阅读说明：本技术 一种含纳米银的抗菌消毒洗手液及其制备方法 (Antibacterial and disinfectant hand sanitizer containing nano-silver and preparation method thereof ) 是由 雷震 赵亮 全晓冬 余雪玲 丁轶 于 2020-05-27 设计创作，主要内容包括：本发明涉及一种含纳米银的抗菌消毒洗手液及其制备方法,该洗手液由以下组分和质量百分比制备而成：0.0005～0.05％的纳米银抗菌消毒剂、10～25％的表明活性剂、1～3％的保湿因子、1～4％的增稠剂、0.5～1％的珠光剂、1～2％的pH调节剂、0.3～0.5％的螯合剂、0.05～0.2％防腐剂、64.25～86.1495％的溶剂。这样,通过具有强效杀菌消毒的纳米银粒子即可在数分钟内杀死多种对人体有害的病菌；同时渗透性强,可由毛孔迅速渗入皮下杀菌,对普通细菌、顽固细菌、耐药菌、真菌以及病毒引起的感染具有良好的防护作用,有效的防止疾病的传播和预防感染,而且广谱抗菌消毒且无任何耐药性。(The invention relates to an antibacterial and disinfectant hand sanitizer containing nano-silver and a preparation method thereof, wherein the hand sanitizer is prepared from the following components in percentage by mass: 0.0005 to 0.05 percent of nano-silver antibacterial disinfectant, 10 to 25 percent of surfactant, 1 to 3 percent of moisturizing factor, 1 to 4 percent of thickening agent, 0.5 to 1 percent of pearling agent, 1 to 2 percent of pH regulator, 0.3 to 0.5 percent of chelating agent, 0.05 to 0.2 percent of preservative and 64.25 to 86.1495 percent of solvent. Therefore, a plurality of germs harmful to human bodies can be killed within a few minutes by the nano silver particles with powerful sterilization and disinfection; meanwhile, the antibacterial agent has strong permeability, can quickly permeate into the pores for sterilization, has good protective effect on infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria, fungi and viruses, effectively prevents the spread of diseases and infection, has broad-spectrum antibacterial and disinfection and does not have any drug resistance.)

1. An antibacterial and disinfectant hand sanitizer containing nano-silver is characterized by being prepared from the following components in percentage by mass: 0.0005 to 0.05 percent of nano-silver antibacterial disinfectant, 10 to 25 percent of surfactant, 1 to 3 percent of moisturizing factor, 1 to 4 percent of thickening agent, 0.5 to 1 percent of pearling agent, 1 to 2 percent of pH regulator, 0.3 to 0.5 percent of chelating agent, 0.05 to 0.2 percent of preservative and 64.25 to 86.1495 percent of solvent.

2. The antiseptic and disinfectant hand sanitizer containing nano silver as claimed in claim 1, wherein the nano silver particles of the antiseptic and disinfectant agent have a particle size of 10-80 nm.

3. The antibacterial and disinfectant hand sanitizer containing nano-silver as claimed in claim 1 or 2, wherein said surfactant is one or more of sodium lauryl sulfate, α -sulfo fatty acid ester, sodium fatty alcohol polyoxyethylene ether sulfate, cocamidopropyl betaine, lecithin, alkyl glucoside 1214, and coconut oil fatty acid diethanolamide.

4. The antiseptic hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein the humectant is one or more of glycerin, propylene glycol, polyethylene glycol, sodium hyaluronate, and ceramide.

5. The antiseptic hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein the thickener is one or more of polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid, sodium chloride, ammonium chloride, potassium chloride.

6. The antibacterial and disinfectant hand sanitizer containing nano-silver as claimed in claim 1 or 2, wherein the pearlizing agent is one of shell powder, mica powder, ethylene glycol monostearate, and ethylene glycol distearate.

7. The antiseptic hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein the pH regulator is one of citric acid, sodium citrate, lactic acid.

8. The antiseptic hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein the chelating agent is one of disodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, and sodium citrate.

9. The antiseptic and disinfectant hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein said antiseptic is chitosan and said solvent is pure water.

10. A method for preparing the antibacterial and disinfectant hand sanitizer containing nano-silver as claimed in any one of claims 1 to 9, which is characterized by comprising the following steps:

a1. weighing the components according to the proportion;

a2. pouring a part of solvent into a container, adding the surfactant into the container, and heating while stirring until the surfactant is completely dissolved;

a3. adding the humectant, the pearling agent, the chelating agent, the preservative and the nano-silver antibacterial disinfectant into a container, heating and stirring the mixture until the mixture is uniformly dispersed, pouring the residual pure water into the container, and cooling the container to room temperature;

a4. respectively adding a pH regulator and a thickening agent into a container, and adjusting the pH value and the viscosity;

a5. dissolving the mixed liquid in the dissolver by using ultrasonic, removing bubbles, and aging to prepare the antibacterial and disinfectant hand sanitizer containing nano silver.

Technical Field

The invention belongs to the technical field of daily washing and nursing, and particularly relates to an antibacterial and disinfectant hand sanitizer containing nano-silver and a preparation method thereof.

Background

Some diseases of human beings are caused by the fact that hands are contacted with pathogenic microorganisms such as bacteria and viruses, so hand disinfection and cleaning are very important and are effective measures for preventing the spread of germs. The routine hand washing is the most effective and simple and feasible method for controlling the spread of diseases and preventing infection, and has good prevention effect on diseases spread by the digestive tract and diseases spread by the respiratory tract. And extensive epidemiological investigations have confirmed that hands are an important route to nosocomial infections. The medical staff has serious hand pathogen contamination after nursing and diagnosis activities, hospital infection can be directly or indirectly transmitted through the hands of the medical staff, and the way is more dangerous than air transmission, so that the infected people account for 30 percent of the incidence rate of the hospital infection due to bacterial transmission.

The hand sanitizer is an article for cleaning hand skin, and certain specific components can play a role in disinfection and sterilization, and mainly comprise chlorine-containing disinfectants, such as Parachlorometaxylenol (PCMX). However, the chlorine-containing disinfectant has certain residual toxicity and also pollutes the environment.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides the nano-silver-containing antibacterial and disinfectant hand sanitizer which has strong sterilization and disinfection effects, can basically kill most of bacteria and fungi in a short time, effectively prevent the spread of diseases and prevent infection, and the preparation method of the nano-silver-containing antibacterial and disinfectant hand sanitizer.

In order to solve the technical problems, the invention adopts the following technical scheme:

an antibacterial and disinfectant hand sanitizer containing nano-silver is prepared from the following components in percentage by mass: 0.0005 to 0.05 percent of nano-silver antibacterial disinfectant, 10 to 25 percent of surfactant, 1 to 3 percent of moisturizing factor, 1 to 4 percent of thickening agent, 0.5 to 1 percent of pearling agent, 1 to 2 percent of pH regulator, 0.3 to 0.5 percent of chelating agent, 0.05 to 0.2 percent of preservative and 64.25 to 86.1495 percent of solvent.

Furthermore, the particle size of the nano-silver particles of the nano-silver antibacterial disinfectant is 10-80 nm.

Further, the surfactant is one or more of sodium dodecyl sulfate, α -sulfo fatty acid ester, sodium fatty alcohol polyoxyethylene ether sulfate, cocamidopropyl betaine, lecithin, alkyl glucoside 1214 and coconut oil fatty acid diethanolamide.

Further, the humectant is one or more of glycerin, propylene glycol, polyethylene glycol, sodium hyaluronate and ceramide.

Further, the thickening agent is one or more of polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid, sodium chloride, ammonium chloride and potassium chloride.

Further, the pearling agent is one of shell powder, mica powder, ethylene glycol monostearate and ethylene glycol distearate.

Further, the pH regulator is one of citric acid, sodium citrate and lactic acid.

Further, the chelating agent is one of disodium ethylene diamine tetraacetate, tetrasodium ethylene diamine tetraacetate and sodium citrate.

Further, the preservative is chitosan, and the solvent is pure water.

A preparation method of an antibacterial and disinfectant hand sanitizer containing nano-silver specifically comprises the following steps:

a1. weighing the components according to the proportion;

a2. pouring a part of solvent into a container, adding the surfactant into the container, and heating while stirring until the surfactant is completely dissolved;

a3. adding the humectant, the pearling agent, the chelating agent, the preservative and the nano-silver antibacterial disinfectant into a container, heating and stirring the mixture until the mixture is uniformly dispersed, pouring the residual pure water into the container, and cooling the container to room temperature;

a4. respectively adding a pH regulator and a thickening agent into a container, and adjusting the pH value and the viscosity;

a5. dissolving the mixed liquid in the dissolver by using ultrasonic, removing bubbles, and aging to prepare the antibacterial and disinfectant hand sanitizer containing nano silver.

The invention mainly has the following beneficial effects:

by adopting the technical scheme, the nano-silver-containing antibacterial and disinfectant hand sanitizer has strong sterilization and disinfection effect and can kill various germs harmful to human bodies within several minutes; meanwhile, the antibacterial agent has strong permeability, can quickly permeate into the pores for sterilization, has good protective effect on infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria, fungi and viruses, effectively prevents the spread of diseases and infection, has broad-spectrum antibacterial and disinfection and does not have any drug resistance.

Drawings

Fig. 1 is a schematic flow chart of a preparation method of the antibacterial and disinfectant hand sanitizer containing nano silver in embodiment 1 of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The nano silver antibacterial disinfectant can be used for efficient and rapid antibacterial disinfection and is non-toxic and harmless, the particle size of nano silver particles of the nano silver antibacterial disinfectant is 10-80 nm, the surfactant is non-toxic and harmless and has no harm to a body, the cleaning capability is good, the irritation to hands is low, for example, the surfactant is sodium dodecyl sulfate (K12), α -sulfofatty acid ester (MES), fatty alcohol polyoxyethylene ether sodium sulfate (AES), cocamidopropyl betaine (CAB), lecithin, alkyl alcohol ether (CAB), polyvinyl alcohol (APEA), polyvinyl alcohol sulfate (PVA), polyvinyl alcohol acetate (PVA-EDTA), polyvinyl alcohol (PVA-EDTA-AA), polyvinyl alcohol (PVA-EDTA), polyvinyl alcohol acetate (PVA-EDTA), polyvinyl alcohol (PVA-EDTA-AA), polyvinyl alcohol (PVA-EDTA-AA), polyvinyl alcohol (PVA-EDTA-AA), polyvinyl alcohol (PVA-AA), polyvinyl alcohol, PVA-AA), polyvinyl alcohol (PVA-AA), sodium chloride.

As shown in fig. 1, the preparation method of the antibacterial and disinfectant hand sanitizer containing nano silver, provided by the invention, specifically comprises the following steps:

step 100, weighing the components according to the proportion;

step 200, pouring a part of solvent into a container, adding the surfactant into the container, heating while stirring until the surfactant is completely dissolved;

step 300, adding the humectant, the pearlescing agent, the chelating agent, the preservative and the nano-silver antibacterial disinfectant into a container, heating while stirring until the components are uniformly dispersed, pouring the residual pure water into the container, and cooling to room temperature;

step 400, respectively adding a pH regulator and a thickening agent into a container, and adjusting the pH value and the viscosity;

step 500, dissolving the mixed liquid in the dissolver by using ultrasonic waves, removing bubbles, and aging to prepare the antibacterial and disinfectant hand sanitizer containing nano silver; wherein the aging time is preferably 2 h.

The nano-silver-containing antibacterial and disinfecting hand sanitizer has high-efficiency antibacterial and disinfecting performance by adopting the nano-silver antibacterial disinfectant containing nano-silver particles, can keep high-efficiency antibacterial and disinfecting effect at low concentration, can ensure no harm to human bodies, and cannot generate drug resistance; the method specifically comprises the following steps: the nano silver particles can kill various germs harmful to human bodies within several minutes by strong sterilization and disinfection; meanwhile, the antibacterial agent has strong permeability, can quickly permeate into the pores for sterilization, has good protective effect on the infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria, fungi and viruses, and has broad-spectrum antibacterial disinfection without any drug resistance.

The antibacterial and disinfectant hand sanitizer containing nano silver and the preparation method thereof are further described by the following embodiments.