阅读说明：本技术 一种用于防治非酒精性脂肪肝的健康食品及其制备方法 (Health food for preventing and treating non-alcoholic fatty liver disease and preparation method thereof ) 是由 刘庆 于 2020-07-06 设计创作，主要内容包括：本发明涉及保健食品领域,具体而言,涉及一种用于防治非酒精性脂肪肝的健康食品及其制备方法。所述食品按重量份计,主要由以下原料制成：红藜麦40～60份、蓝莓6～10份、葡萄8～15份、绿豆5～8份、蒲公英5～8份、菠菜5～8份以及水飞蓟油3-5份,其可在一定程度上防治非酒精性脂肪肝。(The invention relates to the field of health-care food, in particular to health-care food for preventing and treating non-alcoholic fatty liver and a preparation method thereof. The food is mainly prepared from the following raw materials in parts by weight: 40-60 parts of quinoa, 6-10 parts of blueberries, 8-15 parts of grapes, 5-8 parts of mung beans, 5-8 parts of dandelion, 5-8 parts of spinach and 3-5 parts of silybum marianum oil, and the composition can be used for preventing and treating non-alcoholic fatty liver to a certain extent.)

1. A health food for preventing and treating non-alcoholic fatty liver disease is characterized by being mainly prepared from the following raw materials in parts by weight: 40-60 parts of quinoa, 6-10 parts of blueberries, 8-15 parts of grapes, 5-8 parts of mung beans, 5-8 parts of dandelion, 5-8 parts of spinach and 3-5 parts of silybum marianum oil.

2. The food product according to claim 1, wherein the food product is made from the following raw materials in parts by weight: 45-60 parts of quinoa, 7-9 parts of blueberries, 10-12 parts of grapes, 6-7 parts of mung beans, 6-7 parts of dandelion, 6-7 parts of spinach and 3-5 parts of silybum marianum oil.

3. The food product according to claim 1 or 2, wherein the particle size of each raw material in the food product is less than 198 μm, preferably less than 165 μm.

4. The food according to claim 1 or 2, wherein the food is in the form of powder, capsule, tablet, granule, oral liquid, powder, and teabag.

5. The food product of claim 4, wherein the food product is in the form of a powder or tablet.

6. The food product according to claim 1 or 2, further comprising adjuvants and/or additives.

7. The food according to claim 6, wherein the auxiliary materials and/or additives account for 0.1-6% by mass of the food.

8. The food product of claim 6, wherein the excipient comprises a dietary and/or pharmaceutical excipient.

9. The food product of claim 6, wherein the additives comprise one or more of diluents, suspending agents, antioxidants, emulsifiers, disintegrants, binders and preservatives.

10. The method for preparing a health food for the prevention and treatment of nonalcoholic fatty liver disease according to any one of claims 1 to 9, comprising: pulverizing the above materials, and mixing.

Technical Field

The invention relates to the field of health-care food, in particular to health-care food for preventing and treating non-alcoholic fatty liver and a preparation method thereof.

Background

Fatty liver (fatty liver) refers to a pathological condition of fat accumulation in liver cells caused by various reasons, and is a common pathological change of liver rather than an independent disease. Fatty liver disease seriously threatens the health of people in China, is the second most serious liver disease of viral hepatitis, has continuously increased incidence rate and is younger in attack age.

The nonalcoholic fatty liver refers to a clinical pathological syndrome which is mainly characterized by fat excessive deposition in liver cells caused by excrements and other definite liver damage factors, and acquired metabolic stress liver injury closely related to insulin resistance and genetic susceptibility. The health risks to humans from non-alcoholic fatty liver disease will continue to increase, and treatment of non-alcoholic fatty liver disease typically requires weight and diet control in combination with some drug treatment.

However, on the one hand, both traditional Chinese medicine and western medicine need to be metabolized by the liver, and the decomposition products are discharged out of the body, which may cause secondary burden or damage to the liver. On the other hand, some drugs are hepatotoxic by themselves. Therefore, it is very promising to develop a functional food having a protective effect on the liver.

In view of the above, the present invention is particularly proposed.

Disclosure of Invention

The first purpose of the present invention is to provide a health food for preventing and treating non-alcoholic fatty liver disease, which can protect the metabolic disease liver to some extent.

The second purpose of the invention is to provide a preparation method of the health food for preventing and treating the non-alcoholic fatty liver, which is simple and convenient to operate.

In order to achieve the above purpose of the present invention, the following technical solutions are adopted:

a health food for preventing and treating non-alcoholic fatty liver disease is mainly prepared from the following raw materials in parts by weight: 40-60 parts of red quinoa, 6-10 parts of blueberries, 8-15 parts of grapes, 5-8 parts of mung beans, 5-8 parts of spinach, 5-8 parts of dandelion, 5-8 parts of spinach and 3-5 parts of silybum marianum oil.

The preparation method of the health food for preventing and treating the non-alcoholic fatty liver disease comprises the following steps: mixing the raw materials.

Compared with the prior art, the invention has the beneficial effects that:

the health food is rich in rutin which has a protective effect on the liver and antioxidant and anti-inflammatory substances, and plays an important role in preventing and treating metabolic diseases. Especially has better repairing function to fatty liver caused by high fat diet or metabolic diseases.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a photograph showing immunohistochemical staining of mouse liver tissue in an experimental example of the present invention: a normal group; b, model group; group C examples.

Detailed Description

A health food for preventing and treating non-alcoholic fatty liver disease is mainly prepared from the following raw materials in parts by weight: 40-60 parts of quinoa, 6-10 parts of blueberries, 8-15 parts of grapes, 5-8 parts of mung beans, 5-8 parts of dandelion, 5-8 parts of spinach and 3-5 parts of silybum marianum oil.

Quinoa (Chenopodium quinoa), amaranthaceae Chenopodium dicotyledonous pseudocereals, annual herbaceous plants, broom-shaped plants with plant height of 0.6-3 m, panicle-shaped inflorescence, flower amphipathy and self-pollination. Chenopodium quinoa is the only single plant which can meet the basic nutritional requirements of human bodies and is confirmed by the international food and agriculture organization of the United nations, is formally recommended to be perfect 'full-nutrition food' most suitable for human beings and has the reputation of 'super grain'.

The red quinoa has the highest content of free phenol and free flavone, can reduce blood plasma and liver cholesterol after being ingested, and reduce obesity-related inflammation, and the red quinoa bran has higher rutin content. Rutin (vitamin P) is one of flavonoid compounds, and is a main bioactive component of red chenopodium quinoa. Rutin has antiinflammatory, antioxidant, and antitumor effects, and can protect liver. The red quinoa also contains flavonoid compounds such as betanin, quercetin and the like, and the compounds are proved to have antioxidant and anti-inflammatory effects. The quinoa and its bran extract can increase superoxide dismutase (SOD) activity, Catalase (CAT) activity and glutathione level. In animal models, rutin enhances the antioxidant defense system and resists oxidative stress of the liver.

Blueberries, also known as blueberries, belong to the plant genus Vaccinium of the Ericaceae family, contain rich nutritional ingredients, and the fruits are round blue berries, fine and smooth in pulp, moderate in sweetness and sourness, and have the reputation of "the king of berries". The fruit contains sugar, acid, vitamins and mineral elements, and also contains abundant anthocyanin, SOD, ursolic acid and other special nutrient components which are rarely contained in other fruits.

Grapes belong to fruits of grapes in the family of the Vitaceae, are deciduous vines, have high nutritional value, and grape juice is known as 'plant milk' by scientists.

Mung beans, also called as planting beans, belong to the genus cowpea in the subfamily Clitoria in Leguminosae, are native areas in China, have a long planting history, are produced in most areas in China, have rich yield and excellent varieties, and are one of the traditional crops in China. The mung bean contains globulin and polysaccharide, and can promote cholesterol in vivo to decompose into cholic acid in liver, accelerate secretion of bile salt, and reduce cholesterol absorption by small intestine.

Herba Taraxaci (Taraxacum mongolicum) is perennial herb of Compositae, is sweet and neutral, and has no toxicity. The dandelion herb contains various nutrients such as dandelion sterol, choline, organic acid, inulin, vitamin C, vitamin D, carotene and the like, and also contains rich trace elements, wherein the most important thing is that the dandelion herb contains a large amount of minerals such as iron, calcium and the like required by a human body, and is a key medicine for entering the liver, entering the stomach, clearing heat and cooling blood.

Spinach (Spinacia oleracea L.) belongs to an annual herbaceous plant of the genus spinach of the family chenopodiaceae, also called persicaria, red root vegetables, parrot vegetables and the like, spinach is rich in a plurality of nutrients such as carotenoid, vitamin C, vitamin K, mineral substances (calcium, iron and the like), spinach belongs to a plant with homology of medicine and food, which is recorded in food therapy materia early, spinach can promote five internal organs, relieve gastrointestinal heat and relieve alcoholism, and is evaluated as one of ten major foods in the world beneficial to human bodies by American Times magazine. Researches show that a plurality of secondary metabolites in spinach, such as flavonoids, phenols, steroids and the like, have various biological activities; spinach contains a small amount of chemical components such as alkaloid, saponin, saccharide, etc. Related pharmacological research shows that the spinach extract has good effects in the aspects of oxidation resistance, tumor resistance, inflammation resistance, hyperlipidemia resistance, blood sugar reduction and the like.

Silybum marianum is a herbal medicine, has been used for thousands of years to protect the liver, and the Silybum marianum seed oil is obtained by pressing from Silybum marianum seeds which are used as both medicine and food, and contains the active ingredient of the parent Silybum marianum, namely silymarin flavonoid. The original ecological silybum marianum seed oil is one of the best seed oils recognized in the world, contains various unsaturated fatty acids such as linoleic acid, oleic acid, linolenic acid and the like, is rich in various vitamins and minerals, particularly vitamin E, zinc and selenium, and is special healthy edible oil with health care effect. The silybum marianum oil also contains sterol components such as P-sitosterol, stigmasterol, etc., and has obvious effect of resisting hepatotoxicity and preventing liver diseases.

In some embodiments, the raw materials of the food may further comprise, in parts by weight:

42 parts of red quinoa, 10 parts of blueberry, 9 parts of grape, 6 parts of mung bean, 7 parts of dandelion, 8 parts of spinach and 4 parts of silybum marianum oil;

50 parts of red quinoa, 9 parts of blueberries, 13 parts of grapes, 7 parts of mung beans, 5 parts of dandelions, 7 parts of spinach and 3 parts of silybum marianum oil;

55 parts of red quinoa, 10 parts of blueberries, 12 parts of grapes, 5 parts of mung beans, 6 parts of dandelions, 6 parts of spinach and 5 parts of silybum marianum oil;

45 parts of red quinoa, 8 parts of blueberry, 8 parts of grape, 8 parts of mung bean, 8 parts of dandelion, 8 parts of spinach and 4 parts of silybum marianum oil;

48 parts of red quinoa, 8 parts of blueberry, 10 parts of grape, 7 parts of mung bean, 6 parts of dandelion, 8 parts of spinach and 5 parts of silybum marianum oil (within the range, the results are basically consistent).

In some embodiments, the food product is made from the following raw materials, by weight: 45-60 parts of quinoa, 7-9 parts of blueberries, 10-12 parts of grapes, 6-7 parts of mung beans, 6-7 parts of dandelion, 6-7 parts of spinach and 3-5 parts of silybum marianum oil.

In some embodiments, the raw materials of the food may further comprise, in parts by weight:

46 parts of red quinoa, 8 parts of blueberry, 10 parts of grape, 6 parts of mung bean, 7 parts of dandelion, 6 parts of spinach and 4 parts of silybum marianum oil;

48 parts of red quinoa, 7 parts of blueberries, 12 parts of grapes, 7 parts of mung beans, 6 parts of dandelions, 7 parts of spinach and 5 parts of silybum marianum oil;

52 parts of red quinoa, 9 parts of blueberry, 11 parts of grape, 6.5 parts of mung bean, 6.5 parts of dandelion, 6 parts of spinach and 3 parts of silybum marianum oil;

60 parts of red quinoa, 9 parts of blueberry, 12 parts of grape, 7 parts of mung bean, 6.5 parts of dandelion, 6.5 parts of spinach, 5 parts of silybum marianum oil and the like (within the range, the results are basically consistent).

In some embodiments, the particle size of each raw material in the food product is less than 198 μm.

In some embodiments, the particle size of each raw material in the food product is less than 165 μm.

In some embodiments, the food product is in a dosage form selected from the group consisting of a powder, a capsule, a tablet, a granule, an oral liquid, a powder, and a teabag.

In some embodiments, the food product is in the form of a powder or tablet.

In some embodiments, the tablet comprises a biscuit, a lozenge, or the like.

In some embodiments, the food product further comprises adjuvants and/or additives.

In some embodiments, the auxiliary materials and/or additives account for 0.1-6% of the food by mass.

In some embodiments, the mass percent can also be 0.5%, 1%, 2%, 5%, 6%, etc. (results are substantially consistent within this range).

In some embodiments, the excipient comprises a dietary and/or pharmaceutical excipient.

In some embodiments, the additive comprises one or more of a diluent, a suspending agent, an antioxidant, an emulsifier, a disintegrant, an adhesive, and a preservative.

Another object of the present invention is to provide a method for preparing the health food for preventing and treating non-alcoholic fatty liver disease, comprising: pulverizing the above materials, and mixing.

In some embodiments, the food product includes adjuvants and/or additives, which are mixed with the raw materials.

In some embodiments, the mixed powder of the present invention can be made into food or health food, and based on the above components, can be made into capsule, tablet, granule, oral liquid, powder, tea bag, etc. directly or by adding proper edible or medicinal adjuvants. The edible or medicinal auxiliary materials which can be added comprise: diluent, suspending agent, antioxidant, emulsifier, disintegrant, adhesive and preservative.

The diluent comprises one or more of vegetable oil, polyethylene glycol 6000 with molecular weight of 200-.

The antioxidant comprises one or more of dibutyl hydroxy toluene (BHT), tert-butyl p-hydroxy anisol (BHA), propyl gallate, tert-butyl hydroquinone (TBHQ), malic acid, glutathione, D-xylose, glycine, alpha-tocopherol, alpha-tocopheryl acetate, sodium sulfite, inositol, ascorbic acid, phytic acid, sodium ascorbate, lecithin, hydroquinone, xylitol, succinic acid, and tea polyphenols.

The suspending agent comprises one or more of Cera flava, xanthan gum, acacia, casein, methylcellulose, carboxymethylcellulose sodium, carbomer, polyvinyl alcohol, hydroxyethyl cellulose, sodium alginate, chitin, chitose, hydroxypropyl methylcellulose, ethyl cellulose, agar, hydroxyethyl methylcellulose, and hydroxypropyl cellulose.

The emulsifier comprises one or more of ethyl hydroxyethyl cellulose, methyl cellulose, glyceryl monostearate, hydroxylated lecithin, acetylated monoglyceride, trihydroxymethane, casein, ethylene glycol monostearate, diacetyl monoglyceride, acetic acid fatty glyceride, xylitol anhydride monooleate, and propylene glycol alginate.

The binder includes Methylcellulose (MC), polyvinylpyrrolidone (PVP), Hydroxypropylcellulose (HPC), Hydroxypropylmethylcellulose (HPMC), polyvinyl alcohol (PVA), Cellulose Acetate Phthalate (CAP), povidone K30, Ethylcellulose (EC), microcrystalline cellulose (CC), acrylic resin, peach gum, maltitol, poloxamer; one or more of sodium alginate, liquid glucose, invert sugar and sucrose monolaurate.

The disintegrating agent comprises one or more of colloidal silicon dioxide, magnesium aluminum silicate, magnesium stearate, pregelatinized starch and croscarmellose sodium.

The antiseptic comprises one or more of sorbic acid, sodium methyl p-hydroxybenzoate, benzoic acid, methyl sorbate, methyl p-hydroxybenzoate, phenyl p-hydroxybenzoate, calcium butyl p-hydroxybenzoate, oleum Caryophylli, benzyl alcohol, and sodium propyl p-hydroxybenzoate.

The skilled in the art can select appropriate above adjuvants according to the required preparation form and the common technical common knowledge and requirements of the preparation form in the field, on the basis of the above components, the raw material powder or extract is directly or added with appropriate edible or medicinal adjuvants, and the preparation can be made according to the conventional preparation technology, and can be made into capsule, tablet, granule, oral liquid, powder, teabag, etc.

In some embodiments, the food product of the invention is consumed in an amount of from 75 to 150g per day, based on the weight of the starting material.

In some embodiments, the amount consumed may also be 80g, 90g, 100g, 110g, 120g, 140g, etc. (with substantially uniform results within this range).

The invention also relates to a method for preventing and treating the non-alcoholic fatty liver disease, which comprises the step of administering an effective dose of the health food to an individual.

In some embodiments, the subject is an animal.

In some embodiments, the subject is a primate.

In some embodiments, the individual is a human.

In some embodiments, the individual also has diabetes.

In some embodiments, the subject is an obese subject.

Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.