阅读说明：本技术 一种用于牛皮癣的天然皮肤修复乳液及其制备办法 (Natural skin repair emulsion for psoriasis and preparation method thereof ) 是由 单士军 于 2019-12-09 设计创作，主要内容包括：本发明公开了一种用于牛皮癣的天然皮肤修复乳液,所述乳液由以下原料组成：辛酸/癸酸甘油三酯、鲸蜡硬脂醇、硅油、合成角鲨烷、甘油硬脂酸酯、甘油、薏米油、余量为去离子水,所述乳液由以下原料配比范围组成：辛酸/癸酸甘油三酯3～5％、鲸蜡硬脂醇3～5％、硅油0.5～3％、合成角鲨烷3～5％、甘油硬脂酸酯1～3.5％、甘油4～8％、薏米油1.5～4.5％、余量为去离子水,本发明结构科学合理,使用安全方便,该乳液可以有效缓解牛皮癣患者皮疹严重程度,降低PASI评分,缓解瘙痒,改善皮肤肥厚脱屑等临床表现,为临床牛皮癣皮肤修护提供了新方法。(The invention discloses a natural skin repair emulsion for psoriasis, which consists of the following raw materials: caprylic/capric triglyceride, cetostearyl alcohol, silicone oil, synthetic squalane, glyceryl stearate, glycerol, pearl barley oil and the balance of deionized water, wherein the emulsion is prepared from the following raw materials in proportion: 3-5% of caprylic/capric triglyceride, 3-5% of cetostearyl alcohol, 0.5-3% of silicone oil, 3-5% of synthetic squalane, 1-3.5% of glyceryl stearate, 4-8% of glycerol, 1.5-4.5% of coix seed oil and the balance of deionized water.)

1. A natural skin repair emulsion for psoriasis characterized by: the emulsion consists of the following raw materials: caprylic/capric triglyceride, cetostearyl alcohol, silicone oil, synthetic squalane, glyceryl stearate, glycerol, Coicis semen oil, and the balance of deionized water.

2. The natural skin repair emulsion for psoriasis according to claim 1, which consists of the following raw materials in proportion range: 3-5% of caprylic/capric triglyceride, 3-5% of cetostearyl alcohol, 0.5-3% of silicone oil, 3-5% of synthetic squalane, 1-3.5% of glyceryl stearate, 4-8% of glycerol, 1.5-4.5% of coix seed oil and the balance of deionized water.

3. The natural skin repair emulsion for psoriasis according to claim 1, which is prepared from the following raw materials in parts by weight: caprylic/capric triglyceride 5%, cetostearyl alcohol 4%, silicone oil 2.2%, synthetic squalane 4%, glyceryl stearate 3%, glycerin 5%, coix seed oil 3.5%, deionized water 73.3%.

4. A method for preparing a natural skin repair emulsion for psoriasis according to any of claims 1 to 3, wherein the Job's tears oil is prepared by:

a1, weighing 50.00g of crushed coix seeds, and putting into a filter paper cylinder;

a2, then putting into a Soxhlet extractor, adding 250ml of diethyl ether, and introducing condensed water;

a3, refluxing and extracting for 8 hours on a water bath at 45 ℃;

a4, and removing ether by rotary evaporator to obtain Coicis semen oil as oily mixture.

5. The method of claim 4, wherein the average yield of the Job's tears oil after multiple parallel tests is 4.86%.

6. The method of claim 4, wherein the natural skin rejuvenating emulsion is prepared by:

s1, putting the raw materials into a reaction kettle, heating to 85 ℃, and slowly stirring in the heating process until the solid of the mixture is completely melted;

s2, after melting, the contents in the reaction kettle are clear and transparent, and the oil phase and the water phase are layered clearly and then homogenized and emulsified by a homogenizer;

s3, stopping heating cold water after homogenizing, slowly cooling, and defoaming in a water bath;

s4, cleaning the storage tank, spraying alcohol, drying, irradiating under an ultraviolet lamp, and storing the emulsion for subsequent experiments.

7. The method for preparing a natural skin repair emulsion for psoriasis as claimed in claim 6, wherein the homogenizing speed in the homogenizing and emulsifying by the homogenizer is 2200-3000rpm, and the homogenizing time is 3-6 min.

8. The method of claim 6, wherein the alcohol concentration of step S4 is 75%, and the UV light irradiation is 15-30 min.

Technical Field

The invention relates to the technical field of dermatosis treatment, in particular to natural skin repair emulsion for psoriasis and a preparation method thereof.

Background

Psoriasis, which is a common chronic easily-relapsed inflammatory skin disease with characteristic skin damage, is initially an inflammatory red papule, is about chestnut grains to mung bean in size, is gradually enlarged or fused into a brownish red plaque, is clear in boundary, has inflammatory halos around the periphery, is obviously infiltrated into a substrate, is covered with multiple layers of dry grey-white or silvery-white scales on the surface, slightly scrapes off the scales on the surface, gradually exposes a layer of pale red and shiny semi-transparent film, is called a film phenomenon, and then scrapes off the film, so that small bleeding points appear, is called a punctate bleeding phenomenon, and the white scales, the shiny films and the punctate bleeding are important characteristics for diagnosing psoriasis, and are called triad signs;

psoriasis is an upgraded version of atopic dermatitis, and the two have a lot of coincidence in pathogenesis and the like, the treatment of the psoriasis is mainly implemented by using external hormones at present, the long-term use of the hormones can cause a large number of side effects, such as skin capillary vessel expansion, skin atrophy and thinning, pigment change, hair aggravation, blood pressure, blood sugar and electrolyte disorder, local induction or aggravation infection, disease hormone resistance, relapse aggravation after drug withdrawal, erythroderma and other serious consequences, and the actual, safe and effective non-hormonal medicaments or skin repair products are not available in the market at present for controlling the disease.

Disclosure of Invention

The invention provides a natural skin repair emulsion for psoriasis and a preparation method thereof, which can effectively solve the problem that the prior market lacks a reliable, safe and effective non-hormone medicament or skin repair product for controlling the psoriasis.

In order to achieve the purpose, the invention provides the following technical scheme: a natural skin repair emulsion for psoriasis, the emulsion consisting of: caprylic/capric triglyceride, cetostearyl alcohol, silicone oil, synthetic squalane, glyceryl stearate, glycerol, Coicis semen oil, and the balance of deionized water.

According to the technical scheme, the emulsion is prepared from the following raw materials in proportion range: 3-5% of caprylic/capric triglyceride, 3-5% of cetostearyl alcohol, 0.5-3% of silicone oil, 3-5% of synthetic squalane, 1-3.5% of glyceryl stearate, 4-8% of glycerol, 1.5-4.5% of coix seed oil and the balance of deionized water.

According to the technical scheme, the emulsion is prepared from the following raw materials in parts by weight: caprylic/capric triglyceride 5%, cetostearyl alcohol 4%, silicone oil 2.2%, synthetic squalane 4%, glyceryl stearate 3%, glycerin 5%, coix seed oil 3.5%, deionized water 73.3%.

A preparation method of natural skin repair emulsion for psoriasis comprises the following steps:

a1, weighing 50.00g of crushed coix seeds, and putting into a filter paper cylinder;

a2, then putting into a Soxhlet extractor, adding 250ml of diethyl ether, and introducing condensed water;

a3, refluxing and extracting for 8 hours on a water bath at 45 ℃;

a4, and removing ether by rotary evaporator to obtain Coicis semen oil as oily mixture.

According to the technical scheme, the average yield of the coix seed oil is 4.86% after multiple parallel tests.

According to the technical scheme, the emulsion is prepared in the following way:

s1, putting the raw materials into a reaction kettle, heating to 85 ℃, and slowly stirring in the heating process until the solid of the mixture is completely melted;

s2, after melting, the contents in the reaction kettle are clear and transparent, and the oil phase and the water phase are layered clearly and then homogenized and emulsified by a homogenizer;

s3, stopping heating cold water after homogenizing, slowly cooling, and defoaming in a water bath;

s4, cleaning the storage tank, spraying alcohol, drying, irradiating under an ultraviolet lamp, and storing the emulsion for subsequent experiments.

According to the technical scheme, the homogenizing speed in the homogenizing emulsification of the homogenizer is 2200-3000rpm, and the homogenizing time is 3-6 min.

According to the technical scheme, the alcohol concentration in the step S4 is 75%, and the ultraviolet lamp irradiates for 15-30 minutes.

Compared with the prior art, the invention has the beneficial effects that: the emulsion has a scientific and reasonable structure, is safe and convenient to use, can effectively repair a damaged skin barrier of a mouse model, reduces the transdermal water loss of the mouse when the skin barrier is damaged by regulating the expression position and the change of the expression quantity of the aquaporin 3 of the skin cells of the mouse, preserves moisture and locks water, inhibits the immune inflammatory reaction of the skin by inhibiting the overexpression of a TOLL-like receptor 2/4 of the skin cells of the mouse, plays a role in treating psoriasis, can effectively relieve the severity of the rash of a psoriasis patient, reduces the PASI score, relieves pruritus, improves the clinical manifestations of pachynsis, desquamation and the like of the skin, and provides a new method for the clinical skin repair and protection of the psoriasis.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:

FIG. 1 is a schematic view of the process for preparing Job's tears seed oil of the present invention;

FIG. 2 is a schematic of the emulsion preparation scheme of the present invention;

FIG. 3 is a schematic representation of the comparison of skin lesion expression and pathological expression in mice of the present invention;

FIG. 4 is a schematic representation of the changes in mouse skin aquaporin 3 and Toll-like receptor 2.4 expression at 28 days of treatment according to the invention;

FIG. 5 is a schematic representation of the degree of skin itching before and after treatment according to the invention;

FIG. 6 is a schematic representation of the degree of skin dryness before and after treatment according to the present invention;

FIG. 7 is a graphical representation of the PASI score before and after treatment according to the present invention;

FIG. 8 is a graph showing a comparison of the effect of the present invention on facial psoriasis patients before and after 2 and 3 weeks of treatment;

fig. 9 is a comparison of the effect of the facial psoriasis patients of the invention three weeks after treatment, with the patients taking a photograph of the comparison structure on a daily basis.

Detailed Description

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.