阅读说明：本技术 电极脑回标尺图的制作方法 (Method for making electrode brain gyrometer diagram ) 是由 高润石 王雪原 任志伟 张国君 遇涛 李勇杰 徐翠萍 杜薇 于 2019-09-17 设计创作，主要内容包括：本发明涉及一种电极标尺图的制作方法,包括：S1、将已埋置电极的患者术后CT薄层扫描进行配准,使得配准后的术后CT与MPR核磁序列处于同一标准空间；S2、将术前MPR核磁序列进行皮层分割,并将不同脑回分别进行标记得到皮层分割模板；S3、将术后CT、术前MRP核磁序列和皮层分割模板导入3D Slicer软件,分别调整透明度；S4、利用3D Slicer软件沿电极长轴对脑部图像进行切割,使该电极的所有电极点都显示在脑部图像的同一平面上,并将显示在同一平面的脑部图像截图后进行图片编辑；S5、图片编辑软件导入空白模板,将所有电极在空白模板相应位置纵向等间距依次连续排列得到电级脑回标尺图。(The invention relates to a method for manufacturing an electrode ruler picture, which comprises the following steps: s1, registering the postoperative CT thin-layer scanning of the patient with the embedded electrode, so that the registered postoperative CT and the registered MPR nuclear magnetic sequences are in the same standard space; s2, performing cortex segmentation on the MPR nuclear magnetic sequence before the operation, and marking different gyrus respectively to obtain cortex segmentation templates; s3, importing a post-operation CT, a pre-operation MRP nuclear magnetic sequence and a cortex segmentation template into 3D Slicer software, and respectively adjusting transparency; s4, cutting the brain image along the long axis of the electrode by using 3D Slicer software, displaying all electrode points of the electrode on the same plane of the brain image, and editing pictures after screenshot the brain image displayed on the same plane; and S5, importing the blank template by the picture editing software, and sequentially and continuously arranging all the electrodes at the corresponding positions of the blank template at equal intervals in the longitudinal direction to obtain the computer gyrometer diagram.)

1. A method for making an electrode gyrometer diagram is characterized by comprising the following steps:

s1, registering the postoperative CT thin-layer scanning of the patient with the embedded electrode, wherein the registration template is a preoperative MPR nuclear magnetic sequence, and the post-registered postoperative CT and MPR nuclear magnetic sequences are in the same standard space;

s2, performing cortex segmentation on the MPR nuclear magnetic sequence before the operation, and marking different gyrus respectively to obtain cortex segmentation templates;

s3, guiding the post-operation CT, the pre-operation MRP nuclear magnetic sequence and the cortex segmentation template into 3D Slicer software, and respectively adjusting the transparency to enable the electrode position and the cortex region to be visible;

s4, cutting the brain image along the long axis of the electrode by using 3D Slicer software, displaying all electrode points of the electrode on the same plane of the brain image, and editing pictures after screenshot the brain image displayed on the same plane;

and S5, importing the blank template by the picture editing software, and sequentially and continuously arranging all the electrodes at the corresponding positions of the blank template at equal intervals in the longitudinal direction to obtain an electronic brain gyrometer diagram for judging the relation between the brain deep electrodes of the stereotactic electroencephalogram and the brain sulcus positions.

2. The method of claim 1, further comprising the step of constructing an electroencephalogram interpretation interface by using an electronic-grade echocardiogram, wherein the left side of the constructed electroencephalogram interpretation interface is the name of anatomical sulci, the middle is a planogram of the positions of the equally-spaced electrodes and the sulci, and the right side is an electroencephalogram, and the name of the sulci, the electrodes and the electroencephalogram of each row correspond to one another.

3. The method of claim 1, wherein the intersection of the plane obtained in step S4 and the coronal plane is a horizontal line, and when the electrodes are not parallel to the coronal plane, there is one or more of such planes; when the electrode is parallel to the coronal plane, the coronal plane passing through the electrode is taken directly.

4. The manufacturing method according to any one of claims 1 to 3, wherein the specific process of guiding the post-operative CT, the pre-operative MRP nuclear magnetic sequence and the cortex segmentation template into the 3D Slicer software and respectively adjusting the transparency comprises the following steps:

and (3) postoperative CT: opacity 20%, window width 1100, gray scale 1200;

preoperative MRP nuclear magnetic sequence: opacity 100%, window width 400, gray scale 200;

a cortex segmentation template: opacity 10%.

5. The method of any one of claims 1 to 3, wherein in step S2, freesurfer software is used to perform cortical segmentation on the pre-operative MPR nuclear magnetic sequence.

6. The method of any of claims 1-3, wherein CT thin layer scanning of the patient with embedded electrodes is performed in registration using a registration module of SMP 12.

7. The production method according to any one of claims 1 to 3, wherein the picture editing software is Photoshop software.

Technical Field

The invention relates to a method for making an electrode gyrometer diagram, and relates to the technical field of epileptic surgery.

Background

Epidemiological survey shows that the prevalence rate of epilepsy in China is 6.8 per thousand, and at least 20-30% of nearly 1000 ten thousand patients with epilepsy are drug-refractory epilepsy, and surgical assessment needs to be considered for the partial patients. Stereotactic electroencephalogram (SEEG) is an invasive electrophysiological examination which is rapidly popularized recently, and plays an important role in diagnosis and treatment of epilepsy and preoperative evaluation, and is also a main means for accurately positioning epileptic regions. The main advantages of SEEG are that the number of implanted electrodes and the position limitation are relatively small, but a problem is caused at the same time, and the electrode group with complex position relation is difficult to display in a common plane display mode. SEEG signal analysis often needs to depend on the image reading experience of an analyst for many years, has high requirements on the memory, the space imagination and the neuroanatomy knowledge of the analyst, and also becomes a threshold for young doctors to learn the pre-operation evaluation of epilepsy.

① shows the whole electrode distribution (as figure 1) by combining the inner side view and the convex side view of the hemisphere, ② shows the specific position of each electrode point (figure 2) by the two-dimensional picture of postoperative CT/preoperative MRI image fusion, the combination of the two modes can show the electrode position from the whole and the local, accords with the reading habit of the conventional image, but does not accord with the electroencephalogram reading habit.

Disclosure of Invention

In view of the above problems, the present invention provides a method for making an electrode gyrometer diagram, which can display the electrode positions according to the electroencephalogram reading habit, so that an electroencephalogram analyst can obtain the electrode gyrometer diagram by side view when needing to look up the electrode positions.

In order to achieve the purpose, the invention adopts the following technical scheme: a method for making an electrode gyrometer plot, the method comprising:

s1, registering the postoperative CT thin-layer scanning of the patient with the embedded electrode, wherein the registration template is a preoperative MPR nuclear magnetic sequence, and the post-registered postoperative CT and MPR nuclear magnetic sequences are in the same standard space;

s2, performing cortex segmentation on the MPR nuclear magnetic sequence before the operation, and marking different gyrus respectively to obtain cortex segmentation templates;

s3, guiding the post-operation CT, the pre-operation MRP nuclear magnetic sequence and the cortex segmentation template into 3D Slicer software, and respectively adjusting the transparency to enable the electrode position and the cortex region to be visible;

s4, cutting the brain image along the long axis of the electrode by using 3D Slicer software, displaying all electrode points of the electrode on the same plane of the brain image, and editing pictures after screenshot the brain image displayed on the same plane;

and S5, importing the blank template by the picture editing software, and sequentially and continuously arranging all the electrodes at the corresponding positions of the blank template at equal intervals in the longitudinal direction to obtain an electronic brain gyrometer diagram for judging the relation between the brain deep electrodes of the stereotactic electroencephalogram and the brain sulcus positions.

The electroencephalogram interpretation method comprises the following steps of constructing an electroencephalogram interpretation interface through an electronic-grade echocardiogram, wherein the left side of the constructed electroencephalogram interpretation interface is the name of anatomical sulci, the middle of the constructed electroencephalogram interpretation interface is a planogram with electrodes and sulci positions arranged at equal intervals, the right side of the constructed electroencephalogram interpretation interface is an electroencephalogram, and the name of each row of sulci, the electrodes and the electroencephalogram are in one-to-one correspondence.

Further, the intersection line of the plane and the coronal plane obtained in the above step S4 is a horizontal line, and when the electrode is not parallel to the coronal plane, there is only one such plane; when the electrode is parallel to the coronal plane, the coronal plane passing through the electrode is taken directly.

Further, guiding the post-operation CT, the pre-operation MRP nuclear magnetic sequence and the cortex segmentation template into 3D Slicer software, and respectively adjusting the transparency specifically comprises the following steps:

and (3) postoperative CT: opacity 20%, window width 1100, gray scale 1200;

preoperative MRP nuclear magnetic sequence: opacity 100%, window width 400, gray scale 200;

a cortex segmentation template: opacity 10%.

Further, in step S2, freesurfer software is used to perform cortical segmentation on the preoperative MPR nuclear magnetic resonance imaging (MPR).

Further, registration of CT thin layer scans of patients with embedded electrodes employed a registration module of SMP 12.

Further, the photo editing software adopts Photoshop software.

Due to the adoption of the technical scheme, the invention has the following advantages: the electrode gyrometer diagram manufactured by the invention can display the position of each electrode in a continuous form, all the electrodes are sequentially and continuously arranged at equal intervals, the mode is consistent with the conventional electroencephalogram interpretation habit, the electrode scalometer diagram can be directly used for replacing the conventional digital serial number, so that electroencephalogram analysts can look over the positions of the electrodes when needing to look over, and the electroencephalogram analysts can directly observe electric signals generated by the cortex, thereby saving the working time and avoiding errors caused by complicated operation.

Drawings

FIG. 1 is a prior art illustration of a global electrode distribution;

FIG. 2 is a schematic view showing electrode points along a long axis one by one in ROSA robot and Meidun force neuronavigation in the prior art;

FIG. 3 is a schematic diagram illustrating a process of making an electrode gyrometer diagram according to the present embodiment;

FIG. 4 is a partial schematic view of the electrode gyrometer of the present embodiment;

fig. 5 is an electroencephalogram interpretation interface configured to cooperate with an electroencephalogram in the present embodiment.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.

As shown in fig. 3, the method for manufacturing an electrode gyrophora ruler map provided in this embodiment includes the following specific steps:

1. because the CT and the nuclear magnetic scan are at different times, the head of the patient is located at different positions in space, and the 3D brain positions of the reconstructed image sequence are different, the CT and the nuclear magnetic scan need to be fused and registered. Specifically, a registration module in SMP12(http:// www.fil.ion.ucl.ac.uk/spm /) can be used for registration, and post-operation CT thin-layer scanning of a patient with embedded electrodes is performed, wherein the registration module is a pre-operation MPR nuclear magnetic sequence, and the post-operation CT sequence obtained by registration fusion should be in the same standard space with MPR.

2. And performing cortex segmentation on the preoperative MPR nuclear magnetic sequence by using freesurfer software, and marking different gyrus respectively to obtain a cortex segmentation template.

3. Importing the three layers into 3D slicer software, respectively adjusting the transparencies of the three layers to make the electrode position and the cortical region visible, and the method specifically comprises the following steps:

first layer post-operative CT opacity 20% Window width (Window): 1100 gray Level (Level): 1200;

second layer preoperative MRP nuclear magnetic sequence opacity 100% Window width (Window): 400 gray Level (Level): 200 of a carrier;

the third layer cortex segmentation template opacity is 10%.

4. And (3D Slicer software is utilized to re-cut the brain image along the long axis of the electrode, so that all electrode points of the electrode are displayed on the same plane of the brain image, and the brain image displayed on the same plane is subjected to screenshot and then subjected to picture editing.

5. The image editing software is led into a blank template, all electrodes are sequentially and continuously arranged at the corresponding positions of the blank template at equal intervals in the longitudinal direction to obtain a computer-grade brain gyrometer diagram, as shown in fig. 4, wherein the electrode brain gyrometer diagram is used for conveniently and accurately judging the relation between the brain deep electrodes and the sulcus gyrometer positions of the stereotactic electroencephalogram, and the method is characterized in that all the electrodes are sequentially and continuously arranged at equal intervals.

In a preferred embodiment, for the step of re-cutting along the long axis of the electrode, since any number of planes can be made through a straight line in space, which is easily ambiguous, this embodiment provides that the intersection line of the obtained plane and the coronal plane is a horizontal line. Such planes are one and only one when the electrodes are not parallel to the coronal plane, and taken directly through the coronal plane of the electrodes when the electrodes are parallel to the coronal plane. This has the advantage that the planes taken are all planes with bilateral symmetry, which is helpful for identifying the gyrus structure.

In a preferred embodiment, an electroencephalogram interpretation interface can be formed by an electronic grade echocardiogram ruler, as shown in fig. 5, for conveniently and accurately interpreting the relationship between the stereotactic electroencephalogram waveform, the stereotactic electroencephalogram deep brain electrode position and the anatomical brain gyrus, the left side of the electroencephalogram interpretation interface is the name of the anatomical brain gyrus, the middle is a plane diagram of the positions of the equally spaced electrodes and the anatomical brain gyrus, the right side is the electroencephalogram, and the name of the brain gyrus, the electrode and the electroencephalogram of each row are in one-to-one correspondence.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope thereof, and although the present application is described in detail with reference to the above embodiments, those of ordinary skill in the art should understand that: numerous variations, modifications, and equivalents will occur to those skilled in the art upon reading the present application and are within the scope of the claims appended hereto.