阅读说明：本技术 一种护肤凝胶及其制备方法 (Skin care gel and preparation method thereof ) 是由 董耀蔚 于 2020-06-23 设计创作，主要内容包括：本发明公开了一种护肤凝胶及其制备方法。属于日化技术领域。该凝胶原料包括透明质酸钠、甘油、燕麦β-葡聚糖、卡波姆、羟乙基纤维素、1,2-己二醇、对羟基苯乙酮、三乙醇胺、沙棘果提取物、苦参根提取物、红景天提取物、银杏提取物、野大豆芽提取物、谷氨酸、蛋氨酸、酵母菌多肽类和人生长激素HGH。该凝胶通过按照一定顺序将各原料在一定温度下混合均质制备而成。与现有技术相比,本发明取得的有益效果：无副作用；利于肌肤吸收；减轻细胞过氧化的程度并抑制I型胶原降解,修复细胞损伤；促进成纤维细胞和胶原蛋白的生成,有效修复细胞,增强皮肤弹性；保湿功能好；有效保持了人生长激素HGH的生物活性和生物利用度,增强了稳定性。(The invention discloses a skin care gel and a preparation method thereof. Belongs to the technical field of daily chemicals. The gel raw materials comprise sodium hyaluronate, glycerol, oat beta-glucan, carbomer, hydroxyethyl cellulose, 1, 2-hexanediol, p-hydroxyacetophenone, triethanolamine, sea buckthorn fruit extract, sophora flavescens root extract, rhodiola rosea extract, ginkgo biloba extract, wild soybean sprout extract, glutamic acid, methionine, saccharomycete polypeptide and human growth hormone HGH. The gel is prepared by mixing and homogenizing the raw materials according to a certain sequence at a certain temperature. Compared with the prior art, the invention has the following beneficial effects: no side effect; is beneficial to the absorption of the skin; the degree of cell peroxidation is reduced, the degradation of type I collagen is inhibited, and cell injury is repaired; promoting the generation of fibroblasts and collagen, effectively repairing cells and enhancing the skin elasticity; the moisture-preserving function is good; effectively maintains the biological activity and bioavailability of human growth hormone HGH, and enhances the stability.)

1. The skin care gel is characterized by comprising the following raw materials in parts by mass: 1-10 parts of sodium hyaluronate, 5-20 parts of glycerol, 5-10 parts of oat beta-glucan, 0.5-1 part of carbomer, 0.1-0.5 part of hydroxyethyl cellulose, 0.1-0.3 part of 1, 2-hexanediol, 0.1-0.8 part of p-hydroxyacetophenone, 0.1-0.5 part of triethanolamine, 3-8 parts of a seabuckthorn fruit extract, 5-10 parts of a sophora flavescens root extract, 2-6 parts of a rhodiola rosea extract, 1-3 parts of a ginkgo biloba extract, 1-5 parts of a wild soybean sprout extract, 0.5-2 parts of glutamic acid, 0.5-2 parts of methionine, 8-23 parts of a saccharomycete polypeptide and 25-35 parts of human growth hormone HGH.

2. The skin care gel of claim 1, comprising the following raw materials in parts by mass: 5 parts of sodium hyaluronate, 13 parts of glycerol, 7 parts of oat beta-glucan, 0.8 part of carbomer, 0.3 part of hydroxyethyl cellulose, 0.2 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone, 0.3 part of triethanolamine, 5 parts of a seabuckthorn fruit extract, 7 parts of a sophora flavescens root extract, 4 parts of a rhodiola rosea extract, 2 parts of a ginkgo extract, 3 parts of a wild soybean sprout extract, 1 part of glutamic acid, 1 part of methionine, 13 parts of yeast polypeptide and 30 parts of human growth hormone HGH.

3. The method for preparing a skin care gel according to claim 1 or 2, wherein the pre-treated human growth hormone HGH is obtained by the step of macromolecular encapsulation of human growth hormone HGH, which comprises the following steps:

(1) preparing human growth hormone HGH into liposome by a nano liposome encapsulation technology;

(2) and (3) preparing the liposome into freeze-dried powder by using trehalose as an excipient to obtain the pretreated human growth hormone HGH.

4. A method of preparing a skin care gel according to claim 3, comprising the steps of:

(1) adding water, sodium hyaluronate, glycerol and oat beta-glucan into a reaction kettle, starting stirring, and heating to 75-80 ℃ to obtain a mixture A;

(2) adding water, carbomer, hydroxyethyl cellulose, 1, 2-hexanediol, p-hydroxyacetophenone and triethanolamine into a reaction kettle, stirring, and heating to 75-80 ℃ to obtain a mixture B;

(3) mixing the mixture A and the mixture B, homogenizing at 10000-12000 rpm/min for 5min, cooling to 40-45 ℃, adding a seabuckthorn fruit extract, a sophora flavescens root extract, a rhodiola rosea extract, a ginkgo extract, a wild soybean sprout extract, glutamic acid, methionine, a yeast polypeptide and a pretreated human growth hormone HGH, and homogenizing at 3000-5000 rpm/min for 1 min;

(4) and continuously cooling to 25-30 ℃.

Technical Field

The invention relates to the technical field of daily chemicals, in particular to a skin care gel and a preparation method thereof.

Background

With age, the turnover rate of the human stratum corneum becomes slower and slower, and at the same time, the lipid synthesis capacity of keratinocytes decreases, or the cell division, growth and differentiation efficiency in the epidermis becomes lower. The stratum corneum barrier function tends to decrease due to the lack of moisturizing factors and lipids in the skin. When the moisture content of the stratum corneum is less than 10%, the skin becomes dry, elastic, wrinkled, and thus skin aging is accelerated. In addition, with the aging, the secretion of various metabolism-regulating hormones in the skin of a human body is decreased, and the function and activity of immune cells are decreased, which results in the decrease in the synthesis of immune proteins and structural proteins constituting a living body. The content and arrangement of collagen, elastin, hyaluronic acid and glycoprotein constituting the skin are changed or reduced, and oxidative stress occurs due to free radicals and active oxygen. Thinning of the skin, increased wrinkles, decreased skin elasticity, dullness of the skin color, and various skin problems frequently occur.

At present, the products related to skin care gel are distributed on the market in many types, and the gel on the market is mainly divided into two types, namely a single-effect type and a full-effect repairing type. In order to better have the functions of beautifying, ultraviolet protection and the like, the gel on the market is often added with some chemical elements and has some toxic and side effects; in addition, the skin care product has the defect of low bioavailability, and most active substances cannot reach the action part and are absorbed even only stay on the surface of the skin and cannot permeate.

In conclusion, the problem to be solved by the technical personnel in the field is how to provide a skin care gel which has no toxic and side effect, high bioavailability and good moisturizing and repairing effects.

Disclosure of Invention

In view of the above, the present invention provides a skin care gel and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

the skin care gel comprises the following raw materials in parts by mass: 1-10 parts of sodium hyaluronate, 5-20 parts of glycerol, 5-10 parts of oat beta-glucan, 0.5-1 part of carbomer, 0.1-0.5 part of hydroxyethyl cellulose, 0.1-0.3 part of 1, 2-hexanediol, 0.1-0.8 part of p-hydroxyacetophenone, 0.1-0.5 part of triethanolamine, 3-8 parts of seabuckthorn fruit extract, 5-10 parts of sophora flavescens root extract, 2-6 parts of rhodiola rosea extract, 1-3 parts of ginkgo biloba extract, 1-5 parts of wild soybean sprout extract, 0.5-2 parts of glutamic acid, 0.5-2 parts of methionine, 8-23 parts of saccharomycete polypeptide and 25-35 parts of human growth hormone HGH

Sodium hyaluronate is the main component constituting intercellular and extracellular matrix and maintains the normal structure and function of cells. Sodium hyaluronate can be combined with 1000 times of water by weight, and the water retention performance of the sodium hyaluronate is positively correlated with the concentration and molecular weight of the sodium hyaluronate. Has unique skin protecting effect, can keep skin moist, smooth, fine, tender and elastic, and has effects of preventing wrinkle, removing wrinkle, and repairing skin physiological function.

The glycerin can absorb moisture in the air to moisten the skin, and a water locking film is formed on the surface of the skin to slow down the loss of moisture in the skin, so that the skin can keep a moist state for a long time, and the dry skin is improved.

The oat beta-glucan has an anti-aging effect, can smooth fine wrinkles, improve skin elasticity and skin texture, has a good transdermal absorption performance due to a unique linear chain molecular structure, promotes fibroblasts to synthesize collagen, promotes wound healing and repairs damaged skin.

Carbomer is a thickening agent that enhances the viscosity of the skin care product. And can protect skin, reduce irritation, resist ultraviolet, sterilize, diminish inflammation, and relieve skin wound.

The hydroxyethyl cellulose has good solubility and viscosity, and can keep balance, keep stability of cosmetic in cold and hot alternate seasons, and has moisture keeping effect.

The 1, 2-hexanediol has extremely high hygroscopicity, water retention and antibacterial property.

P-hydroxyacetophenone is a high-temperature auxiliary activity stabilizer, exists in cosmetics as a preservative, and is harmless to human skin.

Triethanolamine is a neutralizer of acidic polymer gel containing carbomer and the like, and forms a stable polymer structure by neutralizing with carboxyl of carbomer and the like, so that the effects of thickening and moisturizing are achieved.

The fructus Hippophae extract contains abundant vitamin C, vitamin E and flavone, and is effective in preventing aging of free radicals.

The extract of the sophora flavescens ait root can balance grease secretion, dredge and astringe pores, clear toxin impurities in skin, promote the growth and repair of damaged vascular nerve cells, recover the activity of subcutaneous capillary cells and enable the skin to be compact, fine and smooth.

The rhodiola rosea extract (1) has stimulation effect on fibroblasts in dermis, promotes the fibroblasts to split and synthesize and secrete collagen, and also secretes collagenase, so that the original collagen is decomposed, but the total secretion is greater than the decomposition, the collagen forms collagen fiber outside the cells, and the increase of the content of the collagen fiber shows that the rhodiola rosea has certain anti-aging effect on the skin; (2) the activity of tyrosinase is inhibited, and the catalytic speed of tyrosinase is reduced, so that the generation of skin melanin can be reduced, the skin pigmentation state can be improved, and the effect of whitening can be achieved; (3) has protective effect on skin ultraviolet radiation injury.

The flavone component contained in the ginkgo extract can block the formation and deposition of pigment in the dermis layer, so as to achieve the effects of whitening skin and preventing and treating pigment plaques, and besides the flavone, the contained trace elements such as manganese, molybdenum and the like can also clear oxygen free radicals and inhibit the growth of melanin; the Ginkgo biloba extract also protects dermal cells, improves blood circulation, and prevents the cells from being oxidized to form wrinkles.

The wild soybean sprout extract can promote the growth of fiber sprout cells, and has skin activating and antiaging effects; meanwhile, the skin moisture can be kept, and the moisturizing effect is achieved.

Glutamic acid is generally used as a pH adjuster and a nutritional aid for cosmetics.

Methionine is used as antistatic agent, antioxidant and skin conditioner in cosmetics, and is water-soluble component for promoting skin metabolism and stimulating cell regeneration.

The saccharomycete polypeptide can protect skin from being damaged by external stress and make skin derive natural and healthy white.

The human growth hormone HGH may be skin-elastic.

Further, the skin care gel comprises the following raw materials in parts by mass: 5 parts of sodium hyaluronate, 13 parts of glycerol, 7 parts of oat beta-glucan, 0.8 part of carbomer, 0.3 part of hydroxyethyl cellulose, 0.2 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone, 0.3 part of triethanolamine, 5 parts of a seabuckthorn fruit extract, 7 parts of a sophora flavescens root extract, 4 parts of a rhodiola rosea extract, 2 parts of a ginkgo extract, 3 parts of a wild soybean sprout extract, 1 part of glutamic acid, 1 part of methionine, 13 parts of yeast polypeptide and 30 parts of human growth hormone HGH.

A preparation method of skin care gel, human growth hormone HGH gets pretreated human growth hormone HGH through macromolecule package step, the concrete operation is:

(1) preparing human growth hormone HGH into liposome by a nano liposome encapsulation technology;

(2) and (3) preparing the liposome into freeze-dried powder by using trehalose as an excipient to obtain the pretreated human growth hormone HGH.

The nano-liposome coating transdermal absorption technology is adopted, and trehalose is used as an excipient to prepare the freeze-dried powder, so that the problem that macromolecular protein is difficult to permeate natural barriers of skin to be fully absorbed is solved. Has the functions of repairing and caring skin, delaying senility and resisting senility. The trehalose is adopted as an excipient, so that the biological polypeptide protein active substance is prevented from losing activity when being used for a long time under the common condition, the strong biological activity and bioavailability of the human growth hormone HGH are effectively maintained, and the stability is enhanced.

Preferably, the method comprises the following steps:

(1) adding water, sodium hyaluronate, glycerol and oat beta-glucan into a reaction kettle, starting stirring, and heating to 75-80 ℃ to obtain a mixture A;

(2) adding water, carbomer, hydroxyethyl cellulose, 1, 2-hexanediol, p-hydroxyacetophenone and triethanolamine into a reaction kettle, stirring, and heating to 75-80 ℃ to obtain a mixture B;

(3) mixing the mixture A and the mixture B, homogenizing at 10000-12000 rpm/min for 5min, cooling to 40-45 ℃, adding a seabuckthorn fruit extract, a sophora flavescens root extract, a rhodiola rosea extract, a ginkgo extract, a wild soybean sprout extract, glutamic acid, methionine, a yeast polypeptide and a pretreated human growth hormone HGH, and homogenizing at 3000-5000 rpm/min for 1 min;

(4) and continuously cooling to 25-30 ℃.

According to the technical scheme, compared with the prior art, the invention has the following beneficial effects: (1) is safe and has no side effect; (2) the texture is clear, and the skin absorption is facilitated; (3) the degree of cell peroxidation is reduced, the degradation of type I collagen is inhibited, and the skin cell injury is repaired; (4) promoting the generation of fibroblasts and collagen, effectively repairing cells, enhancing the elasticity of skin, and improving stem lines and roughness; (5) the moisture-keeping function is good, so that the water content of the skin stratum corneum is greatly improved after 1 hour, and can be well maintained after 4 hours of use; (6) effectively maintains the strong biological activity and bioavailability of the human growth hormone HGH and enhances the stability.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The fructus Hippophae extract is obtained from Saint Biotechnology GmbH of Shaanxi province;

the extract of Sophora flavescens is obtained from Wang Biotech limited of Henan kang;

rhodiola rosea extracts were purchased from shanxi pannier biotechnology limited;

the Ginkgo biloba extract was obtained from Xian Lvtian Biotechnology GmbH;

the wild soybean sprout extract is purchased from Saint Biotechnology GmbH of Ningshan country;

yeast polypeptides were purchased from Guangzhou Shiming chemical Co., Ltd.

The present invention does not mention the procurement of materials from commercial sources; the unrecited experimental method is a conventional experimental method, and is not described in detail herein.