阅读说明：本技术 一种水飞蓟素护肤品的制备方法 (Method for preparing silymarin skin care product ) 是由 武俊明 于 2019-12-16 设计创作，主要内容包括：本发明公开了一种水飞蓟素护肤品的制备方法,用水飞蓟素与葡甲胺溶解在无水乙醇中,加热后对无水乙醇进行回收,得到水飞蓟素葡甲胺原料；再与去离子水混合均匀置于搅拌器中进行搅拌,最后加入明胶和甘油后进行搅拌,再加入苯甲酸钠,超声处理得所需水飞蓟素护肤品。本发明解决了传统的直接采用水飞蓟素制备相关护肤品带来的护肤品长期使用导致面部皮肤油脂过多,毛孔睹塞的不足之处；并通过超声波混匀技术使得水飞蓟素葡甲胺和苯甲酸钠均匀的分布在其它基质中的同时,水飞蓟素葡甲胺而不会被分解破坏。(The invention discloses a method for preparing a silymarin skin care product, which comprises the steps of dissolving silymarin and meglumine in absolute ethyl alcohol, heating, and then recovering the absolute ethyl alcohol to obtain a silymarin meglumine raw material; mixing with deionized water, stirring in a stirrer, adding gelatin and glycerol, stirring, adding sodium benzoate, and ultrasonic processing to obtain the desired silymarin skin care product. The invention overcomes the defects that the skin care product is too much in facial skin grease and pores are blocked due to long-term use of the traditional skin care product which is brought by directly adopting silymarin to prepare the related skin care product; and the silymarin meglumine and sodium benzoate are uniformly distributed in other matrixes by an ultrasonic uniformly mixing technology, and the silymarin meglumine cannot be decomposed and damaged.)

1. A preparation method of a silymarin skin care product is characterized by comprising the following steps:

(1) firstly, weighing 1 part of silymarin and 0.2-0.5 part of meglumine by weight, dissolving in absolute ethyl alcohol which is 3-5 times of the total weight of the silymarin and the meglumine, heating to slightly boil, and keeping for 40-50 min to obtain a solution A;

(2) recovering absolute ethyl alcohol in the solution A to obtain a silymarin meglumine raw material;

(3) weighing the silymarin meglumine raw material and deionized water according to the weight ratio of 1 (5-12), uniformly mixing, and placing in a stirrer for stirring for 5-10 min to obtain a solution B;

(4) adding gelatin and glycerol into the solution B, wherein the weight of the gelatin is 2-3 times that of silymarin meglumine, and the gelatin is 5-7 times that of the silymarin meglumine, and stirring for 10-15 min;

(5) and adding sodium benzoate with the weight of 0.01-0.003 times of that of the silymarin meglumine into the stirred solution, and putting the solution into an ultrasonic mixer for ultrasonic treatment for 20-40 min to obtain the silymarin skin care product.

2. The method for preparing a silymarin skin care product according to claim 1, wherein the silymarin skin care product comprises the following steps: the method for recovering the absolute ethyl alcohol in the step (2) is as follows:

A) adding the solution A into a rotary water bath film evaporator, heating at 70-100 ℃ and rotating at the rotating speed of 60-100 r/min; after the solution starts to reflux, opening vacuum with the vacuum degree of more than-0.06 MPa, recovering ethanol, and heating and selecting simultaneously;

B. closing vacuum, heating at 100 deg.C, rotating at a rotating speed until the silymarin meglumine solution becomes pasty, and vacuum filtering to remove all ethanol in the silymarin meglumine solution;

C. taking completely dried crisp silymarin meglumine, and crushing to 60-80 meshes of water to obtain a silymarin meglumine fine powder raw material for later use.

3. The method for preparing a silymarin skin care product according to claim 1, wherein the silymarin skin care product comprises the following steps: in the step (3), the stirring speed is 50-70 r/min.

4. The method for preparing a silymarin skin care product according to claim 1, wherein the silymarin skin care product comprises the following steps: in the step (4), the stirring speed is 150-200 r/min.

5. The method for preparing a silymarin skin care product according to claim 1, wherein the silymarin skin care product comprises the following steps: and (5) carrying out ultrasonic treatment at the frequency of 35-45 Hz.

6. The method for preparing a silymarin skin care product according to claim 1, wherein the silymarin skin care product comprises the following steps: the ultrasonic treatment temperature in the step (5) is 25-35 ℃.

Technical Field

The invention relates to the field of skin care products, in particular to a preparation method of a silymarin skin care product.

Background

Research data show that silymarin has anti-aging and anti-radiation effects clinically, according to the above effect characteristics of silymarin, many research units at home and abroad actively develop the research of silymarin for cosmetic skin care products, at present, although the technical requirement that cosmetics are not layered in a container is solved through the technology of coating the silymarin with water and oil, the method of coating with water and oil only can solve the separation of macromolecular of silymarin due to the special property of fat-soluble substances, and cannot fundamentally change the characteristic that silymarin is not beneficial to skin absorption, and the current silymarin skin care products have the following problems: (1) silymarin is distributed unevenly and unstably in the cosmetic matrix; (2) has the problems of difficult absorption by skin and easy blockage of skin pores after long-term use.

Disclosure of Invention

The purpose of the invention is as follows: in order to overcome the defects in the prior art, the invention provides a preparation method of a silymarin skin care product, which not only fundamentally solves the problem that the silymarin is insoluble in skin and is absorbed, but also is easy to master and popularize in the whole production process.

The technical scheme is as follows: in order to solve the technical problems, the technical scheme adopted by the invention is as follows: a method for preparing silymarin skin care product comprises the following steps:

(1) firstly, weighing 1 part of silymarin and 0.2-0.5 part of meglumine by weight, dissolving in absolute ethyl alcohol which is 3-5 times of the total weight of the silymarin and the meglumine, heating to slightly boil, and keeping for 40-50 min to obtain a solution A;

(2) recovering absolute ethyl alcohol in the solution A to obtain a silymarin meglumine raw material;

(3) weighing the silymarin meglumine raw material and deionized water according to the weight ratio of 1 (5-12), uniformly mixing, and placing in a stirrer for stirring for 5-10 min to obtain a solution B;

(4) adding gelatin with the weight 2-3 times of that of silymarin meglumine and glycerol with the weight 5-7 times of that of the silymarin meglumine into the solution B, and stirring for 10-15 min;

(5) and adding sodium benzoate with the weight of 0.01-0.003 times of that of the silymarin meglumine into the stirred solution, and putting the solution into an ultrasonic mixer for ultrasonic treatment for 20-40 min to obtain the silymarin skin care product.

Further, the method for recovering the absolute ethyl alcohol in the step (2) is as follows:

A) adding the solution A into a rotary water bath film evaporator, heating at 70-100 ℃ and rotating at the rotating speed of 60-100 r/min; after the solution starts to reflux, opening vacuum with the vacuum degree of more than-0.06 MPa, recovering ethanol, and heating and selecting simultaneously;

B. closing vacuum, heating at 100 deg.C, rotating at a rotating speed until the silymarin meglumine solution becomes pasty, and vacuum filtering to remove all ethanol in the silymarin meglumine solution;

C. taking completely dried crisp silymarin meglumine, and crushing to 60-80 meshes of water to obtain a silymarin meglumine fine powder raw material for later use.

Furthermore, the stirring speed in the step (3) is 50-70 r/min.

Furthermore, the stirring speed in the step (4) is 150-200 r/min.

Furthermore, the ultrasonic treatment frequency in the step (5) is 35-45 Hz.

Furthermore, the ultrasonic treatment temperature in the step (5) is 25-35 ℃.

Has the advantages that: the invention has the following advantages: 1) the technical problem of the preparation and application of the skin care product caused by the water insolubility of the silymarin is solved, the silymarin is easily absorbed by the skin, and the phenomenon of blocking skin pores is avoided after long-term use; 2) in the prepared silymarin skin care product, silymarin is uniformly distributed in a skin care product matrix, and is stable and not layered; 3) by ultrasonic solubilization technology, the technical problem that silymarin meglumine is unstable in glyceryl is solved; meanwhile, the damage of the effective components of the silymarin caused by the action of ultrasonic waves is avoided.

Detailed Description

The present invention will be described in further detail with reference to the following examples: