A leak blood detection device for extracorporeal circulation pipeline
阅读说明：本技术 一种用于体外循环管路的漏血检测装置 (A leak blood detection device for extracorporeal circulation pipeline ) 是由 冯新庆 胡勇 冯庆申 冯立军 冯羽亮 于 2019-11-24 设计创作，主要内容包括：本发明公开一种用于体外循环管路的漏血检测装置,包括电源模块、微控制器、光源控制模块、温度测量模块和存储模块,所述电源模块的电源输出端与所述微控制器、所述光源控制模块、所述温度测量模块和所述存储模块的电源输入端连接；所述微控制器的信号输入输出端与所述光源控制模块的信号输入输出端通信连接,所述微控制器的信号输入输出端与所述温度测量模块的信号输入输出端通信连接；所述微控制器的信号输入输出端与所述存储模块的信号输入输出端通信连接。本发明通过电路的巧妙设计,光传感器为数字式,直接输出数字信号,避免了信号放大过程、模数转换过程产生的误差,使得漏血检测装置的灵敏度更高、误报率降低。(The invention discloses a blood leakage detection device for an extracorporeal circulation pipeline, which comprises a power supply module, a microcontroller, a light source control module, a temperature measurement module and a storage module, wherein the power supply output end of the power supply module is connected with the power supply input ends of the microcontroller, the light source control module, the temperature measurement module and the storage module; the signal input and output end of the microcontroller is in communication connection with the signal input and output end of the light source control module, and the signal input and output end of the microcontroller is in communication connection with the signal input and output end of the temperature measurement module; and the signal input and output end of the microcontroller is in communication connection with the signal input and output end of the storage module. The invention has the advantages that through the ingenious design of the circuit, the optical sensor is digital, the digital signal is directly output, the errors generated in the signal amplification process and the analog-to-digital conversion process are avoided, the sensitivity of the blood leakage detection device is higher, and the false alarm rate is reduced.)
1. The blood leakage detection device for the extracorporeal circulation pipeline is characterized by comprising a power supply module, a microcontroller (8), a light source control module, a temperature measurement module and a storage module, wherein the power supply output end of the power supply module is electrically connected with the power supply input ends of the microcontroller (8), the light source control module, the temperature measurement module and the storage module; the signal input and output end of the microcontroller (8) is in communication connection with the signal input and output end of the light source control module, the signal input and output end of the microcontroller (8) is in communication connection with the signal input and output end of the temperature measurement module, and the signal input and output end of the microcontroller (8) is in communication connection with the signal input and output end of the storage module.
2. The apparatus of claim 1, wherein the power module comprises a power chip XC6206P331MR, a leg 3 of the power chip XC6206P331MR provides a voltage of 5.0V, and a leg 3 of the power chip XC6206P331MR is grounded via a capacitor C5; the leg 2 of the power supply chip XC6206P331MR provides 3.3V, the leg 2 of the power supply chip XC6206P331MR is grounded through a capacitor C6, and the leg 1 of the power supply chip XC6206P331MR is grounded.
3. The device according to claim 2, wherein the microcontroller (8) is a microcontroller LPC824M201JDH20, and the power chip XC6206P331MR provides a voltage of 3.3V for the microcontroller LPC824M201JDH 20; the input and output ends of the microcontroller LPC824M201JDH20 are in communication connection with the input and output ends of the light source control module, the input and output ends of the microcontroller LPC824M201JDH20 are in communication connection with the signal input and output ends of the storage module, and the input and output ends of the microcontroller LPC824M201JDH20 are in communication connection with the signal input and output ends of the temperature measurement module.
4. The blood leakage detection device for extracorporeal circulation circuit according to claim 3, wherein the light source control module comprises an indicator lamp, a light source driving circuit (6), an analog switch (7) and a light sensor; the signal input and output end of the microcontroller LPC824M201JDH20 is in communication connection with the signal input and output end of the analog switch (7), the signal output end of the analog switch (7) is connected with the signal input end of the light source driving circuit (6), the signal output end of the microcontroller LPC824M201JDH20 is connected with the signal input end of the indicator light, and the signal input and output end of the light sensor is in communication connection with the signal input and output end of the microcontroller LPC824M201JDH 20; the power supply chip XC6206P331MR provides 5.0V voltage for the analog switch (7), and the power supply chip XC6206P331MR provides 3.3V voltage for the optical sensor.
5. The device according to claim 4, wherein the analog switch (7) is a dual channel switch ADG884BCPZ, and the power supply output of the power chip XC6206P331MR is electrically connected to the power input of the dual channel switch ADG884BCPZ, leg 1, leg 3 and leg 9, providing a voltage of 5.0V; the signal input/output terminal pins 7 and 8 of the microcontroller LPC824M201JDH20 are in communication connection with the signal input/output terminal pins 5 and 7 of the dual-channel switch ADG884BCPZ, and the signal output terminal pins 2 and 10 of the dual-channel switch ADG884BCPZ are connected with the signal input terminal of the light source driving circuit (6); leg 6 and leg 11 of dual-channel switch ADG884BCPZ are grounded, leg 4 of dual-channel switch ADG884BCPZ is grounded through resistor R8, and leg 8 of dual-channel switch ADG884BCPZ is grounded through resistor R7.
6. The blood leakage detection device for extracorporeal circulation circuit according to claim 5, wherein the light source driving circuit (6) comprises a yellow-green light source driving circuit and an infrared light source driving circuit, the yellow-green light source driving circuit comprises a voltage regulator TL431BQDBZRQ1, a yellow-green light emitting diode YG, an NPN0805 triode Q2, the signal output terminal pin 10 of the dual-channel switch ADG884BCPZ is connected with the positive electrode of the yellow-green light emitting diode YG, and the positive electrode of the yellow-green light emitting diode YG is connected with the pin 1 of the voltage regulator TL431BQDBZRQ1 through a resistor R5; the cathode of the yellow-green light emitting diode YG is connected with a leg 2 of an NPN0805 triode Q2, a leg 1 of an NPN0805 triode Q2 is connected with a leg 1 of a voltage stabilizer TL431BQDBZRQ1, a leg 3 of an NPN0805 triode Q2 is connected with a leg 2 of the voltage stabilizer TL431BQDBZRQ1, and the yellow-green light emitting diode YG is grounded through a resistor R6; the tube leg 1 of the voltage stabilizer TL431BQDBZRQ1 is connected to the ground through a capacitor C1;
the infrared light source driving circuit comprises a voltage stabilizer TL431BQDBZRQ1, an infrared light emitting diode IR and an NPN0805 triode Q1, wherein a signal output end tube leg 2 of the dual-channel switch ADG884BCPZ is connected with the anode of the infrared light emitting diode IR, the anode of the infrared light emitting diode IR is connected with a tube leg 1 of the voltage stabilizer TL431BQDBZRQ1 through a resistor R1, the cathode of the infrared light emitting diode IR is connected with a tube leg 2 of an NPN0805 triode Q1, a tube leg 1 of the NPN0805 triode Q1 is connected with a tube leg 1 of the voltage stabilizer TL431BQDBZRQ1, a tube leg 3 of the NPN0805 triode Q1 is connected with the tube leg 2 of the voltage stabilizer TL BQZRQ 1, and then is grounded through a resistor R2; leg 1 of voltage regulator TL431BQDBZRQ1 is connected to ground through capacitor C2.
7. The device of claim 6, wherein the indicator light is a Dual LED1206 Dual color light, and a leg 4 of a red indicator light in the Dual LED1206 Dual color light is connected to a signal output terminal of the microcontroller LPC824M201JDH20 through a resistor R3; the green indicator light leg 2 in the Dual LED1206 Dual-color light is connected with the signal output end of the microcontroller LPC824M201JDH20 through a resistor R4.
8. The blood leakage detection device for extracorporeal circulation circuit according to claim 7, wherein the light sensor comprises an infrared light sensor (3) and a yellow-green light sensor (4), the infrared light sensor (3) and the yellow-green light sensor (4) each comprise a light sensor Si1153-AA00-GMR for detecting the luminous intensity of the yellow-green light source (2) and the infrared light source (1), respectively; the signal input and output terminal tube leg 1 and tube leg 2 of the optical sensor Si1153-AA00-GMR are in communication connection with the signal input and output terminal tube leg 9 and tube leg 10 of the microcontroller LPC824M201JDH 20; the yellow-green light emitting diode YG is a yellow-green light source (2), and the infrared light emitting diode IR is an infrared light source (1).
9. The device according to claim 3, wherein the temperature measuring module is a temperature sensor (5) ADT75BRMZ, and the microcontroller LPC824M201JDH20 is connected to a communication port of the temperature sensor ADT75BRMZ to read the temperature detected by the temperature sensor ADT75 BRMZ.
10. The device of claim 3, wherein the memory is a programmable memory AT24C256, and a signal input/output terminal of the programmable memory AT24C256 is communicatively connected to a signal input/output terminal of the microcontroller LPC824M201JDH 20.
Technical Field
The invention relates to the technical field of medical instruments. In particular to a blood leakage detection device for an extracorporeal circulation pipeline.
Background
The dialysis blood leakage sensor is an important component of the dialysis machine, and can give an alarm in time when bubbles exist in dialysate, a dialyzer breaks membranes and blood overflows, so that the safety of a patient in the treatment process is ensured. The blood leakage sensor is formed by combining a light emitting side and a light receiving side, and the basic principle is optical monitoring. When the blood leakage happens, because the red blood cells are suspended in the dialysate, a shading effect is generated, the light intensity received by the light receiving side is reduced, the converted voltage is reduced, and the blood leakage alarm can happen when the voltage is reduced by a certain amplitude.
The traditional blood leakage sensor has the defects that the circuit is complex in arrangement, and the sensitivity of the temperature sensor and the light sensor is poor, so that the blood leakage detection device frequently gives an alarm or cannot monitor the occurrence of blood leakage, and the safety of a patient in the treatment process cannot be ensured.
Disclosure of Invention
Therefore, the technical problem to be solved by the present invention is to provide a blood leakage detection device for extracorporeal circulation pipeline, which has high detection sensitivity and low false alarm rate.
In order to solve the technical problems, the invention provides the following technical scheme:
a blood leakage detection device for an extracorporeal circulation pipeline comprises a power supply module, a microcontroller, a light source control module, a temperature measurement module and a storage module, wherein the power supply output end of the power supply module is electrically connected with the power supply input ends of the microcontroller, the light source control module, the temperature measurement module and the storage module; the signal input and output end of the microcontroller is in communication connection with the signal input and output end of the light source control module, the signal input and output end of the microcontroller is in communication connection with the signal input and output end of the temperature measurement module, and the signal input and output end of the microcontroller is in communication connection with the signal input and output end of the storage module.
In the blood leakage detection device for the extracorporeal circulation pipeline, the power supply module comprises a power supply chip XC6206P331MR, a
In the blood leakage detection device for the extracorporeal circulation pipeline, the microcontroller is the microcontroller LPC824M201JDH20, and the power chip XC6206P331MR provides 3.3V voltage for the
The blood leakage detection device for the extracorporeal circulation pipeline comprises a light source control module, a light source control module and a control module, wherein the light source control module comprises an indicator lamp, a light source driving circuit, an analog switch and a light sensor; the signal input and output end of the microcontroller LPC824M201JDH20 is in communication connection with the signal input and output end of the analog switch, the signal output end of the analog switch is connected with the signal input end of the light source driving circuit, the signal output end of the microcontroller LPC824M201JDH20 is connected with the signal input end of the indicator light, and the signal input and output end of the light sensor is in communication connection with the signal input and output end of the
In the blood leakage detection device for the extracorporeal circulation pipeline, the analog switch is a dual-channel switch ADG884BCPZ, and the power output end of the power chip XC6206P331MR is electrically connected with the power input
The blood leakage detection device for the extracorporeal circulation pipeline comprises a yellow-green light source driving circuit and an infrared light source driving circuit, wherein the yellow-green light source driving circuit comprises a voltage stabilizer TL431BQDBZRQ1, a yellow-green light-emitting diode YG and an NPN0805 triode Q2, a signal output
The infrared light source driving circuit comprises a voltage stabilizer TL431BQDBZRQ1, an infrared light emitting diode IR and an NPN0805 triode Q1, wherein a signal output
In the blood leakage detection device for the extracorporeal circulation pipeline, the indicator lamp is a Dual LED1206 Dual-color lamp, and a
The blood leakage detection device for the extracorporeal circulation pipeline comprises an infrared light sensor and a yellow-green light sensor, wherein the infrared light sensor and the yellow-green light sensor both comprise light sensors Si1153-AA00-GMR which are respectively used for detecting the luminous intensity of a yellow-green light source and the luminous intensity of an infrared light source; the signal input and output
Above-mentioned a leak blood detection device for extracorporeal circulation pipeline, the temperature measurement module is temperature sensor (5) ADT75BRMZ, microcontroller LPC824M201JDH20 with temperature sensor ADT75 BRMZ's communication port is connected, reads the temperature that temperature sensor ADT75BRMZ detected.
In the blood leakage detection device for the extracorporeal circulation circuit, the memory is a programmable memory AT24C256, and a signal input/output end of the programmable memory AT24C256 is in communication connection with a signal input/output end of the
The technical scheme of the invention achieves the following beneficial technical effects:
the invention leads the sensitivity of the blood leakage detection device to be higher and the false alarm rate to be reduced through the ingenious design of the circuit.
(1) The microcontroller LPC824M201JDH20 is used as an ultra-low power consumption 32-bit microcontroller, a timer is arranged in the microcontroller, the microcontroller can control the light sensor to read the photometric quantity within a millisecond level, the reaction time is short, and the sensitivity is high.
(2) The ingenious design of the analog switch is a single-pole double-throw (SPDT) switch, the analog switch has ultralow on-resistance which is less than 0.4 omega in the whole temperature range, so that the current signal sent by the microcontroller has minimum switching distortion, and the yellow-green light source driving circuit and the infrared light source driving circuit are controlled to alternately work.
(3) The yellow-green light source driving circuit and the infrared light source driving circuit both adopt adjustable precise shunt voltage regulators TL431BQDBZRQ1, so that the current is more stable, the intensity of the infrared light source (infrared light emitting diode IR) and the yellow-green light source (yellow-green light emitting diode YG) is controllable, the consistency is good, and the detection error caused by current fluctuation is eliminated.
(4) The temperature sensor ADT75BRMZ has high precision, can be accurate within the range of +/-1.0 ℃, and is convenient for light source compensation under different temperatures.
(5) The optical sensor is digital, and directly outputs digital signals, thereby avoiding errors generated in the signal amplification process and the analog-to-digital conversion process.
(6) The light source and the sensor are arranged on two sides of the probe, the control panel is arranged on the rear side of the probe, and the integrated product is convenient to produce and maintain. A circular detection cavity is arranged in the middle of the probe, and the blood leakage detection kettle of the special pipeline is arranged in the circular detection cavity, so that the installation is convenient and simple.
Drawings
FIG. 1 is a schematic view of a blood leakage detecting device for an extracorporeal circuit according to the present invention;
FIG. 2 is a circuit diagram of a power module of the blood leakage detecting device for extracorporeal circulation circuit according to the present invention;
FIG. 3 is a circuit diagram of a microcontroller of the blood leakage detection device for an extracorporeal circuit according to the present invention;
FIG. 4 is a circuit diagram of an analog switch and a circuit diagram of an optical driving circuit of the blood leakage detecting device for extracorporeal circulation lines according to the present invention;
FIG. 5 is a circuit diagram of an indicator light of the blood leakage detecting device for an extracorporeal circuit according to the present invention;
FIG. 6 is a circuit diagram of an optical sensor of the blood leakage detecting device for extracorporeal circulation circuit according to the present invention;
FIG. 7 is a circuit diagram of a temperature sensor of the blood leakage detecting device for extracorporeal circulation circuit according to the present invention;
FIG. 8 is a circuit diagram of the memory of the blood leakage detecting device for extracorporeal circulation circuit according to the present invention;
FIG. 9 shows the light source turn-on alternation frequency of the blood leakage detecting device for extracorporeal circulation circuit according to the present invention;
FIG. 10 graph of hemoglobin absorbance.
The reference numbers in the figures denote: 1-an infrared light source; 2-yellow-green light source; 3-an infrared light sensor; 4-yellow-green light sensor; 5-a temperature sensor; 6-light source driving circuit; 7-an analog switch; 8-a microcontroller; 9-transparent pipeline.
Detailed Description
As shown in fig. 1, a blood leakage detection device for an extracorporeal circulation pipeline comprises a power supply module, a
As shown in fig. 2, the power module includes a power chip XC6206P331MR, a
As shown in fig. 3, the
As shown in fig. 4, the light source control module includes a light
The light source and the sensor are arranged at two sides of the probe, the control panel is arranged at the rear side of the probe, a circular detection cavity is arranged in the middle of the probe, the
In order to ensure that the detection device can rapidly switch between the
As shown in fig. 4, the
As shown in fig. 4, the light
The infrared light source driving circuit comprises a voltage stabilizer TL431BQDBZRQ1, an infrared light emitting diode IR and an NPN0805 triode Q1, wherein a signal output
The yellow-green light source driving circuit and the infrared light source driving circuit both adopt adjustable precise shunt voltage regulators TL431BQDBZRQ1, so that the current is more stable, the intensity of the infrared light source and the yellow-green light source is controllable, the consistency is good, and the detection error caused by current fluctuation is eliminated.
As shown in fig. 5, the indicator light is Dual LED1206 Dual-color light, and a
As shown in fig. 6, the light sensor includes an
Since the light transmittance of blood changes at different temperatures, the intensity change of the infrared light source and the yellow-green light source at different temperatures needs to be detected, and specifically, as shown in fig. 9, the
The detection device is also provided with a memory for storing the detection values of the optical sensors at different temperatures, because the detection values of the detection device at different temperature states need to be called as references. As shown in fig. 8, the memory is a programmable memory AT24C256, and a signal input/output terminal of the programmable memory AT24C256 is communicatively connected to a signal input/output terminal of the
The specific detection method and the working principle are as follows:
the yellow-green light emitting diode YG is a 3mm yellow-green light source with a wavelength of 570 nm; the infrared light emitting diode IR is a 3mm infrared light source with the wavelength of 880 nm.
1. Obtaining a standard value:
1-1 infrared
1-2 as shown in fig. 9, the
The 1-3
1-4 in a constant temperature room, the environmental temperature is from 0 ℃ to 40 ℃, and the blood leakage detector records the yellow-green light standard value Syg and the infrared light standard value Sir at the temperature, so as to obtain a group of standard value data from 0 ℃ to 40 ℃ and form a query table.
1-5, calculating the current standard value according to the current temperature inquiry and a difference value calculation method.
2. Measuring
2-1 the infrared
The 2-2
The 2-3
As shown in FIG. 10, it is clear from the hemoglobin absorbance curve that hemoglobin absorbs light having a wavelength of 570nm more and absorbs light having a wavelength of 880nm less. When blood leakage occurs, hemoglobin becomes oxyhemoglobin, so that the yellow-green light luminance value Byg changes significantly, while the infrared light luminance value Bir does not change significantly.
2-4 searching for a standard value at the corresponding temperature,
if Byg < Syg × Cyg
And Bir > Sir x Cir,
it can be determined that blood leakage has occurred.
Where Syg is a standard value of yellow-green light brightness, Sir is a standard value of infrared light brightness, Cyg is a determination coefficient of yellow-green light brightness, and Cir is a determination coefficient of infrared light brightness.
3. Cyg calculation of the brightness determination coefficient of yellow-green light and Cir calculation of the brightness determination coefficient of infrared light
3-1, according to different detection precision requirements, taking 10 samples with different oxygen absorption degrees in blood, respectively filling
3-2 reads the brightness value of yellow-green light at this time as Lyg, and reads the brightness value of infrared light as Lir.
3-3 calculation of Cyg yellow-green light brightness determination coefficient and Cir calculation of infrared light brightness determination coefficient
Cyg＝Lyg÷Syg
Cir＝Lir÷Sir
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications are possible which remain within the scope of the appended claims.
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