阅读说明：本技术 肿瘤定位装置 (Tumor positioning device ) 是由 万方宁 叶定伟 朱耀 于 2018-07-12 设计创作，主要内容包括：本发明提供了一种肿瘤体外定位穿刺装置,所述肿瘤体外定位穿刺装置包括：固定板、至少三根固定针、两根刻度针及滑块,所述至少三根固定针和所述两根刻度针均垂直固定于所述固定板上,所述滑块上开设有容置活检针的引导孔和容置两刻度针的滑孔,所述引导孔的轴线与所述滑孔的轴线垂直。通过至少三根固定针可以实现对肿瘤位置固定,结合两根刻度针、滑块及活检针三者的配合,可获得肿瘤三维坐标(即确定了肿瘤穿刺取样坐标),从而在体外准确定位肿瘤,结合影像检查定位信息,可以取得特定位置肿瘤标本,通过基因检测,可获得与影像学检查对应的分子水平信息,为后续的精准影像研究奠定基础。(The invention provides a tumor in-vitro positioning and puncturing device, which comprises: the biopsy needle fixing device comprises a fixing plate, at least three fixing needles, two scale needles and a sliding block, wherein the at least three fixing needles and the two scale needles are vertically fixed on the fixing plate, a guide hole for containing a biopsy needle and a sliding hole for containing the two scale needles are formed in the sliding block, and the axis of the guide hole is perpendicular to the axis of the sliding hole. The tumor position can be fixed through at least three fixing needles, and by combining the cooperation of the two scale needles, the sliding block and the biopsy needle, the three-dimensional coordinate of the tumor (namely the tumor puncture sampling coordinate) can be obtained, so that the tumor can be accurately positioned in vitro, and by combining with image examination positioning information, a tumor specimen at a specific position can be obtained.)

1. An in vitro tumor localization device, comprising: the biopsy needle fixing device comprises a fixing plate, at least three fixing needles, two scale needles and a sliding block, wherein the at least three fixing needles and the two scale needles are vertically fixed on the fixing plate, a guide hole for containing a biopsy needle and a sliding hole for containing the two scale needles are formed in the sliding block, and the axis of the guide hole is perpendicular to the axis of the sliding hole.

2. The tumor locating device of claim 1, wherein each of the retaining pins includes a pin shaft and a base, the base being fixedly connected to a root of the pin shaft.

3. The tumor localization device of claim 2, wherein the needle shaft is i-shaped in cross-section.

4. The tumor locating device of claim 2, wherein each of the graduated pins comprises a graduated rod and a base, and the base is fixedly connected with the root of the graduated rod.

5. The tumor locating device of claim 3, wherein the fixing plate comprises a first fixing plate and a second fixing plate arranged in parallel with the first fixing plate, the base of the fixing needle and the base of the calibration needle are both clamped by the first fixing plate and the second fixing plate, and the needle rod and the calibration rod both pass through the second fixing plate; the second fixing plate is provided with two parallel sliding grooves, and each scale rod can slide along one sliding groove.

6. The tumor localization device of claim 5, wherein the first fixation plate and the second fixation plate are fixedly connected by at least two screws.

7. The tumor locating device of claim 1, wherein three of the at least three fixation pins are evenly spaced.

8. The tumor locating apparatus of claim 1, wherein the at least three fixing pins are fixed to a predetermined area of the fixing plate, and the two calibration pins are fixed to the fixing plate adjacent to the predetermined area.

9. The tumor localization device of claim 1, further comprising a biopsy needle received in the guide hole.

Technical Field

The invention relates to the technical field of medical instruments, in particular to an in-vitro tumor positioning device.

Background

At present, the multi-parameter MRI, PET or CT examination can reflect the difference of different properties or metabolism in the same solid tumor, but the problem of positioning with pathology detection and molecular detection is not well solved. Clinically, the heterogeneity of tumor has been found to be very obvious by multi-point sampling, however, the sampling is random and can not correspond to the image data, so there is an insurmountable gap between the imaging examination and the cell and molecular examination.

Aiming at the problem that the cell and molecule examination and the imaging examination in the prior art can not be in one-to-one correspondence, the technical personnel in the field are always searching for a solution.

Disclosure of Invention

The invention aims to provide a tumor in-vitro positioning device, which solves the problem that molecular examination in the prior art can not correspond to imaging examination, so that genetic mutation or expression mutation of tumor or treatment response to optional medicines can not be predicted through the imaging examination, and thus accurate diagnosis and treatment can not be realized.

In order to solve the above technical problem, the present invention provides a tumor in vitro positioning device, comprising: the biopsy needle fixing device comprises a fixing plate, at least three fixing needles, two scale needles and a sliding block, wherein the at least three fixing needles and the two scale needles are vertically fixed on the fixing plate, a guide hole for containing a biopsy needle and a sliding hole for containing the two scale needles are formed in the sliding block, and the axis of the guide hole is perpendicular to the axis of the sliding hole.

In the tumor positioning device, each fixing needle comprises a needle rod and a base, and the base is fixedly connected with the root part of the needle rod.

In the tumor positioning device, the cross section of the needle rod is I-shaped.

In the tumor positioning device, each scale needle comprises a scale rod and a base, and the base is fixedly connected with the root part of the scale rod.

In the tumor positioning device, the fixing plate comprises a first fixing plate and a second fixing plate arranged in parallel with the first fixing plate, the base of the fixing needle and the base of the scale needle are clamped by the first fixing plate and the second fixing plate, and the needle rod and the scale rod pass through the second fixing plate; the second fixing plate is provided with two parallel sliding grooves, and each scale rod can slide along one sliding groove.

In the tumor positioning device, the first fixing plate and the second fixing plate are fixedly connected through at least two screws.

In the tumor positioning device, three fixing needles of the at least three fixing needles are uniformly distributed at equal intervals.

In the tumor positioning device, the at least three fixing needles are fixed on a predetermined area of the fixing plate, and the two calibration needles are fixed on the fixing plate close to the predetermined area.

In the tumor locating device, the biopsy needle is further included, and the biopsy needle is accommodated in the guide hole.

In the tumor localization apparatus provided by the present invention, the tumor localization apparatus includes: the biopsy needle fixing device comprises a fixing plate, at least three fixing needles, two scale needles and a sliding block, wherein the at least three fixing needles and the two scale needles are vertically fixed on the fixing plate, a guide hole for containing a biopsy needle and a sliding hole for containing the two scale needles are formed in the sliding block, and the axis of the guide hole is perpendicular to the axis of the sliding hole. Can realize fixed to the tumour position through three at least fixed needles, combine two scale needles, slider and biopsy needle three's cooperation, obtain tumour three-dimensional coordinate (having confirmed tumour puncture sample coordinate promptly) to improve tumour location precision, made the molecular inspection can correspond with the imaging inspection, improved diagnosis treatment.

Drawings

FIG. 1 is a schematic structural diagram of a tumor locating apparatus according to an embodiment of the present invention;

FIG. 2 is a schematic structural diagram of a fixing needle of the tumor positioning device according to an embodiment of the present invention;

FIG. 3 is a schematic structural diagram of a calibration needle in the tumor positioning device according to an embodiment of the present invention;

FIG. 4 is a schematic structural diagram of a slider in the tumor positioning apparatus according to an embodiment of the present invention;

FIG. 5 is a schematic structural diagram of a first fixing plate of the tumor positioning device according to an embodiment of the present invention;

fig. 6 is a schematic structural diagram of a second fixing plate in the tumor positioning device according to an embodiment of the present invention.

In the figure, 1-fixed plate; 11-a first fixing plate; 12-a second fixing plate; 2-fixing the needle; 21-a needle bar; 22, 33-base; 3-a graduated needle; 31-a graduated rod; 4-a slide block; 41-a guide hole; 42-a slide hole; 5-biopsy needle.

Detailed Description

The tumor locating device according to the present invention will be described in detail with reference to the accompanying drawings and specific embodiments. Advantages and features of the present invention will become apparent from the following description and from the claims. It is to be noted that the drawings are in a very simplified form and are not to precise scale, which is merely for the purpose of facilitating and distinctly claiming the embodiments of the present invention.

Referring to fig. 1 and 4, fig. 1 is a schematic structural diagram of a tumor locating device according to the present invention; fig. 4 is a schematic structural diagram of a slider in the tumor positioning device according to an embodiment of the present invention. As shown in fig. 1 and 4, the tumor localization apparatus includes: the biopsy needle fixing device comprises a fixing plate 1, at least three fixing needles 2, two scale needles 3 and a sliding block 4, wherein the at least three fixing needles 2 and the two scale needles 3 are all vertically fixed on the fixing plate 1, a guide hole 41 for accommodating a biopsy needle 5 and a sliding hole 42 for accommodating the two scale needles 3 are formed in the sliding block 4, and the axis of the guide hole 41 is perpendicular to the axis of the sliding hole 42. In this embodiment, the number of the sliding holes 42 on the sliding block 4 is two, and the sliding block 4 is sleeved on the two scale needles and can slide along the axial direction of the scale needle 3.

As shown in fig. 4, the tumor localization apparatus further comprises a biopsy needle 5, the biopsy needle 5 being received in the guide hole 41.

In order to better stabilize the position of the tumor, three fixing needles 2 of the at least three fixing needles 2 are uniformly distributed at equal intervals to form a plane, and the tumor is inserted on the at least three fixing needles 2 when the fixing needle is applied.

In order to facilitate the acquisition of the location coordinates of the tumor, the at least three fixing needles 2 are fixed on a predetermined region of the fixing plate 1, and the two calibration needles 3 are fixed on the fixing plate 1 adjacent to the predetermined region, so that the two calibration needles 3 can measure the coordinates of the tumor inserted on the at least three fixing needles 2.

Please refer to fig. 2, which is a schematic structural diagram of a fixing needle 2 in the tumor positioning device according to an embodiment of the present invention. As shown in fig. 2, each fixing pin 2 includes a pin shaft 21 and a base 22, and the base 22 is fixedly connected to a root of the pin shaft 21. Preferably, the cross section of the needle rod 21 is I-shaped, so that tumor rotation is prevented, and stability is increased; the base 22 is used to be perpendicular to the fixing plate 1 after being fixed to the fixing plate 1.

Please refer to fig. 3, which is a schematic structural diagram of a calibration needle in a tumor positioning device according to an embodiment of the present invention. As shown in fig. 3, each of the index pins 3 includes an index rod 31 and a base 33, and the base 33 is fixedly connected to a root of the index rod 31.

Referring to fig. 1, fig. 5 and fig. 6, fig. 5 is a schematic structural view of a first fixing plate in a tumor positioning device according to an embodiment of the present invention; fig. 6 is a schematic structural diagram of the second fixing plate 12 in the tumor positioning device according to an embodiment of the present invention. As shown in fig. 1, 5 and 6, the fixing plate 1 includes a first fixing plate 11 and a second fixing plate 12 parallel to the first fixing plate 11, the base 22 of the fixing pin 2 and the base 33 of the calibration pin 3 are both clamped by the first fixing plate 11 and the second fixing plate 12, and the pin rod 21 and the calibration rod 31 both pass through the second fixing plate 12; the second fixing plate 12 has two parallel sliding grooves, and each of the calibration rods 31 can slide along one of the sliding grooves. The first fixing plate 11 and the second fixing plate 12 are fixedly connected by at least two screws. As shown in fig. 1, in this embodiment, the first fixing plate 11 and the second fixing plate 12 are fixedly connected by four screws, and each screw passes through a threaded hole at a corner of the first fixing plate 11 and the second fixing plate 12 to fix the two.

In practical tumor positioning application, please refer to fig. 1, which illustrates the use method of the tumor positioning device of the present invention by taking three fixing needles 2 as an example:

firstly, selecting three fixing needles 2 and two scale needles 3 with proper sizes to be fixed on a fixing plate 1 according to the size of a tumor;

secondly, inserting the tumor into the three fixing needles 2, and obtaining the two-dimensional size of the tumor by longitudinally and transversely photographing (namely pathological photographing);

and thirdly, fitting according to the three-dimensional model generated by MRI or CT and pathological photographing. Determining a sampling point to be selected;

fourthly, adjusting the positions of the two scale needles 3 on the second fixing plate 12 according to the coordinates of the sampling points to determine the abscissa (namely the first axis coordinate); adjusting the position of the slide block 4 to determine a vertical coordinate (i.e. a second axis coordinate);

the fifth step: an 18G BARD disposable puncture biopsy gun (which can be a puncture biopsy gun of other types) is used for placing the biopsy needle 5 into the guide hole 41 of the slide block 4, so that the needle point of the biopsy needle 5 is close to the tumor, and the third axis coordinate is determined according to the scale on the puncture biopsy gun. At this point, the biopsy gun may be fired to sample.

The device solves the linkage problem between the image examination and the pathological molecular diagnosis by three-dimensionally positioning the tumor in vitro and by puncture sampling with determined coordinates. In other words, by means of in vitro positioning puncture, pathological sections or fresh tissues corresponding to MRI examination signals or CT signals can be obtained for common pathological detection or gene detection. And obtaining a prediction model according to the correlation analysis of the gene detection data and the imaging parameters. After the model is established, when the image result is obtained, the molecular mutation condition of a subsequent patient can be predicted, and then treatment decision is guided.

In summary, in the tumor localization apparatus provided by the present invention, the tumor localization apparatus includes: the biopsy needle fixing device comprises a fixing plate, at least three fixing needles, two scale needles and a sliding block, wherein the at least three fixing needles and the two scale needles are vertically fixed on the fixing plate, a guide hole for containing a biopsy needle and a sliding hole for containing the two scale needles are formed in the sliding block, and the axis of the guide hole is perpendicular to the axis of the sliding hole. Can realize fixed to the tumour position through three at least fixed needles, combine two scale needles, slider and biopsy needle three's cooperation, obtain tumour three-dimensional coordinate (having confirmed tumour puncture sample coordinate promptly) to improve tumour location precision, made the molecular inspection can correspond with the imaging inspection, improved diagnosis treatment.

The above description is only for the purpose of describing the preferred embodiments of the present invention, and is not intended to limit the scope of the present invention, and any variations and modifications made by those skilled in the art based on the above disclosure are within the scope of the appended claims.