阅读说明：本技术 稳定光源 (Stable light source ) 是由 林伟成 林艳 柳邦源 黄伟任 罗全胜 方桂锋 于 2019-11-25 设计创作，主要内容包括：本发明涉及化学发光免疫分析仪的校准光源技术领域,尤其涉及一种稳定光源,其包括灯体、调档模块、光探测器和反馈模块；调档模块能够调节灯体的档位,一个档位对应灯体的一个发光强度,光探测器用于探测发光强度,反馈模块用于根据光探测器探测到的发光强度调节通过灯体的电流,以使灯体在同一档位上维持同一发光强度。本发明提供的稳定光源,不但能够缓解灯体的光衰问题,还能够减小因不确定原因导致灯体发光强度偏高的问题,提高了校准精确度的稳定性；此外,便于实现化学发光免疫分析仪的多点校准,提高校准效果。(The invention relates to the technical field of calibration light sources of chemiluminescence immunoassay analyzers, in particular to a stable light source, which comprises a lamp body, a gear shifting module, a light detector and a feedback module, wherein the lamp body is provided with a light source; the gear shifting module can adjust gears of the lamp body, one gear corresponds to one luminous intensity of the lamp body, the light detector is used for detecting the luminous intensity, and the feedback module is used for adjusting the current passing through the lamp body according to the luminous intensity detected by the light detector so that the lamp body maintains the same luminous intensity at the same gear. The stable light source provided by the invention can relieve the problem of light attenuation of the lamp body, can reduce the problem of high luminous intensity of the lamp body caused by uncertain reasons, and improves the stability of calibration accuracy; in addition, the multi-point calibration of the chemiluminescence immunoassay analyzer is convenient to realize, and the calibration effect is improved.)

1. A stable light source is characterized by comprising a lamp body (100), a gear shifting module, a light detector (200) and a feedback module; the gear shifting module can adjust gears of the lamp body (100), one gear corresponds to one luminous intensity of the lamp body, the light detector (200) is used for detecting the luminous intensity, and the feedback module is used for adjusting the current passing through the lamp body (100) according to the luminous intensity detected by the light detector (200) so that the lamp body (100) maintains the same luminous intensity at the same gear.

2. The stabilized light source of claim 1, further comprising a light-tight sealed housing (300), wherein the lamp body (100) and the light detector (200) are fixed in the sealed housing (300), and the sealed housing (300) has a light-tight hole (321).

3. A stabilized light source according to claim 2, wherein the aperture of the light-transmitting hole (321) is in the range of 0.05-0.3 mm, preferably 0.1 mm.

4. The stabilized light source according to claim 2, wherein a light diffusion plate (400) is fixedly disposed outside the closed casing (300), and the light diffusion plate (400) can diffuse the light emitted from the light-transmitting hole (321).

5. The stable light source of claim 4, further comprising a light guide pillar (500), wherein the light diffusion plate (400) has a blind hole, one end of the light guide pillar (500) is close to the light hole (321), and the other end is inserted into the blind hole.

6. The stable light source of claim 5, wherein a fixing block (600) is connected to one end of the closed housing (300) having the light hole (321), the fixing block (600) has a positioning hole facing the light hole (321), and a portion of the light guide pillar (500) near the light hole (321) is installed in the positioning hole.

7. The stable light source of claim 6, wherein the closed housing (300) comprises a cylinder (310) and a micro-porous plate (320) having the light-transmitting holes (321), one end of the cylinder (310) is closed, the micro-porous plate (320) and the fixing block (600) are sequentially installed in the cylinder at the other end of the cylinder (310) from inside to outside, and both the micro-porous plate (320) and the fixing block (600) are detachably connected with the cylinder (310).

8. The stabilized light source according to claim 1, wherein the light detector (200) is a photodiode.

9. The stable light source according to any one of claims 1 to 8, wherein the gear shifting module comprises a plurality of gear shifting branches connected in parallel, each gear shifting branch has an MOS transistor therein, each MOS transistor is provided with a toggle switch (700), and the toggle switch (700) is used for adjusting the on/off of the MOS transistor.

10. The stabilized light source according to any of claims 2-8, further comprising a battery for supplying power to the lamp body, wherein a low dropout linear regulator is connected between the battery and the lamp body (100).

Technical Field

The invention relates to the technical field of calibration light sources of chemiluminescence immunoassay analyzers, in particular to a stable light source.

Background

The chemiluminescence immunoassay analyzer comprises two parts, namely an immunoreaction system and a chemiluminescence analysis system, wherein the chemiluminescence analysis system utilizes chemiluminescence substances to be catalyzed by a catalyst and oxidized by an oxidant to form an excited intermediate, when the excited intermediate returns to a stable ground state, photons are simultaneously emitted, and a luminescence signal measuring instrument is utilized to measure the yield of light quantum. The immunoreaction system is to label the luminous matter (excited to produce excited state intermediate under the excitation of reactant) directly onto antigen (chemiluminescence immunoassay) or antibody (immunochemiluminescence assay), or to act enzyme on the luminous substrate.

The core detecting device in the chemiluminescence immune analyzer is a photomultiplier, single photons are detected and transmitted to an amplifier, high-voltage current is added for amplification, the amplifier converts analog current into digital current, the digital current transmits a luminous signal to a computer through a data line and calculates to obtain a clinical result, and the chemiluminescence immune analyzer needs to be calibrated in order to ensure the accuracy of the clinical result.

At present, a deuterium lamp, a xenon lamp or an LED lamp is generally used as a calibration light source, and a photomultiplier tube is used for detecting the calibration light source to calibrate the chemiluminescence immunoassay analyzer.

In summary, how to overcome the above-mentioned defects of the prior calibration light source for calibrating the chemiluminescence immunoassay analyzer is a technical problem to be solved by those skilled in the art.

Disclosure of Invention

The invention aims to provide a stable light source to solve the technical problem that the calibration accuracy of a calibration light source for calibrating a chemiluminescence immunoassay analyzer in the prior art is unstable.

The invention provides a stable light source, which comprises a lamp body, a gear shifting module, a light detector and a feedback module; the gear shifting module can adjust gears of the lamp body, one gear corresponds to one luminous intensity of the lamp body, the light detector is used for detecting the luminous intensity, and the feedback module is used for adjusting the current passing through the lamp body according to the luminous intensity detected by the light detector, so that the same luminous intensity of the lamp body is maintained at the same gear.

Preferably, as an implementation mode, the stable light source further includes a light-tight closed housing, the lamp body and the light detector are both fixed in the closed housing, and the closed housing is provided with a light hole.

Preferably, as an embodiment, the aperture of the light hole is in the range of 0.05-0.3 mm, preferably 0.1 mm.

Preferably, as an embodiment, a light diffusion plate is fixedly provided outside the closed casing, and the light diffusion plate can diffuse the light passing through the light transmission hole.

Preferably, as an implementation mode, the light stabilizing source further includes a light guide pillar, a blind hole is formed in the light diffusion plate, one end of the light guide pillar is close to the light transmission hole, and the other end of the light guide pillar is inserted into the blind hole.

Preferably, as an implementation mode, one end of the closed shell, which is provided with the light hole, is connected with a fixed block, the fixed block is provided with a positioning hole facing the light hole, and the part of the light guide column, which is close to the light hole, is installed in the positioning hole.

Preferably, as an implementable mode, the closed shell comprises a barrel and a microporous plate with light transmission holes, one end of the barrel is closed, the microporous plate and the fixed block are sequentially installed in the barrel at the other end of the barrel from inside to outside, and the microporous plate and the fixed block are detachably connected with the barrel.

Preferably, as an implementation mode, the light detector is a photodiode.

Preferably, as an implementable mode, the module of shifting gears includes a plurality of parallelly connected branch circuits of shifting gears, each all have MOS (metal oxide semiconductor) pipe in the branch circuit of shifting gears, each MOS pipe department all installs toggle switch, toggle switch is used for adjusting the break-make of MOS pipe.

Preferably, as an implementation mode, the stable light source further includes a battery for supplying power to the lamp body, and a low dropout regulator is connected between the battery and the lamp body.

Compared with the prior art, the invention has the advantages that:

the invention provides a stable light source which mainly comprises a lamp body, a gear shifting module, a light detector and a feedback module, wherein the gear shifting module can adjust gears of the lamp body, one gear corresponds to one luminous intensity of the lamp body, namely the luminous intensity of the lamp body can be changed before and after the gear shifting module changes the gear; the light detector can detect the luminous intensity of the lamp body and can transmit the detected luminous intensity of the lamp body to the feedback module, and the feedback module can adjust the current passing through the lamp body according to the luminous intensity detected by the light detector.

When the luminous intensity of the lamp body is lower than the luminous intensity which the lamp body should have at the current gear due to the light attenuation problem of the lamp body, the feedback module can increase the current passing through the lamp body to increase the luminous intensity of the lamp body so as to maintain the luminous intensity of the lamp body at the luminous intensity which the lamp body should have at the current gear; when the luminous intensity of the lamp body is higher than the luminous intensity of the lamp body which should be at the current gear due to certain uncertain reasons, the feedback module can reduce the current passing through the lamp body to reduce the luminous intensity of the lamp body, so that the luminous intensity of the lamp body is maintained at the luminous intensity which should be at the current gear.

That is to say, when the lamp body is adjusted to a certain gear by the gear shifting module, under the combined action of the optical detector and the feedback module, the luminous intensity of the lamp body can be always kept at the same value, so that the problem of light attenuation of the lamp body can be relieved, the problem of high luminous intensity of the lamp body caused by uncertain reasons can be reduced, and the stability of calibration accuracy is improved.

It should be noted that the number of adjustable gears of the gear shifting module can be set as required, and can be one or more; if set up the gear into a plurality ofly, the accessible is adjusted the gear for the lamp body sends the light of different intensity, is convenient for realize the multiple spot calibration of chemiluminescence immunoassay appearance, improves the calibration effect.

The feedback module itself mentioned in the present invention is a common negative feedback circuit, and the detailed structure of the feedback module is not described in detail in the present invention.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic cross-sectional view of a stabilized light source according to an embodiment of the present invention;

FIG. 2 is an enlarged schematic view of portion A of FIG. 1;

FIG. 3 is an enlarged schematic view of portion B of FIG. 2;

FIG. 4 is an exploded view of a stabilized light source provided by an embodiment of the present invention;

fig. 5 is an enlarged schematic view of a portion C in fig. 4.

Icon: 100-a lamp body; 200-a light detector; 300-a closed housing; 400-a light diffuser plate; 500-a light guide; 600-fixing block; 700-toggle switch;

310-a cylinder body; 320-a microporous plate;

311-a main body; 312-a sleeve;

321-light hole.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "inside", "outside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and operate, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted" and "connected" are to be interpreted broadly, e.g., as being either fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

The present invention will be described in further detail below with reference to specific embodiments and with reference to the attached drawings.

Referring to fig. 1 to 5, the stable light source provided in this embodiment mainly includes a lamp body 100, a shift module, a light detector 200, and a feedback module, where the shift module can adjust a shift of the lamp body 100, and one shift corresponds to a light-emitting intensity of the lamp body 100, that is, the light-emitting intensity of the lamp body 100 changes before and after the shift module changes the shift; the light detector 200 can detect the luminous intensity of the lamp body 100 and can transmit the detected luminous intensity of the lamp body 100 to the feedback module, and the feedback module can adjust the current passing through the lamp body 100 according to the luminous intensity detected by the light detector 200.

When the light attenuation problem of the lamp body 100 causes the luminous intensity to be lower than the luminous intensity that the lamp body 100 should have in the current gear, the feedback module can increase the current passing through the lamp body 100 to increase the luminous intensity of the lamp body 100, so that the luminous intensity of the lamp body 100 is maintained at the luminous intensity that the lamp body 100 should have in the current gear; when the light intensity of the lamp body 100 is higher than the light intensity that the current gear should have due to some uncertain reason, the feedback module can reduce the current passing through the lamp body 100 to reduce the light intensity of the lamp body 100, so that the light intensity of the lamp body 100 is maintained at the light intensity that the current gear should have.

That is to say, when the lamp body 100 is adjusted to a certain gear by the gear shifting module, under the combined action of the light detector 200 and the feedback module, the luminous intensity of the lamp body 100 can be always kept at the same value, which not only can alleviate the problem of light attenuation of the lamp body 100, but also can reduce the problem of high luminous intensity of the lamp body 100 caused by uncertain reasons, and improve the stability of the calibration accuracy.

It should be noted that the number of adjustable gears of the gear shifting module can be set as required, and can be one or more; if set up the gear into a plurality ofly, the accessible is adjusted the gear for lamp body 100 sends the light of different intensity, is convenient for realize the multiple spot calibration of chemiluminescence immunoassay appearance, improves the calibration effect.

The feedback module mentioned in this embodiment is a commonly used negative feedback circuit, and the detailed structure thereof is not described in this embodiment.

Preferably, referring to fig. 1 to fig. 3, a light-tight closed housing 300 may be disposed in the stable light source provided in this embodiment, the lamp body 100 and the light detector 200 are both fixed in the closed housing 300, a light hole 321 is formed in the closed housing 300, and light emitted from the lamp body 100 can be emitted through the light hole 321 for the chemiluminescence immunoassay analyzer to collect, thereby implementing calibration.

It should be noted that, because the enclosed housing 300 itself is opaque, the light detector 200 in the enclosed housing 300 is not affected by external light, so that the luminous intensity detected by the light detector 200 is not affected by the change of the external luminous intensity, which is convenient to ensure the accuracy of the luminous intensity received by the feedback module, and improve the reliability of maintaining the same luminous intensity of the lamp body 100 at the same gear.

Preferably, the aperture range of the light hole 321 on the close housing 300 is 0.05-0.3 mm, so as to limit the light entering the close housing 300 from the light hole 321 within a small range, further reduce the possibility of influencing the light intensity detected by the light detector 200 due to the external light intensity variation, and improve the reliability of the lamp body 100 maintaining the same light intensity at the same gear.

In particular, the aperture of the light hole 321 on the close housing 300 may be set to 0.1mm, so as to reduce the difficulty in processing the light hole 321 on the basis of ensuring the reliability that the lamp body 100 maintains the same light emitting intensity at the same shift.

Preferably, a light diffusion plate 400 may be disposed outside the closed housing 300, and the light diffusion plate 400 may diffuse the light transmitted through the light transmission holes 321, so that a photomultiplier tube (PMT) of the chemiluminescent immunoassay analyzer detects the light on the light diffusion plate 400.

Further, still can set up light guide column 500 in the concrete structure of steady light source, and set up the blind hole on light diffuser plate 400, light guide column 500's one end is close to light trap 321, the blind hole on the other end inserts light diffuser plate 400, so that the light that is passed through by light trap 321 can lead to light diffuser plate 400 through light guide column 500 on, so, light guide column 500 just can give off light to light diffuser plate 400 along circumference on, be convenient for improve the homogeneity of light intensity on light diffuser plate 400, improve the calibration accuracy.

Specifically, the end of the closed housing 300, which is provided with the light hole 321, is connected to the fixing block 600, the fixing block 600 is provided with a positioning hole opposite to the light hole 321, and the portion of the light guide column 500, which is close to the light hole 321, is installed in the positioning hole, so as to fix the light guide column 500.

The specific structure of the closed shell 300 comprises a cylinder body 310 and a microporous plate 320 with a light hole 321, wherein one end of the cylinder body 310 is closed, and the microporous plate 320 and a fixed block 600 are sequentially arranged in the cylinder at the other end of the cylinder body 310 from inside to outside so as to realize closing; the micro-porous plate 320 and the fixing block 600 are both detachably connected with the barrel body 310 to form a structure similar to a pen container. When the lamp body 100 and/or the optical detector 200 in the closed housing 300 need to be replaced, the micro plate 320 and the fixing block 600 can be detached from the cylinder 310, then the lamp body 100 and/or the optical detector 200 in the closed housing 300 can be taken out and replaced by a new lamp body 100 and/or optical detector 200, and finally the micro plate 320 and the fixing block 600 can be mounted on the cylinder 310, so that the lamp is very convenient, the closed housing 300 can be conveniently used for multiple times, and the cost is saved. If the shift module and/or the feedback module are also installed in the closed housing 300, the shift module and/or the feedback module may be replaced by replacing the lamp body 100 as described above.

The specific structure of the cylinder body 310 comprises a main body 311 and a sleeve 312, wherein an external thread is arranged at one end of the main body 311 close to the micro-porous plate 320, an internal thread is arranged on the sleeve 312, and the internal thread at one end of the sleeve 312 can be matched with the external thread on the main body 311; all set up the external screw thread on micropore board 320 and the fixed block 600, and the external screw thread on micropore board 320 and the fixed block 600 can with the interior screw-thread fit of sleeve 312, realize dismantling the connection.

Specifically, the lamp body 100 is connected to a circular plate, and an annular groove may be disposed on an inner wall of the end of the main body 311 where the sleeve 312 is installed, so that the circular plate can abut against a wall of the annular groove, and the lamp body 100 abuts against the micro plate 320, so that the lamp body 100 is fixed in the sealed housing 300 by utilizing the abutting action of the annular groove on the main body 311 and the micro plate 320 on the lamp body 100 and the circular plate, thereby facilitating the disassembly and assembly.

In particular, the sealing case 300 may be made of ferrous metal, which not only satisfies the requirement of the sealing case 300 for light-tight, but also ensures the structural strength of the sealing case 300 itself and prolongs the service life.

In particular, a photodiode may be used as the light detector 200.

Including a plurality of parallelly connected gear shifting branch roads in the gear shifting module, all have the MOS pipe in each gear shifting branch road, all install toggle switch 700 in each MOS pipe department, can adjust the break-make of MOS pipe through controlling this toggle switch 700, and then, through the selective access to the gear shifting branch road, realize the selection to different gears.

In this embodiment, resistors with different resistances may be respectively disposed in each shift branch to achieve the shift purpose.

It should be noted that, the toggle switch 700 is used to control the MOS transistor, and then the MOS transistor controls the on/off of the shift branch, so that the influence of the mechanical contact of the toggle switch 700 on the resistance of the shift branch can be reduced, and the problem of interference of mechanical vibration generated when the toggle switch 700 is toggled on signals can be reduced.

In addition, a battery may be used to supply power to the lamp body, and a low voltage linear regulator may be connected between the battery and the lamp body 100 to provide a pure and stable voltage to the lamp body 100, so as to improve the stability of the intensity of the light emitted from the lamp body 100.

Preferably, the gear shifting module and the feedback module can be installed in the closed housing 300, so that the lamp body 100, the gear shifting module, the light detector 200 and the feedback module are all sealed in the closed housing 300, the integrity is stronger, the use and the carrying are convenient, and the field calibration of the instrument is convenient to realize.

In particular, an LED lamp can be selected as the lamp body 100 provided in this embodiment, the operating voltage of the LED lamp is low (about 3V), and a common battery can provide voltage for the LED lamp; the repeated switching of the LED lamp has little influence on the service life, and is suitable for being used as a stable light source for calibrating a chemiluminescence immunoassay analyzer; the LED lamp is small in size, is more convenient to use and carry, and is more convenient for realizing field calibration of an instrument; the LED lamp generates less heat, and is not damaged by poor heat dissipation when installed in the sealed housing 300; the LED lamp is firm and durable, and the probability of damage caused by collision can be reduced; the light beam of the LED lamp is concentrated and stable, and the calibration accuracy can be improved.

In summary, the embodiments of the present invention disclose a stable light source, which overcomes many technical defects of the conventional calibration light source for calibrating a chemiluminescence immunoassay analyzer. According to the stable light source provided by the embodiment of the invention, when the lamp body 100 is adjusted to a certain gear by the gear shifting module, under the combined action of the optical detector 200 and the feedback module, the luminous intensity of the lamp body 100 can be always kept at the same value, so that the problem of light attenuation of the lamp body 100 can be relieved, the problem of high luminous intensity of the lamp body 100 caused by uncertain reasons can be reduced, and the stability of calibration accuracy is improved. In addition, the gears can be adjusted, so that the lamp body 100 emits light with different intensities, multi-point calibration of the chemiluminescence immunoassay analyzer is facilitated, and the calibration effect is improved.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.