阅读说明：本技术 一种抗扭结人工血管及其制备方法 (Anti-kink artificial blood vessel and preparation method thereof ) 是由 闫冬环 杜广武 于 2019-12-18 设计创作，主要内容包括：本发明涉及一种抗扭结人工血管及其制备方法,人工血管包括设置于内层的膨体聚四氟乙烯管,设置于外层的聚对苯二甲酸乙二醇酯织物,设置于内层和外层之间的氟化乙烯丙烯支撑环,所述氟化乙烯丙烯支撑环与所述膨体聚四氟乙烯管同轴,所述氟化乙烯丙烯支撑环为螺旋结构,所述螺旋结构的螺距为1.5mm-3mm。该人工血管可以180°弯曲而不打折。(The invention relates to an anti-kink artificial blood vessel and a preparation method thereof, wherein the artificial blood vessel comprises an expanded polytetrafluoroethylene tube arranged on an inner layer, a polyethylene glycol terephthalate fabric arranged on an outer layer, and a fluorinated ethylene propylene support ring arranged between the inner layer and the outer layer, wherein the fluorinated ethylene propylene support ring is coaxial with the expanded polytetrafluoroethylene tube, the fluorinated ethylene propylene support ring is of a spiral structure, and the pitch of the spiral structure is 1.5mm-3 mm. The artificial blood vessel can be bent by 180 degrees without being folded.)

1. An anti-kink artificial blood vessel characterized by: including setting up in the inflation polytetrafluoroethylene pipe of inlayer, set up in outer polyethylene glycol terephthalate fabric, set up the fluorinated ethylene propylene support ring between inlayer and skin, fluorinated ethylene propylene support ring with inflation polytetrafluoroethylene pipe is coaxial, fluorinated ethylene propylene support ring is helical structure, helical structure's pitch is 1.5mm-3 mm.

2. The kink-resistant artificial blood vessel according to claim 1, characterized in that: the inner diameter of the expanded polytetrafluoroethylene tube is 3mm-8mm, and the thickness of the expanded polytetrafluoroethylene tube is 0.1mm-0.2 mm.

3. The kink-resistant artificial blood vessel according to claim 1, characterized in that: the spiral structure is connected with the inner layer expanded polytetrafluoroethylene tube and the outer layer polyethylene glycol terephthalate fabric through silica gel.

4. The kink-resistant artificial blood vessel according to claim 1, characterized in that: the fluorinated ethylene propylene support ring is formed by spirally winding a fluorinated ethylene propylene belt around the outer wall of the expanded polytetrafluoroethylene tube.

5. The kink-resistant artificial blood vessel according to claim 4, characterized in that: the width of the fluorinated ethylene propylene belt is 0.1mm-0.3mm, and the thickness of the fluorinated ethylene propylene belt is 0.02-0.04 mm.

6. The kink-resistant artificial blood vessel according to claim 1, characterized in that: and an anticoagulant coating is coated on the inner wall of the expanded polytetrafluoroethylene tube.

7. The kink-resistant artificial blood vessel according to claim 6, characterized in that: the anticoagulant coating is a heparin coating which is combined by covalent bonds.

8. The kink-resistant artificial blood vessel according to claim 1, characterized in that: the expanded polytetrafluoroethylene tube is prepared by thermoforming a multilayer expanded polytetrafluoroethylene film.

9. A preparation method of an anti-kink artificial blood vessel is characterized by comprising the following steps: comprises the following steps

a, rolling an expanded polytetrafluoroethylene film on a shaft with a set diameter to form a tube, and then carrying out heat setting treatment at 300-350 ℃ to form an expanded polytetrafluoroethylene tube;

b, spirally winding a fluorinated ethylene propylene belt outside the expanded polytetrafluoroethylene tube, wherein the thread pitch is 1.5-3 mm;

c, coating silica gel on the surface of the fluorinated ethylene propylene belt, then sleeving the polyethylene terephthalate fabric on the outer layer of the fluorinated ethylene propylene belt, and taking down a sample from a shaft after heat treatment to obtain the kink-resistant artificial blood vessel.

10. The method for preparing an anti-kink artificial blood vessel according to claim 1, characterized in that: the heat treatment in the step c is specifically carried out for 15min to 20min at the temperature of 110 ℃ to 130 ℃.

Technical Field

The invention relates to an artificial blood vessel, in particular to an anti-kink artificial blood vessel and a preparation method thereof.

Background

As the aging process of the population accelerates, the incidence of Chronic Kidney Disease (CKD) worldwide increases year by year. Hemodialysis is the most common renal replacement therapy for end-stage renal disease (ESRD) patients worldwide, and the precondition of hemodialysis is to have a reliable vascular access, and the quality of the vascular access directly affects the dialysis and the quality of life of the patients.

Limited by the quality and quantity of autologous blood vessels, vascular access is currently established primarily with artificial blood vessels. Most artificial blood vessels in the market are prepared from expanded polytetrafluoroethylene, and the artificial blood vessels are poor in anti-kink performance and easy to flatten. Once the artificial blood vessel is kinked or broken, the blood flow of the blood vessel is obstructed, so that the artificial blood vessel cannot be used continuously. And because the diameter is small, thrombus is easily formed, thereby influencing the patency rate.

Disclosure of Invention

The invention provides an anti-kink artificial blood vessel, which aims to solve the problems of poor anti-kink performance and easiness in kinking or folding of the existing artificial blood vessel.

The technical scheme adopted by the invention is as follows: the utility model provides an antitorque knot artificial blood vessel, sets up in outer polyethylene glycol terephthalate fabric including setting up in the expanded polytetrafluoroethylene pipe of inlayer, sets up the fluorinated ethylene propylene support ring between inlayer and skin, fluorinated ethylene propylene support ring with expanded polytetrafluoroethylene pipe is coaxial, fluorinated ethylene propylene support ring is helical structure, and the pitch is the less, and the antitorque knot performance is better, and when the pitch was greater than 3mm, the performance was relatively poor, can not 180 crooked, the pitch of helical structure is 1.5mm-3 mm.

Further, the larger the inner diameter of the tube, the worse the bending resistance, and when the inner diameter is more than 8mm, 180 degree bending is impossible. In addition, the larger the thickness, the worse the bending resistance. The inner diameter of the expanded polytetrafluoroethylene tube is 3mm-8mm, and the thickness of the expanded polytetrafluoroethylene tube is 0.1mm-0.2 mm.

Further, the spiral structure is connected with the inner-layer expanded polytetrafluoroethylene tube and the outer-layer polyethylene terephthalate fabric through silica gel.

Furthermore, the fluorinated ethylene propylene support ring is formed by spirally winding a fluorinated ethylene propylene belt around the outer wall of the expanded polytetrafluoroethylene tube.

Furthermore, the width of the fluorinated ethylene propylene belt is 0.1mm-0.3mm, and the thickness of the fluorinated ethylene propylene belt is 0.02-0.04 mm. The larger the width, the wider the coverage at a given pitch. When the blood vessel is too thick, the blood vessel will be hard to be anastomosed with the autologous blood vessel, and the anastomosis is not easy.

Further, an anticoagulant coating is coated on the inner wall of the expanded polytetrafluoroethylene tube, and the anticoagulant coating is a heparin coating which is combined through covalent bonds.

The inner layer expanded polytetrafluoroethylene tube is in a straight tube shape.

Furthermore, the expanded polytetrafluoroethylene tube is prepared by multilayer expanded polytetrafluoroethylene film thermoforming.

The invention also provides a preparation method of the kink-resistant artificial blood vessel, which comprises the following steps

a, rolling an expanded polytetrafluoroethylene film on a shaft with a set diameter to form a tube, and then carrying out heat setting treatment at 300-350 ℃ to form an expanded polytetrafluoroethylene tube;

b, spirally winding a fluorinated ethylene propylene belt outside the expanded polytetrafluoroethylene tube, wherein the thread pitch is 1.5-3 mm;

c, coating silica gel on the surface of the fluorinated ethylene propylene belt, then sleeving the polyethylene terephthalate fabric on the outer layer of the fluorinated ethylene propylene belt, and taking down a sample from a shaft after heat treatment to obtain the kink-resistant artificial blood vessel.

Further, the heat treatment in the step c is specifically carried out at 110-130 ℃ for 15-20 min.

The beneficial effects produced by the invention comprise: the vessel can be bent through 180 ° without being kinked. The silica gel layer can restore automatically after puncture, reduces blood outflow. The fluorinated ethylene propylene support ring prevents the vessel from collapsing.

Drawings

FIG. 1 is a schematic view of a kink-resistant vascular prosthesis according to the present invention;

in the figure, 1, polyethylene terephthalate fabric, 2, expanded polytetrafluoroethylene tube, 3, fluorinated ethylene propylene support ring, 4 and silica gel.

Detailed Description

The present invention is explained in further detail below with reference to the drawings and the specific embodiments, but it should be understood that the scope of the present invention is not limited to the specific embodiments.

As shown in fig. 1, the kink-resistant artificial blood vessel in this embodiment includes an expanded polytetrafluoroethylene tube 2 disposed on an inner layer, a polyethylene terephthalate fabric 1 disposed on an outer layer, a fluorinated ethylene propylene support ring 3 disposed between the inner layer and the outer layer, the fluorinated ethylene propylene support ring 3 being coaxial with the expanded polytetrafluoroethylene tube 2, the fluorinated ethylene propylene support ring 3 being a spiral structure, the expanded polytetrafluoroethylene tube 2 being prepared by thermoforming a multilayer expanded polytetrafluoroethylene film, the inner diameter of the tube being 3mm to 8mm, the thickness of the tube being 0.1mm to 0.2mm, the fluorinated ethylene propylene support ring 3 between the inner layer and the outer layer being a fluorinated ethylene propylene tape spirally wound on the outer wall of the expanded polytetrafluoroethylene tube 2 to form a spiral structure, the pitch being 1.5mm to 3 mm. The polyethylene terephthalate fabric 1 is woven from polyethylene terephthalate yarns.

In the embodiment, the fluorinated ethylene propylene support ring 3 is connected with the inner layer and the outer layer through the silica gel 4, specifically, the silica gel 4 solution is coated on the surface of the fluorinated ethylene propylene support ring 3, and then the fluorinated ethylene propylene support ring is dried and shaped, wherein the width of the adopted fluorinated ethylene propylene belt is 0.1mm-0.3mm, and the thickness of the adopted fluorinated ethylene propylene belt is 0.02-0.04 mm.

In order to prevent the formation of thrombus, the inner wall of the expanded polytetrafluoroethylene tube 2 is coated with an anticoagulant coating, and the anticoagulant coating is a heparin coating which is combined by covalent bonds.

Preparation method example:

step 1, winding a 0.01mm thick expanded polytetrafluoroethylene film on a smooth shaft with the inner diameter of 5mm, winding 15 layers, and performing heat setting treatment at 320 ℃ for 20min to form an expanded polytetrafluoroethylene tube 2.

And 2, spirally winding a fluorinated ethylene propylene strip with the width of 0.2mm and the thickness of 0.03mm on the outer surface of the expanded polytetrafluoroethylene tube 2, wherein the thread pitch is 2.5 mm.

And 3, immersing the prepared sample into a silica gel solution with the concentration of 30% for 5min, and performing heat treatment at 120 ℃ for 15 min. The dip coating is repeated for 3 times, and at the last time, the polyethylene terephthalate fabric is sleeved on the outermost layer and then heat treatment is carried out. After drying, the sample was removed from the spindle. And then, preparing a coating by self-assembly on the inner wall of the expanded polytetrafluoroethylene tube, and crosslinking the coating to obtain a sample.

The product was tested for kink radius and found to be 3 mm. The product was tested for anticoagulation and the prothrombin time was increased by 25s over the uncoated sample.

The above description is only a preferred embodiment of the present invention, and the present invention is not limited to the content of the embodiment. It will be apparent to those skilled in the art that various changes and modifications can be made within the technical scope of the present invention, and any changes and modifications made are within the protective scope of the present invention.