阅读说明：本技术 一种减压沸腾专用无泡多酶清洗剂及其制备方法 (Special foamless multienzyme cleaning agent for reduced pressure boiling and preparation method thereof ) 是由 王卫 施君君 于 2020-05-08 设计创作，主要内容包括：本发明公开了一种减压沸腾专用无泡多酶清洗剂,包含如下质量百分比的原料：增溶剂1%~20%、复合表面活性剂5%~30%、无机助剂添加剂1~10%、复合酶1%~10%、分散添加剂1~5%、溶剂2%~15%、杀菌剂1%~3%、螯合剂1%~3%、缓蚀剂0.1~3%,余量为水。本发明还公开了其制备方法,减压沸腾专用无泡多酶清洗剂制备简单方便,泡沫高度在常温下为无泡,去污高效,且具有阻垢、杀菌抑菌性能,尤其适合在减压沸腾的条件下对手术器械进行清洗消毒。(The invention discloses a special foamless multienzyme cleaning agent for reduced pressure boiling, which comprises the following raw materials in percentage by mass: 1-20% of solubilizer, 5-30% of composite surfactant, 1-10% of inorganic auxiliary additive, 1-10% of complex enzyme, 1-5% of dispersing additive, 2-15% of solvent, 1-3% of bactericide, 1-3% of chelating agent, 0.1-3% of corrosion inhibitor and the balance of water. The invention also discloses a preparation method thereof, and the special foamless multienzyme cleaning agent for reduced pressure boiling is simple and convenient to prepare, has foamless foam height at normal temperature, high decontamination efficiency, scale inhibition, sterilization and bacteriostasis performances, and is particularly suitable for cleaning and disinfecting surgical instruments under the condition of reduced pressure boiling.)

1. A special foamless multienzyme cleaning agent for decompression boiling is characterized in that: comprises that

1 to 20 percent of solubilizer,

5 to 30 percent of composite surfactant,

1-10% of inorganic additive,

1 to 10 percent of complex enzyme,

1 to 5 percent of dispersing additive,

2 to 15 percent of solvent,

1 to 3 percent of bactericide,

1 to 3 percent of chelating agent,

0.1 to 3 percent of corrosion inhibitor,

the balance being water.

2. The special foamless multienzyme cleaning agent for reduced pressure boiling according to claim 1, which is characterized in that: the solubilizer is one or more of sodium xylene sulfonate, Tomamine Ampoteric 400, TRITON H-66, Crofateric ™ PI and alkyl glycoside.

3. The special foamless multienzyme cleaning agent for reduced pressure boiling according to claim 1, which is characterized in that: the composite surfactant is a mixture of two or more of nonionic surfactant, anionic surfactant and amphoteric surfactant.

4. The special foamless multienzyme cleaning agent for reduced pressure boiling according to claim 1, which is characterized in that: the inorganic additive is one or a mixture of two of sodium citrate, sodium formate, 4A zeolite, sodium carbonate, sodium bicarbonate, sodium phosphate, potassium pyrophosphate, sodium tripolyphosphate and borax.

5. The special foamless multienzyme cleaning agent for reduced pressure boiling according to claim 1, which is characterized in that: the complex enzyme is a composition of two or more of amylase, protease, cellulase and lipase.

6. The special foamless multienzyme cleaning agent for reduced pressure boiling according to claim 1, which is characterized in that: the solvent is one or a composition of more of isopropanol, ethanol, propylene glycol, glycerol, ethylene glycol ethyl ether, propylene glycol butyl ether and dipropylene glycol butyl ether.

7. The special foamless multienzyme cleaning agent for reduced pressure boiling according to claim 1, which is characterized in that: the decontamination dispersant is one of polyacrylic acid sodium salts.

8. The special foamless multienzyme cleaning agent for reduced pressure boiling according to claim 1, which is characterized in that: the bactericide is one or more of 1, 2-benzisothiazolin-3-one, 2-methyl-4-isothiazolinone-3-one, diazo-Jima, nipagin methyl ester, benzethonium chloride, dodecyl dipropylenetriamine, coco alkyl benzyl dimethyl ammonium chloride and bisdecyl dimethyl ammonium chloride.

9. The special foamless multienzyme cleaning agent for reduced pressure boiling according to claim 1, which is characterized in that: the chelating agent is one or more of hydroxyethylidene diphosphonic acid, diethylenetriamine pentamethylene phosphonic acid, ethylene diamine tetra methylene phosphonic acid sodium, sodium tripolyphosphate, silicate, sodium glucoheptonate, tetrasodium glutamate diacetate and trisodium methylglycine diacetate.

10. A preparation method of a special foamless multienzyme cleaning agent for decompression boiling is characterized in that: the method comprises the following steps:

the water-soluble organic solvent-based water-based paint is prepared by mixing and stirring solubilizer, chelating agent, surfactant, solvent, bactericide, inorganic auxiliary additive, dispersing additive and water in a stirring kettle until the solubilizer, the chelating agent, the surfactant, the solvent, the bactericide, the inorganic auxiliary additive, the dispersing additive and the water are dissolved.

Technical Field

The invention relates to a special foamless multienzyme cleaning agent for reduced pressure boiling and a preparation method thereof, in particular to a special foamless multienzyme cleaning agent for reduced pressure boiling and a preparation method thereof, and belongs to the technical field of cleaning agents.

Background

According to the clear regulations in medical institution disinfection technical specifications, hospital infection management specifications and endoscope cleaning and disinfection technical operation specifications issued by the ministry of health, the used operation and multiplexing instruments are sterilized after being thoroughly cleaned, and any organic matters such as residues of blood stain tissues and the like and inorganic matters remaining on the medical instruments can block the penetration of sterilization factors and influence the sterilization quality. Therefore, the cleaning is an important link before the sterilization work, and any factor neglecting the cleaning link can cause the final failure of the sterilization work, influence the medical quality of hospitals and bring potential safety hazards to patients.

With the continuous application of new technologies and methods in disinfection supply centers, there is now a new cleaning technology, i.e., boiling cleaning under reduced pressure, which is now widely used in disinfection supply centers. The cleaning technology principle of decompression boiling is to heat the cleaning liquid in the cleaning cavity and then to pump out air to decompress the cavity. The pressure in the cavity is reduced, the boiling point of the cleaning liquid is gradually reduced, and the liquid begins to boil. Air is introduced into the cleaning liquid, the cleaning liquid is vigorously boiled and shaken, and then dirt is thoroughly peeled off. The steam in the pipe is compressed and liquefied along with the sudden rise of the pressure in the cavity due to the water-gas phase air, and meanwhile, the cleaning liquid enters the pipe and dirt in the pipe is removed through reciprocating washing. Finally, the pressure in the cavity is reduced, the boiling point of the cleaning liquid is gradually reduced, the liquid starts to boil, and the cavity is filled with steam.

The technology puts higher requirements on the cleaning agent, firstly, the foam performance of the cleaning agent is required to be ultralow or even no foam, the temperature range of no foam is between normal temperature and 55 ℃, the machine is damaged due to too high foam, and the circulating pump is burnt off due to too high foam. Secondly, the cleaning agent needs to have higher wetting and dispersing performance, and most importantly, the cleaning agent is compatible with the materials of the conventional surgical instruments: 304 stainless steel/316 stainless steel/416 stainless steel/420 stainless steel/aluminum/anodized aluminum/titanium alloy/brass.

Although common medical cleaning agents in the market belong to low-foam products, the systems are nonionic and enzyme-added compound systems, nonionic can be foamless at high temperature, but the normal-temperature foam is too high to meet the three harsh conditions. Especially, the foam performance is still in danger of overflowing the cabin under the condition of forty degrees, and the difference is quite large even under the condition of normal temperature.

Disclosure of Invention

The invention aims to overcome the defect that the conventional medical multienzyme cleaning agent cannot be used for reduced pressure boiling cleaning, and provides a special foamless multienzyme cleaning agent for reduced pressure boiling, which has the following technical scheme:

the invention relates to a special foamless multienzyme cleaning agent for decompression boiling, which comprises

1 to 20 percent of solubilizer,

5 to 30 percent of composite surfactant,

1-10% of inorganic additive,

1 to 10 percent of complex enzyme,

1 to 5 percent of dispersing additive,

2 to 15 percent of solvent,

1 to 3 percent of bactericide,

1 to 3 percent of chelating agent,

0.1 to 3 percent of corrosion inhibitor,

the balance being water.

Further, the solubilizing agent is one or more selected from sodium xylene sulfonate, Tomamine Ampoteric 400, TRITON H-66, and CRODATERIC. PI.

Further, the composite surfactant is a mixture of two or more of a nonionic surfactant, an anionic surfactant and an amphoteric surfactant.

Further, the nonionic surfactant is C₆~C₁₈The molecular structural formulA of the polyoxyethylene ether is R-A-OH, R is C₅~C₁₈Linear or branched alkyl, A is- (OC)₂H₄) X-wherein X is 1 to 9.

More preferably, the nonionic surfactant can be one or a mixture of a plurality of short carbon chain (C3-C7) alkyl glycoside.

More preferably, the nonionic surfactant may be a mixture of one or more of isomeric alcohol ethers, fatty alcohol ether-capped surfactants.

More preferably, the anionic surfactant is one or a mixture of more of sodium alkyl benzene sulfonate, alpha-olefin sulfonate, alkyl sulfonate, alpha-sulfo fatty acid methyl ester, fatty acid sulfo alkyl ester, fatty alcohol sulfate, secondary alkyl sulfate, fatty alcohol polyoxyethylene ether sulfate and alcohol ether phosphate.

More preferably, the zwitterionic surfactant is one or a mixture of more of carboxylic acid based betaines, sulphobetaines, ammonium oxide and imidazoline based surfactants.

Further, the inorganic auxiliary additive is one or a mixture of any two of sodium citrate, sodium formate, 4A zeolite, sodium carbonate, sodium bicarbonate, sodium phosphate, potassium pyrophosphate, sodium tripolyphosphate and borax.

Further, the complex enzyme is a composition of two or more of amylase, protease, cellulase and lipase.

More preferably, the mass content of the complex enzyme preparation in the cleaning agent is 5-7%, and the mass ratio of the complex enzyme preparation is 5-7: 2-4: 0.1-0.2: 0.1 to 0.2 of protease: amylase: lipase: and (3) cellulase.

Further, the solvent is one or a combination of more of isopropanol, ethanol, propylene glycol, glycerol, ethylene glycol ethyl ether, propylene glycol butyl ether and dipropylene glycol butyl ether.

Further, the decontamination dispersant is one of polyacrylic acid sodium salts.

Further, the bactericide is one or a mixture of more of 1, 2-benzisothiazolin-3-one, 2-methyl-4-isothiazolinone-3-one, diazo-Jima, nipagin methyl ester, benzethonium chloride, dodecyl dipropylenetriamine, coco alkyl benzyl dimethyl ammonium chloride and bisdecyl dimethyl ammonium chloride.

Further, the chelating agent is one or more of hydroxyethylidene diphosphonic acid (HEDP), diethylenetriamine pentamethylene phosphonic acid (DTPMPA), ethylene diamine tetra methylene phosphonic acid sodium (EDTMPS), sodium tripolyphosphate, silicates, sodium glucoheptonate (Crodaquest A300), tetrasodium glutamate diacetate (GLDA 47) and trigion M.

Furthermore, the corrosion inhibitor is one or a combination of more of benzotriazole, diundecanoic acid, organic ternary polycarboxylic acid, organic boric acid ester, short-chain phosphoric acid and phosphate.

The invention also relates to a preparation method of the special foamless multienzyme cleaning agent for decompression boiling, which comprises the following steps:

the water-soluble organic solvent-based water-based paint is prepared by mixing and stirring solubilizer, chelating agent, surfactant, solvent, bactericide, inorganic auxiliary additive, dispersing additive and water in a stirring kettle until the solubilizer, the chelating agent, the surfactant, the solvent, the bactericide, the inorganic auxiliary additive, the dispersing additive and the water are dissolved.

Further, the specific method comprises the following steps:

adding 80% deionized water into a stirring kettle, adding a solubilizer, heating and stirring until the solubilizer is dissolved;

adding surfactant C₈~C₁₈Polyoxyethylene ether, anionic surfactant, zwitterionic surfactant and solvent are stirred until the polyoxyethylene ether, the anionic surfactant, the zwitterionic surfactant and the solvent are dissolved;

adding the chelating agent and stirring until the mixture is uniform.

Cooling to room temperature, adding an inorganic additive and a sodium polyacrylate, and stirring until the inorganic additive and the sodium polyacrylate are dissolved;

adding bactericide, solvent and corrosion inhibitor, and stirring until the bactericide, the solvent and the corrosion inhibitor are dissolved;

and adding the rest deionized water, stirring and filtering to obtain the special foamless multienzyme cleaning agent for reduced pressure boiling.

Compared with the prior art, the invention has the following beneficial effects:

the special bubble-free multienzyme cleaning agent for reduced pressure boiling is simple and convenient to prepare, has high decontamination efficiency, no bubbles in diluted working solution at normal temperature to 50 ℃, has wetting, scale inhibition, dispersion, sterilization and bacteriostasis performances, and is suitable for cleaning surgical instruments in various departments of hospitals, particularly in disinfection supply centers.

The principle of the invention is that the composite material is compounded into a foamless material through a surfactant and the like, meanwhile, a solubilizer is utilized to ensure the stability of the system, and the inorganic auxiliary agent, the dispersant and the bactericide are cooperated to sterilize the biological membrane, and the two are synchronously carried out until the surface is clean. And finally, protecting the hard surface from rust through a corrosion inhibitor in the cleaning agent. The special foamless multienzyme cleaning agent for reduced pressure boiling has the advantages of simple preparation process and method, reliable performance, environmental protection, no toxicity, no harm and no pollution, and is an ideal hard surface cleaning agent.

Detailed Description

The invention is further described below. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.

The invention relates to a special foamless multienzyme cleaning agent for decompression boiling, which comprises

1 to 20 percent of solubilizer,

5 to 30 percent of composite surfactant,

1-10% of inorganic additive,

1 to 10 percent of complex enzyme,

1 to 5 percent of dispersing additive,

2 to 15 percent of solvent,

1 to 3 percent of bactericide,

1 to 3 percent of chelating agent,

0.1 to 3 percent of corrosion inhibitor,

the balance being water.