阅读说明：本技术 转谷氨酰胺酶处理的产品 (Transglutaminase-treated products ) 是由 怡·陈 肖恩·柯林斯 黄励婷 埃里克·斯特克 辉·许 于 2018-01-29 设计创作，主要内容包括：本申请涉及转谷氨酰胺酶处理的产品。本申请涉及转谷氨酰胺酶用于处理各种产品的用途,所述产品包括医疗装置诸如组织移植物、组织基质或其他源自组织的材料,以及合成品。转谷氨酰胺酶可以施加至医疗装置,以提供诸如粘连抗性或磨损抗性的优点。(The present application relates to transglutaminase treated products. The present application relates to the use of transglutaminase for the treatment of various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, as well as synthetics. Transglutaminase can be applied to medical devices to provide advantages such as adhesion resistance or abrasion resistance.)

1. A medical device, comprising:

an implant body portion comprising a collagen-containing tissue matrix; and

a surface region comprising a portion that has been treated to have a transglutaminase coating, wherein the surface region provides at least one of anti-blocking properties or anti-wear properties to the exterior surface.

2. The medical device of claim 1, wherein the implant body portion comprises a sheet of collagen-containing tissue matrix.

3. The medical device of claim 1, wherein the collagen-containing tissue matrix comprises an acellular tissue matrix.

4. The medical device of claim 1, wherein the collagen-containing tissue matrix is produced from tissue derived from a tissue selected from the group consisting of: fascia, fat, pericardial tissue, dura, umbilical cord tissue, placental tissue, cardiac valve tissue, ligament tissue, tendon tissue, arterial tissue, venous tissue, neural connective tissue, bladder tissue, ureter tissue, muscle, and intestinal tissue.

5. The medical device of claim 1, wherein the collagen-containing tissue matrix is produced from skin-derived tissue.

6. The medical device of claim 1, wherein the collagen-containing tissue matrix comprises a dermal tissue matrix.

7. The medical device of claim 1, wherein the device is dry.

8. The medical device of claim 1, further comprising a synthetic substrate, wherein the collagen-containing tissue matrix is in contact with the synthetic substrate.

9. The medical device of claim 8, wherein the synthetic substrate comprises a synthetic mesh.

10. The medical device of claim 8, wherein the synthetic substrate comprises polypropylene filaments.

11. The medical device of claim 1, wherein the collagen-containing tissue matrix comprises a particulate acellular tissue matrix.

12. The medical device of claim 11, wherein the particulate acellular tissue matrix has been suspended and stabilized to produce a stable three-dimensional shape, and wherein the three-dimensional shape is in the form of a sheet.

13. The medical device of claim 1, wherein the collagen-containing tissue matrix comprises a particulate acellular tissue matrix and a synthetic mesh substrate, wherein the particulate acellular tissue matrix forms a covering over the synthetic mesh substrate and an outer surface of the tissue matrix has increased resistance to adhesion or abrasion when implanted in a patient.

14. A method of producing the medical device of claim 1, comprising:

selecting a collagen-containing tissue matrix;

applying a composition comprising transglutaminase to at least a portion of a surface area of the collagen-containing tissue matrix; and

allowing the transglutaminase to perform an enzymatic activity on at least a portion of the surface region of the collagen-containing tissue matrix to produce a region of collagen-containing tissue matrix having at least one of anti-adhesion properties or anti-wear properties.

15. The method of claim 14, wherein the composition comprises an aqueous solution.

16. The method of claim 14, further comprising inactivating said transglutaminase.

17. The method of claim 16, wherein the enzyme is inactivated by heating.

18. The method of claim 14, wherein the method comprises attaching the collagen-containing tissue matrix to a synthetic substrate prior to applying the composition comprising transglutaminase to the collagen-containing tissue matrix.

19. The method of claim 18, wherein the collagen-containing tissue matrix is a particulate matrix, and wherein attaching the collagen-containing tissue matrix to a synthetic substrate comprises applying a slurry of the collagen-containing tissue matrix to the synthetic substrate.

20. The method of claim 19, further comprising stabilizing or drying the slurry.

21. The method of claim 20, wherein the composition comprising the transglutaminase is applied after stabilization or drying.