阅读说明：本技术 一种注射型美容整形用面部填充剂组合物及其制备方法 (An injectable facial filler composition for skin care and plastic, and its preparation method ) 是由 张广利 于 2021-07-30 设计创作，主要内容包括：本发明公开了一种注射型美容整形用面部填充剂组合物及其制备方法。包括玻尿酸为2～3ml、β-磷酸三钙为0.3～0.6g、地塞米松和利多卡因混合物0.2～0.4ml。S1：采用注射器抽取地塞米松和利多卡因混合物；S2：将β-磷酸三钙倒入到地塞米松和利多卡因混合物中进行混合,得到胶状混合物；S3：将胶状混合物与玻尿酸进行搅拌混合,得到面部填充剂。本面部填充剂通过将玻尿酸与β-磷酸三钙颗粒进行混合形成混悬液进行填充,具有很高的相容性；同时,本面部填充剂通过对玻尿酸进行选取,与β-磷酸三钙颗粒混合后,可以实现对面部不同部位的填充,适用范围较广。(The invention discloses an injection type face filler composition for beauty and plastic and a preparation method thereof. Comprises 2-3 ml of hyaluronic acid, 0.3-0.6 g of beta-tricalcium phosphate and 0.2-0.4 ml of a mixture of dexamethasone and lidocaine. S1: drawing the mixture of dexamethasone and lidocaine by using a syringe; s2: pouring beta-tricalcium phosphate into a mixture of dexamethasone and lidocaine, and mixing to obtain a colloidal mixture; s3: mixing the colloidal mixture with hyaluronic acid under stirring to obtain face filler. The face filler is filled by mixing hyaluronic acid and beta-tricalcium phosphate particles to form a suspension, and has high compatibility; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.)

1. An injectable cosmetic face filler composition characterized by comprising: the hyaluronic acid injection comprises a mixture of hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 2-3 ml, the beta-tricalcium phosphate is 0.3-0.6 g, and the mixture of dexamethasone and lidocaine is 0.2-0.4 ml.

2. An injectable cosmetic face pack composition according to claim 1, wherein: the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.3g, and the mixture of dexamethasone and lidocaine is 0.3 ml.

3. An injectable cosmetic face pack composition according to claim 1, wherein: the mixture of dexamethasone and lidocaine is formed by mixing dexamethasone and lidocaine according to the proportion of 1-5.

4. An injectable cosmetic face pack composition according to claim 1, wherein: the hyaluronic acid is any one of small-molecule hyaluronic acid or medium-molecule hyaluronic acid.

5. The method for preparing the injectable cosmetic/plastic face pack composition according to any one of claims 1 to 4, wherein the method comprises the steps of: the method comprises the following steps:

s1: drawing the mixture of dexamethasone and lidocaine by using a syringe;

s2: pouring beta-tricalcium phosphate into a mixture of dexamethasone and lidocaine, and mixing to obtain a colloidal mixture;

s3: mixing the colloidal mixture with hyaluronic acid under stirring to obtain face filler.

Technical Field

The invention relates to the technical field of injection type cosmetic materials, in particular to an injection type face filler composition for cosmetic and plastic and a preparation method thereof.

Background

With the improvement of living standard of people, people pay more and more attention to the pursuit of external beauty, and various cosmetic reshaping is generally adopted by people.

Hyaluronic acid, also known as uronic acid and hyaluronic acid, is also called as a azululosidic carbon-based acid in the medical literature, and is a linear polymer polysaccharide composed of disaccharide units (glucuronic acid-N-ethylsulfanylglucose), which is a substance naturally present in tissues and also one of the components of human dermal tissues. The injection of hyaluronic acid is to inject hyaluronic acid into the depressed or abundant part of the skin fold, such as the lip, cheek, nose bridge, chin, scar, etc. by means of filler, so as to reach the effect of eliminating wrinkles and changing appearance immediately. At present, most people have a choice to build the nose for injection of hyaluronic acid, because the nose is not used for operation, does not hurt the skin, has good effect, has good biocompatibility and functions of storing moisture, and can make the skin look very full and elastic. Therefore, hyaluronic acid is a widely appreciated cosmetic product.

However, hyaluronic acid is metabolized in human bodies, belongs to a transient filling material, lasts for about 6 months, and therefore needs to be injected for a long time, so that economic, time and psychological burdens of customers are increased; meanwhile, the hyaluronic acid has insufficient supporting force at the positions of the nose, nasolabial sulcus, chin, temples and the like, so that the forming is not ideal and the effect is influenced.

Disclosure of Invention

The invention aims to overcome the problems that the existing hyaluronic acid facial filler needs to be injected for a long time and has insufficient supporting force at the positions of nose, nasolabial sulcus, chin, temple and the like, and provides an injection type facial filler composition for beautifying and reshaping and a preparation method thereof.

An injection type face filler composition for beautifying and reshaping comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and a lidocaine mixture, wherein the hyaluronic acid is 2-3 ml, the beta-tricalcium phosphate is 0.3-0.6 g, and the dexamethasone and the lidocaine mixture is 0.2-0.4 ml.

Further, the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.3g, and the mixture of dexamethasone and lidocaine is 0.3 ml.

Further, the mixture of dexamethasone and lidocaine is formed by mixing dexamethasone and lidocaine according to the proportion of 1-5.

Furthermore, the hyaluronic acid is medium-small molecule hyaluronic acid or any one of medium-large molecule hyaluronic acid.

A preparation method of an injection type face filler composition for cosmetic and plastic comprises the following steps:

s1: drawing the mixture of dexamethasone and lidocaine by using a syringe;

s2: pouring beta-tricalcium phosphate into a mixture of dexamethasone and lidocaine, and mixing to obtain a colloidal mixture;

s3: mixing the colloidal mixture with hyaluronic acid under stirring to obtain face filler.

The invention has the beneficial effects that: the face filler is filled by mixing hyaluronic acid and beta-tricalcium phosphate particles to form a suspension, and has high compatibility; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.

Detailed Description

The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict.

Example 1:

an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 2ml, the beta-tricalcium phosphate is 0.3g, and the dexamethasone and lidocaine are 0.2 ml.

The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 1.

The hyaluronic acid is medium-small molecule hyaluronic acid.

The face filler prepared by mixing medium and small molecular hyaluronic acid with beta-tricalcium phosphate, dexamethasone and lidocaine can be used for filling nasolabial sulcus and temples.

Example 2:

an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine mixture, wherein the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.6g, and the dexamethasone and lidocaine mixture is 0.4 ml.

The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 2.

The hyaluronic acid is medium-small molecule hyaluronic acid.

The face filler prepared by mixing medium and small molecular hyaluronic acid with beta-tricalcium phosphate, dexamethasone and lidocaine can be used for filling nasolabial sulcus and temples.

Example 3:

an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 2ml, the beta-tricalcium phosphate is 0.3g, and the dexamethasone and lidocaine are 0.2 ml.

The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 2.

The hyaluronic acid is medium-macromolecule hyaluronic acid.

The face filler prepared by mixing the medium-macromolecule hyaluronic acid with the beta-tricalcium phosphate, the dexamethasone and the lidocaine can be used for filling the nose and the chin.

Example 4:

an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine mixture, wherein the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.6g, and the dexamethasone and lidocaine mixture is 0.4 ml.

The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 3.

The hyaluronic acid is medium-macromolecule hyaluronic acid.

The face filler prepared by mixing the medium-macromolecule hyaluronic acid with the beta-tricalcium phosphate, the dexamethasone and the lidocaine can be used for filling the nose and the chin.

Example 5:

an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.3g, and the dexamethasone and lidocaine are 0.3 ml.

The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 5.

The hyaluronic acid is medium-small molecule hyaluronic acid.

The face filler prepared by mixing medium and small molecular hyaluronic acid with beta-tricalcium phosphate, dexamethasone and lidocaine can be used for filling nasolabial sulcus and temples.

Example 6:

an injection type face filler composition for cosmetic and plastic comprises hyaluronic acid, beta-tricalcium phosphate, dexamethasone and lidocaine, wherein the hyaluronic acid is 3ml, the beta-tricalcium phosphate is 0.3g, and the dexamethasone and lidocaine are 0.3 ml.

The mixture of dexamethasone and lidocaine consists of dexamethasone and lidocaine which are mixed according to the proportion of 1: 4.

The hyaluronic acid is medium-macromolecule hyaluronic acid.

The face filler prepared by mixing the medium-macromolecule hyaluronic acid with the beta-tricalcium phosphate, the dexamethasone and the lidocaine can be used for filling the nose and the chin.

Example 7:

a preparation method of an injection type face filler composition for cosmetic and plastic comprises the following steps:

s1: drawing the mixture of dexamethasone and lidocaine by using a syringe;

s2: pouring beta-tricalcium phosphate into a mixture of dexamethasone and lidocaine, and mixing to obtain a colloidal mixture;

s3: mixing the colloidal mixture with hyaluronic acid under stirring to obtain face filler.

Hyaluronic acid and beta-tricalcium phosphate particles are mixed to form a suspension for filling, and the suspension has good compatibility with surrounding tissues after filling and has no rejection and allergic reaction. The results showed that no significant fibrous capsule formation was seen around the material, and that no BMP2 was expressed. The stable porous crystal balls form a stable bracket for the growth of blood vessels and cells, the stable framework forms a result of lasting curative effect and no displacement, and the beta-tricalcium phosphate and the hyaluronic acid can be safely used as a tissue filler in combination.

As in the following table: the experimental effects of examples 1 to 6 were shown.

The above table shows that the facial filler is filled by mixing hyaluronic acid and beta-tricalcium phosphate particles to form a suspension, and has high compatibility; meanwhile, the face filler can be used for filling different parts of the face after hyaluronic acid is selected and mixed with beta-tricalcium phosphate particles, and the application range is wide.

The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.