阅读说明：本技术 抗菌洁肤露 (Antibacterial skin cleaning lotion ) 是由 杨镒 于 2020-09-11 设计创作，主要内容包括：本发明公开了一种抗菌洁肤露。所述一种抗菌洁肤露,包括下述质量百分比原料：十二烷基硫酸铵1-3％；椰油酰胺丙基甜菜碱2.5-5.5％；椰油酰两性基二乙酸二钠3-5％；十二烷基硫酸钠4-8％；月桂醇聚醚-10 0.5-2.5％；抗菌表面活性剂1.5-6.5％；甘油4.5-8.5％；余量为水。本发明的抗菌洁肤露,有效去除身体污垢,抗菌卫生,并能够持久肌肤清爽。(The invention discloses an antibacterial skin cleansing lotion. The antibacterial skin cleansing lotion comprises the following raw materials in percentage by mass: 1-3% of ammonium dodecyl sulfate; 2.5-5.5% of cocamidopropyl betaine; 3-5% of cocoyl amphodiacetate disodium; 4-8% of sodium dodecyl sulfate; 100.5 to 2.5 percent of laureth; 1.5 to 6.5 percent of antibacterial surfactant; 4.5 to 8.5 percent of glycerin; the balance being water. The antibacterial skin cleaning lotion disclosed by the invention can effectively remove body dirt, is antibacterial and sanitary, and can keep skin fresh and cool for a long time.)

1. The antibacterial skin cleansing lotion is characterized by comprising the following raw materials in percentage by mass:

1-3% of ammonium dodecyl sulfate;

2.5-5.5% of cocamidopropyl betaine;

3-5% of cocoyl amphodiacetate disodium;

4-8% of sodium dodecyl sulfate;

100.5 to 2.5 percent of laureth;

4.5 to 8.5 percent of glycerin;

the balance being water.

2. The antibacterial skin cleansing lotion is characterized by comprising the following raw materials in percentage by mass:

1-3% of ammonium dodecyl sulfate;

2.5-5.5% of cocamidopropyl betaine;

3-5% of cocoyl amphodiacetate disodium;

4-8% of sodium dodecyl sulfate;

100.5 to 2.5 percent of laureth;

1.5 to 6.5 percent of antibacterial surfactant;

4.5 to 8.5 percent of glycerin;

the balance being water.

3. The antibacterial skin cleansing lotion according to claim 2, wherein said antibacterial surfactant is prepared by the following method:

step 1: adding bromo-diethyl maleate, N-dimethyl-3, 5-pyridinediamine and 6-methyl-2-pyridinecarbonyl bromide into a solvent N, N-dimethylformamide at the temperature of 130 ℃ and 160 ℃, reacting for 4-5 hours, cooling, filtering, washing and drying to obtain an intermediate product;

step 2: adding the intermediate product into bromododecane at the temperature of 100 ℃ and 120 ℃, reacting for 3-4 hours, cooling, filtering and drying.

Technical Field

The invention relates to an antibacterial skin cleansing lotion.

Background

The surfactant, which is known as "industrial monosodium glutamate", is widely used in various fields of national economic development due to its functions of washing, wetting or anti-sticking, emulsifying or demulsifying, foaming or defoaming, solubilizing, dispersing, preserving, antistatic, etc. With the rapid development of science and technology and economy, the traditional surfactant cannot meet the production and living needs of people, and the requirement on the surfactant industry is higher and higher.

In the field of daily chemical products, the requirement on antibiosis and bacteriostasis is high, so that the development of an antibacterial surfactant suitable for daily chemical products is a real demand.

The skin cleaning lotion is a daily chemical product for effectively removing body stains, usually has a good stain removal effect, but is not ideal in antibacterial and bacteriostatic properties.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to be realized by the following technical scheme:

the invention discloses an antibacterial skin cleansing lotion which comprises the following raw materials in percentage by mass:

1-3% of ammonium dodecyl sulfate;

2.5-5.5% of cocamidopropyl betaine;

3-5% of cocoyl amphodiacetate disodium;

4-8% of sodium dodecyl sulfate;

100.5 to 2.5 percent of laureth;

4.5 to 8.5 percent of glycerin;

the balance being water.

Adding ammonium lauryl sulfate, cocamidopropyl betaine, disodium cocoyl amphodiacetate, laureth-10 and glycerol into water at 40-50 ℃, stirring and mixing uniformly, and cooling to room temperature to obtain the antibacterial skin cleansing lotion.

Preferably, the antibacterial skin cleansing lotion comprises the following raw materials in percentage by mass:

1-3% of ammonium dodecyl sulfate;

2.5-5.5% of cocamidopropyl betaine;

3-5% of cocoyl amphodiacetate disodium;

4-8% of sodium dodecyl sulfate;

100.5 to 2.5 percent of laureth;

1.5 to 6.5 percent of antibacterial surfactant;

4.5 to 8.5 percent of glycerin;

the balance being water.

Adding ammonium lauryl sulfate, cocamidopropyl betaine, disodium cocoyl amphodiacetate, laureth-10, an antibacterial surfactant and glycerol into water at 40-50 ℃, stirring and mixing uniformly, and cooling to room temperature to obtain the antibacterial skin cleansing lotion.

The ammonium lauryl sulfate, the cocamidopropyl betaine, the disodium cocoyl amphodiacetate and the disodium cocoyl amphodiacetate are surfactants with good decontamination performance and mild performance, so that the skin is cleaned and is not damaged; laureth-10 as an emulsifier imparts a silky but not greasy feel to the product; the glycerin is an excellent humectant with low cost, and the antibacterial performance of the skin cleansing lotion can be further improved by adding the antibacterial surfactant.

Further, the preparation method of the antibacterial surfactant comprises the following steps:

step 1: adding bromo-diethyl maleate and N, N-dimethyl-3, 5-pyridine diamine into a solvent N, N-dimethylformamide at the temperature of 130 ℃ and 160 ℃, reacting for 4-5 hours, cooling, filtering, washing and drying to obtain an intermediate product;

step 2: and adding the intermediate product into bromododecane at the temperature of 100 ℃ and 120 ℃, reacting for 3-4 hours, cooling, filtering, and drying to obtain the antibacterial surfactant.

Preferably, the first and second electrodes are formed of a metal,

in step 1, n-hexane is used for washing.

In the step 1, the mass ratio of the diethyl bromomaleate to the N, N-dimethyl-3, 5-pyridine diamine is (18-28) to (39-66).

In the step 1, the mass ratio of the diethyl bromomaleate to the N, N-dimethylformamide is (4-14): 100.

In the step 2, the mass ratio of bromododecane to the intermediate product is 100: (28-48).

In the invention, diethyl bromomaleate reacts with NN, N-dimethyl-3, 5-pyridine diamine to obtain pyridyl amide compound, and further reacts with bromododecane to obtain pyridine quaternary ammonium salt surfactant, besides, the diethyl bromomaleate, the bromododecane and the N, N-dimethyl-3, 5-pyridine diamine participate in the reaction, and the introduction of dimethylamino groups in the diethyl bromomaleate, the bromododecane and the N, N-dimethyl-3, 5-pyridine diamine further improves the antibacterial and bacteriostatic performance of the surfactant.

Further preferably, a method for preparing an antibacterial surfactant comprises the following steps:

step 1: adding bromo-diethyl maleate, N-dimethyl-3, 5-pyridinediamine and 6-methyl-2-pyridinecarbonyl bromide into a solvent N, N-dimethylformamide at the temperature of 130 ℃ and 160 ℃, reacting for 4-5 hours, cooling, filtering, washing and drying to obtain an intermediate product;

step 2: and adding the intermediate product into bromododecane at the temperature of 100 ℃ and 120 ℃, reacting for 3-4 hours, cooling, filtering, and drying to obtain the antibacterial surfactant.

Preferably, the first and second electrodes are formed of a metal,

in step 1, n-hexane is used for washing.

In the step 1, the mass ratio of the diethyl bromomaleate, the N, N-dimethyl-3, 5-pyridine diamine and the 6-methyl-2-pyridine carbonyl bromide is (18-28): (25-40): (14-26).

In the step 1, the mass ratio of the diethyl bromomaleate to the N, N-dimethylformamide is (4-14): 100.

In the step 2, the mass ratio of bromododecane to the intermediate product is 100: (28-48).

In the invention, the pyridyl amide compound is obtained by reacting diethyl bromomaleate, N-dimethyl-3, 5-pyridinediamine and 6-methyl-2-pyridinecarbonyl bromide, and the antibacterial performance of the subsequent surfactant can be improved by newly introducing the 6-methyl-2-pyridinecarbonyl bromide, probably due to the introduction of bromine.

The antibacterial skin cleaning lotion disclosed by the invention can effectively remove body dirt, is antibacterial and sanitary, and can keep skin fresh and cool for a long time.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a test chart of the antibacterial ratio of the antibacterial cleansing lotion to Escherichia coli.

FIG. 2 is a test chart of the bactericidal rate of antibacterial skin-cleaning Candida albicans.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The invention discloses an antibacterial skin cleansing lotion which comprises the following raw materials in percentage by mass:

1-3% of ammonium dodecyl sulfate;

2.5-5.5% of cocamidopropyl betaine;

3-5% of cocoyl amphodiacetate disodium;

4-8% of sodium dodecyl sulfate;

100.5 to 2.5 percent of laureth;

4.5 to 8.5 percent of glycerin;

the balance being water.

Adding ammonium lauryl sulfate, cocamidopropyl betaine, disodium cocoyl amphodiacetate, laureth-10 and glycerol into water at 40-50 ℃, stirring and mixing uniformly, and cooling to room temperature to obtain the antibacterial skin cleansing lotion.

Preferably, the antibacterial skin cleansing lotion comprises the following raw materials in percentage by mass:

1-3% of ammonium dodecyl sulfate;

2.5-5.5% of cocamidopropyl betaine;

3-5% of cocoyl amphodiacetate disodium;

4-8% of sodium dodecyl sulfate;

100.5 to 2.5 percent of laureth;

1.5 to 6.5 percent of antibacterial surfactant;

4.5 to 8.5 percent of glycerin;

the balance being water.

Adding ammonium lauryl sulfate, cocamidopropyl betaine, disodium cocoyl amphodiacetate, laureth-10, an antibacterial surfactant and glycerol into water at 40-50 ℃, stirring and mixing uniformly, and cooling to room temperature to obtain the antibacterial skin cleansing lotion.

The ammonium lauryl sulfate, the cocamidopropyl betaine, the disodium cocoyl amphodiacetate and the disodium cocoyl amphodiacetate are surfactants with good decontamination performance and mild performance, so that the skin is cleaned and is not damaged; laureth-10 as an emulsifier imparts a silky but not greasy feel to the product; the glycerin is an excellent humectant with low cost, and the antibacterial performance of the skin cleansing lotion can be further improved by adding the antibacterial surfactant.

Name of raw materials	CAS number
		Ammonium dodecyl sulfate	2235-54-3
Cocoamidopropyl betaine	86438-79-1
		Cocoiloyl amphodiacetic acid disodium salt	68650-39-5
Sodium dodecyl sulfate	151-21-3
		Laureth-10	6540-99-4

The invention discloses a preparation method of an antibacterial surfactant, which comprises the following steps:

step 1: adding bromo-diethyl maleate and N, N-dimethyl-3, 5-pyridine diamine into a solvent N, N-dimethylformamide at the temperature of 130 ℃ and 160 ℃, reacting for 4-5 hours, cooling, filtering, washing and drying to obtain an intermediate product;

step 2: and adding the intermediate product into bromododecane at the temperature of 100 ℃ and 120 ℃, reacting for 3-4 hours, cooling, filtering, and drying to obtain the antibacterial surfactant.

Preferably, the first and second electrodes are formed of a metal,

in step 1, n-hexane is used for washing.

In the step 1, the mass ratio of the diethyl bromomaleate to the N, N-dimethyl-3, 5-pyridine diamine is (18-28) to (39-66).

In the step 1, the mass ratio of the diethyl bromomaleate to the N, N-dimethylformamide is (4-14): 100.

In the step 2, the mass ratio of bromododecane to the intermediate product is 100: (28-48).

In the invention, diethyl bromomaleate reacts with N, N-dimethyl-3, 5-pyridinediamine to obtain pyridyl amide compound, and further reacts with bromododecane to obtain pyridine quaternary ammonium salt surfactant, besides, the diethyl bromomaleate, the bromododecane and the N, N-dimethyl-3, 5-pyridinediamine participate in the reaction, and the introduction of the dimethylamino group in the diethyl bromomaleate, the bromododecane and the N, N-dimethyl-3, 5-pyridinediamine further improves the antibacterial and bacteriostatic performance of the surfactant.

Further preferably, a method for preparing an antibacterial surfactant comprises the following steps:

step 1: adding bromo-diethyl maleate, N-dimethyl-3, 5-pyridinediamine and 6-methyl-2-pyridinecarbonyl bromide into a solvent N, N-dimethylformamide at the temperature of 130 ℃ and 160 ℃, reacting for 4-5 hours, cooling, filtering, washing and drying to obtain an intermediate product;

step 2: and adding the intermediate product into bromododecane at the temperature of 100 ℃ and 120 ℃, reacting for 3-4 hours, cooling, filtering, and drying to obtain the antibacterial surfactant.

Preferably, the first and second electrodes are formed of a metal,

in step 1, n-hexane is used for washing.

In the step 1, the mass ratio of the diethyl bromomaleate, the N, N-dimethyl-3, 5-pyridine diamine and the 6-methyl-2-pyridine carbonyl bromide is (18-28): (25-40): (14-26).

In the step 1, the mass ratio of the diethyl bromomaleate to the N, N-dimethylformamide is (4-14): 100.

In the step 2, the mass ratio of bromododecane to the intermediate product is 100: (28-48).

In the invention, the pyridyl amide compound is obtained by reacting diethyl bromomaleate, N-dimethyl-3, 5-pyridinediamine and 6-methyl-2-pyridinecarbonyl bromide, and the new introduction of the 6-methyl-2-pyridinecarbonyl bromide can improve the antibacterial performance of the subsequent surfactant, possibly due to the introduction of bromine.

The pyridine amide quaternary ammonium salt surfactant is prepared by carrying out amidation reaction on diethyl bromomaleate and N, N-dimethyl-3, 5-pyridine diamine to obtain a pyridine amide compound, and adding 6-methyl-2-pyridine carbonyl bromide on the basis of the substances, and introducing bromine to further improve the antibacterial and bacteriostatic properties of the surfactant. And bromododecane is added to obtain the pyridine amide biquaternary ammonium salt surfactant, so that molecules can be easily adsorbed and extend into bacteria, and the bacteria die. The possible reasons for this are one: the molecular structure of the pyridine amide biquaternary ammonium salt surfactant of the invention introduces amide group and ester group, and also introduces bromine element, dimethyl amino group and biquaternary ammonium saltThe structure ensures that the surfactant has good antibacterial and mildewproof performance in the using process. II, secondly: the pyridine amide quaternary ammonium salt surfactant contains three N with positive charges in the molecule⁺The positive charge density on the nitrogen atoms in the molecules is increased through induction, which is more beneficial to the adsorption of the bactericide molecules on the surface of bacteria, increases the permeability of cell walls and enables the bacteria bodies to be cracked; meanwhile, the zigzag long-chain alkyl structure can wrap bacteria and puncture the inside of a cell body, so that bacterial cytoplasm leaks, and the antibacterial performance is further enhanced. And the pyridine quaternary ammonium salt has good surface activity, can be highly gathered on the surface of thalli, and influences the metabolism of bacteria. The antibacterial surfactant has complementary advantages, is synergistic, and effectively improves antibacterial property.