阅读说明：本技术 颅内植入引流装置及小动物颅内给药和脑脊液采集器 (Intracranial implantation drainage device and small animal intracranial administration and cerebrospinal fluid collector ) 是由 欧毅超 冯展鹏 周明锋 龚浩东 武广森 李凯 王兴勤 彭君洁 刘亚伟 漆松涛 于 2020-04-09 设计创作，主要内容包括：本发明公开了一种颅内植入引流装置,并公开了具备其的小动物颅内给药和脑脊液采集器,其中颅内植入引流装置包括有留置管、盖帽及颅骨固定器,颅骨固定器具备套设在留置管上的固定器本体,固定器本体上设置若干孔壁带有第一螺纹的通孔,将留置管植入颅骨后,选取合适的通孔并利用固定螺丝穿过通孔与颅骨连接,即实现将固定器本体固定在颅骨上,从而更好地将留置管锁定在颅骨中,避免其在外力干扰下容易发生滑动,导致移位或者脱落,固定性能好,此发明用于生物医学实验研究领域。(The invention discloses an intracranial implantation drainage device and discloses a small animal intracranial administration and cerebrospinal fluid collector with the intracranial implantation drainage device, wherein the intracranial implantation drainage device comprises an indwelling tube, a cap and a skull fixer, the skull fixer is provided with a fixer body sleeved on the indwelling tube, a plurality of through holes with first threads on the wall of each through hole are arranged on the fixer body, after the indwelling tube is implanted into a skull, a proper through hole is selected and a fixing screw penetrates through the through hole to be connected with the skull, namely, the fixer body is fixed on the skull, so that the indwelling tube is better locked in the skull, the phenomenon that the indwelling tube is easy to slide under the interference of external force to cause displacement or falling is avoided, and the fixing performance is good.)

1. Intracranial implantation drainage device, its characterized in that, with a location inner core removable assecmbly, intracranial implantation drainage device includes:

an indwelling tube;

the cap is detachably arranged at the top end of the indwelling tube;

the skull fixer comprises a fixing screw and a fixer body sleeved on the indwelling tube, wherein the fixer body is provided with a plurality of through holes penetrating from the upper surface to the lower surface of the fixer body, and the hole wall of each through hole is uniformly provided with a first thread matched with the fixing screw.

2. The intracranial-implantable drainage device as recited in claim 1, wherein: the middle part of the fixer body forms a central hole for the indwelling pipe to pass through, and the through holes are uniformly distributed around the central hole.

3. The intracranial-implantable drainage device as recited in claim 2, wherein: at least one circle of locking ring is arranged around the hole wall of the central hole, and the locking rings are made of rubber.

4. The intracranial-implantable drainage device as recited in claim 1, wherein: the indwelling tube comprises a tube body and a connector sleeved on the upper end of the tube body, the cap is installed on the connector, a plurality of scale marks are marked on the outer wall of the tube body, and the scale marks are distributed along the axial direction of the tube body at equal intervals.

5. The intracranial-implantable drainage device as recited in claim 4, wherein: the block includes the top piece, winds the side wall spare that the surrounding edge of top piece set up, the internal thread is formed with towards the inner surface of side wall spare, the lateral wall setting of connector and the external screw thread of internal thread adaptation.

6. The intracranial implant drainage device as recited in claim 5, wherein: a puncture hole is formed in the middle of the top piece and is sealed through at least one cover film.

7. The intracranial-implantable drainage device as recited in claim 4, wherein: the positioning inner core comprises a clamping part and a puncture needle fixed below the clamping part, and the diameter of the cross section of the puncture needle is smaller than that of the cross section of the tube body.

8. The intracranial implant drainage device as recited in claim 7, wherein: the needle point structure of the puncture needle is conical.

9. The intracranial drug administration and cerebrospinal fluid collector for small animals is characterized by comprising a spliced and combined puncture connecting mechanism and the intracranial implant drainage device as claimed in any one of claims 1 to 6, wherein the puncture connecting mechanism comprises a needle head, a connecting hose and a connecting bolt head which are sequentially connected, and the needle head is inserted into a cover cap and extends into an indwelling tube.

10. The small animal intracranial administration and cerebrospinal fluid collector as claimed in claim 9, wherein: at least one blocking device is arranged on the connecting hose, and each blocking device is a blocking clamp.

Technical Field

The invention relates to the field of biomedical experimental research, in particular to an intracranial implantation drainage device and a small animal intracranial administration and cerebrospinal fluid collector.

Background

In neuroscience research, intracranial drug injection and cerebrospinal fluid collection of experimental animals are of great importance. By means of intracranial specific region administration and cerebrospinal fluid collection, researchers can locally regulate and control the neurophysiological processes of specific regions and specific cells through drugs, hormones, molecular compounds and other substances, so that the intrinsic pathophysiological mechanism can be understood and elucidated. The technology can be applied to the fields of neural molecule regulation, neural circuits, neural region/nuclear group functions, neural system drug screening and the like in the research of brain science, and is a basic and important research means.

The current common intracranial administration method has poor practicability and limited using effect, and has the following problems: the application method is single, the fixation is poor, the slippage is easy, the local administration range is limited, repeated operation is needed for many times, the leakage is easy due to poor tightness, the animal trauma is serious due to many times of operation experiments, and most of the metal materials can not be used for follow-up magnetic resonance imaging research and the like.

Disclosure of Invention

The invention aims to at least solve one of the technical problems in the prior art and provide an intracranial implantation drainage device which has good fixation performance and is not easy to slide and displace.

The invention also provides a small animal intracranial administration and cerebrospinal fluid collector with the intracranial implantation drainage device.

An intracranial implant drainage device according to an embodiment of the first aspect of the invention, which is detachably assembled with a positioning inner core, the intracranial implant drainage device comprising an indwelling tube; the cap is detachably arranged at the top end of the indwelling tube; the skull fixer comprises a fixing screw and a fixer body sleeved on the indwelling tube, wherein the fixer body is provided with a plurality of through holes penetrating from the upper surface to the lower surface of the fixer body, and the hole wall of each through hole is uniformly provided with a first thread matched with the fixing screw.

The intracranial implantation drainage device according to the embodiment of the invention has at least the following beneficial effects: the intracranial implantation drainage device comprises an indwelling tube, a cap and a skull fixer, wherein the skull fixer is provided with a fixer body sleeved on the indwelling tube, the fixer body is provided with a plurality of through holes with first threads on the hole wall, after the indwelling tube is implanted into the skull, a proper through hole is selected and is connected with the skull by penetrating the through hole through a fixing screw, so that the fixer body is fixed on the skull, the indwelling tube is better locked in the skull, the phenomenon that the indwelling tube slides easily under the interference of external force to cause displacement or falling is avoided, and the fixing performance is good; in addition, the intracranial implantation drainage device can be implanted in a ventricular system and used for collecting and analyzing components of cerebrospinal fluid for multiple times.

According to some embodiments of the invention, the fixing screw is made of plastic, and the indwelling tube, the cap and the fixator body are made of non-metal materials, so that the experimental animal with the intracranial implantation drainage device implanted in the brain can be used for subsequent researches such as magnetic resonance, electrophysiology and the like.

According to some embodiments of the invention, the central portion of the anchor body forms a central bore through which the indwelling tube passes, and the through-bores are evenly distributed around the central bore.

According to some embodiments of the invention, at least one ring of locking rings is provided around the wall of the central bore, each locking ring being made of rubber.

According to some embodiments of the invention, the indwelling tube comprises a tube body and a connector sleeved at the upper end of the tube body, the cap is mounted on the connector, the outer wall of the tube body is marked with a plurality of scale marks, the scale marks are distributed at equal intervals along the axial direction of the tube body, and the outer wall of the tube body can be provided with a plurality of side holes as required.

According to some embodiments of the invention, the cap comprises a top piece, a side piece arranged around the periphery of the top piece, the inner surface of the side piece is formed with an internal thread, and the side wall of the connector is provided with an external thread matched with the internal thread. The cap can be sterilized, repeatedly punctured for use, and can be used for multiple times or simultaneously given with multiple medicines, so that repeated operation is reduced, and experimental animals are protected.

According to some embodiments of the invention, a puncture is provided in a central portion of the top member, the puncture being closed by at least one cover membrane.

According to some embodiments of the invention, the positioning core comprises a clamping portion and a puncture needle fixed below the clamping portion, and the cross-sectional diameter of the puncture needle is smaller than that of the tube body.

According to some embodiments of the invention, the needle tip structure of the needle is tapered.

The small animal intracranial administration and cerebrospinal fluid collector comprises a spliced and combined puncture connecting mechanism and the intracranial implantation drainage device, wherein the puncture connecting mechanism comprises a needle head, a connecting hose and a connecting bolt head which are sequentially connected, and the needle head is inserted into a cap and extends into an indwelling tube.

According to the small animal intracranial administration and cerebrospinal fluid collector provided by the embodiment of the invention, by configuring the intracranial implantation drainage device provided by the embodiment of the first aspect of the invention, the times of repeated operation due to the displacement of the indwelling tube in the administration process can be reduced, and the wound caused to the experimental small animal is reduced; in addition, the intracranial administration and cerebrospinal fluid collector of the small animal can be combined with a living body moving frame and is used for the study of administration of experimental animals in a waking state, chemogenetics of a specific brain area and the like.

According to some embodiments of the invention, at least one shut-off device is provided on the connecting hose, each shut-off device being a shut-off clip.

Drawings

The invention will be further described with reference to the accompanying drawings in which:

FIG. 1 is an overall block diagram of an intracranial implant drainage device according to an embodiment of the invention;

FIG. 2 is a block diagram of a holder body of a skull holder according to an embodiment of the invention;

FIG. 3 is an exploded view of the indwelling tube and the cap according to the embodiment of the present invention;

FIG. 4 is a schematic structural view of a positioning core according to an embodiment of the present invention;

FIG. 5 is a schematic view of an assembly of an intracranial implant drainage device and positioning core in accordance with an embodiment of the invention;

FIG. 6 is a block diagram of a small animal intracranial administration and cerebrospinal fluid collector according to an embodiment of the present invention;

fig. 7 is a schematic structural view of a puncture connection mechanism according to an embodiment of the present invention.

Detailed Description

Reference will now be made in detail to the present preferred embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to like elements throughout.

In the description of the present invention, it should be understood that the orientation or positional relationship referred to in the description of the orientation, such as the upper, lower, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, the meaning of a plurality of means is one or more, the meaning of a plurality of means is two or more, and larger, smaller, larger, etc. are understood as excluding the number, and larger, smaller, inner, etc. are understood as including the number. If the first and second are described for the purpose of distinguishing technical features, they are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.