阅读说明：本技术 细条状脱细胞真皮基质的应用 (Application of thin strip-shaped acellular dermal matrix ) 是由 童艳梅 于 2020-06-04 设计创作，主要内容包括：本申请公开了细条状脱细胞真皮基质的一种应用,属于医药技术领域,即在制备防治皮肤萎缩和/或松弛的材料中的应用。其优点表现在：取材于动物皮肤组织并经特殊理化处理的ADM,制备成细条状材料后,完整地保留了原有组织的立体支架结构,作为细胞支架,其具有诱导组织生成的作用,在植入人体后能被人体组织细胞识别为自体组织,很快有新生血管和成纤维细胞长入,引导细胞沿其胶原支架有序生长,达到补充、修复乃至重建组织的目的。从而形成有效的紧致感和饱满度。由于形成的自身组织含量丰厚,故维持时间也远超其它材料。(The application discloses an application of a slender acellular dermal matrix, belongs to the technical field of medicines, and particularly relates to an application of the slender acellular dermal matrix in preparation of materials for preventing and treating skin atrophy and/or relaxation. Its advantages are: the ADM which is obtained from animal skin tissues and is subjected to special physicochemical treatment is prepared into a thin strip-shaped material, so that the three-dimensional scaffold structure of the original tissue is completely reserved and used as a cell scaffold, the ADM has the function of inducing tissue generation, can be recognized as autologous tissue by human tissue cells after being implanted into a human body, and can quickly grow new blood vessels and fibroblasts to guide the cells to orderly grow along the collagen scaffold, thereby achieving the purposes of supplementing, repairing and even reconstructing the tissue. Thereby forming an effective tightness and fullness. Because the formed self-tissue content is rich, the maintenance time is far longer than that of other materials.)

1. Application of thin strip-shaped acellular dermal matrix in preparing materials for preventing and treating skin atrophy and/or relaxation.

2. The use of claim 1, wherein the acellular dermal matrix is a porous three-dimensional network.

3. The use of claim 1, wherein the acellular dermal matrix is a xenogenic acellular dermal matrix.

4. The use of claim 1, wherein the acellular dermal matrix is made from porcine skin.

5. The use according to claim 1, wherein said strip-shaped acellular dermal matrix is made of a sheet-shaped acellular dermal matrix.

6. Use according to claim 1, wherein the skin is facial, neck, hand or abdominal skin.

7. The use of claim 1, wherein the strip-shaped acellular dermal matrix is implanted in subcutaneous tissue.

8. The use of claim 7, wherein the thin strip of acellular dermal matrix is implanted in the subcutaneous tissue of the forehead, cheek, periocular, perioral, nose, neck, back of the hand, or abdomen.

Technical Field

The application relates to the technical field of medicines, in particular to application of a slender acellular dermal matrix.

Background

People who love beauty are all pursuing full, light, tender and white skin and always look young. However, with the increase of age, collagen is lost, and the phenomena of skin atrophy and relaxation are always inevitable. Skin atrophy refers to the progressive decrease in the stroma and thinning of the skin, which eventually presents an atrophic change.

Acellular Dermal Matrix (ADM) is a currently common dermal scaffold material, and is prepared by removing epidermal layers in allogeneic or xenogeneic full-thickness skins and cell components in dermal tissues and only preserving dermal extracellular matrix with an intact fiber lattice structure. The acellular dermal matrix contains a normal collagen framework structure and an intact basement membrane, and has the characteristics of low immunogenicity, low toxicity and the like of human implants. Scientists in China research and develop acellular dermal matrixes and clinical application of the acellular dermal matrixes to successfully develop xenogenic (pig) skin substitutes, and the xenogenic (pig) skin substitutes can be used for treating different types of burn wounds.

Disclosure of Invention

The application provides application of a thin strip-shaped acellular dermal matrix.

The following technical scheme is adopted in the application:

application of thin strip-shaped acellular dermal matrix in preparing materials for preventing and treating skin atrophy and/or relaxation.

Further, the acellular dermal matrix is a porous three-dimensional network structure.

Further, the acellular dermal matrix is a xenogenic acellular dermal matrix.

Further, the acellular dermal matrix is prepared by taking pigskin as a raw material.

Further, the thin strip-shaped acellular dermal matrix is made of a sheet-shaped acellular dermal matrix.

Further, the skin is facial, neck, hand or abdominal skin.

Further, the thin strip-shaped acellular dermal matrix is implanted into subcutaneous tissues.

Further, the thin strip-shaped acellular dermal matrix is implanted into the subcutaneous tissue of the forehead, the cheek, the periphery of the eye, the periphery of the mouth, the nose, the neck, the back of the hand or the abdomen.

The above-mentioned at least one technical scheme that this application adopted can reach following beneficial effect:

the materials used in the wire carving art are PPDO (poly (p-dioxanone), PLLA (poly (l-lactic acid)), PDO (poly (p-dimethylhydroxyhexanone), PGLA (poly (lactide)), etc., which all have a certain effect of inducing the generation of collagen in the body, but since the wire body itself has no three-dimensional scaffold structure, the content of the generated collagen is very limited, the maintenance time is short, and the clinical satisfaction of patients with loose and atrophied skin is not high. The material is prepared from animal skin tissue through ADM subjected to special physicochemical treatment into a thin strip material, completely maintains the three-dimensional scaffold structure of the original tissue, is used as a cell scaffold, has the function of inducing tissue generation, can be recognized as autologous tissue by human tissue cells after being implanted into a human body, has new blood vessels and fibroblasts growing into the autologous tissue rapidly, and guides the cells to grow orderly along the collagen scaffold, thereby achieving the purposes of supplementing, repairing and reconstructing the tissue. Thereby forming an effective tightness and fullness. Because the formed self-tissue content is rich, the maintenance time is far longer than that of other materials.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:

FIG. 1 is a comparison of an ophthalmic pre-and post-operative view of an embodiment of the present application.

Fig. 2 is a comparison of cheek and perioral surgery according to the examples of the present application.

Fig. 3 is a comparison before and after a neck surgery according to an embodiment of the present application.

FIG. 4 is a comparison of a hand before and after surgery according to an embodiment of the present application.

FIG. 5 is a comparison of abdominal before and after surgery according to an embodiment of the present application.

Detailed Description

In order to make the objects, technical solutions and advantages of the present application more apparent, the technical solutions of the present application will be described in detail and completely with reference to the following specific embodiments of the present application and the accompanying drawings. It should be apparent that the described embodiments are only some of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.