阅读说明：本技术 缓解呼吸道炎症精油制剂、含该制剂口罩片及其制备方法 (Essential oil preparation for relieving respiratory tract inflammation, mask tablet containing essential oil preparation and preparation method of mask tablet ) 是由 王文翠 姚雷 白璐 于 2020-06-19 设计创作，主要内容包括：本发明公开了一种缓解呼吸道炎症精油制剂、含该制剂口罩片及其制备方法,属于天然香料研究开发技术领域,精油制剂包括：芳樟精油、绿花白千层精油、胶冷杉精油、大籽蒿精油、柠檬精油、月桂精油、依兰精油、丝柏精油；本发明制备的口罩安全防护效果佳,具有特殊功效,隔离效果好,不仅方便于功效精油的使用,同时对外界不良气体也具有吸附效果,有效阻隔外界污染物；配方精油在实验过程中,对呼吸道炎症2种有关酶活性的抑制率达到50％以上,对呼吸道炎症表现出了正向作用；缓释控制效果好,在37℃呼出气体温度下,有效控制精油的释放量达到0.06-0.08g每天,延长精油口罩的使用率,使用寿命长达5-6d。(The invention discloses an essential oil preparation for relieving respiratory tract inflammation, a mask tablet containing the preparation and a preparation method thereof, belonging to the technical field of natural spice research and development, wherein the essential oil preparation comprises the following components: linaloe essential oil, melaleuca viridis essential oil, fir essential oil, artemisia sieboldii essential oil, lemon essential oil, bay essential oil, ylang essential oil and cypress essential oil; the mask prepared by the invention has good safety protection effect, special effect and good isolation effect, is convenient for using functional essential oil, has adsorption effect on external harmful gas, and effectively blocks external pollutants; in the experimental process, the inhibition rate of the essential oil in the formula on 2 related enzyme activities of the respiratory inflammation reaches over 50 percent, and the essential oil has positive effect on the respiratory inflammation; the slow release control effect is good, the release amount of the essential oil is effectively controlled to reach 0.06-0.08g per day at the temperature of the exhaled air of 37 ℃, the use rate of the essential oil mask is prolonged, and the service life is as long as 5-6 d.)

1. The essential oil preparation for relieving the respiratory tract inflammation is characterized by comprising the following components in parts by weight:

2. a mask containing the essential oil preparation for relieving respiratory inflammation according to claim 1, wherein the mask comprises an outer layer, a middle layer and an inner layer;

the inner layer and the outer layer are made of non-woven fabrics, the middle layer is made of double-layer melt-blown non-woven fabrics, an essential oil adsorption material is arranged on the double-layer melt-blown non-woven fabrics, and the essential oil preparation for relieving the respiratory inflammation is adsorbed on the essential oil adsorption material.

3. The mask containing an essential oil preparation for relieving respiratory inflammation according to claim 2, wherein the amount of the essential oil adsorbent in the mask is 1.5-2 g.

4. The mask containing the essential oil preparation for relieving the respiratory inflammation according to claim 2, wherein the speed of releasing the essential oil preparation for relieving the respiratory inflammation by the essential oil adsorbing material in the mask is 0.06-0.08g/d, and the service life is 5-6 d.

5. The mask containing an essential oil preparation for relieving airway inflammation according to claim 2, wherein the essential oil adsorbing material comprises macroporous adsorbent resin.

6. The mask containing an essential oil preparation for relieving airway inflammation according to claim 5, wherein the macroporous adsorbent resin comprises HP20O resin, SP850 resin, SP70 resin;

the particle size distribution of the HP20O resin is more than or equal to 0.25 mm; the effective grain diameter of the SP850 resin is 250 um; the SP70 resin has a pore diameter of 7.3nm, an average particle diameter of 527um and a specific surface area of 885m²/g。

7. The mask containing an essential oil preparation for relieving airway inflammation according to claim 6, wherein the HP20O resin: SP850 resin: the mass ratio of the SP70 resin is 1-2:1: 1.

8. A method for preparing a mask containing an essential oil preparation for relieving respiratory inflammation according to any one of claims 2 to 7, comprising the steps of:

A. preparing an essential oil preparation for relieving respiratory inflammation, and preparing an essential oil adsorption material; and the essential oil preparation for relieving the respiratory tract inflammation is adsorbed in the essential oil adsorbing material;

B. an essential oil adsorption material for adsorbing an essential oil preparation for relieving respiratory inflammation is loaded in the middle layer of the mask;

C. and compounding the inner layer, the middle layer and the outer layer to obtain the composite material.

9. The method for preparing a mask containing an essential oil preparation for relieving respiratory inflammation according to claim 8, wherein the step A specifically comprises the following steps:

a. preparing an essential oil preparation for relieving respiratory inflammation and an essential oil adsorption material according to a formula; then mixing the prepared essential oil preparation for relieving the respiratory tract inflammation and tween 80 uniformly; the mass ratio of the essential oil preparation for relieving the respiratory tract inflammation to the Tween 80 is 1:1-1: 3;

b. adding a mixed solution of an essential oil preparation for relieving respiratory inflammation and tween 80 into purified water to obtain an essential oil aqueous solution; the mass concentration of the essential oil preparation for relieving the respiratory tract inflammation in the essential oil aqueous solution is 10 percent;

c. adsorbing an essential oil aqueous solution on an essential oil adsorbing material by a chromatography, wherein the mass ratio of the essential oil aqueous solution to the essential oil adsorbing material is 1: 5; the adsorption flow rate is 5-10 drops/min.

10. The method for preparing a mask containing an essential oil preparation for relieving respiratory inflammation according to claim 8, wherein the step B specifically comprises the following steps:

dividing the double-layer melt-blown non-woven fabric pressing line of the middle layer into areas of 0.5 x0.5cm-1 x1cm, and uniformly adding an essential oil adsorption material after adsorbing and relieving the respiratory inflammation essential oil preparation into each area.

Technical Field

The invention belongs to the technical field of natural spice research and development, and particularly relates to an essential oil preparation for relieving respiratory tract inflammation, a mask tablet containing the preparation and a preparation method of the mask tablet.

Background

Respiratory inflammation is a common, multiple disease of the respiratory system. According to the statistics of death causes of ten main diseases in part of cities and the first ten rural areas in 2006, respiratory diseases (excluding lung cancer) account for the fourth (13.1%) and the third (16.4%) of death causes in cities and rural areas. Respiratory inflammation is caused by a plurality of pathogenic factors, such as air pollution, smoking, population aging, biological factor inhalation (for example, new coronary pneumonia which is caused by the contact of human bodies and the inhalation of new coronary viruses in the global outbreak in 2020), and other factors. Because of the diversity of pathogenic factors and the complexity of the disease course, no specific medicine is available for respiratory tract inflammation at present, and the prevention is mainly performed.

Among a plurality of prevention and treatment measures, researches show that the plant extracted essential oil has a good effect on respiratory tract inflammation, and due to the special properties of the essential oil, the essential oil has a good curative effect only by inhalation through a respiratory system without oral administration and injection means, and meanwhile, due to the strong volatility of the essential oil and the atomization means, the pollution of PM2.5 particles caused by atomization of conventional medicine powder can be avoided, and the use and the safety are high. However, the conventional method for inhaling essential oil needs an aroma diffuser, which brings inconvenience to the use.

Disclosure of Invention

In order to solve the defects in the prior art, the invention aims to provide an essential oil preparation for relieving respiratory tract inflammation, a mask tablet containing the preparation and a preparation method of the mask tablet.

The purpose of the invention is realized by the following technical scheme: an essential oil preparation for relieving respiratory tract inflammation comprises the following components in parts by weight:

beyond this range, the inflammation-relieving effect is not very good, and the preference and acceptance of the human population are also poor.

A mask containing essential oil preparation for relieving respiratory inflammation comprises an outer layer, a middle layer and an inner layer; the inner layer and the outer layer are made of non-woven fabrics, the middle layer is made of double-layer melt-blown non-woven fabrics, an essential oil adsorption material is arranged on the double-layer melt-blown non-woven fabrics, and the essential oil preparation for relieving the respiratory inflammation is adsorbed on the essential oil adsorption material.

Preferably, the dosage of the essential oil adsorption material in each mask is 1.5-2 g.

Preferably, the speed of releasing the essential oil preparation for relieving respiratory inflammation by the essential oil adsorption material in the mask is 0.06-0.08g/d (realized by controlling the addition amount of the essential oil adsorption material), and the using time is 5-6 d.

Preferably, the essential oil adsorption material comprises a macroporous adsorption resin.

Preferably, the macroporous adsorbent resin comprises HP20O resin, SP850 resin, SP70 resin (mitsubishi resin);

the particle size distribution of the HP20O resin is more than or equal to 0.25 mm; the effective grain diameter of the SP850 resin is 250 um; the SP70 resin has a pore diameter of 7.3nm, an average particle diameter of 527um and a specific surface area of 885m²/g。

Preferably, the HP20O resin: SP850 resin: the mass ratio of the SP70 resin is 1-2:1: 1.

A method for preparing a mask containing an essential oil preparation for relieving respiratory tract inflammation comprises the following steps:

A. preparing an essential oil preparation for relieving respiratory inflammation, and preparing an essential oil adsorption material; and the essential oil preparation for relieving the respiratory tract inflammation is adsorbed in the essential oil adsorbing material;

B. an essential oil adsorption material for adsorbing an essential oil preparation for relieving respiratory inflammation is loaded in the middle layer of the mask;

C. and compounding the inner layer, the middle layer and the outer layer to obtain the composite material.

Preferably, the step a specifically includes the following steps:

a. preparing an essential oil preparation for relieving respiratory inflammation and an essential oil adsorption material according to a formula; then mixing the prepared essential oil preparation for relieving the respiratory tract inflammation and tween 80 uniformly; the mass ratio of the essential oil preparation for relieving the respiratory tract inflammation to the Tween 80 is 1:1-1: 3;

b. adding a mixed solution of an essential oil preparation for relieving respiratory inflammation and tween 80 into purified water to obtain an essential oil aqueous solution; the mass concentration of the essential oil preparation for relieving the respiratory tract inflammation in the essential oil aqueous solution is 10 percent;

c. adsorbing an essential oil aqueous solution on an essential oil adsorbing material by a chromatography, wherein the mass ratio of the essential oil aqueous solution to the essential oil adsorbing material is 1: 5; the adsorption flow rate is 5-10 drops/min.

Preferably, the step B specifically includes the steps of:

and dividing the double-layer melt-blown non-woven fabric pressing line of the middle layer into areas of 0.5 x0.5cm-1 x1cm, uniformly adding an essential oil adsorption material after an essential oil preparation for adsorbing and relieving respiratory inflammation into each area, and ensuring that the air permeability of the mask is not influenced.

The invention can effectively solve the problem, after the essential oil is adsorbed by the carrier, the using amount of the essential oil can be controlled, the using time of the essential oil can be prolonged, the portability of the essential oil in the using process is brought, meanwhile, the invention can block respiratory tract inflammation caused by direct contact with the outside air while treating inflammation, and has the function of prevention. A great deal of research has also found that the plant essential oil has good killing effect on some viruses, and therefore, the essential oil is combined with the mask through the way, on one hand, the existing respiratory inflammation can be treated, on the other hand, the isolation effect of the conventional mask is improved, and the respiratory inflammation can be prevented to a certain extent.

In summary, compared with the prior art, the invention has the following beneficial effects:

(1) according to the invention, a formula comprising 2-5 parts of linaloe essential oil, 2-4 parts of melaleuca alternifolia essential oil, 2-4 parts of rubber fir essential oil, 1-2 parts of artemisia sieboldii essential oil, 1-2 parts of lemon essential oil, 0.5-1 part of laurel essential oil, 0.5-1 part of ylang essential oil and 0.5-1 part of cypress essential oil is adopted, so that respiratory tract inflammation can be effectively relieved; in the experimental process, the inhibition rate of the essential oil in the formula on 2 related enzyme activities of the respiratory inflammation reaches over 50 percent, and the essential oil has positive effect on the respiratory inflammation;

(2) the invention selects HP20O (the particle size distribution is more than or equal to 0.25mm), SP850 (the effective particle size is 250um), SP70 (the invention accords with FDA standard, the aperture is 7.3nm, the average particle size is 527um, and the specific surface area is 885m2/g), and the mixture ratio of the three resins is HP 20: SP 850: SP70 ═ 1:1: 1-2:1:1, the mixed resin is prepared, so that the effective adsorption of the essential oil is realized, the release amount of the essential oil is controlled, the release time of the essential oil is prolonged, and the effect of adsorbing external polluted gas and microorganisms is achieved;

(3) the mask prepared by the invention has good safety protection effect, special effect and good isolation effect, is convenient for using functional essential oil, has adsorption effect on external harmful gas, and effectively blocks external pollutants; the slow release control effect is good, the release amount of the essential oil is effectively controlled to reach 0.06-0.08g per day at the temperature of the exhaled air of 37 ℃, the use rate of the essential oil mask is prolonged, and the service life is as long as 5-6 d.

Description of the drawings:

other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:

fig. 1 is a process flow chart of a method for preparing a mask containing an essential oil preparation for relieving respiratory inflammation in example 3.

Detailed Description

The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It will be apparent to those skilled in the art that various changes and modifications can be made without departing from the spirit and scope of the invention. The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, which ranges of values are to be considered as specifically disclosed herein, the invention is described in detail below with reference to specific examples: