阅读说明：本技术 一种螯合型聚维酮碘溶液及其制备方法 (Chelated povidone iodine solution and preparation method thereof ) 是由 胡进成 杨军 王芝丽 邹同高 于 2020-07-10 设计创作，主要内容包括：本发明公开了一种螯合型聚维酮碘溶液及其制备方法,属于兽药消毒液领域。包括碘粉0.1-10份、改性聚乙烯吡咯烷酮0.1-10份、增效剂0.5-3份；酸性电位水10-30份,稳定剂0.1-0.5份。本发明能够负载上的碘就更多,提高了碘的含量,有效碘含量增加,杀菌效果好,杀菌效果更加稳定,延长保质期,提高了整个溶液的安全性,降低了对动物的刺激,且对皮肤、粘膜都损伤小。(The invention discloses a chelating povidone iodine solution and a preparation method thereof, belonging to the field of veterinary disinfectant. Comprises 0.1 to 10 portions of iodine powder, 0.1 to 10 portions of modified polyvinylpyrrolidone and 0.5 to 3 portions of synergist; 10-30 parts of acid potential water and 0.1-0.5 part of stabilizer. The iodine-enriched biological sterilization solution can be loaded with more iodine, improves the iodine content, increases the effective iodine content, has good sterilization effect and more stable sterilization effect, prolongs the shelf life, improves the safety of the whole solution, reduces the stimulation to animals, and has little damage to the skin and mucous membranes.)

1. The chelating povidone-iodine solution is characterized in that: the paint comprises the following components in parts by weight: 0.1-10 parts of iodine powder, 0.1-10 parts of modified polyvinylpyrrolidone and 0.5-3 parts of synergist; 10-30 parts of acid potential water and 0.1-0.5 part of stabilizer.

The synergist is potassium iodide and potassium iodate;

the stabilizer is sodium chloride.

2. The chelated povidone-iodine solution of claim 1, wherein: comprises the following components in percentage by weight: 5-10 parts of iodine powder, 5-10 parts of modified polyvinylpyrrolidone and 0.5-1 part of synergist; 20-30 parts of acid potential water and 0.1-0.2 part of stabilizer.

3. The chelated povidone-iodine solution of claim 1, wherein: comprises the following components in percentage by weight: 5-10 parts of iodine powder, 5-10 parts of modified polyvinylpyrrolidone and 0.8-1 part of synergist; 25 parts of acid potential water and 0.15 part of stabilizer.

4. The chelated povidone-iodine solution of any one of claims 1-3, wherein: the preparation method of the modified polyvinylpyrrolidone comprises the following steps:

(1) mixing magnetic mesoporous silica and chitosan at 60-80%; obtaining a carrier;

(2) reacting polyvinylpyrrolidone with a carrier at the temperature of 180-200 ℃ for 24h to obtain the modified polyvinylpyrrolidone.

5. The chelated povidone-iodine solution of claim 4, wherein: the preparation method of the modified polyvinylpyrrolidone comprises the following steps of (1) mixing the magnetic mesoporous silica carrier and the chitosan according to a ratio of 1: (5-10).

6. The chelated povidone-iodine solution of claim 4, wherein: in the preparation method of the modified polyvinylpyrrolidone, in the step (2), the weight ratio of the polyvinylpyrrolidone to the carrier is (1-3) to 1.

7. The process for the preparation of a solution of chelated povidone-iodine as claimed in any of claims 1 to 3, wherein: the weight ratio of potassium iodide to potassium iodate in the synergist is 2: 3.

8. A method of preparing a chelated povidone-iodine solution as defined in claim 1, wherein: the method comprises the following steps:

s1: under the condition of 60-90 ℃, iodine powder, modified polyvinylpyrrolidone and synergist are fully mixed, and then acid potential water is added to obtain a mixed solution;

s2: adding deionized water into the mixed solution for constant volume, adding stabilizer, mixing, and adjusting pH to 4.5-5.0 with pH regulator to obtain chelated povidone-iodine solution.

9. The method of preparing a chelated povidone-iodine solution as claimed in claim 8, wherein: in step S2, the pH adjusting agent is sodium bicarbonate or sodium carbonate.

Technical Field

The invention relates to the field of veterinary disinfectant, and in particular relates to a chelating povidone-iodine solution and a preparation method thereof.

Background

Povidone iodine (Povidone iodine), also known as Povidone iodine, is a loose complex of elemental iodine and a polymeric carrier, which has a carrier and solubilizing effects. Amorphous powders with a yellowish brown to reddish brown color at room temperature. Slightly smelly, easily soluble in water or ethanol, the aqueous solution is acidic, and insoluble in diethyl ether, chloroform, acetone, ethane and carbon tetrachloride. The povidone iodine aqueous solution has no defects of iodine tincture, light coloring, easy elution, small irritation to mucous membrane, no need of ethanol for deiodination, no corrosive action and low toxicity. Can be used for treating suppurative dermatitis, dermatophyte infection, small-area mild burn and scald, and also for disinfecting small-area skin and mucous membrane wound.

Povidone iodine is a high-efficiency low-toxicity disinfectant, has good killing effect on bacteria, spores, viruses and fungi, and particularly has good killing effect on viruses and bacterial propagules. Under the concentration of 15ppm, the compound can kill propagules of various bacteria within 1 minute, takes longer time for killing tubercle bacillus, 1.5 hours for killing fungi and longer time for spore. The product has strong bactericidal effect under acidic condition, and weak bactericidal effect under alkaline condition. The excessive organic matters can weaken and even disappear the sterilization effect of the povidone iodine. Therefore, the sterilizing agent is very suitable for drinking water sterilization of chickens, ducks and geese, pig sterilization in pigsties, environmental sterilization, aquaculture and the like. However, the general povidone iodine has weak stability and low safety, can easily cause over-excitation reaction in the aspect of cultivation, reduces the safety of animals, damages the skin and the mucous membrane of the animals, and easily causes drug resistance of flora.

Disclosure of Invention

In order to solve the problems, the invention provides a chelated povidone-iodine solution which is stable in sterilization effect and high in safety.

The invention also provides a preparation method of the chelating povidone-iodine solution.

In order to achieve the purpose, the invention is realized by the following technical scheme:

the chelated povidone-iodine solution comprises the following components in parts by weight: 0.1-10 parts of iodine powder, 0.1-10 parts of modified polyvinylpyrrolidone and 0.5-3 parts of synergist; 10-30 parts of acid potential water and 0.1-0.5 part of stabilizer.

The synergist is potassium iodide and potassium iodate;

the stabilizer is sodium chloride.

Preferably, the chelated povidone-iodine solution comprises the following components in percentage by weight: 5-10 parts of iodine powder, 5-10 parts of modified polyvinylpyrrolidone and 0.5-1 part of synergist; 20-30 parts of acid potential water and 0.1-0.2 part of stabilizer.

Preferably, the chelated povidone-iodine solution comprises the following components in percentage by weight: 5-10 parts of iodine powder, 5-10 parts of modified polyvinylpyrrolidone and 0.8-1 part of synergist; 25 parts of acid potential water and 0.15 part of stabilizer.

Further, the preparation method of the modified polyvinylpyrrolidone comprises the following steps:

(1) mixing magnetic mesoporous silica and chitosan; obtaining a carrier;

(2) reacting polyvinylpyrrolidone with a carrier at the temperature of 180-200 ℃ for 24h, removing and drying to obtain the modified polyvinylpyrrolidone.

Further, in the preparation method of the modified polyvinylpyrrolidone, in the step (1), the ratio of the magnetic mesoporous silica carrier to the chitosan is 1: (5-10).

Preferably, in the step (1) of the preparation method of the modified polyvinylpyrrolidone, the ratio of the magnetic mesoporous silica carrier to the chitosan is 1: 8.

further, in the step (2) of the preparation method of the modified polyvinylpyrrolidone, the weight ratio of the polyvinylpyrrolidone to the carrier is (1-3): 1.

Preferably, the weight ratio of the polyvinylpyrrolidone to the carrier in step (2) of the preparation method of the modified polyvinylpyrrolidone is 3: 1.

Further, the weight ratio of potassium iodide to potassium iodate in the synergist is 2: 3.

The preparation method of the chelated povidone-iodine solution comprises the following steps:

s1: under the condition of 60-90 ℃, iodine powder, modified polyvinylpyrrolidone and synergist are fully mixed, and then acid potential water is added to obtain a mixed solution;

s2: adding deionized water into the mixed solution for constant volume, adding stabilizer, mixing, and adjusting pH to 4.5-5.0 with pH regulator to obtain chelated povidone-iodine solution.

Further, in step S2, the pH adjusting agent is sodium bicarbonate or sodium carbonate.

The chelating povidone-iodine solution and the preparation method thereof have the beneficial effects that:

(1) the polyvinylpyrrolidone adopted in the invention is modified polyvinylpyrrolidone, the magnetic mesoporous silica is used as a carrier, and the polyvinylpyrrolidone and chitosan are subjected to grafting and polymerization reaction on the carrier, so that more amino groups are obtained and exposed, more iodine can be loaded, the iodine content is improved, the effective iodine content is increased, and the sterilization effect is good.

(2) Through the graft crosslinking of polyvinylpyrrolidone and chitosan, the energy of the obtained macromolecular molecular bond is higher, the macromolecular molecular bond is not easy to replace again after iodine is loaded, and the sterilization effect is more stable.

(3) The invention also adds acidic potential water which has high-efficiency sterilization effect and is not usually used for long-acting sterilization liquid because of instability, but a small amount of sodium chloride is added as a stabilizer in the invention, so that the stability of the acidic potential water can be improved, and the shelf life can be prolonged.

(4) The povidone iodine is obtained by mixing the modified polyvinylpyrrolidone and the iodine powder, and the addition of the potassium iodide and the potassium iodate can improve the content of effective iodine, stabilize iodine molecules in the povidone iodine and improve the stability of a povidone iodine solution. Simultaneously, the disinfectant is mixed with the acidic potential water, and the two materials have synergistic effect, so that the disinfectant has double effects and improves the disinfectant effect. The acidic potential water is adopted for fusion, so that the safety of the whole solution is improved, the stimulation to animals is reduced, and the damage to the skin and the mucosa is small.

Detailed Description

The present invention will be described in further detail with reference to the following examples.