阅读说明：本技术 一种3d打印的伤口定制化的创可贴的制备方法 (Preparation method of 3D-printed wound customized band-aid ) 是由 许太林 何学成 张学记 于 2019-09-25 设计创作，主要内容包括：本发明属于卫生用品领域,具体涉及一种3D打印的契合外伤伤口大小、形状和受伤部位的创口贴的3D打印的伤口定制化的创可贴的制备方法。所述的伤口定制化程序包括伤口形状和受伤部位的图像信息采集,计算机图像识别和建模生成模型文件以匹配伤口的形状,大小和受伤部位；模型文件经3D打印生成创可贴基材。所述的创可贴基材可集成抗菌、凝血、保湿、透气、消炎等一种或多种功能以加速伤口愈合；本发明提供的这种3D打印的伤口定制化的创可贴既能贴合不同的受伤部位,又能契合伤口的轮廓和大小。创口贴形状可调,敷药精准,制作简单,方便快捷,特别适用于对不同形状和不同部位外伤伤口的精准治疗。(The invention belongs to the field of sanitary products, and particularly relates to a preparation method of a 3D-printed wound bandage with customized wound, which is matched with the size and shape of an traumatic wound and the wound of an injured part. The wound customization program comprises the steps of collecting image information of the shape and the injured part of the wound, and generating a model file by computer image recognition and modeling so as to match the shape, the size and the injured part of the wound; and 3D printing the model file to generate the base material of the band-aid. The adhesive bandage base material can integrate one or more functions of antibiosis, blood coagulation, moisture preservation, ventilation, inflammation diminishing and the like to accelerate wound healing; the wound customized woundplast printed in 3D mode provided by the invention can be attached to different wounded parts and can be matched with the outline and size of a wound. The shape of the adhesive bandage is adjustable, the medicine application is accurate, the manufacture is simple, the operation is convenient and fast, and the adhesive bandage is particularly suitable for the accurate treatment of trauma wounds with different shapes and different positions.)

1. A preparation method of a 3D printed wound customized band-aid is characterized by comprising the following steps:

s1) acquiring image information of the wound or the injured part;

s2) processing the image information acquired in S1) to generate a three-dimensional model matched with the corresponding wound shape;

s3) preparing printing paste;

s4) 3D printing the slurry of S3) according to the three-dimensional model of S2) to form an active substrate;

s5) assembling an adhesive back lining layer on the active substrate obtained in the step S4 to obtain the wound customized band-aid.

2. The preparation method according to claim 1, wherein the specific steps of S1) are as follows: and a scanner or other intelligent equipment is adopted to collect image information of the wound to be treated, and the collected image information is sent to the PC.

3. The preparation method according to claim 2, wherein the specific steps of S2) are as follows:

s2.1) determining coordinate data of the wound contour by sequentially carrying out black-and-white processing, binarization processing and eight-connectivity method on the received image information, and generating a two-dimensional vector diagram of the wound contour by tracing the obtained coordinate data;

and S2.2) importing the two-dimensional vector diagram for generating the wound outline into the system, generating a three-dimensional model matched with the corresponding wound shape by using an extrusion command, storing the three-dimensional model in an STL file format, storing the three-dimensional model in an SD card, and printing the three-dimensional model.

4. The preparation method according to claim 1, wherein the specific steps of S3) are as follows:

s3.1) adding the nano particle material subjected to drug modification selection into deionized water to prepare an aqueous solution;

s3.2) adding gelatin into deionized water, heating and carrying out ultrasonic treatment to obtain a gelatin solution;

s3.3) respectively measuring the aqueous solution prepared in the S3.1) and the gelatin solution obtained in the S3.2) and pouring the aqueous solution and the gelatin solution into a container, and carrying out oil bath light-proof magnetic stirring at the temperature of 90-110 ℃ for 25-35min to form the gelatin solution doped with the nano particles in situ;

s3.4) carrying out ultrasonic treatment on the gelatin solution for 25-35min, and storing the cooled slurry in a dark place for subsequent printing.

5. The preparation method according to claim 1, wherein the specific steps of S4) are as follows:

s4.1) heating the slurry prepared in the step S3) to 33-39 ℃ to be melted, and then sending the melted slurry into a printer to start printing;

and S4.2) gradually cooling the slurry solution after layered printing for re-solidification, accumulating layer by layer to form a mixed solution which is dripped on the model after printing is finished, and obtaining a fully solidified active base material after 15-25 min.

6. The preparation method according to claim 5, wherein the specific steps of S5) are as follows:

s5.1) selecting a backing layer according to the wound type, and fixing the backing layer on an inner cavity of the PCL backing layer;

s5.2) transferring and fixing the active substrate prepared in the step S4) on the inner cavity of the PCL backing layer to complete the assembly.

7. The preparation method according to claim 5, wherein the mixed solution is a solution of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide in ethanol in a mass ratio of 5: 2.

8. the preparation method according to claim 6, wherein the wound determination in S5) comprises the following specific steps: for wounds with flat parts, the adhesive backing layer is one or more of a pressure-sensitive bandage, an adhesive tape and a film; for a wound site with a complex curved surface structure, the adhesive backing layer is generated by 3D printing after scan modeling of the wound site.

9. The preparation method according to claim 4, wherein the nanoparticle material in S3.1) is a material with one or more functions of sterilization, blood coagulation, moisture retention, air permeability and inflammation diminishing, and includes but is not limited to silver nitrate, titanium dioxide, benzalkonium chloride and hyaluronic acid.

10. A wound-customized adhesive bandage, characterized in that it is prepared by the method according to any one of claims 1-9.

Technical Field

The invention belongs to the field of sanitary products, and particularly relates to a preparation method of a 3D-printed wound bandage with customized wound, which is matched with the size and shape of an traumatic wound and the wound of an injured part.

Background

The skin is the largest organ of the human body and is the primary barrier isolating the internal environment of the human body from the external environment. Wounds (particularly surgical wounds) are the rapid reactions of the human body after injuries such as cuts, lacerations and the like. Effective diagnostic and therapeutic measures are taken, which are crucial to reducing mortality and morbidity from wound infections: the wound is effectively and timely treated, and can be quickly healed; on the contrary, the patients may be suppurative and infected, and even cause systemic infection, which endangers life. The use of wound dressings is an effective method of treating wounds. As a mature commercial wound dressing product, the medical adhesive bandage can play the basic functions of diminishing inflammation, stopping bleeding and protecting wounds of the wounds, and is convenient, effective and quick. However, the size and the style of the existing band-aid are quite monotonous, the band-aid is not matched with the shape of a wound or cannot take all the wounds into consideration, and part of the wound surface is still exposed; or over-covering the wound, causing the skin surrounding the wound to turn white and soft and secondary infections. In addition, the wound dressings on the market have single appearance, and for wounds of some special parts such as heels, elbows, fingers and the like, the wound dressings in common shapes are difficult to be completely fixed and attached, so that accurate and effective treatment effects cannot be realized.

The 3D printing technology can directly generate entities with any geometric shapes by utilizing a pre-designed computer digital model file in a layer-by-layer printing mode without an original blank or a model, thereby greatly shortening the production period of products, effectively improving the production rate and reducing the production cost. In recent years, with the continuous increase of precise and personalized medical requirements, the 3D printing technology plays an increasingly important role in the medical field. For example, 3D printing has been widely used to customize medical devices (hearing aid housings, complex surgical devices and 3D printed pharmaceuticals), human organs (teeth, blood vessels, liver, muscle tissue). It has become possible to use 3D printed wound dressings for wound care of specific shapes and sizes. The Chinese invention (application No. 201710340553.5) introduces a bandage printer which can print out a bandage at any time by drawing a required shape on a display screen when the bandage is needed. However, the hand-painted and printed band-aid cannot well match the real wound shape and the outline of the injured part, and a great improvement space exists.

Disclosure of Invention

In order to solve the problems, the invention provides a 3D printed wound customized band-aid. The adhesive bandage printed by the 3D printed adhesive bandage has the advantages of integration, high wound matching degree, accurate administration and the like, and an efficient and feasible scheme is provided for accurate and personalized nursing of wounds. The invention has the advantages that the woundplast which is fit with the wound shape and the wound part is printed in a customized manner, unnecessary wound exposure or covering is reduced, and meanwhile, the woundplast can be more closely attached to the wound part and can be printed for use at any time.

The invention is realized by the following technical scheme: a preparation method of a 3D printed wound customized band-aid specifically comprises the following steps:

s1) acquiring wound image information or an image of the injured part;

s2) processing the image information acquired in S1) to generate a three-dimensional model matched with the corresponding wound shape;

s3) preparing printing paste;

s4) 3D printing the slurry of S3) according to the three-dimensional model of S2) to form an active substrate;

s5) assembling an adhesive back lining layer on the active substrate obtained in the step S4 to obtain the wound customized band-aid.

Further, the specific steps of S1) are: and a scanner or other intelligent equipment is adopted to acquire image data of the wound to be treated, and the acquired image data is acquired and sent to the PC.

Further, the specific steps of S2) are:

s2.1) determining coordinate data of the wound contour by sequentially carrying out black-and-white processing, binarization processing and eight-connectivity method on the received image information, and generating a two-dimensional vector diagram of the wound contour by tracing the obtained coordinate data;

and S2.2) importing the two-dimensional vector diagram for generating the wound outline into the system, generating a three-dimensional model matched with the corresponding wound shape by using an extrusion command, storing the three-dimensional model in an STL file format, storing the three-dimensional model in an SD card, and printing the three-dimensional model.

Further, the specific steps of S3) are:

s3.1) adding the nano particle material subjected to drug modification selection into deionized water to prepare an aqueous solution;

s3.2) adding gelatin into deionized water, heating and carrying out ultrasonic treatment to obtain a gelatin solution;

s3.3) respectively measuring the aqueous solution prepared in the step S3.1) and the gelatin solution obtained in the step S3.2) by using a micro-pipette, pouring the aqueous solution and the gelatin solution into a container, carrying out oil bath and light-proof magnetic stirring at the temperature of 90-110 ℃ for 25-35min, and forming the gelatin solution doped with the nano particles in situ;

s3.4) carrying out ultrasonic treatment on the gelatin solution for 25-35min, and storing the cooled slurry in a dark place for subsequent printing.

Further, the specific steps of S4) are:

s4.1) heating the slurry prepared in the S3 to 33-39 ℃ to be melted, and then sending the melted slurry into a printer to start printing;

and S4.2) gradually cooling the slurry solution after layered printing for re-solidification, accumulating layer by layer to form a mixed solution which is dripped on the model after printing is finished, and obtaining a fully solidified active base material after 15-25 min.

Further, the specific steps of S5) are:

s5.1) selecting a backing layer according to the wound type, and fixing the backing layer on an inner cavity of the PCL backing layer;

s5.2) transferring and fixing the active substrate prepared in the step S4) on the inner cavity of the PCL backing layer to complete the assembly.

Further, the mixed solution is 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and an ethanol solution of N-hydroxysuccinimide in a mass ratio of 5: 2.

further, the wound determination in S5) includes: for wounds with a common flat part, the adhesive backing layer is one or more of a pressure-sensitive bandage, an adhesive plaster and a film; for a wound site with a complex curved surface structure, the adhesive backing layer is generated by 3D printing after scan modeling of the wound site.

Further, the nanoparticle material in S3.1) is a material with one or more functions of sterilization, blood coagulation, moisture retention, air permeability and inflammation diminishing, including but not limited to silver nitrate, titanium dioxide, benzalkonium chloride and hyaluronic acid.

The wound customized band-aid is prepared by adopting the method.

The invention has the beneficial effects that: due to the adoption of the technical scheme, the 3D-printed wound customized band-aid provided by the invention can be attached to different injured parts and can be matched with the outline and size of a wound. The shape of the adhesive bandage is adjustable, the medicine application is accurate, the manufacture is simple, the operation is convenient and fast, and the adhesive bandage is particularly suitable for the accurate treatment of trauma wounds with different shapes and different positions.

Drawings

The invention will be further explained with reference to the drawings

Fig. 1 is a schematic view of wound identification provided in an embodiment of the present invention.

FIG. 2 is an image identification and modeling diagram of different wound shapes provided by an embodiment of the present invention.

Fig. 3 is a schematic view of a 3D printed woundplast substrate according to an embodiment of the invention.

Fig. 4 is a graph showing the bactericidal effect of the 3D printed gelatin-based hydrogel substrate with moisturizing function provided by the embodiment of the invention.

Fig. 5 is a graph showing the swelling ratio of a 3D-printed gelatin-based hydrogel with bactericidal function according to an embodiment of the present invention as a function of time.

Fig. 6 is a schematic view of a 3D printed fingertip-fitted adhesive backing layer provided by an embodiment of the present invention.

Fig. 7 is a schematic view illustrating that the 3D printed band-aid provided by the embodiment of the invention is firmly attached to a fingertip.

Detailed description of the preferred embodiments

In order to facilitate the technical means, creation features, achievement of the purpose and the efficacy of the invention, the invention is further explained by combining the specific implementation examples. It should be noted that the present invention is not limited by the above-mentioned embodiments, and the embodiments and descriptions are only for illustrating the principle of the present invention, and various changes and modifications of the present invention are possible without departing from the spirit and scope of the present invention, which fall within the scope of the claimed invention. The scope of the invention is defined by the appended claims and equivalents thereof.

The invention relates to a preparation method of a 3D-printed wound customized woundplast, which specifically comprises the following steps:

s1) acquiring wound image information or an image of the injured part;

s2) processing the image information acquired in S1) to generate a three-dimensional model matched with the corresponding wound shape;

s3) preparing printing paste;

s4) 3D printing the slurry of S3) according to the three-dimensional model of S2) to form an active substrate;

s5) assembling an adhesive back lining layer on the active substrate obtained in the step S4), and obtaining the wound customized band-aid.

Further, the specific steps of S1) are: and a scanner or other intelligent equipment is adopted to collect image information of the wound to be treated, and the collected image information is sent to the PC.

Further, the specific steps of S2) are:

s2.1) determining coordinate data of the wound contour by sequentially carrying out black-and-white processing, binarization processing and eight-connectivity method on the received image information, and generating a two-dimensional vector diagram of the wound contour by tracing the obtained coordinate data;

and S2.2) importing the two-dimensional vector diagram for generating the wound outline into the system, generating a three-dimensional model matched with the corresponding wound shape by using an extrusion command, storing the three-dimensional model in an STL file format, storing the three-dimensional model in an SD card, and printing the three-dimensional model.

Further, the specific steps of S3) are:

s3.1) adding the nano particle material subjected to drug modification selection into deionized water to prepare an aqueous solution;

s3.2) adding gelatin into deionized water, heating and carrying out ultrasonic treatment to obtain a gelatin solution;

s3.3) respectively measuring the aqueous solution prepared in the S3.1) and the gelatin solution obtained in the S3.2) and pouring the aqueous solution and the gelatin solution into a container, and carrying out oil bath light-proof magnetic stirring at the temperature of 90-110 ℃ for 25-35min to form the gelatin solution doped with the nano particles in situ;

s3.4) carrying out ultrasonic treatment on the gelatin solution for 25-35min, and storing the cooled slurry in a dark place for subsequent printing.

Further, the specific steps of S4) are:

s4.1) heating the gelatin solution prepared in the step S3 to 33-39 ℃ to melt, and then sending the gelatin solution into a printer to start printing;

s4.2) gradually cooling the gelatin solution after layered printing for re-solidification, accumulating layer by layer to form a mixed solution which is dripped on the model after printing is finished, and obtaining a fully solidified active base material after 15-25 min.

Further, the specific steps of S5) are:

s5.1) selecting a backing layer according to the wound type, and fixing the backing layer on an inner cavity of the PCL backing layer;

s5.2) transferring and fixing the active substrate prepared in the step S4) on the inner cavity of the PCL backing layer to complete the assembly.

Further, the mixed solution is 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and an ethanol solution of N-hydroxysuccinimide in a mass ratio of 5: 2.

further, the wound determination in S5) includes: for wounds with a common flat part, the adhesive backing layer is one or more of a pressure-sensitive bandage, an adhesive plaster and a film; for a wound site with a complex curved surface structure, the adhesive backing layer is generated by 3D printing after scan modeling of the wound site.

Further, the nanoparticle material in S3.1) is a material with one or more functions of sterilization, blood coagulation, moisture retention, air permeability and inflammation diminishing, including but not limited to silver nitrate, titanium dioxide, benzalkonium chloride and hyaluronic acid.

The wound customized band-aid is prepared by adopting the method.