阅读说明：本技术 一种抑菌、护肤功效组合的皂用组合物及其制备方法和应用 (Soap composition with combined antibacterial and skin-care effects and preparation method and application thereof ) 是由 刘伟毅 王珍明 李乔铭 于 2019-11-28 设计创作，主要内容包括：本发明涉及一种抑菌、护肤功效组合的皂用组合物及其制备方法和应用,包括以下重量份组分：野菊花300～800份,黄芩300～800份,马齿苋300～800份。制备方法如下：按重量份称取野菊花300～800份,黄芩300～800份,马齿苋300～800份,加水煎煮,提取2次,第一次加入水量为上述三种组分总重量的8～12倍,煎煮0.5～2小时,第二次加入水量为上述三种组分总重量的6～10倍,煎煮0.1～1小时,过滤后合并滤液,常压浓缩至0.5～2g生药/mL,备用；将步骤(1)所得水提浓缩液加入1～3倍重量的乙醇,边加边搅拌,放置10～15小时,分离上清液,减压浓缩至无醇味,于50～80℃真空干燥,即得抑菌、护肤功效组合的悦清浊皂用组合物。与现有技术相比,本发明具有很好的抗菌、抑菌、护肤效果。(The invention relates to a soap composition with combined antibacterial and skin-care effects, a preparation method and application thereof, wherein the soap composition comprises the following components in parts by weight: 300-800 parts of wild chrysanthemum flower, 300-800 parts of scutellaria baicalensis and 300-800 parts of purslane. The preparation method comprises the following steps: weighing 300-800 parts of wild chrysanthemum, 300-800 parts of scutellaria and 300-800 parts of purslane by weight, adding water for decoction, extracting for 2 times, wherein the water added for the first time is 8-12 times of the total weight of the three components, decocting for 0.5-2 hours, the water added for the second time is 6-10 times of the total weight of the three components, decocting for 0.1-1 hour, filtering, combining filtrate, and concentrating under normal pressure to 0.5-2 g crude drug/mL for later use; and (2) adding ethanol with the weight being 1-3 times that of the water extraction concentrated solution obtained in the step (1), stirring while adding, standing for 10-15 hours, separating supernatant, concentrating under reduced pressure until no alcohol smell exists, and drying in vacuum at 50-80 ℃ to obtain the pleasant and turbid soap composition with combined antibacterial and skin care effects. Compared with the prior art, the invention has good antibacterial, bacteriostatic and skin-care effects.)

1. The soap composition with combined bacteriostatic and skin-care effects is characterized by being a purified product extracted and purified by a clear and turbid formula consisting of the following three raw materials, wherein the clear and turbid formula comprises the following components: 300-800 parts of wild chrysanthemum flower, 300-800 parts of scutellaria baicalensis and 300-800 parts of purslane.

2. The composition for the antibacterial and anti-inflammatory medicated soap as claimed in claim 1, wherein the clear and turbid formula comprises the following components in parts by weight: 400-600 parts of wild chrysanthemum flower, 400-600 parts of scutellaria baicalensis and 400-600 parts of purslane.

3. The composition for the antibacterial and anti-inflammatory medicinal soap as claimed in claim 1, wherein the weight ratio of the wild chrysanthemum flower, the scutellaria baicalensis and the purslane in the medicinal soap is 1:1: 1.

4. The soap composition with combined bacteriostatic and skin-care effects according to claim 1, wherein the wild chrysanthemum flower contains flavonoid compounds and flavone glucoside compounds.

5. The soap composition with combined bacteriostatic and skin-care effects according to claim 1, wherein said scutellaria baicalensis contains flavonoids.

6. The soap composition with a combination of bacteriostatic and skin-care effects according to claim 1, wherein the purslane contains purslane amide.

7. A method for preparing the soap composition with combination of bacteriostasis and skin care effects as defined in any one of claims 1 to 6, wherein the method comprises the following steps:

(1) extraction of

Weighing 300-800 parts of wild chrysanthemum, 300-800 parts of scutellaria and 300-800 parts of purslane by weight, adding water for decoction, extracting for 2 times, wherein the water added for the first time is 8-12 times of the total weight of the three components, decocting for 0.5-2 hours, the water added for the second time is 6-10 times of the total weight of the three components, decocting for 0.1-1 hour, filtering, combining filtrate, and concentrating under normal pressure to 0.5-2 g crude drug/mL for later use;

(2) purification of

And (2) adding ethanol with the weight being 1-3 times that of the water extract concentrated solution obtained in the step (1), stirring while adding, standing for 10-15 hours, separating supernatant, concentrating under reduced pressure until no alcohol smell exists, and drying in vacuum at 50-80 ℃ to obtain the antibacterial and anti-inflammatory medicinal soap composition.

8. The method for preparing the antibacterial and anti-inflammatory medicinal soap composition as claimed in claim 7, wherein the obtained soap composition with combined antibacterial and skin-care effects comprises 10-15 wt% of flavonoids, 5-8 wt% of flavone glucosides and 10-20 wt% of purslane amide.

9. The application of the soap composition with combined bacteriostatic and skin-care effects as claimed in any one of claims 1 to 6, wherein the purified product obtained by extracting and purifying the clear and turbid formula is added into a soap base of the medicated soap to prepare the medicated soap with combined bacteriostatic and skin-care effects.

10. The application of the soap composition with combined bacteriostatic and skin-care effects according to claim 9, wherein the addition amount of the purified substance in the soap base is 0.3-2% of the weight of the soap base.

Technical Field

The invention relates to a soap, in particular to a soap composition with combined antibacterial and skin-care effects, a preparation method and application thereof.

Background

The medicated soap has the functions of cleaning and decontaminating, and also has the functions of antibiosis and sterilization, and is widely applied to life and medicine. The medical soap is a preferred article for household to deal with bacteria because of strong functions of decontamination, antibiosis, itching relieving and inflammation diminishing, but in actual life, many medical soaps on the market are not widely adopted by families, wherein the main reason is that the traditional medical soap has strong pungent smell. The traditional medicated soap is mainly added with certain irritant chemical substances such as phenolic compounds, boric acid compounds and sulfur compounds, has obvious irritation to the skin, is particularly serious for children and women with delicate skin, and is easy to cause skin allergy after being frequently used.

Many Chinese herbs are used in various cosmetics according to their physical and chemical properties. Traditional Chinese medicines with antibacterial and anti-inflammatory effects, such as scutellaria baicalensis, which are heat-clearing and dampness-drying medicines, have anti-inflammatory and antiallergic effects and a wide antibacterial spectrum as shown by modern pharmacological studies, and therefore, are added into functional cosmetics. In addition, literature research shows that lipid and wax-containing substances such as aloe, coix seed, rhamnus and the like can cover the surface of skin or mucosa to play a role in protecting the surface of the skin or mucosa, and have the functions of resisting bacteria, diminishing inflammation, resisting allergy and the like. In addition, polyphenol catechin and catechin in green tea have antioxidant, free radical scavenging and bactericidal effects, so that tea polyphenol and other substances in green tea extract are also commonly used as raw materials of antibacterial cosmeceutical.

Currently, antibacterial medicated soap products are available on the market at home and abroad, such as Shanghai medicated soap, Naeis sulphur medicated soap, Australia Gamophen medicinal antibacterial soap and the like. The facial soap added with natural Chinese herbal medicine components, such as the comfortable acne-removing facial soap made from herborist flag, is added with saffron, aloe, honeysuckle and other components to achieve the effects of resisting bacteria and removing acnes.

Chinese patent application CN102766548A discloses an antibacterial, anti-inflammatory, skin-care and beauty-care medicated soap and a preparation method thereof, wherein the components of the medicated soap comprise 87-92 parts of soap base, 6-9 parts of propolis extract and 2-4 parts of essential oil by mass. The novel medicinal soap is prepared by adding propolis extract with special effect and plant essential oil with auxiliary curative effect on soap base. The medicated soap disclosed by the invention can resist bacteria and diminish inflammation, has a certain curative effect on wound healing, is mild in performance and has the effects of protecting skin and beautifying. The propolis extract has antibacterial and anti-inflammatory effects, is terpene and organic acid compounds in the propolis extract, and has the effects of resisting bacteria, relieving itching, diminishing inflammation, stopping bleeding, preventing freezing, preventing cracking, softening cutin, resisting ulcer, protecting ulcer surface and promoting necrotic tissue to fall off; the antibacterial and anti-inflammatory effects are very limited, and mainly play a role in beautifying.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide an antibacterial and anti-inflammatory medicinal soap composition with remarkable effect and a preparation method thereof.

The purpose of the invention can be realized by the following technical scheme: the antibacterial and anti-inflammatory medicinal soap composition is characterized by comprising the following components in parts by weight: 300-800 parts of wild chrysanthemum flower, 300-800 parts of scutellaria baicalensis and 300-800 parts of purslane.

The medicinal soap comprises the following components in parts by weight: 400-600 parts of wild chrysanthemum flower, 400-600 parts of scutellaria baicalensis and 400-600 parts of purslane.

The weight ratio of the wild chrysanthemum flower, the scutellaria baicalensis and the purslane in the medicinal soap is 1:1: 1.

The wild chrysanthemum contains flavonoid compounds and flavone glucoside compounds.

The scutellaria baicalensis contains flavonoid compounds.

The purslane contains purslane amide.

A preparation method of a soap composition with combined bacteriostatic and skin-care effects is characterized by comprising the following steps:

(1) extraction of

Weighing 300-800 parts of wild chrysanthemum, 300-800 parts of scutellaria and 300-800 parts of purslane by weight, adding water for decoction, extracting for 2 times, wherein the water added for the first time is 8-12 times of the total weight of the three components, decocting for 0.5-2 hours, the water added for the second time is 6-10 times of the total weight of the three components, decocting for 0.1-1 hour, filtering, combining filtrate, and concentrating under normal pressure to 0.5-2 g crude drug/mL for later use;

(2) purification of

And (2) adding ethanol with the weight being 1-3 times that of the water extract concentrated solution obtained in the step (1), stirring while adding, standing for 10-15 hours, separating supernatant, concentrating under reduced pressure until no alcohol smell exists, and drying in vacuum at 50-80 ℃ to obtain the antibacterial and anti-inflammatory medicinal soap composition.

The soap composition with combined antibacterial and skin-care effects contains 10-15 wt% of flavonoid compounds, 5-8 wt% of flavone glucoside compounds and 10-20 wt% of purslane amide.

The invention adopts three Chinese herbal medicines, namely the wild chrysanthemum flower, the baical skullcap root and the purslane, which have the properties of heat-clearing and detoxifying medicines, heat-clearing and dampness-drying medicines, heat-clearing and detoxifying medicines or blood-activating and stasis-removing medicines as raw materials, and utilizes the synergistic effect of the three medicines to obtain the composition with the effects of anti-inflammatory curative effect and improving microcirculation.

Wherein:

1. flos Chrysanthemi Indici is dry head-shaped inflorescence of Chrysanthemum indicum L. Collected in the beginning of blooming in autumn and winter, and dried in the sun or steamed and dried in the sun. It has the actions of clearing heat and removing toxicity, purging fire and pacifying liver. Can be used for treating furuncle, carbuncle, swelling, conjunctival congestion, swelling and pain, dizziness, and vertigo. Proper dosage is for external application, and the decoction is washed externally or the ointment is prepared for external application.

The wild chrysanthemum flower mainly contains components such as flavonoids and flavone glucosides, wherein the flavonoids comprise diosgenin (geraniol), luteolin (luteolin), apigenin (apigenin), kaempferol (kaempferol), chrysophanol (chrysophanol), linarin (linarin), farnesin (acacetin), farnesin 7-O- (6 '-O-acetyl) - β -D-glucose (acacetin 7-O- (6' -O-acetyl) - β -D-glucopyranoside), and the flavone glucosides comprise luteolin-7-O- β -D-glucoside (luteolin-7-O- β -D-glucopyranoside), and the other components comprise β -sitosterol.

The wild chrysanthemum flower has the efficacies of clearing away heat and toxic material, dispelling wind and heat, and clearing liver and improving eyesight, is called as broad-spectrum antibiotic in Chinese herbal medicines in folk, can prevent and treat bacillary dysentery, cold, enteritis, constipation and other diseases when being used as a medicine or tea drink, and contains various effective components such as volatile oil, flavonoid substances, wild chrysanthemum lactone, wild chrysanthemum alcohol, β -carotene, chlorogenic acid and the like.

In-vitro antibacterial tests show that the wild chrysanthemum has a broad-spectrum antibacterial effect, has a strong inhibiting effect on staphylococcus aureus, diphtheria bacillus, typhoid bacillus, escherichia coli, proteus bacillus, dysentery bacillus, escherichia coli, pseudomonas aeruginosa and shigella flexneri, and has a remarkable anti-inflammatory effect.

Flos Chrysanthemi Indici also has antiviral effect. The wild chrysanthemum extract can play a role in multiple links, can directly inactivate viruses when being incubated with the viruses, can inhibit the viruses from adsorbing and penetrating into cell membranes to infect cells, and simultaneously has a certain effect on the viruses which enter the cells.

2. The Scutellariae radix is dried root of Scutellaria baicalensis Georgi of Labiatae. Collected in spring and autumn, removed root hair and silt, dried in the sun, removed rough skin and dried in the sun. It has the actions of clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing abortion. Can be used for treating damp-warm syndrome, summer dampness, chest distress, emesis, dampness, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, suppurative sore, and threatened abortion.

The scutellaria baicalensis mainly contains flavonoids and other components, wherein the content of the flavonoids: baicalin (baicailin), baicalein (baicalein), wogonin (wogonoside), wogonin (wogonin), and the like. And others: oroxin A (oxylin A), oroxin A-7-glucuronide (oxylin A-7-glucuronide), baicalein I (skullcapflavone I), baicalein II (skllcapflavone II), norwogonin (norwogonin), chrysin (chrysin), and 5,7,4 '-trihydroxy-8-methoxyflavone (5,7, 4' -hydroxy-8-methoxyflavone).

The Scutellariae radix extract has antibacterial and antiinflammatory effects. The scutellaria decoction has obvious in-vitro antibacterial effect and has good antibacterial activity on gram-positive cocci, gram-negative bacilli and fungi. The Gaoyan adopts an in vitro cytopathic effect method to screen the antiviral curative effect of the scutellaria baicalensis, and finds that the scutellaria baicalensis has obvious effect on respiratory syncytial virus. The scutellaria has better treatment effect on patients with acute eczema and has less adverse reaction. In clinic, the scutellaria baicalensis is also used as a main drug and externally applied as a treatment method to treat various skin diseases, such as radiodermatitis, acne, pityriasis capitis and the like.

Baicalin also has antiviral effect, and can inhibit various viruses, such as influenza virus, respiratory syncytial virus, human immunodeficiency virus, hepatitis B virus, Coxsackie virus, etc. Experiments of Liuwenhui prove that the aqueous extract and the alcohol extract of the scutellaria baicalensis can be used for resisting influenza viruses, and the alcohol extract is superior to the aqueous extract. Research on the Dolina shows that the scutellaria aqueous extract can play a role in resisting RSV by regulating disordered lipid metabolism after intervening PC, SM and TG metabolism.

3. Purslane (academic name: Portulaca oleracea L.): is an annual herb of Caryophyllales, Portulacaceae, and has no hair. Lying down with stems, spreading over the ground, and making the branches light green or dark red. The leaves are intergrown, the leaves are flat and thick, are like a crenellated shape, the upper part is dark green, and the lower part is light green or has dark red; the petiole is thick and short. The flower has no peduncle, and blooms in the noon; leaf-shaped; sepals are green and helmet-shaped; yellow petals, inverted egg shape; stamen anthers are yellow; the ovary has no hair. A capsule egg-shaped; the seeds are fine, inclined spherical, black brown and glossy. The flowering period is 5-8 months, and the fruit period is 6-9 months.

Purslane is an annual herb of the purslane family. Five compounds were isolated from 70% ethanol extracts of purslane and identified as purslane amide a (1), purslane amide B (2), purslane amide E (3), and hesperidin (4) and caffeic acid (5) the whole herb contains large amounts of noradrenaline (noradrenaline) and large amounts of potassium salts including potassium nitrate, potassium chloride, potassium sulfate and other potassium salts. Also contains dopa (dopa), dopamine (dopamine), betanin (betanidin), isobetanin (isobetanidin), betanin (betanin), isobetanin (isobetanin), oxalic acid (oxalic acid), malic acid (malic acid), citric acid (citric acid), glutamic acid (glutamic acid), aspartic acid (aspartic acid), alanine (alanine) and glucose (glucose), fructose (fructose), sucrose (sucrose), etc.

Herba Portulacae is the whole plant of Portulaca oleracea L. The whole herb is used for medicine, and has the effects of clearing away heat and toxic materials, and dispelling blood and swelling. Clear heat, cool blood and treat dysentery, mainly for heat-toxicity, bloody dysentery and damp-heat dysentery. Herba Portulacae can eliminate abdominal mass, relieve thirst, treat female leukorrhagia with reddish discharge, remove heat, remove toxic substance, and relieve carbuncle, and can be used for treating pyocutaneous disease due to fire toxin. Purslane is sour and cold, enters heart channel to remove blood, and has the functions of cooling blood, stopping bleeding, detoxifying and treating carbuncle, and enters large intestine to clear heat, cool blood and stop dysentery, which is commonly used for bloody dysentery and sore toxicity. Purslane is mainly used as an external prescription in clinic, and accounts for the largest proportion in the prescription of skin diseases, so that the purslane is used for treating skin allergy symptoms such as eczema, urticaria and the like.

The application of the soap composition with combined antibacterial and skin-care effects is characterized in that purified substances extracted and purified from the clear and turbid prescription are added into a soap base of the medicinal soap to prepare the medicinal soap with combined antibacterial and skin-care effects.

The adding amount of the purified substance in the soap base is 0.3-2% of the weight of the soap base. The soap base is commercially available soap base. The content of fatty acid in the soap base is more than or equal to 78 percent, the content of free acid (calculated by oleic acid) is less than or equal to 0.8 percent, the content of chloride (calculated by NaCL) is less than or equal to 0.7 percent, the content of ethanol insoluble substances is less than or equal to 2 percent, and the content of water and volatile substances is less than or equal to 14 percent; the fatty acid solidification point is 39-43 ℃.

Compared with the prior art, the invention adopts three Chinese herbal medicines with the properties of heat-clearing and detoxifying drugs, heat-clearing and dampness-drying drugs, heat-clearing and detoxifying drugs or blood-activating and stasis-removing drugs, namely the wild chrysanthemum flower, the scutellaria baicalensis and the purslane as raw materials, and flavonoid compounds, flavonoid glucoside compounds, purslane amide and the like in the extract obtained after extraction and purification have synergistic effect to obtain the composition with the effects of anti-inflammatory curative effect and improving microcirculation.

Detailed Description

The following examples are given for the detailed implementation and specific operation of the present invention, but the scope of the present invention is not limited to the following examples.