阅读说明：本技术 一种液相色谱仪用微型高压静态混合器 (Miniature high-pressure static mixer for liquid chromatograph ) 是由 韩雪 李乃杰 杜福新 封娇 杨三东 唐涛 李彤 于 2019-12-11 设计创作，主要内容包括：本发明公开一种液相色谱仪用微型高压静态混合器,其包括：主体套筒(1)、底座(2)、支撑环(3)、单孔密封垫(4)、多孔密封垫(5)、混合腔(6)、端部密封垫(7),所述主体套筒(1)与所述底座(2)连接,内部串联安装有至少两组所述混合腔(6),所述混合腔(6)由所述支撑环(3)及其两端密封垫组成,密封垫包括：所述单孔密封垫(4)、所述多孔密封垫(5)、所述端部密封垫(7)；本发明通过所述密封垫单孔、多孔设计改变通过所述混合腔(6)流体的中心流速,使其形成复杂湍流,增加混合效率；其内部组件串联安装形式具有结构简单、组装方便,加工成本低,体积小、通用性好等特点。(The invention discloses a miniature high-pressure static mixer for a liquid chromatograph, which comprises: main part sleeve (1), base (2), support ring (3), the sealed pad of haplopore (4), the sealed pad of porous (5), hybrid chamber (6), the sealed pad of tip (7), main part sleeve (1) with base (2) are connected, and internal series installs at least two sets of hybrid chamber (6), hybrid chamber (6) by support ring (3) and the sealed pad of both ends are constituteed, and sealed the pad includes: the single-hole sealing gasket (4), the multi-hole sealing gasket (5) and the end sealing gasket (7); the central flow velocity of the fluid passing through the mixing cavity (6) is changed through the single-hole and multi-hole design of the sealing gasket, so that the fluid forms complex turbulence and the mixing efficiency is increased; the internal components of the device are installed in series, and the device has the characteristics of simple structure, convenience in assembly, low processing cost, small size, good universality and the like.)

1. A miniature high-pressure static mixer for a liquid chromatograph is characterized by comprising: the device comprises a main body sleeve (1), a base (2), a support ring (3), a single-hole sealing gasket (4), a multi-hole sealing gasket (5), a mixing cavity (6) and an end sealing gasket (7);

the main sleeve (1) is of a columnar structure, a liquid inlet port is formed in one side end of the main sleeve, and an external thread is formed in the other side end of the main sleeve; the interior of the main body sleeve (1) is of a blind hole structure, and an opening on the end face of the blind hole is communicated with the liquid inlet interface;

the base (2) is of a prismatic cap-shaped structure, one end of the base is provided with an internal thread, and the base is connected with the main sleeve (1) through the thread; the prismatic surface of the base (2) is provided with a liquid outlet port, and the center of the inner surface of the threaded side of the base (2) is provided with a hole and is communicated with the liquid outlet port through a pore channel;

one end of the support ring (3) is provided with the single-hole sealing gasket (4), the other end of the support ring is provided with the porous sealing gasket (5), and a cavity formed by the single-hole sealing gasket and the porous sealing gasket is the mixing cavity (6); at least two groups of mixing cavities (6) are axially and serially arranged in the blind hole of the main body sleeve (1);

only one single-hole sealing gasket (4) or one porous sealing gasket (5) is arranged between any two adjacent supporting rings (3);

the number of the end part sealing gaskets (7) is 2, and the end part sealing gaskets are respectively arranged at the two tail ends of the mixing cavities (6) which are connected in series; the other side of the support ring (3) provided with the end sealing gasket (7) is provided with the porous sealing gasket (5).

2. The miniature high-pressure static mixer for liquid chromatograph according to claim 1, wherein said mixing chambers (6) are 10 groups.

3. The micro high-pressure static mixer for liquid chromatograph according to claim 1, characterized in that the support ring (3) outer diameter is the same as the blind hole bore of the main body sleeve (1).

4. The micro high-pressure static mixer for liquid chromatograph according to claim 1, wherein the surface of the porous sealing gasket (5) is symmetrically distributed with 4 through holes.

5. The micro high-pressure static mixer for liquid chromatograph according to claim 1, characterized in that said end gasket (7) is provided with a through hole in the center.

6. The micro high-pressure static mixer for liquid chromatograph according to claim 1, characterized in that the through hole of the single-hole gasket (4) is provided at the surface center.

7. The miniature high-pressure static mixer for liquid chromatograph according to claim 1, wherein the hollow circular radius of the cross section of the mixing cavity (6) varies along the whole inflow-outflow direction of the fluid, the variation trend is from small to large, from large to small, or from small to large and then small, and the distribution position of the through holes of the porous sealing gasket (5) corresponding to the mixing cavity (6) is adjusted towards the center correspondingly.

8. The micro high-pressure static mixer for liquid chromatograph according to claim 2, characterized in that the main body sleeve (1) has a length ranging from 80mm to 95mm and an outer diameter ranging from 15mm to 25 mm.

9. The micro high-pressure static mixer for liquid chromatograph according to claim 1, wherein the material of the single-hole gasket (4), the multi-hole gasket (5), and the end gasket (7) is polyetheretherketone.

10. The micro high-pressure static mixer for liquid chromatograph of claim 1, wherein the main sleeve (1) is made of stainless steel.

Technical Field

The invention relates to a mixer, in particular to a miniature high-pressure static mixer for a liquid chromatograph.

Background

The static mixer for the liquid chromatograph mixes two or more different solvents with different elution capacities conveyed by the high-pressure constant-flow pump, increases the elution capacity of the liquid and is suitable for chromatographic separation of different mixtures. To ensure that the pressure of the entire liquid chromatography system is constant, the static mixer must be able to withstand the high pressures equivalent to that of the system. The mixer for the liquid chromatograph is required to realize the maximum mixing efficiency under the minimum mixing volume, and the whole liquid cavity has no dead angle and no residual liquid, and the liquid replacement is rapid.

At present, the common structures of the static mixer for the chromatograph mainly include the following two types:

1. coil structure static mixer: the liquid is mixed in the pipeline with specific length by the diffusion effect generated by the thermal motion of liquid molecules, so as to achieve the required mixing effect. Chinese patent CN100423823C discloses a micromixer device and a method for its preparation, the device in this invention comprising a substrate comprising one or more fluid inlet conduits and a mixing channel, said mixing channel having a depth and a width, said mixing channel being adapted to convey fluids to be mixed therein in a substantially helical flow pattern, said helical flow pattern being substantially parallel to the top surface of the substrate, said mixing channel being connected to a product conduit. However, such a mixer has a long pipeline and a large hysteresis volume, which affects the chromatographic separation effect.

2. Slice slotted stack static mixer: in order to increase the liquid interface area and realize mixing by utilizing the flow splitting and confluence of liquid, Chinese patent CN105107401B discloses a cross micro-mixer with symmetrical fan-shaped annular baffles, which comprises a cover plate and a base body, wherein a cross flow channel and a plurality of mixing units which are connected in sequence are arranged between the cover plate and the base body, and each mixing unit consists of a contraction flow channel, a narrow straight flow channel, an arc flow channel and a fan-shaped annular baffle which is positioned at the outlet of the arc flow channel and connected in sequence. However, the sheet is difficult to notch, the surface roughness of the notch and the requirements of the assembly and assembly process are high, and the cost is high.

In operation, the mixers can be combined in series and parallel, but the method increases the volume of the mixer while improving the mixing effect, and delays the gradient change.

In view of the foregoing, there is a need for a new static mixer that is low cost, easy to assemble, and capable of efficiently mixing multiphase flow liquids at low volumes and high pressures.

Disclosure of Invention

In view of the above, the present invention provides a miniature high-pressure static mixer with high mixing efficiency, simple structure, less parts and good versatility, to solve the above-mentioned disadvantages of the prior art.

For this purpose, the present invention is implemented by the following technical means.

A miniature high-pressure static mixer for a liquid chromatograph, comprising: the device comprises a main body sleeve, a base, a support ring, a single-hole sealing gasket, a multi-hole sealing gasket, a mixing cavity and an end sealing gasket;

the main sleeve is of a columnar structure, a liquid inlet port is formed in one end of the main sleeve, and an external thread is formed in the other end of the main sleeve; the interior of the main sleeve is of a blind hole structure, and an opening on the end face of the blind hole is communicated with the liquid inlet interface;

the base is of a prism cap-shaped structure, and one end of the base is provided with an internal thread and is connected with the main sleeve through a thread; the prismatic surface of the base is provided with a liquid outlet port, and the center of the inner surface of the threaded side of the base is provided with a hole and is communicated with the liquid outlet port through a pore channel;

one end of the support ring is provided with the single-hole sealing gasket, the other end of the support ring is provided with the porous sealing gasket, and a cavity formed by the porous sealing gasket is the mixing cavity; at least two groups of mixing cavities are axially and serially arranged in the blind hole of the main body sleeve;

only one single-hole sealing gasket or one porous sealing gasket is arranged between any two adjacent supporting rings;

the number of the end part sealing gaskets is 2, and the end part sealing gaskets are respectively arranged at two tail ends of the mixing cavities which are connected in series; and the other side of the support ring provided with the end sealing gasket is provided with the porous sealing gasket.

Further, the mixing chambers are 10 groups; furthermore, the length range of the sleeve main body is 80mm-95mm, and the outer diameter range is 15mm-25 mm.

Further, the outer diameter of the support ring is the same as the aperture of the blind hole of the main body sleeve.

Furthermore, 4 through holes are symmetrically distributed on the surface of the porous sealing gasket.

Furthermore, a through hole is formed in the center of the end sealing gasket.

Further, the through-hole of the single-hole gasket is provided at the center of the surface.

Furthermore, the radius of the hollow circle of the cross section of the mixing cavity changes along the overall inflow-outflow direction of the fluid, the change trend is from small to large, from large to small or from small to large and then to small, and the distribution positions of the through holes of the porous sealing gasket corresponding to the mixing cavity are correspondingly changed.

Further, the sealing gasket is made of polyether-ether-ketone.

Further, the main sleeve is made of stainless steel.

The invention has the following advantages:

1. the invention is formed by connecting a plurality of mixing cavities in series, wherein two ends of each mixing cavity are used in a cross matching way by a single-hole sealing gasket and a multi-hole sealing gasket, a plurality of mobile phases enter a cavity from a single hole and flow out from a plurality of holes to enter the next cavity to form local turbulence, the central flow rate of mixed liquid is changed, and the effect of increasing the multiphase mixing efficiency is achieved.

2. The main sleeve is processed by adopting a seamless stainless steel pipe, the volume of the cavity is adjusted in a stepless manner, the production cost is low, and the processing is simple and convenient.

3. The invention can change the number of the mixing cavities by changing the depth of the blind hole in the main sleeve without adding connecting elements, and can simply realize the best mixing effect under the condition of the minimum mixing volume according to different flow rates and different initial conditions; the number of the series-connected mixing unit kits can be flexibly increased or decreased according to the actual use requirement, so that the mixer can achieve an ideal mixing effect under the minimum mixing volume.

4. The liquid inlet and the liquid outlet are arranged at two ends, so that mixed liquid can enter and exit from the bottom in a vertical installation state, and bubbles in the liquid can be discharged more easily.

Furthermore, the invention can be expanded into a variable cross-section structure with the inner diameter of the mixing cavity sequentially from small to large, or from large to small, or from small to large and then to small. When the central flow rate is changed by the single-hole sealing structure and the multi-hole sealing structure, the diameter of a mixed liquid channel is changed by different inner diameters of the mixing cavity, and the movement of the mixed liquid is changed from laminar flow to complex turbulent flow, so that the effect of bidirectional optimized mixing is further achieved.

Drawings

In order to illustrate the embodiments of the present invention more clearly, the drawings that are needed in the embodiments will be briefly described below, it is obvious that the drawings in the following description are only one or several embodiments of the present invention, and that other drawings can be obtained by those skilled in the art without inventive effort.

The distribution of the same structures in the figures is for the purpose of describing the invention only and is not intended to indicate or imply that the structures referred to must have a particular distribution and therefore should not be considered as limiting the invention.

FIG. 1 is a half sectional view in the embodiment 1 of the present invention;

FIG. 2 is a front view of a one-hole gasket according to example 1 of the present invention;

FIG. 3 is a front view of the porous gasket in example 1 of the present invention;

FIG. 4 is a schematic view of the vertically installed outer part in embodiment 1 of the present invention;

FIG. 5 is a graph of the results of a comparison of the present invention with a conventional mixer of the same volume;

FIG. 6 is a half sectional view in the embodiment 2 of the present invention;

FIG. 7 is a side view of a gasket in example 2 of the present invention.

In the figure:

1-a body sleeve; 2-a base; 3-a support ring; 4-single hole sealing gasket; 5-a porous gasket; 6-a mixing chamber; 7-end gasket.

Detailed Description

The invention will be further explained with reference to the drawings.