 11 is a view showing the back surface of the same detection device.
Fig. 12 is a block diagram of the same detection device.
Detailed Description
An embodiment of the present invention will be described with reference to fig. 1 to 12.
Fig. 1 is a perspective view showing a
Fig. 2 is a schematic top view of the
Fig. 3 is a sectional view taken along line I-I of fig. 2. A plurality of
The
The
The
The
The specific contents of the
Fig. 4 is a sectional view of the
The
The microneedle 20 has a substantially conical or substantially pyramidal shape, and the diameter or the maximum dimension of the base portion is, for example, about 50 μm to 200 μm. The height of the
The plurality of
The shape of the hollow 21a is not particularly limited. The size of the hollow 21a can be appropriately set in consideration of the composition of the fluid to be collected and the like. For example, when the fluid contains a solid substance and the solid substance interferes with the measurement performed by the
When the
The
The manufacturing sequence of the
First, the water-soluble particles are mixed with the material of the
Next, as shown in fig. 5, the dispenser (dispenser) or the like is filled with the adjusted viscous material, the tip of the dispenser D is brought close to the
Next, when the dispenser D is slowly lifted up and separated from the
Next, the prototype 21p is immersed in water to dissolve the water-soluble particles 23. As shown in fig. 8, when the water-soluble particles 23 are removed, the portions where the water-soluble particles 23 exist become
Finally, when the distal end portion of the
As shown in fig. 9, when the attached coating material is dried, a
The operation when the
When the tip of the microneedle 20 is pressed against the skin of the user, the microneedle penetrates the skin from the tip and entirely enters the skin. Due to the presence of the cured
Since the
The blood entered from the
The blood that has reached the
As described above, according to the
Further, since the
In the
The time that the
In addition, according to the method for manufacturing a microneedle in the present embodiment, after the prototype 21p of the
In the studies of the inventors using pig blood, it was found that a sufficient amount of blood for continuous blood glucose measurement can be obtained by using 15
Further, since the microneedle 20 has the
The
Fig. 10 shows an example of a detection device 100 to which the
Fig. 11 is a diagram showing the back surface of the detection apparatus 100. A
Fig. 12 is a block diagram of the detection apparatus 100. The detection device 100 includes a
As another embodiment, the following structure is also possible: a detachable storage medium is provided in place of the
After the end of the measurement, the user takes out the
In the above, a wristwatch-type detection device worn on the wrist is exemplified, but the form of the detection device is not limited thereto, and the shape and the wearing part of the detection device may not be particularly limited as long as the microneedle 20 can be held on the skin with a constant pressure. For example, a clip-shaped structure used by being clipped to an earlobe, a patch-shaped structure used by having an adhesive portion and being attached to the skin of the abdomen or chest, and the like are also possible.
While the embodiment of the present invention and the examples of the embodiment have been described above, the technical scope of the present invention is not limited to the above-described embodiment, and various modifications, additions, deletions, and combinations of the components may be made without departing from the spirit of the present invention, without departing from the scope of the present invention.
For example, the microneedles in the present invention may be formed by methods other than the above-described methods. For example, the microneedle can be formed at the inlet hole by filling a biodegradable material mixed with water-soluble particles into a mold to which the shape of the body is transferred, bonding the mold to the
In the microneedle of the present invention, the manner of coating can be changed in various ways. In the case where the coating layer is formed of a material that dissolves rapidly in the skin, the coating layer may cover the entire side surface of the main body. In the case where the coating layer covers only the distal end portion of the main body, if the coating layer is formed of a biodegradable material, the coating layer may not necessarily be quickly dissolved in the skin. Further, due to the relationship between the size of the hollow hole and the size of the main body, etc., the coating layer may not be provided as long as the tip portion of the formed main body is ensured to be in a sharp state. That is, in the microneedles of the present invention, a coating is not necessary.
Further, a plurality of sets of intermediate flow paths and reaction chambers may be provided, and different sensors may be arranged. This enables detection of a plurality of items to be continuously performed using one detection chip.
The detection chip of the present invention can be used for obtaining various body fluids that can be obtained subcutaneously, without being limited to blood. For example, since tissue fluid, lymph fluid, or the like can be obtained, the detection chip of the present invention can cope with a very wide range of detection by selecting an appropriate sensor and disposing it in the reaction chamber.
Industrial applicability
The present invention can be applied to a detection chip and a detection device.
Description of the reference numerals
1, detecting a chip;
10 a substrate;
11 an inflow hole;
12 micro flow path;
a 16 capillary pump section;
18 a reaction chamber;
19 a sensor;
20 microneedles;
21a main body;
21a void;
22 coating;
100, detecting the device.
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