阅读说明：本技术 一种促渗透的基质组合物、其制备方法及其应用 (Permeation-promoting matrix composition, preparation method and application thereof ) 是由 邓志攀 孟卫华 苏云龙 沈政 曾伟锋 邓锟健 于 2020-06-16 设计创作，主要内容包括：本发明公开了一种促渗透的基质组合物、其制备方法及其应用,促渗透的基质组合物包括按重量份计的有效成分：肌醇5-20份；甜菜碱1-10份；乳化剂1-10份；多元醇10-30份；制备方法：将乳化剂和多元醇加入80-90℃的溶剂中,搅拌溶解均匀后保温,然后降温,加入肌醇和甜菜碱,混匀后得到促渗透的基质组合物；促渗透的基质组合物,克服了化妆护肤产品营养成分难于渗透人体皮肤的缺陷,是一种组方简单、安全不刺激的基质组合物。(The invention discloses a penetration-promoting matrix composition, a preparation method and application thereof, wherein the penetration-promoting matrix composition comprises the following effective components in parts by weight: 5-20 parts of inositol; 1-10 parts of betaine; 1-10 parts of an emulsifier; 10-30 parts of polyhydric alcohol; the preparation method comprises the following steps: adding an emulsifier and polyhydric alcohol into a solvent at 80-90 ℃, stirring and dissolving uniformly, keeping the temperature, then cooling, adding inositol and betaine, and mixing uniformly to obtain a permeation-promoting matrix composition; the penetration-promoting matrix composition overcomes the defect that the nutrient components of the cosmetic skin care product are difficult to penetrate the skin of a human body, and is simple in formula, safe and non-irritating.)

1. The penetration-promoting matrix composition is characterized by comprising the following effective components in parts by weight:

2. the penetration-enhancing matrix composition of claim 1, comprising the following active ingredients in parts by weight:

3. the penetration enhancing matrix composition of claim 1, wherein the emulsifier is soy hydrogenated lecithin.

4. The penetration enhancing matrix composition of claim 1, wherein the polyol is at least one of glycerol and 1, 3-butanediol.

5. The penetration-enhancing matrix composition of claim 1, further comprising a solvent.

6. A method of preparing a penetration enhancing matrix composition, comprising:

adding 1-10 parts by weight of emulsifier and 10-30 parts by weight of polyalcohol into a solvent at the temperature of 80-90 ℃, stirring and dissolving uniformly, keeping the temperature, then cooling, adding 5-20 parts by weight of inositol and 1-10 parts by weight of betaine, and mixing uniformly to obtain the permeation-promoting matrix composition.

7. A method of preparing a penetration enhancing matrix composition according to claim 6, wherein: the solvent is water.

8. A method of preparing a penetration enhancing matrix composition according to claim 6, wherein: the holding time is 5 min.

9. A method of preparing a penetration enhancing matrix composition according to claim 6, wherein: cooling to 40-45 deg.C.

10. Use of a penetration enhancing matrix composition characterized by: the penetration enhancing matrix composition is added to a skin care product.

Technical Field

The invention relates to a penetration-promoting matrix composition, a preparation method and application thereof, belonging to the technical field of functional skin care products.

Background

The human skin is a natural barrier between human and the external environment, generally, external substances are difficult to permeate through the horny layer of the skin, and the effective part cannot have the corresponding effect, and although most of the cosmetics in the current market are added with a lot of effective nutrient components, the nutrient components are difficult to penetrate through the horny layer of the human skin and reach the dermal layer of the effective part. Therefore, in order to overcome the skin barrier effect and promote the effective components to enter the dermis layer of the skin so as to play various physiological regulation effects on skin cells, certain components with permeation promotion functions can be added when cosmetics or medicines are prepared, so that the transdermal absorption rate of the original effective components is increased, and the transdermal absorption of the nutrient components of the cosmetics and skin care products is greatly improved.

Disclosure of Invention

In order to overcome the disadvantages of the prior art, the first object of the present invention is to provide a penetration-promoting base composition which overcomes the defect that the nutritional ingredients of cosmetic skin care products are difficult to penetrate human skin, and is a base composition with simple formulation, safety and no irritation.

A second object of the present invention is to provide a process for the preparation of the above-mentioned penetration enhancing matrix composition.

A third object of the present invention is to provide a use of the above penetration enhancing matrix composition.

The first purpose of the invention can be achieved by adopting the following technical scheme: a penetration-promoting matrix composition comprises the following effective components in parts by weight:

further, the composition comprises the following effective components in parts by weight:

further, the emulsifier is soybean hydrogenated lecithin.

Further, the polyhydric alcohol is at least one of glycerin and 1, 3-butanediol.

Further, the penetration enhancing matrix composition further comprises a solvent.

The second purpose of the invention can be achieved by adopting the following technical scheme: a preparation method of a permeation-promoting matrix composition comprises the steps of adding 1-10 parts by weight of an emulsifier and 10-30 parts by weight of a polyalcohol into a solvent at a temperature of 80-90 ℃, uniformly stirring and dissolving, keeping the temperature, then cooling, adding 5-20 parts by weight of inositol and 1-10 parts by weight of betaine, and uniformly mixing to obtain the permeation-promoting matrix composition.

Further, the solvent is water.

Further, the holding time was 5 min.

Further, the temperature is reduced to 40-45 ℃.

The third purpose of the invention can be achieved by adopting the following technical scheme: the application of penetration-promoting matrix composition is to add the penetration-promoting matrix composition into skin care products.

Compared with the prior art, the invention has the beneficial effects that:

1. inositol in the permeation promoting matrix composition plays a role in stabilizing osmotic pressure balance inside and outside human cells, protecting the cells from being damaged by osmotic pressure, and betaine plays a role in combining and conveying water, so that water-soluble nutrient substances are better transferred into the cells;

2. the polyhydric alcohol in the permeation-promoting matrix composition has a good moisturizing effect while assisting in promoting permeation, and can be synergistically enhanced with inositol and betaine to promote absorption;

3. the permeation-promoting matrix composition is applied to skin care cosmetic products, is mild and non-irritating, effectively promotes active substances to permeate deep layers of skin, and helps the skin to absorb nutrient components; the skin-care cosmetic additive does not cause allergy, irritation and the like to users when added into skin-care cosmetic products, is safe to use and has obvious effect on the effect of promoting penetration.

Detailed Description

The invention will be further described with reference to specific embodiments:

a penetration-promoting matrix composition comprises the following effective components in parts by weight:

among them, hydrogenated soybean lecithin is produced by BST of Korea.

Wherein inositol and betaine are produced by DuPont of America.

Wherein glycerin is produced by Malaysia Spinosa, and 1, 3-butanediol is produced by Japan xylonite.

The preparation method of the penetration-promoting matrix composition comprises the following steps:

adding soybean hydrogenated lecithin, glycerol and 1, 3-butanediol into water of 80-90 deg.C, stirring for dissolving, maintaining the temperature for 5min, cooling to 40-45 deg.C, adding inositol and betaine, and mixing to obtain permeation promoting matrix composition.

The soybean hydrogenated lecithin with the component proportion of 1-10 parts can better permeate through skin keratinocytes and can be used as a transmission channel of nutrient components of cosmetics, so that more nutrient components can permeate into the deep skin; 5-20 parts of inositol has the effects of stabilizing osmotic pressure balance inside and outside human cells, protecting the cells from being damaged by osmotic pressure, and leading the betaine to have the effects of combining and conveying water so as to better transmit water-soluble nutrient substances into the cells; the polyhydric alcohol has good moisturizing effect while assisting in promoting penetration, and can be synergistically enhanced with lecithin, inositol and betaine to promote absorption.