阅读说明：本技术 一种头箍式脑功能成像仪 (Head band type brain function imaging instrument ) 是由 程茜 解维娅 张梦娇 陈盈娜 封婷 张浩南 高雅 吴诗颖 陈一铭 覃宇 赵文丞 于 2019-10-21 设计创作，主要内容包括：本发明涉及一种头箍式脑功能成像仪,该成像仪包括：圆形耳壳：设有两个且固定在双耳外；带状测量臂：为长条形柔性曲面带并贴合颅骨设置,并且在与颅骨接触的下表面沿臂长方向设有带状光发射及透光模块和带状超声相控阵发射及接收模块；连接带：为可伸缩式的弹性连接带,通过调节长度用以适应不同被试者头部颅骨外围,其一端与圆形耳壳连接,另一端与带状测量臂连接；主机：用以驱动发射激光和超声信号,并接收产生的光声信号和反射回的超声信号进行成像。与现有技术相比,本发明可固定于头部,不影响被试者自由移动,减轻其心理负担,可用于脑部神经网络活动的检测与成像等优点。(The invention relates to a head band type brain function imager, which comprises: a circular earshell: two are arranged and fixed outside the double ears; a strip-shaped measuring arm: the flexible curved belt is a strip-shaped flexible curved belt and is attached to the skull, and a strip-shaped light emitting and transmitting module and a strip-shaped ultrasonic phased array emitting and receiving module are arranged on the lower surface, which is in contact with the skull, along the arm length direction; connecting a belt: the measuring instrument is a telescopic elastic connecting belt, is used for adapting to the peripheries of head craniums of different testees by adjusting the length, and has one end connected with the circular earmuff and the other end connected with the belt-shaped measuring arm; a host computer: the device is used for driving and transmitting laser and ultrasonic signals, and receiving the generated photoacoustic signals and the reflected ultrasonic signals for imaging. Compared with the prior art, the invention can be fixed on the head, does not influence the free movement of a testee, reduces the psychological burden of the testee, and can be used for the detection and imaging of brain neural network activities.)

1. A head band brain function imager, comprising:

round ear shell (13): two strip-shaped measuring arms (14) are arranged and fixed outside the two ears and used for driving the strip-shaped measuring arms to rotate to different positions of the skull so as to realize the full-coverage imaging of the whole brain and the skull;

strip-shaped measuring arm (14): the skull-bone ultrasonic acoustic phased array device is characterized in that the device is a strip-shaped flexible curved surface belt and is attached to a skull, a strip-shaped light emitting and transmitting module (141) and a strip-shaped ultrasonic phased array emitting and receiving module (142) are arranged on the lower surface, which is in contact with the skull, along the arm length direction, the strip-shaped light emitting and transmitting module (141) and the strip-shaped ultrasonic phased array emitting and receiving module (142) are fixed in a strip-shaped measuring arm (14) through fixing clamping grooves and used for emitting uniform pulse light into the skull, penetrating through an emitting and receiving belt to irradiate a brain tissue area to be imaged to generate an opto-acoustic signal, and the strip-shaped ultrasonic phased array emitting and receiving module (142) is fixed in the strip-shaped measuring arm through the fixing clamping grooves and used for emitting an ultrasonic;

connecting band (1): the telescopic elastic connecting band is used for adapting to the peripheries of the head and the skull of different testees by adjusting the length, one end of the telescopic elastic connecting band is connected with the circular concha (13), and the other end of the telescopic elastic connecting band is connected with the belt-shaped measuring arm (14);

a host computer: the cable is connected with a strip-shaped light emitting and transmitting module (141) and a strip-shaped ultrasonic phased array emitting and receiving module (142) in a strip-shaped measuring arm (14) sequentially through a round earshell (13) and a connecting band (1) so as to drive to emit laser and ultrasonic signals and receive the generated photoacoustic signals and the reflected ultrasonic signals for imaging.

2. The head band type brain function imager according to claim 1, wherein the circular earmuff (13) comprises a circular semi-closed housing (131) and a rotating ring (132) rotating within the opening range of the circular semi-closed housing (131), the opening of the circular semi-closed housing (131) is set to three-quarters of the size of the circular ring, and the rotating angle range is 0-270 °.

3. The head band type brain function imaging instrument according to claim 1, wherein the round earmuff (13) is provided with a mounting hole at an end away from the connecting band (1) for assembling cables of the ribbon light emitting and transmitting module (141) and the ribbon ultrasonic phased array emitting and receiving module (142).

4. The head band type brain function imaging instrument according to claim 2, wherein the connecting band (1) and the band-shaped measuring arm (14) are provided with one or more sets, which are respectively rotatably connected with the rotating ring (132) of the round concha (13).

5. The head band type brain function imager according to claim 1, wherein the strip light emitting and transmitting module (141) comprises a pulse light source and a flexible light guide rod (4) which are sequentially arranged along a light path, the flexible light guide rod (4) is attached to a skull for homogenizing pulse light emitted by the pulse light source, the pulse light source is connected with a host through a cable, and the pulse light source comprises an embedded LED array light source (3) and an external laser emitting laser light source for emitting pulse light with multiple wavelengths.

6. The head band type brain function imager according to claim 1, wherein the ultrasonic phased array transmitting and receiving module (142) comprises an array element plate (5) and an ultrasonic sound head, the top end of the array element plate is connected with a host through a cable, the bottom end of the array element plate is connected with the ultrasonic sound head, and the ultrasonic sound head comprises a flexible composite PZT array (8), a matching layer (9) and a sound lens (10) which are sequentially arranged from inside to outside.

7. A head-band brain function imager as claimed in claim 1, wherein said band-shaped measuring arm (14) further comprises a transparent water-tight layer (12) disposed on the surface in contact with the skull of the brain to provide protection.

8. The head band type brain function imager of claim 1, wherein the light feeding modes of the band-shaped light emitting and transmitting module (141) and the band-shaped ultrasonic phased array transmitting and receiving module (142) comprise a single-side light feeding mode and a double-side light feeding mode, and specifically comprise:

in the single-side light feeding mode: the strip-shaped light emitting and transmitting module and the strip-shaped ultrasonic phased array emitting and receiving module are respectively arranged at the left side and the right side in the strip-shaped measuring arm (14) in parallel, and an array element plate (5) in the strip-shaped ultrasonic phased array emitting and receiving module is obliquely arranged, and the angle between the array element plate and a normal line of an emitting and receiving belt is 50-80 degrees;

in the double-side light-feeding mode: the strip-shaped light emitting and transmitting modules are arranged in two, the strip-shaped ultrasonic phased array emitting and receiving module is only arranged in one, the two strip-shaped light emitting and transmitting modules are respectively arranged on the left side and the right side of the strip-shaped ultrasonic phased array emitting and receiving module, and the array element plate in the strip-shaped ultrasonic phased array emitting and receiving module is perpendicular to the bottom surface of the strip-shaped measuring arm (14).

9. The head band type brain function imaging instrument according to claim 1, wherein both ends of the connecting band (1) are fixed to the connecting position between the band-shaped measuring arm (14) and the rotating ring (132), and the connecting band (1) and the band-shaped measuring arm (14) are rotated by the rotating ring.

10. The head band type brain function imager according to any one of claims 1-9, wherein the work flow of the brain function imager is as follows:

1) controlling a plurality of channels to simultaneously emit ultrasonic waves after beam forming according to an excitation signal of a host in the photoacoustic ultrasonic bimodal synchronous imaging system, and irradiating a brain tissue area to be detected through a skull;

2) the strip-shaped pulse light source emits pulse light, the pulse light is homogenized by the flexible light guide rod and is transmitted to the same tissue area to be detected covered by the strip-shaped ultrasonic phased array emitting and receiving module through skull bone, and photoacoustic signals are generated;

3) the ultrasonic signal reflected by the tissue area is received by the banded ultrasonic phased array transmitting and receiving module, and the photoacoustic signal is received through setting time delay after the ultrasonic signal is triggered by pulse light;

4) the received ultrasonic signals and the photoacoustic signals are transmitted to the host through the cable, and synchronous photoacoustic and ultrasonic bimodal imaging of the brain tissues in the skull is realized.

Technical Field

The invention relates to the field of medical imaging, in particular to a head band type brain function imaging instrument.

Background

Ultrasound imaging for medical diagnosis is widely used in medical diagnosis because of its advantages of non-ionizing radiation, high resolution imaging of anatomical structures, low price, etc. Photoacoustic imaging is a medical imaging method which is newly developed in recent years and can realize imaging of physicochemical properties of a tissue. The method combines the advantages of high contrast of pure optical imaging and high penetrability of pure ultrasound, can provide high contrast and high axial resolution, can obtain the blood vessel distribution form and partial functional information of tissues, and has wide application prospect in the fields of biomedical clinical diagnosis and functional imaging such as hemodynamics, oncology and the like.

If the ultrasonic and photoacoustic dual-mode simultaneous detection and imaging can be realized, the structural imaging with higher resolution can be provided for the focus, the functional imaging of the tissue physical and chemical properties with high resolution and high contrast can be provided on the basis of structural information, and more bases can be provided for clinical diagnosis.

The existing imaging device is too large in volume, inconvenient to operate, harsh in MRI application conditions, incapable of participating in all metals during examination, radioactive in CT and PET and not suitable for pregnant women or infants; in the imaging process, most techniques need to ensure that the head of a testee and a probe do not move relatively, and most testees are imaged under the anesthesia state and cannot move freely; at present, a device and a method for carrying out ultrasonic and photoacoustic nondestructive detection on the brain in the skull are also lacked, the device and the method are mostly used for independent detection, integrated detection equipment is not formed, or an optical method is adopted, only near infrared brain imaging can be carried out on cerebral cortex, and structural imaging can not be carried out on brain tumor in the skull to determine the position of the tumor.

For example, chinese patent CN 104545814a discloses a photoacoustic imaging apparatus worn on the head of an animal, which has the disadvantages that only the brain of the animal can be photoacoustic imaged, and the information of the physical structure of the tissue is lacked; chinese patent CN 108056777 a discloses a device for measuring oxygenated hemoglobin and deoxygenated hemoglobin and a near-infrared brain imaging apparatus, however, the device has the disadvantage that only near-infrared brain imaging can be performed on cerebral cortex, and structural imaging cannot be performed on brain tumor in skull to determine the location of tumor.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a head band type brain function imager.

The purpose of the invention can be realized by the following technical scheme:

a head-band brain function imager, comprising:

circular earshell 13: two strip-shaped measuring arms 14 are arranged and fixed outside the two ears and used for driving the strip-shaped measuring arms to rotate to different positions of the skull, so that the whole brain and the skull are imaged in a full-coverage manner;

strip-shaped measuring arm 14: the strip-shaped flexible curved surface belt is arranged to be attached to a skull, a strip-shaped light emitting and transmitting module 141 and a strip-shaped ultrasonic phased array emitting and receiving module 142 are arranged on the lower surface, which is in contact with the skull, of the lower surface along the arm length direction, the strip-shaped light emitting and transmitting module 141 is fixed in the strip-shaped measuring arm 14 through a fixing clamping groove and used for emitting uniform pulse light into the skull, penetrating through the emitting and receiving belt to irradiate a brain tissue area to be imaged to generate photoacoustic signals, the strip-shaped ultrasonic phased array emitting and receiving module 142 is fixed in the strip-shaped measuring arm through the fixing clamping groove and used for emitting ultrasonic signals, penetrating through the emitting and receiving belt to irradiate the brain tissue area to be imaged to generate photoacoustic signals, and receiving the reflected ultrasonic signals and;

connecting belt 1: the measuring head is a telescopic elastic connecting belt, is used for adapting to the peripheries of head craniums of different testees by adjusting the length, and one end of the measuring head is connected with a circular earflap 13 while the other end is connected with a belt-shaped measuring arm 14;

a host computer: the cable is connected with a strip-shaped light emitting and transmitting module 141 and a strip-shaped ultrasonic phased array emitting and receiving module 142 in the strip-shaped measuring arm 14 respectively through the round earmuff 13 and the connecting band 1 in sequence, so as to drive to emit laser and ultrasonic signals, and receive the generated photoacoustic signals and the reflected ultrasonic signals for imaging.

The circular earmuff 13 comprises a circular semi-closed housing 131 and a rotating ring 132 rotating within the opening range of the circular semi-closed housing 131, the opening of the circular semi-closed housing 131 is set to be three quarters of the size of a circular ring, and the rotating angle range is 0-270 degrees.

The round ear shell 13 is provided with a mounting hole at one end far away from the connecting band 1 for assembling cables of the strip-shaped light emitting and transmitting module 141 and the strip-shaped ultrasonic phased array emitting and receiving module 142.

The connecting band 1 and the band-shaped measuring arm 14 are provided with one or more groups which are respectively connected with the rotating ring 132 of the round ear shell 13 in a rotating way.

The strip light emitting and transmitting module 141 includes the pulsed light source and the flexible light guide rod 4 that set gradually along the light path, the flexible light guide rod 4 laminate the skull setting for make the pulsed light homogenization of pulsed light source transmission, pulsed light source pass through the cable conductor and be connected with the host computer, pulsed light source include embedded LED array light source 3 and external laser instrument transmission laser light source, be used for transmitting the pulsed light of a plurality of wavelengths.

Banded supersound phased array transmit and receive module 142 include array element board 5 and supersound sound head, array element board top pass through the cable conductor and be connected with the host computer, the supersound sound head is connected to the bottom, supersound sound head include flexible compound PZT array 8, matching layer 9 and the acoustic lens 10 that sets gradually from inside to outside.

The strip-shaped measuring arm 14 further comprises a transparent water-tight layer 12 which is arranged on the contact surface with the brain skull for providing protection.

The light feeding modes of the strip-shaped light emitting and transmitting module 141 and the strip-shaped ultrasonic phased array emitting and receiving module 142 include a single-side light feeding mode and a double-side light feeding mode, and specifically include:

in the single-side light feeding mode: the strip-shaped light emitting and transmitting module and the strip-shaped ultrasonic phased array emitting and receiving module are respectively arranged at the left side and the right side in the strip-shaped measuring arm 14 in parallel, the array element plate 5 in the strip-shaped ultrasonic phased array emitting and receiving module is obliquely arranged, and the angle between the array element plate and the normal line of the emitting and receiving strip is 50-80 degrees;

in the double-side light-feeding mode: banded light emission and printing opacity module is equipped with two, and banded supersound phased array emission and receiving module only sets up one to two banded light emission and printing opacity modules set up respectively in the left and right sides of banded supersound phased array emission and receiving module, and array element board and the perpendicular setting of banded measuring arm 14 bottom surface in the banded supersound phased array emission and receiving module.

The two ends of the connecting belt 1 are fixed with the connecting position between the belt-shaped measuring arm 14 and the rotating ring 132, and the connecting belt 1 and the belt-shaped measuring arm 14 are driven by the rotating ring to rotate.

The brain function imager has the working process that:

1) controlling a plurality of channels to simultaneously emit ultrasonic waves after beam forming according to an excitation signal of a host in the photoacoustic ultrasonic bimodal synchronous imaging system, and irradiating a brain tissue area to be detected through a skull;

2) the strip-shaped pulse light source emits pulse light, the pulse light is homogenized by the flexible light guide rod and is transmitted to the same tissue area to be detected covered by the strip-shaped ultrasonic phased array emitting and receiving module through skull bone, and photoacoustic signals are generated;

3) the ultrasonic signal reflected by the tissue area is received by the banded ultrasonic phased array transmitting and receiving module, and the photoacoustic signal is received through setting time delay after the ultrasonic signal is triggered by pulse light;

4) the received ultrasonic signals and the photoacoustic signals are transmitted to the host through the cable, and synchronous photoacoustic and ultrasonic bimodal imaging of the brain tissues in the skull is realized.

Compared with the prior art, the invention has the following advantages:

the method comprises the following steps of photoacoustic and ultrasonic simultaneous real-time detection: the mode that the light emitting module of the pulse light source and the multi-channel ultrasonic probe are combined together is adopted, simultaneous detection of two signals of photoacoustic and ultrasonic is achieved, and simultaneous real-time obtaining of ultrasonic and photoacoustic information of the brain in the skull can be achieved by adopting the same probe device for detection.

Secondly, information is rich: the optoacoustic is particularly sensitive to blood vessels, has unique advantages in the aspect of oxyhemoglobin saturation detection, and can simultaneously obtain physical structure information and histochemical information of the brain in the skull by combining ultrasonic imaging, so that detected tissue signal information is richer; the ultrasonic array part adopts a flexible composite PZT array, acoustic impedance is matched with biological tissues, sensitivity is high, bandwidth is wide, and more microstructure information of brain tissues in the skull can be obtained.

Thirdly, various clinical requirements are met: the method can be used for detecting and imaging brain neural network activity, detecting bleeding and extravasated blood conditions of traumatic cerebral hemorrhage, judging and grading malignancy degree of brain tumor, detecting the size of the tumor and evaluating the treatment effect.

Fourthly, the bedside can move: the device is of a head hoop type, is safe and light, can be worn by a testee to move freely, and can be used for detecting beside a bed, so that the psychological burden of the testee is relieved.

Fifthly, space is sufficient: when a set of strip-shaped light emitting modules and light transmitting modules are arranged, the array element board is obliquely arranged, enough space can be reserved for arranging the strip-shaped light emitting modules and the light transmitting modules, and therefore the size can be reduced.

Sixthly, the detection effect is good: two groups of strip-shaped light emitting modules and light transmitting modules are arranged and are respectively positioned on two sides of the array element plate, so that the detection effect can be improved.

Drawings

Fig. 1 is an external structural view of a head band type brain function imager.

Fig. 2 is a front view of the external structure of the head band type brain function imager.

FIG. 3 is a top view of a dual-side light-feeding mode according to an embodiment of the present invention.

FIG. 4 is a top view of a single-sided right-side light feed mode according to an embodiment of the present invention.

FIG. 5 is a top view of a single-sided left-side light feeding mode according to an embodiment of the present invention.

Fig. 6 is a light path diagram of the strip-shaped light emitting module and the light-transmitting module when the light emitting module is an embedded LED light source according to the embodiment of the invention.

The notation in the figure is:

1. connecting band, 2, cable conductor, 3, LED array light source, 4, leaded light stick, 5, array element board, 6, the backing, 7, FPC, 8, flexible compound PZT array, 9, matching layer, 10, acoustic lens, 11, fixed slot, 12, transparent watertight layer, 14, banded measuring arm, 141, banded light emission and printing opacity module, 142, banded supersound phased array transmission and receiving module, 13, circular ear shell, 131, ring shape semi-closed shell, 132, rotatory ring.

Detailed Description

The invention is described in detail below with reference to the figures and specific embodiments.