阅读说明：本技术 脂氨基酸和二醇的新组合物，用于制备其的方法，以及由其产生的化妆品或药物组合物 (Novel composition of lipoamino acids and diols, process for preparing same, and cosmetic or pharmaceutical compositions produced therefrom ) 是由 杰罗姆·吉尔博 乔治·达科斯塔 维尔日妮·巴尔特 于 2018-12-12 设计创作，主要内容包括：披露了一种脂氨基酸和二醇的新组合物,一种用于制备其的方法,以及一种由其产生的化妆品或药物组合物。(A novel composition of lipoamino acids and diols, a process for preparing the same, and a cosmetic or pharmaceutical composition produced therefrom are disclosed.)

1. A composition (C)₁) Every 100% of its mass comprises:

(a) -a mass proportion of the compound having formula (I) or of the mixture of compounds having formula (I) greater than or equal to 50% and less than or equal to 95% by mass:

X-[CH₂]_p-C(＝O)-Y-OH (I)，

wherein p represents an integer of 5 or more and 8 or less, and Y representsOrHaving the formula (II)_a) The divalent group of (a):

-[N(R₃)-CH(R₂)-C(＝O)-]_m- (II_a)，

wherein R is₃Represents a hydrogen atom or a methyl group, m represents an integer of 1 or more and 4 or less, and R₂Represents a hydrogen atom or a group selected from the group consisting of methyl, isopropyl, isobutyl, 1-methylpropyl, benzyl and 3-aminopropyl groups;orHaving the formula (II)_b) The divalent group of (a):

wherein R is₄Represents a hydrogen atom or a hydroxyl group, and n represents an integer of 1 or more and 4 or less; and X representsOrMethyl radicalOrMethylene group (CH)₂＝)，OrA monovalent group having the formula (III):

HO-Y’-C(＝O)- (III)，

wherein Y' representsOrThe divalent radical of formula (IIa) as defined above,orSaid divalent radical of formula (IIb) as defined previously, it being understood that when X represents said radical of formula (III), Y and Y' are identical;

(b) -a mass proportion of more than 0 mass% and less than or equal to 15 mass% of a mixture comprising from three to eight atoms andorIs represented by the formula (IV)_a)OrIs represented by the formula (IV)_b) The diols represented by:

R^a ₁-C(R^b ₁)(OH)-C(OH)(R^c ₁)(R^d ₁) (IV_a)，

wherein the radical R^a ₁、R^b ₁、R^c ₁And R^d ₁Each independently of the others represents a hydrogen atom or a saturated aliphatic group containing from one to five carbon atoms,

R^a ₁-C(R^b ₁)(OH)-[C(R^e ₁)(R^f ₁)]_t-C(OH)(R^c ₁)(R^d ₁) (IV_b)，

wherein t is equal to one, two or three, the radical R^a ₁、R^b ₁、R^c ₁、R^d ₁、R^e ₁And R^f ₁Each independently of the others, represents a hydrogen atom or a saturated aliphatic radical containing from one to five carbon atoms, it being understood that the radical R^a ₁Or R^b ₁At least one and/or a group R^c ₁Or R^d ₁At least one of (a) does not represent a hydrogen atom;

(c) -a mass proportion of the compound having formula (V) or a mixture of compounds having formula (V) greater than or equal to 0 mass% and less than or equal to 5 mass%:

X-[CH₂]_p-C(＝O)-OH (V)，

wherein X represents a methyl group or a vinyl group (CH)₂-CH-), p represents an integer greater than or equal to 5 and less than or equal to 8, or a mixture of said compounds having formula (V); and

(d) -a mass proportion of water greater than 0 mass% and less than 50 mass%,

it is understood that the pH of the composition is less than or equal to 3.

2. The composition (C) as claimed in claim 1₁) Characterized in that, in the formulae (I) and (V), X represents a methyl group.

3. The composition (C) as claimed in claim 2₁) Characterized in that, in formula (I), the divalent radical Y represents a radical of formula (II)_a1) The divalent group of (a):

-[NH-CH(R₂)-C(＝O)-]_m- (II_a1)，

wherein m represents an integer of one or more and four or less, and R₂Represents a hydrogen atom or a group selected from the group consisting of methyl, isopropyl, isobutyl, 1-methylpropyl, benzyl or 3-aminopropyl groups.

4. The composition (C) as claimed in claim 3₁) Wherein in formula (I), the divalent group Y represents a group of formula (II'_a1) The divalent group of (a):

-NH-CH₂-C(＝O)- (II’_a1)。

5. the composition (C) as claimed in claim 4₁) Characterized in that, in the formulae (I) and (V), the monovalent radical X- (CH)₂)_p-C (═ O) -represents an octanoyl group.

6. The composition (C) as claimed in claim 2₁) Characterized in that, in the formulae (I) and (V), the monovalent radical X- (CH)₂)_p-C (═ O) -represents a 10-undecenoyl group and Y represents a compound having formula (II)_a2) The divalent group of (a):

- [ NH-CH (benzyl) -C (═ O) -]_m- (II_a2)。

7. The composition (C) according to any one of claims 1 to 6₁) Characterized in that it comprises from three to eight atoms andorGeneral formula (IVa)OrThe diol represented by the formula (IVb) is selected from 1, 2-propanediol, 1, 2-butanediol, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol, 1, 2-octanediol, 2, 3-butanediol, 2, 3-pentanediol, 2, 3-hexanediol, 2, 5-hexanediol or 2-methyl-2, 4-pentanediol.

8. The composition (C) as claimed in claim 7₁) Characterized in that it comprises from three to eight atoms andorIs represented by the formula (IV)_a)OrIs represented by the formula (IV)_b) Watch (A)The diol is selected from 1, 2-propanediol, 1, 2-butanediol, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol or 2-methyl-2, 4-pentanediol.

9. A process for preparing a composition (C) as claimed in any one of claims 1 to 8₁) Characterized in that it comprises the following successive steps:

-step a) During this step, the composition will contain from three to eight atoms andorIs represented by the formula (IV)_a)OrIs represented by the formula (IV)_b) The diol represented is mixed with water to form a mixture (S)₁) Said mixture comprising from 5 to 70% by mass of said compound of formula (IV) per 100% of its mass_a) Or has the formula (IV)_b) And from 30 to 95 mass% of water;

-step b) During this step, will have the formula (VI)_a)：

Or has the formula (VI)_b) The compound of (1):

or has the formula (VI)_a) Or (VI)_b) And at least one compound of the formula (VI)_a) Or (VI)_b) Is added to the mixture (S) in a certain proportion₁) So that the mixture (M) obtained₁) Contains from 5 to 50 mass% of the compound of formula (VI) per 100 mass% thereof_a) Or (VI)_b) Or said compound having the formula (VI)_a) And/or (VI)_b) And from 50 to 95% by mass of the mixture (S)₁)；

-a step c) during which sodium hydroxide or potassium hydroxide is added to the mixture (M)₁) To form a polymer having a molecular weight greater than or equal toMixture (M) at a pH equal to 9₂)；

-a step d) during which an acid chloride having formula (VII):

X-[CH₂]_p-C(＝O)-Cl (VII)，

wherein X and p are as defined above for formula (I), or a mixture of acid chlorides of formula (VII) is poured into said mixture (M)₂) While maintaining said pH at a value greater than or equal to 9 by the combined addition of sodium hydroxide or potassium hydroxide, said step e) resulting in the formation of a mixture (M)₃)；

-a step e) during which the mixture (M) is mixed₃) Acidifying until a pH value of less than or equal to 3 is reached;

-a step f) of decantation for the purpose of discharging the mother liquor;

-if necessary or if desired, at least one step g), washing with brine after decantation to obtain said desired composition.

10. A process for preparing a cosmetic, dermocosmetic, dermopharmaceutical or pharmaceutical composition (C) for topical use, said composition comprising: a compound having the formula (I ') or a mixture of compounds having the formula (I') in a mass proportion of 5% by mass or more and 30% by mass or less:

X-[CH₂]_p-C(＝O)-Y-O^-M⁺(I’)，

wherein X represents a methyl group or a vinyl group (CH)₂CH-), p represents an integer greater than or equal to 5 and less than or equal to 12, M⁺Represents a sodium cation, Y representsOrHaving the formula (II)_a) The divalent group of (a):

-[N(R₃)-CH(R₂)-C(＝O)-]_m- (II_a)，

wherein R is₃Represents a hydrogen atom or a methyl group, m represents an integer of 1 or more and 4 or less, and R₂Represents a hydrogen atom or a group selected from the group consisting of methyl, isopropyl, isobutyl, 1-methylpropyl, benzyl and 3-aminopropyl groups;orHaving the formula (II)_b) The divalent group of (a):

wherein R is₄Represents a hydrogen atom or a hydroxyl group, and n represents an integer of 1 or more and 4 or less; and X representsOrMethyl radicalOrMethylene group (CH)₂＝)，OrA monovalent group having the formula (III):

HO-Y’-C(＝O)- (III)，

wherein Y' representsOrSaid compound having formula (II) as defined above_a) The divalent group of (a) is,orSaid divalent radical of formula (IIb) as defined above, it being understood that when X represents said radical of formula (III), Y and Y' are identical;

(b) -a mass proportion of more than 5 mass% and less than or equal to 30 mass% of a mixture comprising from three to eight atoms andorIs represented by the formula (IV)_a)OrIs represented by the formula (IV)_b) The diols represented by:

R^a ₁-C(R^b ₁)(OH)-C(OH)(R^c ₁)(R^d ₁) (IV_a)，

wherein the radical R^a ₁、R^b ₁、R^c ₁And R^d ₁Each independently of the others represents a hydrogen atom or a saturated aliphatic group containing from one to five carbon atoms,

R^a ₁-C(R^b ₁)(OH)-[C(R^e ₁)(R^f ₁)]_t-C(OH)(R^c ₁)(R^d ₁) (IV_b)，

wherein t is equal to one, two or three, the radical R^a ₁、R^b ₁、R^c ₁、R^d ₁、R^e ₁And R^f ₁Each independently of the others represents a hydrogen atom or contains from one to five carbon atomsSaturated aliphatic radical, it being understood that the radical R^a ₁Or R^b ₁At least one of (A) and a radical R^c ₁Or R^d ₁At least one of (a) does not represent a hydrogen atom;

(d) -a mass proportion of water of more than 40 mass% and less than 90 mass%,

it is understood that the pH of the composition (C) is less than or equal to 9 and greater than or equal to 5.5,

said method is characterized in that it comprises a step h) during which the necessary amounts of a diol of formula (IVa) or of formula (Vb), an aqueous sodium hydroxide solution and water are added simultaneously or sequentially to a composition (C) according to any one of claims 1 to 8₁) Until the ratio and the pH value as defined above are reached.