阅读说明：本技术 一种高透阻菌型透析原纸的制备方法 (Preparation method of high-permeability and bacterium-resistant type dialysis base paper ) 是由 黄学英 戴贤中 周晓光 张�诚 刘祥波 孙兵 于 2020-04-29 设计创作，主要内容包括：本发明涉及造纸技术领域,公开了一种高透阻菌型透析原纸的制备方法,步骤为(1)制浆：浆料包括70~80%的漂白本色针叶木浆及20%~30%的漂白阔叶木浆；(2)浆料改性：向浆料中加入浆料质量15~25%的改性黄连素,60~70℃下搅拌反应30~60min后加入PAE湿强剂、浆内胶和AKD,搅拌均匀后得到改性浆料；(3)抄造；(4)压榨和前干燥；(5)表面施胶、干燥和压光后得到所述高透阻菌型透析原纸。本发明在打浆过程中用改性黄连素对纸浆纤维进行改性,既可以减少纤维之间原有的氢键结构,从而提高纸页的透气性,又可以通过黄连素的抑菌性能提高纸页的阻菌效果,使制得的透析原纸可以兼具高透气性和阻菌性。(The invention relates to the technical field of papermaking, and discloses a preparation method of high-permeability and high-resistance bacteria type dialysis base paper, which comprises the following steps of (1) pulping: the pulp comprises 70-80% of bleached natural softwood pulp and 20-30% of bleached hardwood pulp; (2) modifying the slurry: adding modified berberine with the mass of 15-25% of the slurry into the slurry, stirring and reacting at 60-70 ℃ for 30-60 min, adding a PAE wet strength agent, intra-slurry glue and AKD, and stirring uniformly to obtain modified slurry; (3) manufacturing paper with pulp; (4) squeezing and pre-drying; (5) and (3) obtaining the high-permeability bacteria-resistant dialysis base paper after surface sizing, drying and calendaring. According to the invention, the modified berberine is used for modifying the paper pulp fibers in the pulping process, so that the original hydrogen bond structure between the fibers can be reduced, the air permeability of the paper sheet is improved, the bacteria-resistant effect of the paper sheet can be improved through the antibacterial property of the berberine, and the prepared dialysis base paper can have high air permeability and bacteria resistance.)

1. A preparation method of high-permeability bacteria-resistant dialysis base paper is characterized by comprising the following steps:

(1) pulping: pulping and then mixing pulp to obtain pulp, wherein the pulp comprises 70-80% of bleached natural softwood pulp and 20-30% of bleached hardwood pulp;

(2) modifying the slurry: adding modified berberine with the mass of 15-25% of the slurry into the slurry, stirring and reacting at 60-70 ℃ for 30-60 min, adding a PAE wet strength agent, intra-slurry glue and AKD, and stirring uniformly to obtain modified slurry;

(3) manufacturing paper: screening the modified pulp on a net to make paper to obtain wet paper sheets;

(4) pressing and pre-drying: squeezing and pre-drying the wet paper sheet to obtain a pre-dried paper sheet;

(5) surface sizing and drying: and (3) carrying out surface sizing, drying and calendaring on the paper sheet after the paper sheet is dried by using a surface sizing agent to obtain the high-permeability and bacterium-resistant dialysis base paper.

2. The preparation method of the dialysis base paper with high permeability and bacterium resistance of claim 1, wherein the preparation method of the modified berberine comprises the following steps:

A) dissolving berberine in N, N-dimethylformamide, reacting for 15-20 min under microwave radiation, adding water with the mass of 1-2 times of that of the solution, diluting, refrigerating at 0-4 ℃ for 10-20 h, filtering and drying to obtain red crystals;

B) dissolving the red crystal in N, N-dimethylformamide, adding dibromoethane and potassium carbonate, stirring and reacting for 20-24 h at 70-80 ℃ under the protection of nitrogen, adding diethyl ether, standing for 8-10 h, filtering and drying in vacuum to obtain yellow powder;

C) dissolving the yellow powder in methanol, adding supersaturated ammonium chloride and 25-28% by mass of ammonia water, carrying out sealed stirring reaction for 8-12 h at 75-85 ℃, carrying out reduced pressure evaporation on the solution after reaction, washing the product with dichloromethane, filtering, evaporating the filtrate, adding the product into 5-8% by mass of sodium hydroxide solution, carrying out stirring reaction for 1-2 h at 75-85 ℃, and evaporating the solution to dryness to obtain the modified berberine.

3. The preparation method of the dialysis base paper with high permeability and bacterium resistance of claim 2, wherein the mass-to-volume ratio of the flavonolicin to the N, N-dimethylformamide in the step A) is 1 g: (20-30 mL) and microwave power of 400-500W.

4. The method for preparing the dialysis base paper with high permeability and bacteria resistance as claimed in claim 2, wherein the mass-to-volume ratio of the red crystal to the N, N-dimethylformamide in the step B) is 1 g: (90-100 mL), the ratio of the dibromoethane, the potassium carbonate and the red crystal added is (10-15 mL): (0.5-0.6 g): 1g, the volume ratio of the added diethyl ether to the N, N-dimethylformamide is (2-3): 1.

5. the preparation method of the dialysis base paper with high permeability and bacteria resistance as claimed in claim 2, wherein the mass volume ratio of the yellow powder to the methanol and the ammonia water in the step C) is (12-15 g): 1mL of: (12-13 mL), the mass-to-volume ratio of the product added into the sodium hydroxide solution to the sodium hydroxide solution is 1 g: (20-50 mL).

6. The preparation method of the high-permeability and bacteria-resistant type dialysis base paper as claimed in claim 1, wherein in the step (1), the beating degree of the bleached natural color softwood pulp is 21-25^oSR, the wet weight is 10-12 g, and the beating degree of the bleached hardwood pulp is 30-35^oSR, wet weight 2.0-4.0 g.

7. The method for preparing the dialysis base paper with high permeability and bacteria resistance according to claim 1 or 2, wherein the sizing agent in the step (2) is cationic starch, and the dosage of each ton of paper is 5-10 kg; the solid content of the PAE wet strength agent is 12-15%, the dosage of each ton of paper is 10-15 kg, and the dosage of AKD each ton of paper is 10-20 kg.

8. The method for preparing the dialysis base paper with high permeability and bacteria resistance as claimed in claim 1, wherein the moisture content of the paper sheet after pre-drying in the step (4) is 5-8%.

9. The method for preparing the dialysis base paper with high permeability and bacteria resistance as claimed in claim 1, wherein the surface sizing agent raw material in the step (5) comprises the following components in a mass ratio of 1: (5-6) the cassava starch and the PVA, wherein the mass concentration of the PVA in the surface sizing agent is 1-3%, and the sizing amount is 1-2 g/m²。

Technical Field

The invention relates to the technical field of papermaking, in particular to a preparation method of high-permeability and high-resistance bacteria type dialysis base paper.

Background

Dialysis paper is generally made into a paper-plastic bag after being coated, printed (printed with ink) and subjected to heat sealing or glue sealing with film materials such as PE or PP and the like, and is used for packaging medical instruments for sterilization, and the bacteria resistance and the air permeability are the two most important indexes. The bacteria resistance refers to the property that the dialysis paper can prevent bacteria in the external environment from permeating, so as to avoid bacterial infection in the sterilization process or after sterilization of medical instruments, and the quality of the bacteria resistance of the dialysis paper is particularly important for the effective storage of sterilized products. The air permeability is that the sterilization mode of the medical apparatus is mainly an ETO ethylene oxide sterilization method and a high-temperature damp-heat steam method, so the dialysis paper needs to have certain air permeability, ethylene oxide gas or steam is allowed to permeate, and the aim of sterilizing the medical apparatus and articles of the package is fulfilled.

Disclosure of Invention

The invention provides a preparation method of high-permeability and bacteria-resistant type dialysis base paper, aiming at overcoming the problems that in the production process of dialysis paper in the prior art, air permeability and bacteria resistance are two contradictory indexes, the larger the glue application amount is, the fewer the pores among fibers are, the better the bacteria resistance is, but the air permeability is reduced, and the dialysis paper is difficult to have good bacteria resistance and air permeability at the same time.

In order to achieve the purpose, the invention adopts the following technical scheme:

a preparation method of high-permeability and bacterium-resistant dialysis base paper comprises the following steps:

(1) pulping: pulping and then mixing pulp to obtain pulp, wherein the pulp comprises 70-80% of bleached natural softwood pulp and 20-30% of bleached hardwood pulp;

(2) modifying the slurry: adding modified berberine with the mass of 15-25% of the slurry into the slurry, stirring and reacting at 60-70 ℃ for 30-60 min, adding a PAE wet strength agent, intra-slurry glue and AKD, and stirring uniformly to obtain modified slurry;

(3) manufacturing paper: screening the modified pulp on a net to make paper to obtain wet paper sheets;

(4) pressing and pre-drying: squeezing and pre-drying the wet paper sheet to obtain a pre-dried paper sheet;

(5) surface sizing and drying: and (3) carrying out surface sizing, drying and calendaring on the paper sheet after the paper sheet is dried by using a surface sizing agent to obtain the high-permeability and bacterium-resistant dialysis base paper.

When the dialysis paper is prepared, the proper pulp proportioning is adopted, and the modified berberine is used for modifying the pulp, so that the air permeability of the dialysis base paper can be improved, and the resistance of the paper can be ensuredAnd (4) bacterial property. The berberine is a natural quaternary ammonium alkaloid separated from traditional Chinese medicine coptis, has excellent antibacterial performance and wide antibacterial spectrum, has an antibacterial effect on various gram positive and negative bacteria in vitro, can effectively prevent bacteria in the external environment from permeating by utilizing the antibacterial performance of the berberine added into dialysis paper, and avoids causing bacterial infection in the sterilization process or after sterilization of packaged medical instruments. Meanwhile, as the berberine is a quaternary ammonium base, after the modified berberine is added into the slurry, OH in the modified berberine^-Can form the hydrogen bond through the hydroxyl of the cellulose molecule in hydrogen bond effect and the thick liquids, replace the hydrogen bond of cellulose molecule self, simultaneously, the quaternary ammonium salt group that positively charges is close to between the cellulose molecule through electrostatic action for the cellulose molecular chain separates, thereby make fibrous structure become loose, reduce tiny fiber content, and do not destroy fibre basic structure, effectively improved the gas permeability of dialysis paper, ethylene oxide gas or steam can effectively permeate through when guaranteeing to disinfect, reach the purpose to packing material medical instrument and article sterilization.

At the same time, the mechanical properties of the paper are reduced by loosening the fiber structure, so that the PAE wet strength agent is added into the pulp to improve the mechanical properties of the paper. The PAE wet strength agent is composed of polyamide epichlorohydrin, and can be added into the pulp to crosslink with fiber to form a net structure, thereby improving the mechanical strength of the paper. After the berberine is added, quaternary ammonium salt groups of the berberine enter the space between cellulose molecular chains, and berberine molecules have no reactive groups, so that the crosslinking between PAE and fibers can be influenced.

Preferably, the preparation method of the modified berberine comprises the following steps:

A) dissolving berberine in N, N-dimethylformamide, reacting for 15-20 min under microwave radiation, adding water with the mass of 1-2 times of that of the solution, diluting, refrigerating at 0-4 ℃ for 10-20 h, filtering and drying to obtain red crystals;

B) dissolving the red crystal in N, N-dimethylformamide, adding dibromoethane and potassium carbonate, stirring and reacting for 20-24 h at 70-80 ℃ under the protection of nitrogen, adding diethyl ether, standing for 8-10 h, filtering and drying in vacuum to obtain yellow powder;

C) dissolving the yellow powder in methanol, adding supersaturated ammonium chloride and 25-28% by mass of ammonia water, carrying out sealed stirring reaction for 8-12 h at 75-85 ℃, carrying out reduced pressure evaporation on the solution after reaction, washing the product with dichloromethane, filtering, evaporating the filtrate, adding the product into 5-8% by mass of sodium hydroxide solution, carrying out stirring reaction for 1-2 h at 75-85 ℃, and evaporating the solution to dryness to obtain the modified berberine.

The invention firstly adopts the step A) to make berberine react under microwave radiation to generate berberberrubine red crystal; then reacting with dibromoethane to obtain bromoethyl berberine through the step B); and finally, the berberine is reacted with ammonia water to obtain aminoethyl modified berberine, so that amino groups are introduced to the surface of the berberine to serve as reaction groups, the berberine can react with hydroxyl groups on the surface of the fiber, chlorine in a PAE wet strength agent and other reaction groups to carry out crosslinking, and the mechanical strength of the paper sheet is improved.

Preferably, the mass-to-volume ratio of the flavonolignans to the N, N-dimethylformamide in the step A) is 1 g: (20-30 mL) and microwave power of 400-500W.

Preferably, the mass-to-volume ratio of the red crystals to the N, N-dimethylformamide in step B) is 1 g: (90-100 mL), the ratio of the dibromoethane, the potassium carbonate and the red crystal added is (10-15 mL): (0.5-0.6 g): 1g, the volume ratio of the added diethyl ether to the N, N-dimethylformamide is (2-3): 1.

preferably, the mass-to-volume ratio of the yellow powder to the methanol and the ammonia water in the step C) is (12-15 g): 1mL of: (12-13 mL), the mass-to-volume ratio of the product added into the sodium hydroxide solution to the sodium hydroxide solution is 1 g: (20-50 mL).

Preferably, in the step (1), the beating degree of the bleached softwood pulp is 21-25 DEG SR, the wet weight is 10-12 g, the beating degree of the bleached hardwood pulp is 30-35 DEG SR, and the wet weight is 2.0-4.0 g.

Preferably, the sizing agent in the step (2) is cationic starch, and the dosage of each ton of paper is 5-10 kg; the solid content of the PAE wet strength agent is 12-15%, the dosage of each ton of paper is 10-15 kg, and the dosage of AKD each ton of paper is 10-20 kg.

Preferably, the moisture content of the paper sheet after the pre-drying in the step (4) is 5-8%.

Preferably, the surface sizing agent raw material in the step (5) comprises a raw material with a mass ratio of 1: (5-6) the cassava starch and the PVA, wherein the mass concentration of the PVA in the surface sizing agent is 1-3%, and the sizing amount is 1-2 g/m²。

Therefore, the invention has the following beneficial effects:

(1) the modified berberine is used for modifying the slurry, so that bacteria in the external environment can be effectively prevented from permeating by utilizing the antibacterial performance of the berberine, and bacterial infection of packaged medical equipment in the sterilization process or after sterilization is avoided;

(2) because berberine is a quaternary ammonium base, the OH in berberine is added into the slurry^-Hydrogen bonds can be formed with hydroxyl groups of cellulose molecules in the pulp through the action of the hydrogen bonds to replace the hydrogen bonds of the cellulose molecules, and meanwhile, the positively charged quaternary ammonium salt groups approach the cellulose molecules through the electrostatic action to separate the cellulose molecular chains, so that the fiber structure becomes loose, the content of fine fibers is reduced, and the air permeability of the dialyzing paper is effectively improved;

(3) the berberine is modified, and the amine group is introduced to the surface of the berberine to serve as a reaction group, so that the berberine can react with the fiber and the reaction group in the PAE wet strength agent to carry out co-crosslinking, the influence on crosslinking between the PAE and the fiber after the berberine is added is avoided, and the mechanical strength of the paper sheet is improved.

Detailed Description

The invention is further described with reference to specific embodiments.

The reagents used in the present invention are commercially available or commonly used in the art unless otherwise specified.