阅读说明：本技术 包含脲酶抑制剂(ui)和硝化抑制剂如2-(3,4-二甲基-1h-吡唑-1-基)琥珀酸(dmpsa)或3,4-二甲基吡唑鎓乙醇酸盐(dmpg)的混合物 (Mixtures comprising Urease Inhibitors (UI) and nitrification inhibitors, such as 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA) or 3, 4-dimethylpyrazolium glycolate (DMPG) ) 是由 B·纳韦 G·帕斯达 A·维瑟迈尔 M·斯塔尔 K-H·施奈德 M·施密德 W·泽鲁拉 于 2018-07-05 设计创作，主要内容包括：本发明涉及包含至少一种特定硝化抑制剂(化合物I)和至少一种脲酶抑制剂(化合物II)作为活性组分的混合物；一种使用至少一种化合物I和至少一种化合物II的混合物改善硝化抑制效果或增强植物健康的方法；包含化合物I和化合物II的混合物在增强植物健康中的用途；包含这些混合物的农业化学组合物；以及包含这些混合物或这些农业化学组合物的植物繁殖材料。(The invention relates to mixtures comprising as active components at least one specific nitrification inhibitor (compound I) and at least one urease inhibitor (compound II); a method for improving nitrification inhibition or enhancing plant health using a mixture of at least one compound I and at least one compound II; use of a mixture comprising compound I and compound II for enhancing plant health; agrochemical compositions comprising these mixtures; and plant propagation material comprising these mixtures or these agrochemical compositions.)

1. A mixture comprising as active ingredients:

1) at least one active compound I (nitrification inhibitor) selected from:

a)2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid and/or derivatives and/or salts thereof,

b) glycolic acid addition salt of 3, 4-dimethylpyrazole (3, 4-dimethylpyrazole)Glycolate) and/or isomers thereof and/or derivatives thereof,

c) citric acid addition salt of 3, 4-dimethylpyrazole (3, 4-dimethylpyrazole)Citrate) and/or isomers thereof and/or derivatives thereof,

d) lactic acid addition salt of 3, 4-dimethylpyrazole (3, 4-dimethylpyrazole)

e) mandelic acid addition salt of 3, 4-dimethylpyrazole (3, 4-dimethylpyrazole)

f)1,2, 4-triazole and/or derivatives and/or salts thereof,

g) 4-chloro-3-methylpyrazole and/or isomers and/or derivatives and/or salts thereof,

h) n- ((3(5) -methyl-1H-pyrazol-1-yl) methyl) acetamide and/or an isomer thereof and/or a derivative thereof and/or a salt thereof,

i) n- ((3(5) -methyl-1H-pyrazol-1-yl) methyl) formamide and/or an isomer and/or a derivative and/or a salt thereof,

j) n- ((3(5), 4-dimethylpyrazol-1-yl) methyl) formamide and/or its isomers and/or its derivatives and/or its salts,

k) n- ((4-chloro-3 (5) -methylpyrazol-1-yl) methyl) carboxamide and/or its isomer and/or its derivative and/or its salt,

l) dicyandiamide, the reaction adduct of urea and formaldehyde or the triazinonyl formaldehyde-dicyandiamide adduct,

m) 2-cyano-1- ((4-oxo-1, 3, 5-triazinane (triazinan) -1-yl) methyl) guanidine,

n)1- ((2-cyanoguanidino) methyl) urea, and

o) 2-cyano-1- ((2-cyanoguanidino) methyl) guanidine,

p) 2-chloro-6- (trichloromethyl) pyridine (chlorhexidine or N-serve),

q) dicyandiamide (DCD, DIDIN),

r)3, 4-dimethylpyrazole phosphate and/or 4, 5-dimethylpyrazole phosphate (DMPP, ENTEC) and/or isomers and/or derivatives thereof,

s)3, 4-dimethylpyrazole and/or 4, 5-Dimethylpyrazole (DMP) and/or its isomers and/or its derivatives and/or its salts and/or its acid addition salts,

t) Ammonium Thiosulfate (ATU),

u) products based on neem and/or components of neem,

v) a supply of linoleic acid,

w) α -linolenic acid, and the mixture is dissolved in water,

x) p-coumaric acid methyl ester,

y) methyl ferulate (I) is prepared,

z) methyl 3- (4-hydroxyphenyl) propionate (MHPP),

aa) a source of the xanthophyll compound,

bb) an brachial-shaped oxalactone,

cc) p-benzoquinone sorgoleon,

dd) 4-amino-1, 2, 4-triazole hydrochloride (ATC),

ee) 1-amido-2-thiourea (ASU),

ff) 2-amino-4-chloro-6-methylpyrimidine (AM),

gg) 2-Mercaptobenzothiazole (MBT),

hh) 5-ethoxy-3-trichloromethyl-1, 2, 4-thiadiazole (tetrazol, clomazole),

ii) 2-Sulphathiazole (ST),

jj) 3-methylpyrazole (3-MP),

kk)1,2, 4-Triazolothiourea (TU),

ll) a cyanamide, in a solvent,

mm) of melamine,

nn) zeolite powder (II) is prepared by the following steps,

oo) a catechol-based compound selected from the group consisting of,

pp) a benzoquinone, to be used,

qq) sodium tetraborate,

rr) of allylthiourea,

ss) chlorate, and

tt) zinc sulfate; and

2) at least one active compound II (urease inhibitor) selected from the following:

p-benzoquinone (P.1), polyphenols (P.2), heterocyclic thiols (P.3), polyacrylamides and derivatives thereof (P.4), diacyl hydroxamic acid (P.5), aminomethylphenols (P.6), aminophenols (P.7), bromo-nitro compounds (P.8), thiourea (P.9), hydroxamates (P.10), sodium chloride (P.11), sodium carbonate (P.12), urea phosphates (P.13), urea nitrates (P.14), ammonium thiosulfate (P.15), calcium chloride (P.16), fluoride salts (P.17), O-diaminophosphineoxime (P.18), phosphinyl sulfonamides (P.19), phosphorodiamidates (P.20), polyphosphoric diamides (P.21), cyclotriphosphates (P.22), N-acylphosphoric triamides (P.23), metal phosphates (P.24), S-aryl (alkyl) diamidothiophosphates (P25), N-N-butyl thiophosphoramides (PT) (P.26), N-acyl phosphoric triamides (P triamides) (P23), N-phosphoric acid amides (P25), N-butyl-phosphoric acid amides (PT) (NPP 19), N-phosphoric acid amides (PT) (P19), N-butyl-phosphoric acid amides) (P25), N-phosphoric acid amides) (P25), N-butyl-phenyl thioamides) (P25), N-butyl-phenyl thioethers) (P amides) (P25), N-phosphoric acid amides) (P5, N-propyl-phosphoric acid amides) (NBP 5, N-phosphoric acid amides), N-phosphoric acid amides (N-phosphoric acid amides) (P amides), N-phosphoric acid amides (N-phosphoric acid amides), N-phosphoric acid amides (N-5-phosphoric acid amides), N-5, N-5-thiosalicylic acid amides (N-phosphoric acid amides), N-5-phosphoric acid amides), N-thiosalicylic acid amides (N-5, N-5-thiosalicylic acid amides (N-thiosalicylic acid amides), N-5, N-5, N-5-thiosalicylic acid amides (N-5-thiosalicylic acid amides), N-5, N-phosphoric acid amides (N-5-N-thiosalicylic acid amides), N-5-phosphoric acid amides), N-5, N-5-thiosalicylic acid amides (P5-thiosalicylic acid amides, N-5-thiosalicylic acid amides, N-5,

thiophosphoric triamides (p.56) of the general formula (Ia):

R¹R²N–P(X)(NH₂)₂(Ia)

wherein

X is sulfur;

R¹and R²Independently of one another, H, substituted or unsubstituted 2-nitrophenyl, C₁-C₂₀Alkyl radical, C₃-C₂₀Cycloalkyl radical, C₆-C₂₀Heterocyclic aryl radicals, C₆-C₂₀Aryl or dialkylaminocarbonyl radicals, in which R is¹And R²Together with the nitrogen atom to which they are attached define a 5-or 6-membered saturated or unsaturated heterocyclic group optionally containing 1 or 2 further heteroatoms selected from nitrogen, oxygen and sulfur;

phosphoric acid triamides (P.57) of the general formula (Ib):

R¹R²N–P(Y)(NH₂)₂(Ib)

wherein

Y is oxygen;

R¹and R²Independently of one another, H, substituted or unsubstituted 2-nitrophenyl, C₁-C₂₀Alkyl radical, C₃-C₂₀Cycloalkyl radical, C₆-C₂₀Heterocyclic aryl radicals, C₆-C₂₀Aryl or dialkylaminocarbonyl radicals, in which R is¹And R²Together with the nitrogen atom to which they are attached define a further hetero atom optionally containing 1 or 2 hetero atoms selected from nitrogen, oxygen and sulfurA 5-or 6-membered saturated or unsaturated heterocyclic group,

N-N-butyl thiophosphoric triamide (NBPT), the adduct of urea and formaldehyde (P.58),

an adduct of N-N-butyl thiophosphoric triamide (NBPT), urea and formaldehyde of formula (Ic) (P.59):

an adduct of N-N-butyl thiophosphoric triamide (NBPT), urea and formaldehyde of formula (Id) (P.60):

N-N-butyl thiophosphoric triamide (NBPT), the adduct of urea and formaldehyde (P.61) of formula (Ie):

2. the mixture according to claim 1, wherein compound I is selected from compound i.a-I.Z:

I.A: 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid,

I.B: salts of 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or of 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid,

and I.C: potassium salt of 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid,

I.D: ammonium salts of 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or of 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid,

I.E: 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or a sodium salt of 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid,

I.F: 3, 4-dimethylpyrazole

I.G: 3, 4-dimethylpyrazole

I.H: 3, 4-dimethylpyrazole

I.J: 3, 4-dimethylpyrazole

I.K:1,2, 4-Triazole (TZ),

I.L: 4-chloro-3-methylpyrazole (ClMP),

I.M: n- ((3(5) -methyl-1H-pyrazol-1-yl) methyl) acetamide,

I.N: n- ((3(5) -methyl-1H-pyrazol-1-yl) methyl) formamide,

I.O: n- ((3(5), 4-dimethylpyrazol-1-yl) methyl) carboxamide,

I.P: n- ((4-chloro-3 (5) -methylpyrazol-1-yl) methyl) carboxamide,

I.Q: dicyandiamide, the reaction adduct of urea and formaldehyde or the triazinonyl formaldehyde-dicyandiamide adduct,

I.R: 2-cyano-1- ((4-oxo-1, 3, 5-triazinan-1-yl) methyl) guanidine,

and I.S: 1- ((2-cyanoguanidino) methyl) urea,

I.T: 2-cyano-1- ((2-cyanoguanidino) methyl) guanidine,

and I.U: 2-chloro-6- (trichloromethyl) pyridine (chlordine or N-serve),

and I.V: dicyandiamide (DCD, DIDIN),

I.W: 3, 4-dimethylpyrazole phosphate and/or 4, 5-dimethylpyrazole phosphate (DMPP, ENTEC) and/or isomers and/or derivatives thereof,

I.X: 3, 4-dimethylpyrazole and/or 4, 5-Dimethylpyrazole (DMP) and/or its isomers and/or its derivatives and/or its salts and/or its acid addition salts,

I.Y: ammonium Thiosulfate (ATU), and

I.Z: neem is used as the main material.

3. The mixture according to claim 1, wherein compound I is 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid.

4. The mixture according to any of claims 1 to 3, wherein compound I is selected from the glycolic acid addition salt of 3, 4-dimethylpyrazole (3, 4-dimethylpyrazole)

5. The mixture according to any of claims 1 to 3, wherein compound II is selected from the group consisting of N-N-butyl thiophosphoric triamide (NBPT) (P.26), N-N-propyl thiophosphoric triamide (NPPT) (P.27), a mixture (P.28) comprising N-N-butyl thiophosphoric triamide (NBPT) and N-N-propyl thiophosphoric triamide (NPPT), a mixture comprising N-N-butyl thiophosphoric triamide (NBPT) and N-N-propyl thiophosphoric triamide (NPPT), wherein NBPT is contained in an amount of 50 to 90 wt.% and NPPT (P.29), phenyl phosphorodiamidate (PPD/PPDA) (P.30) and 2-nitrophenyl phosphorotriamide (2-NPT) (P.31) are contained in an amount of 10 to 50 wt.%, based on the total amount of active urease inhibitors.

6. The mixture according to any of claims 1 to 5, wherein compound I is the potassium, sodium, magnesium or ammonium salt of 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or of 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid.

7. The mixture according to any of claims 1 to 6, wherein compound II is a mixture (P.28) comprising N-N-butyl thiophosphoric triamide (NBPT) and N-N-propyl thiophosphoric triamide (NPPT).

8. The mixture according to any of claims 1 to 7, wherein compound I and compound II are present in synergistically effective amounts and/or in synergistically effective amounts of NI and/or in synergistically effective amounts of UI and/or in synergistically effective amounts of plant health.

9. The mixture according to any of claims 1 to 8, wherein compound I and compound II are present in a weight ratio of from 250:1 to 1: 250.

10. The mixture according to any of claims 1 to 8, wherein compound I and compound II are present in a weight ratio of 100:1 to 6.5: 1.

11. The mixture according to any one of claims 1 to 8, wherein compound I and compound II are present in a weight ratio of 100:1 to 19: 1.

12. The mixture according to any of claims 1 to 11, wherein compound I is a potassium or ammonium salt of 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid and wherein compound I and compound II are present in a weight ratio of 100:1 to 19: 1.

13. The mixture according to any of claims 1 to 11, wherein compound II is a mixture (p.28) comprising N-butyl thiophosphoric triamide (NBPT) and N-propyl thiophosphoric triamide (NPPT) and wherein compound I and compound II are present in a weight ratio of 100:1 to 19: 1.

14. The mixture according to any of claims 1 to 11, wherein compound I is a potassium or ammonium salt of 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid and/or of 2- (4, 5-dimethyl-1H-pyrazol-1-yl) succinic acid, compound II is a mixture (p.28) comprising N-butyl thiophosphoric triamide (NBPT) and N-propyl thiophosphoric triamide (NPPT) and wherein compound I and compound II are present in a weight ratio of 100:1 to 19: 1.

15. The mixture of any of claims 1-14, further comprising a fertilizer.

16. The mixture of any of claims 1-14, further comprising a urea-containing fertilizer.

17. An agrochemical composition comprising an adjuvant and a mixture according to any one of claims 1 to 16.

18. Use of a mixture as defined in any one of claims 1 to 16 or an agrochemical composition as defined in claim 17 for nitrification inhibition, for increasing the efficiency of utilization of a urea-containing fertilizer or for urease inhibition or for enhancing plant health.

19. A method of increasing the efficiency of utilization of a urea-containing fertilizer or the inhibition of urease with an effective amount of a mixture as defined in any one of claims 1 to 16 or an agrochemical composition as defined in claim 17.

20. A method of enhancing the health of a plant, comprising treating the plant or plant propagation material or the soil in which the plant is to be grown with an effective amount of a mixture as defined in any one of claims 1 to 16 or a composition as defined in claim 17.

21. A method as claimed in claim 19 or 20, wherein the at least one compound I and the at least one compound II are applied to the plant propagules as a mixture or separately, simultaneously or sequentially.

22. Plant propagation material comprising a mixture as defined in any one of claims 1 to 16 or a composition as defined in claim 17 in an amount of 0.1 to 10kg of active substance per 100kg of seeds.

example 1:

the compositions and mixtures of the invention have been tested for nitrification inhibition as follows:

the soil is sampled fresh from the field (e.g. Limburgerhof), dried and sieved through a 500 μm sieve. Approximately 200mg of soil was placed in each well of a 48-well plate. The compositions or mixtures of the invention were added at a concentration of 10ppm dissolved in 1% DMSO or only DMSO. Add 6. mu. mol ammonium sulfate and 4.8mg NaClO per well₃。

The samples were then incubated at room temperature for up to 72 hours after the incubation period 64mg KCl was added and mixed. Mu.l of the supernatant was placed in a fresh plate and 260. mu.l of the color reaction solution (from Merck No. 1.11799.0100) was added.

Measurements were performed using a Tecan plate reader at 540nm wavelength.