阅读说明：本技术 复配型消毒剂组合物及消毒方法 (Compound disinfectant composition and disinfection method ) 是由 张晓琮 于 2019-10-09 设计创作，主要内容包括：本发明涉及一种复配型消毒剂组合物,由包括如下重量百分比的原料组分制成：2,2-二溴-3-次氮基丙酰胺5％～25％、化妆品可接受的醇类溶剂10％～50％、甲基化的低级二元醇5％～55％、及水0％～65％；其中,所述甲基化的低级二元醇的碳链长度小于10个碳原子。该复配型消毒剂组合物以2,2-二溴-3-次氮基丙酰胺(DBNPA)作为主要功能成分,协同适当的溶剂组分制成液体DBNPA产品,且产品消毒效果好、稳定性好,采用的均为化妆品行业可接受的原料,无毒、无腐蚀性,适用于化妆品行业的设备消毒。(The invention relates to a compound disinfectant composition, which is prepared from the following raw materials in percentage by weight: 5 to 25 percent of 2, 2-dibromo-3-nitrilopropionamide, 10 to 50 percent of alcohol solvent acceptable for cosmetics, 5 to 55 percent of methylated lower dihydric alcohol and 0 to 65 percent of water; wherein the methylated lower diol has a carbon chain length of less than 10 carbon atoms. The compound disinfectant composition takes 2, 2-dibromo-3-nitrilopropionamide (DBNPA) as a main functional component, and is prepared into a liquid DBNPA product in cooperation with a proper solvent component, the product has a good disinfection effect and good stability, all adopted raw materials are acceptable in the cosmetic industry, and the compound disinfectant composition is non-toxic, non-corrosive and suitable for equipment disinfection in the cosmetic industry.)

1. The compound disinfectant composition is characterized by being prepared from the following raw material components in percentage by weight:

wherein the methylated lower diol has a carbon chain length of less than 10 carbon atoms.

2. The compound disinfectant composition according to claim 1, characterized in that it is prepared from the following raw material components in percentage by weight:

3. the complex disinfectant composition according to claim 1 or 2, wherein said methylated lower glycol has a carbon chain length of 2 to 6 carbon atoms.

4. A compound disinfectant composition according to claim 3 wherein said methylated lower diol is selected from at least one of the group consisting of methyl propylene glycol, 3-methyl-1, 3-butanediol and 2-methyl-2, 4-pentanediol.

5. The compound disinfectant composition according to claim 4, wherein said methylated lower glycol is present in a weight ratio of 0.5 to 1.5: 1: 0.5 to 1.5 parts of methyl propylene glycol, 3-methyl-1, 3-butanediol and 2-methyl-2, 4-pentanediol.

6. The complex disinfectant composition according to claim 1 or 2, wherein said cosmetically acceptable alcoholic solvent is selected from at least one of propylene glycol, PEG200 and PEG 400.

7. The compound disinfectant composition according to any of claims 1 to 2 and 4 to 5, further comprising the following raw material components in percentage by weight:

0.5% -3% of stabilizer, and

0.04 to 0.5 percent of regulating stabilizer.

8. The complex disinfectant composition according to claim 7, wherein said stabilizer is selected from at least one of sodium bromide, 2-dibromomalonamide, and bronopol.

9. The compound disinfectant composition according to claim 8, wherein said stabilizer is a mixture of 1: 0.5-1.5: 0.5:1.5 of sodium bromide, bronopol and 2, 2-dibromomalonamide.

10. The complex disinfectant composition according to claim 7, wherein said conditioning stabilizer is selected from at least one of citric acid, sulfamic acid and p-hydroxybenzoic acid.

11. The compound disinfectant composition according to any of claims 1 to 2 and 4 to 5, further comprising the following raw material components in percentage by weight:

0.5-2% of sodium Alcohol Ether Sulphate (AES) and/or benzalkonium bromide (also known as benzalkonium bromide).

12. A method for disinfecting cosmetic production equipment, characterized in that the disinfection is carried out using the complex disinfectant composition according to any one of claims 1 to 11.

Technical Field

The invention relates to a traditional Chinese medicine preparation, in particular to a compound disinfectant composition and a disinfection method.

Background

The existing disinfection means of cosmetic production enterprises are mainly fumigation by using 75% alcohol or formaldehyde, and the two components mainly have the following defects: (1) the sterilization effect is not ideal; (2) the components are stable, and are easy to remain in the cosmetics if the cleaning is not thorough; (3) the disinfection effect is poor for pipelines and joints of production equipment; (4) the service life is long, and the microorganisms are easy to generate drug resistance.

2, 2-dibromo-3-nitrilopropionamide (DBNPA) is a newly emerging bromine-containing disinfection component, is more commonly used in the industries of water treatment, seawater desalination, paper making and the like, but is less used in cosmetic production enterprises. The main reasons for limiting the application of DBNPA are as follows: (1) the pure DBNPA is unstable and easy to decompose, and the use effect is influenced; (2) the pure DBNPA product has heavy smell in use and affects workers; (3) the pure DBNPA product has less usage amount, is easy to make mistakes in dissolution and dilution, and influences the usage; (4) the liquid DBNPA in the existing market contains components which are not easily accepted by the cosmetic industry, such as ethylene glycol, diethylene glycol, tetraethylene glycol and the like; (5) the stabilizer in the liquid DBNPA in the existing market often contains components such as hydrochloric acid, sulfuric acid and the like, so that the corrosion to equipment is large, especially for cosmetic production enterprises, the equipment is basically made of stainless steel, and the cosmetic production is often intermittent or periodic, so that if chloride ions or sulfate radicals are left, the corrosion to the equipment is large, and meanwhile, the number of pipelines and interfaces of the equipment is large, so that the residues are easily generated.

Disclosure of Invention

Based on this, there is a need for a compound disinfectant composition. The compound disinfectant composition takes 2, 2-dibromo-3-nitrilopropionamide (DBNPA) as a main functional component, and is prepared into a liquid DBNPA product in cooperation with a proper solvent component, the product has a good disinfection effect and good stability, all adopted raw materials are acceptable in the cosmetic industry, and the compound disinfectant composition is non-toxic, non-corrosive and suitable for equipment disinfection in the cosmetic industry.

A compound disinfectant composition is prepared from the following raw materials in percentage by weight:

wherein the methylated lower diol has a carbon chain length of less than 10 carbon atoms.

In one embodiment, the compound disinfectant composition is prepared from the following raw material components in percentage by weight:

in one embodiment, the methylated lower diol has a carbon chain length of 2 to 6 carbon atoms.

In one embodiment, the methylated lower diol is selected from at least one of methyl propylene glycol, 3-methyl-1, 3-butanediol, and 2-methyl-2, 4-pentanediol.

In one embodiment, the methylated lower diol is a mixture of 0.5 to 1.5 by weight: 1: 0.5 to 1.5 parts of methyl propylene glycol, 3-methyl-1, 3-butanediol and 2-methyl-2, 4-pentanediol.

In one embodiment, the cosmetically acceptable alcoholic solvent is selected from at least one of propylene glycol, PEG200, and PEG 400.

In one embodiment, the compound disinfectant composition further comprises the following raw material components in percentage by weight:

0.5% -3% of stabilizer, and

0.04 to 0.5 percent of regulating stabilizer.

In one embodiment, the stabilizer is selected from at least one of sodium bromide, 2-dibromomalonamide, and bronopol.

In one embodiment, the stabilizer is a mixture of 1: 0.5-1.5: 0.5:1.5 of sodium bromide, bronopol and 2, 2-dibromomalonamide.

In one embodiment, the conditioning stabilizer is selected from at least one of citric acid, sulfamic acid and p-hydroxybenzoic acid.

In one embodiment, the compound disinfectant composition further comprises the following raw material components in percentage by weight:

0.5-2% of sodium Alcohol Ether Sulphate (AES) and/or benzalkonium bromide (also known as benzalkonium bromide).

The invention also provides a disinfection method of the cosmetic production equipment, and the compound disinfectant composition is adopted for disinfection.

Compared with the prior art, the invention has the following beneficial effects:

on the premise of reasonably preparing each raw material component, the compound disinfectant composition takes 2, 2-dibromo-3-nitrilopropionamide (DBNPA) as a main disinfection effective component and is matched with an alcohol solvent acceptable for cosmetics, and on the basis, methylated lower dihydric alcohol is taken as an auxiliary solvent, so that the dispersion rate and uniformity of DBNPA in a system are greatly improved under the condition of not adopting components which are not easily acceptable in the cosmetic industry, and the stability, especially the low-temperature stability of DBNPA can be obviously improved. Meanwhile, when the compound disinfectant composition is diluted in a water body, the dispersion is uniform and the speed is high, and the disinfection effect is good.

In addition, the compound disinfectant composition adopts raw materials which are acceptable in the cosmetic industry, is safe, nontoxic and non-corrosive, is easy to degrade, wash and leave little residue, and is suitable for equipment disinfection in the cosmetic industry.

Drawings

FIGS. 1-2 are comparative plots of the slime release test for example VII and a control;

FIG. 3 is a graph comparing the corrosion effects of stainless steel of example two and a control.

Detailed Description

The composite disinfectant composition and the disinfecting method according to the present invention will be described in further detail with reference to specific examples.

The embodiment of the invention provides a compound disinfectant composition which is prepared from the following raw material components in percentage by weight:

wherein the methylated lower diol has a carbon chain length of less than 10 carbon atoms.

In the above-mentioned complex disinfectant composition, the cosmetically acceptable alcoholic solvent is different from the methylated lower dihydric alcohol, is a non-methylated alcoholic solvent, and is cosmetically acceptable (refer to the catalogue of cosmetic raw materials, abbreviated as INCI catalogue). Specifically, the alcohol may be a monohydric alcohol, a dihydric alcohol or a polymer alcohol. The water used as the raw material component has little influence on the disinfection or stability of the compound disinfectant composition, and can be added or not added according to the dilution requirement.

Preferably, the compound disinfectant composition is prepared from the following raw material components in percentage by weight:

preferably, the carbon chain length of the methylated lower diol is 2 to 6 carbon atoms. Specifically, the methylated lower diol is at least one selected from the group consisting of methylpropanediol, 3-methyl-1, 3-butanediol, and 2-methyl-2, 4-pentanediol.

More preferably, the methylated lower diol comprises at least 2-methyl-2, 4-pentanediol, whereby the freeze resistance of the disinfectant composition may be optimized. More preferably, the methylated lower diol is a mixture of 0.5 to 1.5 by weight: 1: 0.5 to 1.5 parts of methyl propylene glycol, 3-methyl-1, 3-butanediol and 2-methyl-2, 4-pentanediol. The three methylated lower dihydric alcohols are used in a compatible manner, and the prepared disinfectant composition has good normal-temperature stability and low-temperature stability, so that the disinfectant composition can obtain wider product stability and is easier to wash.

In some specific embodiments, the cosmetically acceptable alcoholic solvent is selected from at least one of propylene glycol, PEG200, and PEG 400. The alcohol solvent acceptable for the cosmetics is high in use safety, the using amount of the alcohol solvent in the disinfectant composition is small, the weight ratio is about 10-50%, the alcohol solvent can be matched with methylated lower dihydric alcohol to achieve a good DBNPA dissolving and dispersing effect, and the risk of high COD in a water body can be greatly reduced.

In some specific embodiments, the compound disinfectant composition further comprises the following raw material components in percentage by weight:

0.5% -3% of stabilizer, and

0.04 to 0.5 percent of regulating stabilizer.

More specifically, the stabilizer is at least one selected from the group consisting of sodium bromide, 2-dibromomalonamide, and bronopol. And/or the regulating stabilizer is at least one selected from citric acid, sulfamic acid and p-hydroxybenzoic acid.

The components of the stabilizer are relatively safe, almost have no influence on a human body, are extremely easy to degrade in the environment, almost have no residue, and have a good stabilizing effect on DBNPA. As for the adjusting stabilizer, the selected weak acids such as organic acid or sulfonic acid and the like have small corrosion to metal equipment, particularly stainless steel equipment, are very suitable for the cosmetic industry, and can achieve better DBNPA stabilizing effect by cooperating with the stabilizer.

Preferably, the stabilizer does not adopt sodium bromide alone, and can be any combination of sodium bromide and 2, 2-dibromomalonamide and bronopol, or only the combination of the 2, 2-dibromomalonamide and the bronopol. The obtained disinfectant composition has better DBNPA stability and higher retention rate.

Further preferably, the stabilizer is a mixture of 1: 0.5-1.5: 0.5:1.5 of sodium bromide, bronopol and 2, 2-dibromomalonamide. The ease of rinsing of the disinfectant composition can thereby be optimized and the residue reduced.

In some specific embodiments, the compound disinfectant composition further comprises the following raw material components in percentage by weight:

0.5 to 2 percent of AES and/or benzalkonium bromide.

The compound disinfectant composition can also be compatible with AES and/or benzalkonium bromide as synergistic components, so that the stability is not influenced, and the sterilization effect of the disinfectant composition is improved. When AES is adopted, the cleaning and stripping effects of the disinfectant composition on stubborn bacterial plaque can be greatly improved; when the benzalkonium bromide is used, the sterilizing effect of the disinfectant composition can be greatly improved, the killing time is shortened, and especially the killing effect on the surface of equipment is improved.

The embodiment of the invention also provides a disinfection method of cosmetic production equipment, which adopts the compound disinfectant composition for disinfection.

Hereinafter, specific examples are shown, and the raw materials used in the examples are all commercially available products unless otherwise specified.