阅读说明：本技术 一种视觉反应与认知关系的监测方法 (Method for monitoring visual response and cognitive relationship ) 是由 谢琦 陈惠娴 吴军 杜磊 谭智霖 廖炎辉 于 2020-05-12 设计创作，主要内容包括：本发明属于生物医学工程的技术领域,具体涉及一种视觉反应与认知关系的监测方法,包括如下步骤,将身体健康的被试者带入磁共振检查室,并让其佩戴MR专业视力校准镜框及镜片,平躺于检查床,进行阅读任务的任务态功能磁共振扫描以及数据采集；所述阅读任务包括BLOCK实验设计；所述阅读任务采用BLOCK实验设计,运行程序,身体健康的被试者先后在裸眼视力和矫正视力下进行阅读任务的功能磁共振检查；利用任务态功能磁共振成像,设计BLOCK实验范式,来监测人脑在不同视觉效果下的反应,可以反映身体健康的被试者在不同的阅读任务时的大脑功能脑区激活水平的变化。(The invention belongs to the technical field of biomedical engineering, and particularly relates to a method for monitoring visual response and cognitive relationship, which comprises the following steps of taking a healthy subject into a magnetic resonance examination room, enabling the subject to wear an MR professional vision calibration mirror frame and lenses, lying on an examination bed, and performing task state functional magnetic resonance scanning and data acquisition of a reading task; the reading task comprises BLOCK experimental design; the reading task adopts BLOCK experimental design and runs a program, and a healthy subject performs functional magnetic resonance examination of the reading task under naked eye vision and corrected vision in sequence; by utilizing task state functional magnetic resonance imaging and designing a BLOCK experimental paradigm, the reaction of the human brain under different visual effects is monitored, and the change of the brain functional brain area activation level of a healthy human subject in different reading tasks can be reflected.)

1. A method for monitoring visual response and cognitive relationship, comprising the steps of: taking a healthy subject into a magnetic resonance examination room, wearing an MR professional vision calibration spectacle frame and lenses, lying on an examination bed, and performing task state functional magnetic resonance scanning and data acquisition of a reading task;

the reading task includes BLOCK experimental design.

2. The method for monitoring visual response and cognitive relationship of claim 1, wherein the scan sequence and parameters of magnetic resonance comprise: a) whole brain T1 weighted vector high resolution structural image scan parameters: TR 1900.0ms, TE2.21 ms, layer thickness 1.00 mm, layer spacing 0.5 mm, matrix 256 × 256, FOV 256 × 256 mm, flip angle 9 °; b) function like EPI _ BOLD scan parameter: TR 2000 ms, TE 30.0 ms, layer thickness 3.6 mm, layer spacing 0.65 mm, FOV 230X 230 mm, flip angle 90 °, measurements 96.

3. The method of claim 1, wherein the reading task comprises a BLOCK design, the BLOCK design comprising cycling 1 task condition 3 times, one task condition comprising reading and resting for a total of 6 BLOCKs.

4. The method for monitoring visual response and cognitive relationship as claimed in claim 1, wherein said BLOCK experiment design, running its program, the healthy subject performs functional magnetic resonance examination of reading task under naked eye vision and corrected vision sequentially.

5. The method as claimed in claim 4, wherein the reading task is performed by fixing a display screen at a far end of the examining table, placing a special coil reflector above the eyes of the head coil, adjusting the angle by the healthy examinee himself, then allowing the healthy examinee to watch the screen carefully, resting when the "+" sign appears in the center of the screen, and reading at normal speed when the text appears on the screen.

Technical Field

The invention belongs to the technical field of biomedical engineering, and particularly relates to a method for monitoring a visual response and cognition relationship.

Background

Functional magnetic resonance imaging is an emerging neuroimaging modality, and the principle thereof is to perform imaging by utilizing the hemodynamic changes in local cerebral blood flow caused by nerve cell activity. It is currently mainly used in the study of human and animal brains. The functional magnetic resonance imaging comprises resting state functional magnetic resonance imaging and task state functional magnetic resonance imaging, the resting state functional magnetic resonance imaging is mainly used for detecting brain spontaneous activity in a resting state of a person, and the task state functional magnetic resonance imaging can detect the functions and activities of different brain areas of the brain according to different tasks.

Disclosure of Invention

In order to overcome the problems in the prior art, the invention aims to provide a method for monitoring the relationship between visual response and cognition, which utilizes the relationship between visual response and cognition monitored by task-state functional magnetic resonance imaging visualization to effectively observe the change of a human cerebral cortex functional area generated by the visual response.

The technical content of the invention is as follows:

the invention provides a method for monitoring a visual response and cognitive relationship, which comprises the following steps:

taking a healthy subject into a magnetic resonance examination room, wearing an MR professional vision calibration spectacle frame and lenses, lying on an examination bed, and performing task state functional magnetic resonance scanning and data acquisition of a reading task; the reading task comprises BLOCK experimental design;

the scan sequence and parameters of the magnetic resonance include: a) whole brain T1 weighted vector high resolution structural image scan parameters: TR 1900.0ms, TE2.21 ms, layer thickness 1.00 mm, layer spacing 0.5 mm, matrix 256 × 256, FOV 256 × 256 mm, flip angle 9 °; b) function like EPI _ BOLD scan parameter: TR 2000 ms, TE 30.0 ms, layer thickness 3.6 mm, layer spacing 0.65 mm, FOV230 x 230 mm, flip angle 90 degrees, measurements 96;

the reading task adopts BLOCK experimental design, the program is compiled and operated by E-Prime 2.0 software, a healthy subject carries out functional magnetic resonance examination of the reading task under naked eye vision and corrected vision in sequence, the specific operation is that a display screen is fixed at the far end of an examination bed, special coil reflectors are placed above two eyes of a head coil, angle adjustment is carried out by the healthy subject, then the healthy subject is enabled to watch a screen seriously, rest when a plus sign appears in the center of the screen, and read silently at normal speed when a text appears on the screen.

Compared with the prior art, the invention has the following beneficial effects:

according to the method for monitoring the visual response and cognitive relationship, the relationship between the visual response and the cognitive function is visually monitored by utilizing task state functional magnetic resonance imaging, and the change of a human cerebral cortex functional area generated by the human visual response is effectively observed; by utilizing task state functional magnetic resonance imaging and designing a BLOCK experimental paradigm, the reaction of the human brain under different visual effects is monitored, and the change of the brain functional brain area activation level of a healthy human subject in different reading tasks can be reflected.

Drawings

FIG. 1 is a BLOCK experimental design program diagram;

FIG. 2 is a fMRI tomographic image of a brain region where the visual effect is more distinct than the activation signal when blurred;

fig. 3 is a fMRI tomographic image of a brain region where an activation signal is stronger when a visual effect is a blur ratio is clear.

Detailed Description

The present invention is described in further detail in the following description of specific embodiments and the accompanying drawings, it is to be understood that these embodiments are merely illustrative of the present invention and are not intended to limit the scope of the invention, which is defined by the appended claims, and modifications thereof by those skilled in the art after reading this disclosure that are equivalent to the above described embodiments.

All the raw materials and reagents of the invention are conventional market raw materials and reagents unless otherwise specified.