阅读说明：本技术 一种含有色氨酸和酪氨酸的防晒剂及其制备方法 (Sunscreen agent containing tryptophan and tyrosine and preparation method thereof ) 是由 严超 马秀侠 乔丽君 刘�文 王思蒙 于 2020-04-24 设计创作，主要内容包括：本发明属于化妆品领域,具体涉及一种含有色氨酸和酪氨酸的防晒剂,按重量份计包括,3-7份色氨酸、3-7份酪氨酸、2-4份亲水性的纳米二氧化钛、2-4份纳米二氧化锌、3-5份气相白炭黑、2-4份鲸蜡醇、1-3份肉豆蔻酸异丙酯、1-3份小麦胚芽油、0-2份鸸鹋油、3-6份甘油、3-5份乙醇、3-5份成膜剂、1-2份乳化剂、1-2份增稠剂、0.2-0.5份防腐剂和55-65份去离子水。本发明的防晒剂具有防晒、保湿护肤一体,无需如现有的防晒剂一样,需要在出门前往往还需要涂抹保湿剂等化妆品。(The invention belongs to the field of cosmetics, and particularly relates to a sunscreen agent containing tryptophan and tyrosine, which comprises, by weight, 3-7 parts of tryptophan, 3-7 parts of tyrosine, 2-4 parts of hydrophilic nano titanium dioxide, 2-4 parts of nano zinc dioxide, 3-5 parts of fumed silica, 2-4 parts of cetyl alcohol, 1-3 parts of isopropyl myristate, 1-3 parts of wheat germ oil, 0-2 parts of emu oil, 3-6 parts of glycerol, 3-5 parts of ethanol, 3-5 parts of a film forming agent, 1-2 parts of an emulsifier, 1-2 parts of a thickening agent, 0.2-0.5 part of a preservative and 55-65 parts of deionized water. The sunscreen agent provided by the invention integrates sunscreen and moisturizing skin care, and cosmetics such as a moisturizing agent and the like are not required to be applied before going out like the existing sunscreen agent.)

1. A sunscreen agent containing tryptophan and tyrosine is characterized by comprising, by weight, 3-7 parts of tryptophan, 3-7 parts of tyrosine, 2-4 parts of hydrophilic nano titanium dioxide, 2-4 parts of nano zinc dioxide, 3-5 parts of fumed silica, 2-4 parts of cetyl alcohol, 1-3 parts of isopropyl myristate, 1-3 parts of wheat germ oil, 0-2 parts of emu oil, 3-6 parts of glycerol, 3-5 parts of ethanol, 3-5 parts of a film forming agent, 1-2 parts of an emulsifier, 1-2 parts of a thickening agent, 0.2-0.5 part of a preservative and 55-65 parts of deionized water.

2. The sunscreen containing tryptophan and tyrosine according to claim 1, wherein the tryptophan is food grade tryptophan with a chiral structure which is all levorotatory.

3. The composition of claim 1 wherein said tyrosine is a food grade tyrosine having a chiral structure that is all levorotatory.

4. The sunscreen agent containing tryptophan and tyrosine according to claim 1, wherein the hydrophilic nano titanium dioxide is prepared by the following method: titanium dioxide with the particle size of 20-30nm is selected and added with water to prepare titanium dioxide slurry, water-soluble sodium silicate with the mass of 5% of the titanium dioxide is added into the titanium dioxide slurry, the pH value of the titanium dioxide slurry is neutralized to 8-11 by using a sulfuric acid solution with the mass concentration of 10%, the reaction is carried out for 5 hours under the conditions of 85 ℃ and stirring, the mixture is filtered, washed to be neutral, dried at 105 ℃, and then ground into powder.

5. The sunscreen agent containing tryptophan and tyrosine according to claim 1, wherein the nano zinc oxide particle size is 15-30 nm.

6. The sunscreen agent containing tryptophan and tyrosine as claimed in claim 1, wherein the fumed silica has a specific surface area of 600-800m³/g。

7. The sunscreen agent containing tryptophan and tyrosine according to claim 1, wherein the film forming agent is selected from one or two of cyclic dimethyl polysiloxane and polyether modified silicone oil; the emulsifier is selected from one or more of tween 60, tween 80, span 60 and span 80.

8. The sunscreen containing tryptophan and tyrosine according to claim 1, wherein the thickener is selected from any one or two of xanthan gum and hydroxyethyl cellulose; the preservative is selected from any one or two of nipagin ester and phenoxyethanol.

9. A process for the preparation of a sunscreen according to claim 1 comprising the steps of:

a. preparing an aqueous phase: uniformly mixing deionized water, glycerol and ethanol according to a proportion, then sequentially adding an emulsifier and a preservative, and uniformly stirring;

b. preparing an oil phase: mixing cetyl alcohol, isopropyl myristate, wheat germ oil, emu oil and film-forming agent in proportion, and stirring;

c. adding the oil phase into the water phase at the rotation speed of 200-300r/min, after the oil phase and the water phase are completely mixed, sequentially adding tryptophan, tyrosine, nano titanium dioxide, nano zinc dioxide and fumed silica, stirring until the oil phase and the water phase are completely and uniformly mixed, and finally adding a thickening agent and stirring into a uniform and stable state.

Technical Field

The invention belongs to the field of cosmetics, and particularly relates to a sunscreen agent containing tryptophan and tyrosine and a preparation method thereof.

Background

The sunlight damage to human skin mainly comes from ultraviolet A (UVA) and ultraviolet B (UVB), wherein UVA acts on the deep layer of the skin and is slow in action but can cause one-time blackening, and UVB acts on the surface layer of the skin to excite skin keratinocytes, relax blood vessels, increase blood flow and make the skin reddish to brown. UVA and UVB cause sunburn, peeling, tanning, etc. to the skin, which in turn causes premature aging of the skin, irreparable damage to the skin, and may also cause skin cancer if chronically affected by UVA and UVB.

Current sunscreen measures against ultraviolet rays mainly include physical sunscreen, which means the use of a substance capable of reflecting sunlight (TiO), and chemical sunscreen₂ZnO) forms a protective film on the surface of skin to reflect ultraviolet rays out, thereby achieving the sun-screening effect, and chemical sun-screening means that chemical substances in the sun-screening product, such as phthalate, convert ultraviolet rays which damage the skin into harmless heat energy and the like to be released. The chemical sun-screening agent can enter skin tissues, has certain irritation to the skin, and can cause damage to the skin when being improperly used.

In some perennial high-temperature areas, the existing sunscreen agent only has a single sunscreen function, and the sunscreen agent can lose the function quickly along with the evaporation effect of high temperature, and is very troublesome because cosmetics such as a humectant and the like need to be applied before going out; however, in the prior art, no technical scheme for solving the problem is found.

Disclosure of Invention

In order to solve the above problems, it is an object of the present invention to provide a sunscreen agent containing tryptophan and tyrosine, which has a sunscreen effect and also provides moisturizing, skin-beautifying, anti-inflammatory and restorative effects.

The invention provides the following technical scheme:

a sunscreen agent containing tryptophan and tyrosine comprises, by weight, 3-7 parts of tryptophan, 3-7 parts of tyrosine, 2-4 parts of nano titanium dioxide, 2-4 parts of nano zinc dioxide, 3-5 parts of fumed silica, 2-4 parts of cetyl alcohol, 1-3 parts of isopropyl myristate, 1-3 parts of wheat germ oil, 0-2 parts of emu oil, 3-6 parts of glycerol, 3-5 parts of ethanol, 3-5 parts of a film forming agent, 1-2 parts of an emulsifier, 1-2 parts of a thickening agent, 0.2-0.5 part of a preservative and 55-65 parts of deionized water.

Preferably, the tryptophan is food grade tryptophan with a chiral structure which is all levorotatory.

Preferably, the tyrosine is food-grade tyrosine with a chiral structure of all levorotation.

Preferably, the preparation method of the hydrophilic nano titanium dioxide comprises the following steps: titanium dioxide with the particle size of 20-30nm is selected and added with water to prepare titanium dioxide slurry, water-soluble sodium silicate with the mass of 5% of the titanium dioxide is added into the titanium dioxide slurry, the pH value of the titanium dioxide slurry is neutralized to 8-11 by using a sulfuric acid solution with the mass concentration of 10%, the reaction is carried out for 5 hours under the conditions of 85 ℃ and stirring, the mixture is filtered, washed to be neutral, dried at 105 ℃, and then ground into powder.

Preferably, the nano zinc oxide particle size is 15-30 nm.

Preferably, the specific surface area of the fumed silica is 600-800m³/g。

Preferably, the film forming agent is selected from one or two of cyclic dimethyl polysiloxane and polyether modified silicone oil; the emulsifier is selected from one or more of tween 60, tween 80, span 60 and span 80.

Preferably, the thickening agent is selected from any one or two of xanthan gum and hydroxyethyl cellulose; the preservative is selected from any one or two of nipagin ester and phenoxyethanol.

The invention also provides a preparation method of the sun-screening agent, which is characterized by comprising the following steps:

a. preparing an aqueous phase: uniformly mixing deionized water, glycerol and ethanol according to a proportion, then sequentially adding an emulsifier and a preservative, and uniformly stirring;

b. preparing an oil phase: mixing cetyl alcohol, isopropyl myristate, wheat germ oil, emu oil and film-forming agent in proportion, and stirring;

c. adding the oil phase into the water phase at the rotating speed of 200-00r/min, after the two are completely mixed, sequentially adding tryptophan, tyrosine, nano titanium dioxide, nano zinc dioxide and fumed silica, stirring until the two are completely and uniformly mixed, finally adding the thickening agent, and stirring to form a uniform and stable state.

The invention has the beneficial effects that:

1. the sunscreen agent provided by the invention integrates sunscreen and moisturizing skin care, and cosmetics such as a moisturizing agent and the like are not required to be applied before going out like the existing sunscreen agent.

2. The tryptophan of the invention has the following characteristics: the selected tryptophan is food grade, is an amino acid in a human body, can be metabolized by the human body, is harmless to users, has a levorotatory chiral structure in molecules, has a strong absorption peak at 280nm, can convert ultraviolet rays into heat energy which is harmless to the skin and releases the heat energy, and the tyrosine has the following characteristics: the selected tyrosine is food grade, is an amino acid in a human body, can be metabolized by the human body, is harmless to users, has a left-handed chiral structure in a molecule, has a certain absorption peak at 280nm, and can convert ultraviolet rays into heat energy which is harmless to the skin and release the heat energy; the hydrophilic nano titanium dioxide has high transparency, no stimulation to skin of a human body, good compatibility with a cosmetic system and strong antibacterial action, not only absorbs ultraviolet rays, but also can reflect or scatter the ultraviolet rays, has better chemical stability and light stability, is nontoxic and tasteless, and also has strong antibacterial action; the nano zinc dioxide has the size of 15 nm-30 nm, the surface is not treated, and the nano zinc dioxide has hydrophilicityThe cosmetic has high transparency, can absorb ultraviolet rays in cosmetics, can reflect or scatter the ultraviolet rays, and has extremely strong antibacterial, bacteriostatic and mildewproof properties; specific surface area of fumed silica of 600m^-800m³The emulsion has high surface activity, can obviously thicken and increase the stability and thixotropy of the product, and is very smooth in application without astringent feeling.

The selected tryptophan and the tyrosine are both in a levorotatory chiral structure, have strong ultraviolet absorption capacity and can play a role of a chemical sun-screening agent; the titanium oxide and the zinc oxide can absorb most of UVA and UVB, and the nano-scale titanium oxide and the nano-scale zinc oxide can reflect and scatter ultraviolet rays, so that the paint has a physical sun-screening effect, and the dosage is not limited by the country; the added fumed silica can form a protective layer on the surfaces of the nano-scale zinc oxide and nano-scale zinc oxide particles, so that the uneven surfaces of the particles are filled, the attraction among the particles is weakened, the possibility of agglomeration is reduced, the system is more uniform and stable, and the additionally obtained thixotropic property can help the product to be uniformly spread on the surface of the skin, the skin feel and hand feel during smearing are improved, and the product performance is comprehensively improved. The added glycerin enables the product to have excellent moisturizing and hydrating effects; the added wheat germ oil has the functions of moistening skin and conditioning skin, can prevent the skin from aging in advance, maintain the health of connective tissues and activate the circulation of the skin, and also has certain effects on whelk, acne, psoriasis, eczema and the like; the added emu oil has strong anti-inflammatory function and excellent skin permeability.

Detailed Description

The present invention will be described in detail with reference to the following examples.