阅读说明：本技术 眼科检测系统及方法 (Ophthalmic detection system and method ) 是由 李鹏 蔡守东 郭曙光 于 2019-11-06 设计创作，主要内容包括：本发明提供一种眼科检测系统,包括样品臂、侧眼拍照成像模块和主体模块,样品臂利用测量光对被检眼的眼前节和眼后节进行检测,侧眼拍照成像模块则监测被检眼在检测过程中的眼动,主体模块用于控制样品臂和侧眼拍照成像模块。本发明还提供一种眼科检测方法。本发明提供的眼科检测系统和眼科检测方法,可以降低被检眼的眼动对检测结果的影响。(The invention provides an ophthalmologic detection system, which comprises a sample arm, a side eye photographing imaging module and a main body module, wherein the sample arm detects the anterior segment and the posterior segment of an eye to be detected by using measuring light, the side eye photographing imaging module monitors eye movement of the eye to be detected in the detection process, and the main body module is used for controlling the sample arm and the side eye photographing imaging module. The invention also provides an ophthalmologic detection method. The ophthalmologic detection system and the ophthalmologic detection method provided by the invention can reduce the influence of the eye movement of the detected eye on the detection result.)

1. An ophthalmologic inspection system for inspecting an eye to be inspected by using measurement light, which is characterized by comprising a sample arm, a lateral eye photographing and imaging module and a main body module,

the sample arm is used for focusing the measuring light on the anterior ocular segment of the eye to be detected and the posterior ocular segment of the eye to be detected respectively, receiving an anterior ocular segment optical signal returned from the anterior ocular segment and a posterior ocular segment optical signal returned from the posterior ocular segment respectively, and transmitting the anterior ocular segment optical signal and the posterior ocular segment optical signal to the main body module;

the side-eye photographing imaging module is used for monitoring the position of the eye to be detected in the detection process to obtain a plurality of position information of the eye to be detected;

the main body module is configured to provide the measurement light to the sample arm, interfere with the anterior ocular segment light signal transmitted from the sample arm by using the reference light, collect an anterior ocular segment interference light signal obtained through the interference, interfere with the posterior ocular segment light signal by using the reference light, collect a posterior ocular segment interference light signal obtained through the interference, and obtain an ocular axial length of the eye to be examined by using the anterior ocular segment interference light signal, the posterior ocular segment interference light signal, and the plurality of position information of the eye to be examined.

2. An ophthalmic inspection system as claimed in claim 1, wherein the side-eye imaging module comprises a camera, and the camera is disposed at the side of the eye to be inspected during the inspection operation, and the camera takes a picture of the side of the eye to be inspected.

3. An ophthalmic detection system as claimed in claim 2, wherein the camera is a telecentric imaging camera.

4. An ophthalmic inspection system as claimed in claim 3, wherein the telecentric imaging camera is an object-side telecentric imaging camera or a double telecentric imaging camera.

5. The ophthalmic detection system of claim 1, wherein the body module comprises a light source, a coupler, and a reference arm assembly, the coupler receiving light from the light source and providing light to the reference arm assembly, the reference arm assembly reflecting the received light back to the coupler as reference light, the coupler providing the measurement light to the sample arm.

6. The ophthalmic inspection system of claim 5, wherein the body module further comprises a detector and a controller, the detector and the side-eye photographing imaging module are electrically connected to the controller, the anterior segment optical signal and the posterior segment optical signal respectively interfere with the reference light in the coupler to form the anterior segment interference optical signal and the posterior segment interference optical signal, the anterior segment interference optical signal and the posterior segment interference optical signal are received by the detector and processed by the controller, and the plurality of position information are also collected by the controller.

7. An ophthalmologic inspection method for inspecting an eye to be inspected by using measurement light, comprising the steps of:

when the condition is switched to the anterior segment OCT detection working condition, focusing the measuring light to the anterior segment of the eye to be detected, receiving an anterior segment optical signal returned from the anterior segment, and collecting first position information of the eye to be detected;

when the condition is switched to the working condition of posterior segment OCT detection, the measuring light is focused to the posterior segment of the eye to be detected, the optical signal of the posterior segment of the eye returned from the posterior segment of the eye is received, and second position information of the eye to be detected is collected;

respectively interfering the anterior ocular segment optical signal and the posterior ocular segment optical signal, collecting the interference optical signal of the anterior ocular segment and the interference optical signal of the posterior ocular segment, and obtaining the preliminary ocular axial length of the eye to be detected by using the interference optical signal of the anterior ocular segment and the interference optical signal of the posterior ocular segment;

and obtaining the real eye axial length of the eye to be detected by using the first position information, the second position information and the preliminary eye axial length.

8. An ophthalmic test method as claimed in claim 7, wherein the acquiring the first position information of the eye to be tested comprises capturing an image of the eye to be tested switched to an anterior segment OCT test condition to obtain a first image; and the step of acquiring the second position information of the eye to be inspected comprises the step of shooting an image of the eye to be inspected, which is switched to a posterior segment OCT (optical coherence tomography) detection working condition, so as to obtain a second image.

9. The ophthalmic examination method according to claim 8, wherein the photographing for switching to the anterior segment OCT examination mode includes photographing for switching to the anterior segment OCT examination mode a lateral image of the eye to be examined, and the photographing for switching to the posterior segment OCT examination mode includes photographing for switching to the posterior segment OCT examination mode a lateral image of the eye to be examined.

10. An ophthalmic detection method as claimed in claim 8, wherein the deriving the true eye axis length of the eye to be inspected using the first position information, the second position information, and the preliminary eye axis length comprises:

obtaining the position of the corneal vertex of the eye to be detected under the condition of detecting the anterior segment OCT from the first image, and recording the position as a first position;

obtaining the position of the corneal vertex of the eye to be detected under the working condition of posterior segment OCT detection from the second image, and recording the position as a second position;

calculating a spatial distance between the first location and the second location;

and calculating the real eye axial length of the eye to be detected by utilizing the space distance between the first position and the second position and the preliminary eye axial length.

Technical Field

The invention relates to the field of photoelectronics, in particular to an ophthalmologic detection system and an ophthalmologic detection method.

Background

The OCT (optical coherence tomography) technology is a new technology, has been effectively applied in the field of ophthalmic detection, can perform three-dimensional imaging on an eye to be detected, and has the advantages of high precision, high speed, and the like. And the method has the potential of detecting and diagnosing all eye diseases at one time and combining with a big data technology and an artificial intelligence technology to realize unmanned operation and intelligent diagnosis.

The axial length of the eye is an important ocular parameter, in the prior art, the measurement of the axial length of the eye to be detected by the OCT technique is realized by measuring the anterior segment and the posterior segment of the eye, respectively, and there is a time difference between the anterior segment measurement and the posterior segment measurement, and the position of the eye to be detected moves due to the time difference, thereby causing measurement errors and even invalidating the measurement result.

Disclosure of Invention

The present invention has been made to solve one or more of the above-mentioned problems, and an ophthalmologic inspection system for inspecting an eye to be inspected by using measurement light is proposed.

The ophthalmologic detection system provided by the embodiment of the invention comprises a sample arm, a side eye photographing imaging module and a main body module, wherein the sample arm is used for focusing measuring light on an anterior segment of an eye to be detected and a posterior segment of the eye to be detected respectively, receiving an anterior segment optical signal returned from the anterior segment of the eye and a posterior segment optical signal returned from the posterior segment of the eye respectively, and transmitting the anterior segment optical signal and the posterior segment optical signal to the main body module; the side-eye photographing imaging module is used for monitoring the position of the eye to be detected in the detection process to obtain a plurality of position information of the eye to be detected; the main body module is used for providing measuring light for the sample arm, interfering with an anterior ocular segment light signal transmitted from the sample arm by utilizing reference light and collecting an anterior ocular segment interference light signal obtained through interference, interfering with a posterior ocular segment light signal by utilizing the reference light and collecting an posterior ocular segment interference light signal obtained through interference, and obtaining the axial length of the eye to be inspected by utilizing the anterior ocular segment interference light signal, the posterior ocular segment interference light signal and a plurality of position information of the eye to be inspected.

Further, the side-eye photographing imaging module comprises a camera, wherein the camera is arranged on the side face of the eye to be inspected under the detection working condition, and the camera photographs the side face of the eye to be inspected.

Further, the camera is a telecentric imaging camera.

Further, the telecentric imaging camera is an object-side telecentric imaging camera or a double telecentric imaging camera.

Further, the body module includes a light source, a coupler and a reference arm assembly, the coupler receives light from the light source and provides light to the reference arm assembly, the reference arm assembly reflects the received light back to the coupler as reference light, and the coupler provides measurement light to the sample arm.

Further, the main body module further comprises a detector and a controller, the detector and the side-eye photographing imaging module are electrically connected with the controller, the anterior ocular segment optical signal and the posterior ocular segment optical signal are respectively interfered with the reference light in the coupler to form an anterior ocular segment interference optical signal and a posterior ocular segment interference optical signal, the anterior ocular segment interference optical signal and the posterior ocular segment interference optical signal are collected by the controller after being received and processed by the detector, and the position information is also collected by the controller.

The embodiment of the invention also provides an ophthalmologic detection method for detecting an eye to be detected by using measuring light, which comprises the following steps: when the condition is switched to the anterior segment OCT detection working condition, the measuring light is focused to the anterior segment of the detected eye, the anterior segment optical signal returned from the anterior segment of the eye is received, and the first position information of the detected eye is collected; when the working condition of the OCT detection of the posterior segment of the eye is switched to, focusing the measuring light to the posterior segment of the eye to be detected, receiving an optical signal of the posterior segment of the eye returned from the posterior segment of the eye, and collecting second position information of the eye to be detected; respectively interfering the anterior ocular segment optical signal and the posterior ocular segment optical signal, collecting the interference optical signal of the anterior ocular segment and the interference optical signal of the posterior ocular segment, and obtaining the preliminary ocular axial length of the eye to be inspected by using the interference optical signal of the anterior ocular segment and the interference optical signal of the posterior ocular segment; and obtaining the real eye axial length of the eye to be detected by using the first position information, the second position information and the preliminary eye axial length.

Further, acquiring first position information of the eye to be inspected comprises shooting an image of the eye to be inspected switched to an anterior segment OCT (optical coherence tomography) detection working condition to obtain a first image; and acquiring second position information of the eye to be inspected, wherein the step of shooting the image of the eye to be inspected switched to the eye posterior segment OCT detection working condition to obtain a second image.

Further, the step of shooting the image of the eye to be detected switched to the anterior segment OCT detection working condition comprises shooting a side image of the eye to be detected switched to the anterior segment OCT detection working condition, and the step of shooting the image of the eye to be detected switched to the posterior segment OCT detection working condition comprises shooting the side image of the eye to be detected switched to the posterior segment OCT detection working condition.

Further, obtaining the actual eye axial length of the eye to be inspected by using the first position information, the second position information and the preliminary eye axial length comprises: obtaining the position of the corneal vertex of the eye to be detected under the working condition of anterior segment OCT detection from the first image, and recording the position as a first position; obtaining the position of the corneal vertex of the eye to be detected under the working condition of posterior segment OCT detection from the second image, and recording the position as a second position; calculating a spatial distance between the first location and the second location; and calculating the real eye axial length of the eye to be detected by using the space distance between the first position and the second position and the preliminary eye axial length.

The invention has the beneficial effects that:

the position of the detected eye is recorded when the detection working condition of the anterior segment OCT is switched to and when the detection working condition of the posterior segment OCT is switched to, so that the displacement of the detected eye in the detection period is judged, the preliminary eye axial length calculated according to the anterior segment optical signal and the posterior segment optical signal can be corrected, and the accuracy of calculating the eye axial length of the detected eye is improved.

Drawings

FIG. 1 is a block diagram of an ophthalmic inspection system according to an embodiment of the present invention.

Fig. 2 is a schematic diagram of the ophthalmic testing system of fig. 1.

Fig. 3 is a schematic configuration diagram of the ophthalmic measurement system of fig. 2 under an anterior segment OCT detection condition.

FIG. 4 is a schematic configuration diagram of the ophthalmic measurement system of FIG. 2 under a condition of posterior segment OCT testing.

Fig. 5 is a schematic diagram of the operation principle of the side-eye photographing imaging module in fig. 2.

Fig. 6 is a schematic view of the installation position of the side-eye photographing imaging module in fig. 2.

Fig. 7 is a schematic diagram of the distribution of the illumination lamps in the illumination light source of fig. 2.

FIG. 8 is a flow chart illustrating the steps of an ophthalmic testing method according to an embodiment of the present invention.

Fig. 9 is a schematic view of the principle of measuring the axial length of the eye in the ophthalmic examination method according to the embodiment of the present invention.

Fig. 10 is an image of an eye to be examined in the embodiment of the present invention.

Detailed Description

The present invention is described in further detail below with reference to specific embodiments and with reference to the attached drawings, it should be emphasized that the following description is only exemplary and is not intended to limit the scope and application of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without any inventive step, are within the scope of the present invention.

Referring to fig. 1, an embodiment of the present invention provides an ophthalmic examination system (hereinafter referred to as "system") for detecting an eye E to be examined by using a measurement light, for example, parameters such as an axial length of the eye and a length of a lens of the eye E to be examined are measured. The ophthalmic test system includes a body module 100, a sample arm 300, and a lateral-eye photographing imaging module 500.

The optical path is illustrated by a dashed-dotted line, the body module 100 generates reference light and provides measurement light to the sample arm 300, the sample arm 300 receives the measurement light and focuses the measurement light on the anterior segment and the posterior segment of the eye E, respectively, the measurement light is reflected at the anterior segment and the posterior segment to generate optical signals, the optical signals are reflected back to the sample arm 300, and the sample arm 300 receives the optical signals and transmits the optical signals to the body module 100. The measuring light is reflected at the anterior segment of the eye to generate an anterior segment light signal, and the measuring light is reflected at the posterior segment of the eye to generate a posterior segment light signal.

In the detection process, the side-eye photographing imaging module 500 monitors the position of the eye to be inspected E to obtain a plurality of position information of the eye to be inspected E and transmits the plurality of position information to the main body module 100.

The main body module 100 receives the anterior ocular segment optical signal, the posterior ocular segment optical signal, and the plurality of position information, generates an anterior ocular segment interference optical signal by using the reference light to interfere with the anterior ocular segment optical signal, generates a posterior ocular segment interference optical signal by using the reference light to interfere with the posterior ocular segment optical signal, and obtains an ocular axial length of the eye to be inspected E by using the anterior ocular segment interference optical signal, the posterior ocular segment interference optical signal, and the plurality of position information.

Referring to fig. 2, in the embodiment of the present invention, the main body module 100 includes a light source 101, a coupler 103, a reference arm assembly 130, a detector 105, a polarization controller 107, a fiber optic probe 108, a focusing lens 109, and a controller 111. The reference arm assembly 130 further includes a reference arm lens 131 and a reference arm mirror 133. The light source 101 may be an OCT light source, which emits weak coherent light with a wavelength of near infrared and transmits the light to the coupler 103, and the coupler 103 splits the received light into two beams, wherein one beam is focused by the reference arm lens 131 and reflected by the reference arm mirror 133 and then returns to the coupler 103 as reference light. The other beam is adjusted in polarization direction by the polarization controller 107, focused by the focusing lens 109, and transmitted to the sample arm 300 as measurement light.

Wherein the fiber probe 108 and the focusing lens 109 are integrally translatable in a direction parallel to a main optical axis of the focusing lens 109 to adjust an optical path length of the measurement light. Specifically, in the embodiment of the present invention, the system further includes an electronic control component (such as a stepping motor), the electronic control component has an electronic control displacement support, the electronic control component is electrically connected to the controller 111, the optical fiber probe 108 and the focusing lens 109 are fixed on the electronic control displacement support, and the controller 111 controls the electronic control component to drive the electronic control displacement support to move, so as to control the integral translation of the optical fiber probe 108 and the focusing lens 109.

In an embodiment of the present invention, the sample arm 300 comprises a scanning assembly 330, a sample arm optical path assembly 350, and an objective lens 370.

The scanning assembly 330 includes a horizontal scanning unit 331 and a vertical scanning unit 333, and the measuring light enters the horizontal scanning unit 331 after being focused by the focusing lens 109, enters the vertical scanning unit 333 after being reflected by the horizontal scanning unit 331, and then enters the sample arm optical path assembly 350 after being reflected by the vertical scanning unit 333. The horizontal scanning unit 331 can rotate so that the measurement light scans the anterior segment or the posterior segment of the eye E in the horizontal direction, and the vertical scanning unit 333 can rotate so that the measurement light scans the anterior segment or the posterior segment of the eye E in the vertical direction.

Specifically, in the embodiment of the present invention, the system further includes an electronic control component (e.g., a motor), the electronic control component has an electrically controlled rotating bracket (e.g., a rotating shaft), the electronic control component is electrically connected to the controller 111, the horizontal scanning unit 331 and the vertical scanning unit 333 are fixed on the electrically controlled rotating bracket, and the controller 111 controls the electronic control component to drive the electrically controlled rotating bracket to rotate, so as to control the rotation angles of the horizontal scanning unit 331 and the vertical scanning unit 333.

It is understood that in other embodiments of the present invention, the system may also control the rotation angles of the horizontal scanning unit 331 and the vertical scanning unit 333 through manual adjustment, and specifically, the system includes a rotating bracket for fixing the horizontal scanning unit 331 and the vertical scanning unit 333, the rotating bracket provides a knob, and the rotation angles of the horizontal scanning unit 331 and the vertical scanning unit 333 are adjusted through manual rotation of the knob.

It is understood that in other embodiments of the present invention, the horizontal scanning unit 331 and the vertical scanning unit 333 may also be controlled to rotate angularly by other mechanical devices or electrical methods, and the design scheme satisfying this requirement is within the scope of the present invention, and will not be described herein again.

In the embodiment of the present invention, the measuring light passes through the scanning component 330 and the sample arm light path component 350 to reach the objective lens 370, and is focused to the anterior segment of the eye E, such as the cornea Ec of the eye E, or is focused to the posterior segment of the eye E, such as the retina Er of the eye E, through the objective lens 370.

The sample arm optical path assembly 350 includes a beam splitter (first beam splitter) 351, a refractive adjustment element 353, and an insertion mirror 355. Specifically, the first dichroic mirror 351 is a dichroic mirror, and transmits light emitted from the light source 101 and reflects light emitted from the fixation light source 701.

Referring to fig. 3, in the condition of anterior segment OCT detection, the insertion mirror 355 is inserted into the optical path, and the measuring light passes through the first beam splitter 351, the diopter adjusting element 353 and the insertion mirror 355 and then is transmitted to the objective lens 370, and finally is focused on the anterior segment of the eye E.

In the embodiment of the present invention, the measurement light is focused on the anterior segment of the eye E, the anterior segment scatters the measurement light and generates an anterior segment light signal, the anterior segment light signal passes through the eye objective 370 and then propagates back to the main body module 100 through the sample arm optical path assembly 350 and the scanning assembly 330 in sequence along the direction opposite to the measurement light, and interferes with the reference light in the coupler 103 to generate an anterior segment interference light signal, and the detector 105 receives the anterior segment interference light signal and processes the anterior segment interference light signal and transmits the processed anterior segment interference light signal to the controller 111. Since the polarization direction of the anterior ocular segment optical signal is controlled by the polarization controller 107 before returning to the coupler 103, the effect of interference is ensured.

Referring to fig. 4, under the condition of detecting the posterior segment OCT, the insertion mirror 353 is withdrawn from the optical path, and the measuring light is transmitted through the first beam splitter 351 and the diopter adjusting element 353 and then transmitted to the objective lens 370, and finally focused on the posterior segment of the eye E to be detected. The light emitted from the fixation light source 701 is reflected by the first beam splitter 351, transmitted by the diopter adjustment element 353, and transmitted to the objective lens 370, and finally focused on the posterior segment of the eye E.

Under the condition of detecting the posterior segment OCT, the position of the measuring light and the light emitted by the vision fixation light source 701 focused in the eye E to be detected can be adjusted by the refractive adjusting element 353, for example, the measuring light can be focused on the retina of the eye E to be detected by moving the refractive adjusting element 353, so as to realize the measurement of the eye E to be detected with myopia or hypermetropia. In particular, the refractive adjustment member 353 is fixed to a translation device (not shown) and is movable by manual or electrical control to achieve refractive adjustment.

In the embodiment of the present invention, after the measurement light is focused on the posterior segment of the eye E to be inspected, the posterior segment scatters the measurement light and generates a posterior segment light signal, the posterior segment light signal passes through the objective lens 370 and then propagates back to the main body module 100 through the sample arm light path assembly 350 and the scanning assembly 330 in sequence along the direction opposite to the measurement light, and interferes with the reference light in the coupler 103 to generate a posterior segment interference light signal, and the detector 105 receives the posterior segment interference light signal, processes the posterior segment interference light signal and transmits the processed posterior segment interference light signal to the controller 111. Since the polarization direction of the posterior segment optical signal is controlled by the polarization controller 107 before returning to the coupler 103, the interference effect is ensured.

Referring to fig. 5, in an embodiment of the present invention, the side-eye photographing and imaging module 500 includes at least one camera, and under a detection condition, the at least one camera is disposed on one side of the head H of the subject, the at least one camera is used for photographing a picture of the subject's eye E, the picture of the subject's eye E includes feature points of the subject's eye E, the feature points include a corneal vertex E_cOuter frame edge E_kAnd the like, which are easily recognized in shape or color. For example, when detecting the left eye of the subject, the at least one camera is disposed on the left side of the head H of the subject, and the camera takes a picture of the left eye; when the right eye of the examinee is detected, the at least one camera is arranged on the right side of the head H of the examinee, and the camera takes a picture of the right eye.

Preferably, the side-eye photographing imaging module 500 includes two cameras, and under the detection condition, the two cameras are respectively disposed on the left side and the right side of the head H of the subject. When detecting the left eye of the examinee, a camera arranged on the left side of the head H of the examinee takes a picture of the left eye of the examinee; when the right eye of the subject is detected, a camera provided on the right side of the head H of the subject takes a picture of the right eye of the subject.

Preferably, the two cameras are telecentric imaging cameras. In this embodiment, the telecentric imaging camera is a double telecentric imaging camera, and in other embodiments of the present invention, the telecentric imaging camera may also be an object-side telecentric imaging camera.

Referring to fig. 6, in the embodiment of the present invention, the system is disposed on a platform (not shown), the system further includes a chin bar 801, a forehead bar 803 and two forehead bar supports 805, the chin bar 801 and the forehead bar supports 805 are all fixedly disposed on the platform, and the two forehead bar supports 805 and the forehead bar 803 are connected end to form an inverted U-shaped structure. Under the detection condition, the chin of the tested person leans on the chin rest 801, and the forehead leans against the forehead rest 803. The two cameras are respectively arranged on the two forehead support posts 805. In other embodiments of the present invention, the two cameras may be disposed on a mechanical structure of the system, the two cameras may move with a probe of the system, and the two cameras are fixedly disposed relative to the probe.

Referring to fig. 1 and fig. 2 again, in the embodiment of the present invention, the system further includes a fixation optical module 700, and the fixation optical module 700 includes a fixation light source 701 and a fixation lens 703. The light emitted by the fixation light source 701 is visible light, the fixation light source 701 is specifically a display screen for displaying a fixation target for the eye E to be inspected to fix the vision, and the display screen can be an LCD screen, an OLED screen, an LED array screen, or the like.

The light emitted from the fixation light source 701 is transmitted through the fixation lens 703 and reflected by the first beam splitter 351, and then is adjusted and bent by the refraction adjusting element 373, and then is focused on the posterior segment of the eye E, such as the retina E of the eye E, via the objective lens 370_r。

Specifically, in the embodiment of the present invention, the fixation position of the eye to be inspected E may be changed by using a fixation mark, and the fixation mark may move up and down, left and right, so as to detect different positions of the eye to be inspected. The light emitted by the vision fixation light source 701 can adjust diopter through the diopter adjustment element 353, if the light emitted by the vision fixation light source 701 cannot be adjusted to be bent, the visual fixation mark has different definition when the eye to be inspected E with different vision is observed, which makes the eye to be inspected feel uncomfortable when the eye to be inspected is fixed, therefore, preferably, the light path emitted by the vision fixation light source 701 can be focused on the posterior segment retina of the eye after being adjusted to be bent through the diopter adjustment element 353, so that the eye to be inspected can see the clear visual fixation mark.

It should be noted that the system provided by the embodiment of the present invention further includes an iris imaging module 900, which is configured to capture an image required for determining parameters such as a corneal central curvature, a pupil diameter, a white-to-white distance, and the like of the eye E, for example, an iris image of the eye E. The iris imaging module 900 is electrically connected to the controller 111, and includes: an illumination light source 901, a spectroscope 902, a vision expanding lens group, a fifth reflector 905, an image pickup lens group and an image pickup device 913. Specifically, the illumination light source 901 is disposed between the objective lens 370 and the eye E, and the illumination light source 901 emits near infrared light. The dichroic mirror 902 is a dichroic mirror, and transmits light output from the illumination light source 901 and reflects light output from the light source 101 and light output from the fixation light source 701.

The light emitted from the illumination light source 901 is irradiated to the anterior segment of the eye E to be inspected, and reflected by the anterior segment to form reflected light, wherein a part of the reflected light is reflected by the cornea of the eye E to be inspected, and a part of the reflected light passes through the cornea to enter the eye E to be inspected, and is diffusely reflected by tissues such as the anterior chamber of the eye E to be inspected.

In the embodiment of the invention, the vision expanding lens group is used for converging the reflected light and comprises a first vision expanding lens 903 and a second vision expanding lens 907; the image pickup lens group is used for imaging the reflected light on the image pickup device and includes a first image pickup lens 909 and a second image pickup lens 911.

The reflected light is transmitted to the fifth reflector 905 through the objective lens 370, the beam splitter 902 and the first expander lens 903, is reflected by the fifth reflector 905, passes through the second expander lens 907, the first camera lens 909 and the second camera lens 911, is focused by the first camera lens 909 and the second camera lens 911 to the camera 913 to form an image of the anterior segment of the eye to be inspected, and the controller 111 collects the image of the anterior segment of the eye to be inspected.

In order to make the subject feel comfortable and to avoid a feeling of pressure due to the close contact with the system, the objective lens 370 is disposed to extend forward from the system, and therefore, the distance between the objective lens 370 and the image pickup device 913 is large. In order to determine parameters such as white-to-white distance, the iris imaging module 900 needs to have a larger imaging range, which is contradictory to the extension of the objective lens 370. The first and second expander lenses 903 and 907 change the propagation directions of light reflected by the cornea and light diffusely reflected by the anterior chamber to converge, and finally form an image of a larger range on the image pickup device 913.

Referring to fig. 7, in the embodiment of the present invention, the illumination light source 901 includes a plurality of illumination lamps 901a, the illumination lamps 901a are uniformly distributed in an annular array, and when the system is in a corneal curvature detection condition, a geometric center of an annular shape formed by the illumination lamps 901a is aligned with a pupil center of the eye E to be detected. Specifically, the illuminating lamps 901a are LED lamps, the number of which is greater than or equal to 4, preferably, in an embodiment of the present invention, the number of the illuminating lamps 901a is 6.

When the system is in the corneal curvature detection condition, light emitted by the 6 illumination lamps 901a is irradiated onto the cornea of the eye E to be detected, reflected by the cornea, and finally detected by the camera 913 through the iris imaging module 900, and a distribution image of the 6 illumination lamps 901a on the cornea is formed on the camera 913. In an embodiment of the present invention, the distribution image is formed together with an image of the anterior segment of the eye to be examined.

The controller 111 collects the images distributed on the cornea by the 6 illuminating lamps 901a, and processes the images by using an algorithm installed in the images to obtain the corneal curvature of the eye to be inspected E, and in the embodiment of the present invention, the controller 111 obtains the corneal central curvature of the eye to be inspected E.

The iris imaging module 900 of the embodiment of the present invention further has a function of monitoring the light path to guide the operator to operate the instrument and to know the related information of the examinee, the system is movably disposed on an operation table (not shown) on which a chin rest 801 is disposed, the examinee fixes the head H of the examinee using the chin rest system, after the fixation mark from the fixation optical module 700 is fixed in the eye E, the examiner controls the movement of the jaw support system and the ophthalmologic measurement system by the operation lever while observing the display screen of the controller 111, so that the anterior segment of the eye E, such as the iris, enters the camera 913 of the iris imaging module 900, and an iris image is presented in the display screen of the controller 111 to guide a doctor in operating an instrument and in understanding information about the eye E to be inspected.

According to the embodiment of the invention, the lateral eye photographing imaging module 500 is arranged to record the positions of the eye E to be detected switched to the anterior segment OCT detection working condition and the posterior segment OCT detection working condition, so that the displacement of the eye E to be detected in the detection period is judged, the preliminary axial length calculated according to the anterior segment optical signal and the posterior segment optical signal can be corrected, and the accuracy of the ophthalmic detection system for calculating the axial length of the eye E to be detected is improved.

The device can also be used for measuring the thickness of the vitreous body, and has the same principle as the principle of measuring the axial length of human eyes. The thickness of the vitreous body can be measured by calculating by a method similar to the method for measuring the axial length of the human eye.

Embodiments of the present invention also provide an ophthalmologic inspection method (hereinafter, referred to simply as "method") for inspecting an eye E to be inspected by using measurement light, for example, parameters such as an axial length of the eye, a length of a lens, and the like of the eye E to be inspected. Referring to fig. 8, the method includes:

and S1, imaging the anterior segment of the eye by OCT. And switching to an anterior segment OCT (optical coherence tomography) detection working condition, focusing the measuring light to the anterior segment of the eye E to be detected, receiving an anterior segment optical signal returned from the anterior segment, and collecting first position information of the eye E to be detected. The plurality of location information includes the first location information.

Specifically, the controller 111 controls the optical fiber probe 108 and the focusing lens 109 to be integrally translated in a direction parallel to a main optical axis of the focusing lens 109 to adjust an optical path length of the measurement light, and after the adjustment, an optical path length which the measurement light passes through after being emitted from the coupler 103 and reaching an anterior segment of the eye E to be inspected and an optical path length which the reference light passes through after being emitted from the coupler 103 and reaching the reference arm mirror 133 are matched with each other.

At the same time, the insertion mirror 355 is controlled to be inserted into the optical path, so that the measurement light is focused on the anterior segment of the eye E.

Meanwhile, the side-eye photographing imaging module 500 photographs the image of the eye to be inspected from the side of the eye to be inspected E to obtain a first image Pc₁To record in the anterior ocular segment OCT detects the position information of the eye E under the working condition, namely the first position information.

And S2, imaging the posterior segment of the eye by OCT. And switching to a working condition of posterior segment OCT detection, focusing the measuring light to the posterior segment of the eye E to be detected, receiving a posterior segment optical signal returned from the posterior segment of the eye, and collecting second position information of the eye E to be detected. The plurality of location information includes the second location information.

Specifically, the controller 111 controls the optical fiber probe 108 and the focusing lens 109 to integrally translate in a direction parallel to a main optical axis of the focusing lens 109 to adjust an optical path of the measurement light, and after the adjustment, an optical path taken by the measurement light after being emitted from the coupler 103 and reaching a posterior segment of the eye E to be inspected and an optical path taken by the reference light after being emitted from the coupler 103 and reaching the reference arm mirror 133 match each other.

At the same time, the insertion mirror 355 is controlled to be drawn out of the optical path, so that the measurement light is focused on the posterior segment of the eye E to be inspected.

Meanwhile, the side-eye photographing imaging module 500 photographs the image of the eye to be inspected from the side of the eye to be inspected E to obtain a second image Pc₂And recording the position information of the detected eye E under the working condition of carrying out posterior segment OCT detection, namely the second position information.

And S3, calculating the preliminary eye axis length. And calculating the preliminary eye axial length of the eye E to be detected according to the anterior ocular segment optical signal and the posterior ocular segment optical signal.

Referring to FIG. 9, 3 rectangular frames K in FIG. 9₁、K₂、K₃The OCT measurement ranges of different parts are represented, the rectangular frame is only schematic, and the actual scanning area can be in a fan-shaped structure and the like.

Under the condition of detecting the anterior segment OCT, the optical path length which the measuring light passes through after emitting from the coupler 103 and reaching the anterior segment of the eye E to be detected is recorded as the anterior segment sample arm optical path LSampleCornea. Specifically, the anterior segment sample arm optical path LSampleCornea is characterized in that the measuring light starts from the coupler 103, is transmitted through the fiber collimator 109, reflected by the scanning assembly 330, transmitted through the first beam splitter 351, the diopter adjusting element 353, the insert lens 355 and the ocular objective 370, and finally irradiates the anterior segment of the eye E (the anterior segment of the eye E to be inspected) (the anterior segment of the eye E is irradiated by the measuring lightIn the examples, the cornea E is used_cFor example) of the optical path.

The anterior segment arm path length, LSampleCornea, consists of two parts, the anterior segment arm intrinsic path length, LCorneaGuYou, and the corneal path length, hCornea, LSampleCornea ═ LCorneaGuYou + hCornea. The anterior segment sample arm intrinsic optical length lcorneagyouou represents the optical length of the measurement light from the coupler 103 to the cornea measurement position CDK of the eye E to be examined. The corneal optical length hCornea represents an optical length of the measurement light from the corneal measurement position CDK of the eye E to the corneal vertex of the eye E. The cornea measuring position CDK and the corneal vertex are located on the optical path of the measuring light together, the optical path length from the coupler 103 to the cornea measuring position CDK of the measuring light is equal to the optical path length from the coupler 103 to the reference arm reflecting mirror 133 of the reference light, and the distance between the cornea measuring position CDK and the corneal vertex is smaller than the detection range of the measuring light in the OCT technology.

Under the condition of detecting the posterior segment OCT, the optical path of the posterior segment of the eye, which is transmitted by the coupler 103 and reaches the eye E to be detected, is recorded as the arm optical path LSampleRetinal of the posterior segment sample. Wherein, the posterior segment sample arm optical path LSampleRetinal characterization measurement light starts from the coupler 103, is transmitted through the fiber collimator 109, reflected by the scanning component 330, transmitted through the first beam splitter 351, the refraction adjusting element 353 and the objective lens 370, and finally irradiates the posterior segment of the eye E (in this embodiment, the retina E is used for the embodiment)_rFor example) of the optical path.

The optical path LSampleRetinal of the posterior segment sample arm consists of two parts, namely a real-time optical path LRethinal of the posterior segment sample arm and an optical path hRetinal of retina, wherein LSampleRetinal is LRethinal + hRetinal. The real-time optical path LRetinal of the posterior segment sample arm represents the optical path of the measuring light from the coupler 103 to the retina measuring position RDK2 of the eye to be inspected E. The retinal optical path hRetinal characterizes the measurement light from the retinal measurement position RDK2 of the eye E to the retina E_rDistance of the center of the inner surface. Wherein, the retina measuring position RDK2 and the retina E_rThe centers of the inner surfaces are located on the optical path of the measuring light, the optical path taken by the measuring light from the coupler 103 to the retina measuring position RDK2 and the optical path taken by the reference light from the coupler 103 to the reference arm mirror 133Equal optical path length, retina measurement position RDK2 and retina E_rThe distance between the centers of the inner surfaces is smaller than the detection range of the measuring light in the OCT technique.

It should be noted that, for the OCT system, as known from the principle of aplanatism, the optical path length of the measurement light from the coupler 103 to the cornea measurement position CDK of the eye to be inspected E under the anterior segment OCT detection condition is equal to the optical path length of the measurement light from the coupler 103 to the retina measurement position RDK2 of the eye to be inspected E under the posterior segment OCT detection condition, that is, lcorneagyouyou ═ LRetinal.

To illustrate the method provided by this embodiment, an intermediate measurement position RDK1 is introduced, and the optical path length of the measurement light from coupler 103 to intermediate measurement position RDK1 is equal to the optical path length of the reference light from coupler 103 to reference arm mirror 133 before insertion mirror 355 is withdrawn from the optical path and the fiber probe 108 and the focusing lens 109 are translated integrally in a direction parallel to the primary optical axis of the focusing lens 109 during the switching of the system from the anterior segment OCT detection mode to the posterior segment OCT detection mode. It can be seen that the posterior segment sample arm real-time optical path lrfinal is equal to the optical path of the measurement light from coupler 103 to the intermediate measurement position RDK 1.

It should be noted that, since the refractive index of the insertion mirror 355 is different from that of air, the intermediate measurement position RDK1 does not coincide with the cornea measurement position CDK, and the distance between the intermediate measurement position RDK1 and the cornea measurement position CDK is the change △ L.

Wherein △ L ═ (n)₁-1)d，n₁D is the thickness of the center of the lens of the insert mirror 355 for the refractive index of the insert mirror 355.

After the insertion mirror 355 is pulled out of the optical path, the optical fiber probe 108 and the focusing lens 109 are integrally translated in a direction parallel to the main optical axis of the focusing lens 109 by a distance X, and after translation, the optical path length of the measurement light from the coupler 103 to the retina measurement position RDK2 is equal to the optical path length of the reference light from the coupler 103 to the reference arm reflecting mirror 133, so that the system is switched from the anterior segment OCT detection condition to the posterior segment OCT detection condition. Wherein the measurement light experiences an optical path length X from the intermediate measurement position RDK1 to the retina measurement position RDK2,the space distance between the middle measuring position RDK1 and the retina measuring position RDK2 is X/n_ha,n_haThe average refractive index of the human eye is a constant.

And finally, solving a primary eye axial length optical path value Leye of the eye E to be detected, wherein the primary eye axial length optical path value Leye meets the following requirements:

Leye＝△L+X-hCornea+hRetinal

where hRetinal and hCornea can be measured from the corresponding OCT images, △ L and X are also known quantities.

And S4, correcting the preliminary eye axis length according to the eye movement amount, and calculating the real eye axis length.

Referring to fig. 10, from the first image, we can obtain: under the working condition of anterior segment OCT detection, the corneal vertex of the eye E to be detected is at Ec₁Position (first position). In the switching process of the anterior segment OCT detection working condition and the posterior segment OCT detection working condition, the eye E to be detected moves, and the eye E to be detected can be obtained from the second image: under the working condition of detecting the posterior segment OCT, the corneal vertex of the eye E to be detected is at Ec₂Position (second position). The eye movement amount Wd of the eye E is the first position Ec₁To a second position Ec₂And Wd satisfies:

Wd＝Wx/Wz*D，

wherein Wx is the number of pixels corresponding to Wd in the width direction of the photosensitive camera of the side-eye photographing imaging module 500, Wz is the total number of pixels in the width direction of the photosensitive camera of the side-eye photographing imaging module 500, and D is the spatial width that can be photographed by the side-eye photographing imaging module 500, and this value can be obtained by factory calibration of an instrument, and is also a known quantity.

The real eye axial length optical path value LeyeJ of the eye E to be detected can be obtained:

LeyeJ＝△L+X-hCornea+hRetinal+Wd

here, Wd is a positive value if the eye E moves closer to the objective lens 370 during the detection, and is a negative value if the eye E moves away from the objective lens 370 during the detection.

Further, the true eye axial length AXL of the eye E to be examined can be obtained:

AXL＝LeyeJ/n_ha。

according to the embodiment of the invention, the position of the eye E to be detected switched to the anterior segment OCT detection working condition and the position of the eye E to be detected switched to the posterior segment OCT detection working condition are recorded, so that the displacement of the eye E to be detected in the detection period is judged, the preliminary eye axial length calculated according to the anterior segment optical signal and the posterior segment optical signal can be corrected, and the accuracy of calculating the eye axial length of the eye E to be detected is improved.

While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.