阅读说明：本技术 固相萃取用微型装置 (Micro device for solid phase extraction ) 是由 诸葛善英 金大宪 金炳贤 尹汝荣 阵耿珠 崔峻源 韩秀妍 于 2018-10-12 设计创作，主要内容包括：本发明涉及一种固相萃取用微型装置,更具体地,提供一种被配置成通过注入填料和溶剂并产生均匀的溶剂流动来进行固相萃取的微型装置。(The present invention relates to a micro device for solid phase extraction, and more particularly, to a micro device configured to perform solid phase extraction by injecting a filler and a solvent and generating a uniform solvent flow.)

1. A micro-device for solid phase extraction, comprising:

an inlet for injecting a solvent and a filler;

an outlet for discharging the solvent; and

a dam formation between the inlet and the outlet, the dam formation comprising a dam that only allows the solvent to flow through but not the filler,

wherein each of the dam formation portion and the dam has a circular cross section with respect to a central axis in a direction extending along the inlet, the cross section being perpendicular to the central axis, and wherein the filler is filled in the dam formation portion in a disc shape with respect to the central axis.

2. The micro-device for solid phase extraction according to claim 1, wherein each of the inlet, the outlet, the dam formation portion, and the dam has a circular cross section with respect to the central axis in the direction extending along the inlet, the cross section being perpendicular to the central axis, and

wherein each of a diameter of the inlet and a diameter of the outlet is less than a diameter of the dam formation.

3. The micro-device for solid phase extraction according to claim 1, wherein the micro-device for solid phase extraction has a first end connected to the inlet and a second end connected to the outlet, the first end and the second end being both ends of the dam formation portion, wherein the dam is located at a position closer to the second end than the first end, and the dam is located at a predetermined distance from the second end.

4. The micro-device for solid phase extraction according to claim 3, wherein each of a shape of the second end portion and a shape of a surface of the dam facing the second end portion has a shape protruding toward the outlet.

5. The micro-device for solid phase extraction according to claim 4, wherein the shape of the second end and the shape of the surface of the dam facing the second end are conical.

6. The micro device for solid phase extraction according to claim 1, wherein the filler is a bead.

7. The micro-device for solid phase extraction according to claim 1, wherein the micro-device has an overall diameter of 25mm to 32mm and an overall length of 10 mm.

8. The micro-device for solid phase extraction according to claim 7,

wherein the filler has a diameter of 35 to 60 μm,

the diameter of the inlet is 0.5mm to 10mm, the length of the inlet is 5mm,

the diameter of the outlet is 0.5mm to 10mm, the length of the outlet is 5mm,

a length from the first end of the dam forming part to a surface of the dam facing the first end is 0.2mm to 0.3mm,

a length from the surface of the dam facing the first end to the second end of the dam forming part is 100 to 150 μm, and

the length of the dam is 30 to 35 μm.

Technical Field

This application claims the benefit of priority from korean patent application No. 10-2017-.

The present invention relates to a micro-device for solid phase extraction, and more particularly, to a micro-device capable of performing solid phase extraction by injecting a filler and a solvent.

Background

Solid phase extraction is a method of adsorbing a target material using a filler having specific properties, such as beads, and purifying and concentrating the target material using a solvent for pretreatment. In this case, a device for packing the pad is required. A small-sized micro-device is used to improve the recovery rate and shorten the pretreatment time. In addition, micro devices are used to detect trace materials. The use of a micro device has the advantage of environmental protection, since it can reduce solvent consumption.

The shape of the conventional micro-device 1 for solid-phase extraction is shown in FIGS. 4a and 4 b. A dam 2 is provided inside the micro device 1 so that the beads 3 cannot pass through but only the fluid flows through. At this time, the flow path is reduced due to the beads accumulating at the rear of the dam, and thus a pressure difference is generated. The smaller the porosity, the larger the pressure difference. In the conventional microdevice of fig. 4a and 4b, dams are installed at the left, right, and center of the device. Therefore, a large amount of fluid flows in the left-right direction, in which the filling distance of the beads is relatively short. As a result, an uneven flow distribution of the fluid is produced.

Disclosure of Invention

Technical problem

In order to solve the problem of uneven flow distribution of fluid in the conventional micro-device for solid phase extraction, a novel micro-device for solid phase extraction is required, which can achieve uniform extraction by flowing fluid at a uniform flow rate.

Technical scheme

The micro-device for solid phase extraction according to the present invention includes:

an inlet for injecting a solvent and a filler;

an outlet for discharging solvent; and

a dam formation between the inlet and the outlet, the dam formation comprising a dam that only allows solvent to flow through but not filler,

wherein each of the dam formation part and the dam has a circular cross section with respect to a central axis in a direction extending along the inlet, the cross section being perpendicular to the central axis, and wherein the filler is filled in the dam formation part in a disc shape with respect to the central axis.

In addition, in the micro-device for solid phase extraction according to the present invention, each of the inlet, the outlet, the dam formation part, and the dam may have a circular cross section with respect to a central axis in a direction in which the inlet extends, the cross section being perpendicular to the central axis, and each of a diameter of the inlet and a diameter of the outlet may be smaller than a diameter of the dam formation part.

In addition, the micro-device for solid phase extraction has a first end portion connected to the inlet and a second end portion connected to the outlet, the first end portion and the second end portion being both ends of the dam forming portion, wherein the dam may be located at a position closer to the second end portion than the first end portion, and the dam may be located at a predetermined distance from the second end portion.

In addition, in the micro-device for solid phase extraction, each of the shape of the second end portion and the shape of the surface of the dam facing the second end portion may have a shape protruding toward the outlet.

In the solid-phase extraction microdevice, the shape of the second end portion and the shape of the surface of the dam facing the second end portion may be conical.

In the micro-device for solid phase extraction, the filler may be beads.

In addition, in the micro-device for solid phase extraction, the total diameter of the micro-device may be 25mm to 32mm, and the total length of the micro-device may be 10 mm.

In addition, in the micro-device for solid phase extraction, the diameter of the filler is 35 to 60 μm,

the diameter of the inlet is 0.5mm to 10mm, the length of the inlet is 5mm,

the diameter of the outlet is 0.5mm to 10mm, the length of the outlet is 5mm,

the length from the first end of the dam-forming portion to the surface of the dam facing the first end is 0.2mm to 0.3mm,

a length from a surface of the dam facing the first end to the second end of the dam forming part is 100 to 150 μm, and

the length of the dam is 30 μm to 35 μm.

Advantageous effects

According to the micro-device for solid phase extraction of the present invention, it is advantageous to form a uniform fluid flow along the central axis of the micro-device for solid phase extraction, thereby achieving uniform solid phase extraction.

Drawings

FIGS. 1a and 1b are front views showing a micro-device for solid phase extraction according to an embodiment of the present invention.

FIG. 2 is a plan view of the solid-phase extraction micro-device shown in FIG. 1 a.

FIG. 3 is a front view of a micro-device for solid-phase extraction according to another embodiment of the present invention.

Fig. 4a and 4b show perspective views of a micro-device for solid phase extraction according to the related art, and show experimental examples of the flow of a solvent and beads.

Detailed Description

The micro-device for solid phase extraction according to the present invention includes:

an inlet for injecting a solvent and a filler;

an outlet for discharging solvent; and

a dam formation between the inlet and the outlet, the dam formation comprising a dam that only allows solvent to flow through but not filler,

wherein each of the dam formation part and the dam has a circular cross section with respect to a central axis in a direction extending along the inlet, the cross section being perpendicular to the central axis, and wherein the filler is filled in the dam formation part in a disc shape with respect to the central axis.

In addition, in the micro-device for solid phase extraction according to the present invention, each of the inlet, the outlet, the dam formation part, and the dam may have a circular cross section with respect to a central axis in a direction in which the inlet extends, the cross section being perpendicular to the central axis, and each of a diameter of the inlet and a diameter of the outlet may be smaller than a diameter of the dam formation part.

In addition, the micro-device for solid phase extraction has a first end portion connected to the inlet and a second end portion connected to the outlet, the first end portion and the second end portion being both ends of the dam forming portion, wherein the dam may be located at a position closer to the second end portion than the first end portion, and the dam may be located at a predetermined distance from the second end portion.

In addition, in the micro-device for solid phase extraction, each of the shape of the second end portion and the shape of the surface of the dam facing the second end portion may have a shape protruding toward the outlet.

In the solid-phase extraction microdevice, the shape of the second end portion and the shape of the surface of the dam facing the second end portion may be conical.

In the micro-device for solid phase extraction, the filler may be beads.

In addition, in the micro-device for solid phase extraction, the total diameter of the micro-device may be 25mm to 32mm, and the total length of the micro-device may be 10 mm.

In addition, in the micro-device for solid phase extraction, the diameter of the filler is 35 to 60 μm,

the diameter of the inlet is 0.5mm to 10mm, the length of the inlet is 5mm,

the diameter of the outlet is 0.5mm to 10mm, the length of the outlet is 5mm,

the length from the first end of the dam-forming portion to the surface of the dam facing the first end is 0.2mm to 0.3mm,

a length from a surface of the dam facing the first end to the second end of the dam forming part is 100 to 150 μm, and

the length of the dam is 30 μm to 35 μm.

Modes for carrying out the invention

Hereinafter, the micro-device for solid phase extraction according to the present invention will be described in detail. The accompanying drawings, which are included to provide a further understanding of the invention, illustrate embodiments of the invention and are not intended to limit the technical scope of the invention.

In addition, the same or corresponding components will be denoted by the same reference numerals regardless of symbols, and a repetitive description thereof will be omitted. The size and shape of each component shown may be exaggerated or minimized for illustrative purposes.

Fig. 1a and 1b show front views of a micro-device 10 for solid phase extraction according to an embodiment of the present invention. The micro-device 10 for solid phase extraction includes an inlet 100, a dam forming portion 200, and an outlet 300. The filler 400 (e.g., beads) and the solvent are injected through the inlet 100, and the injected filler 400 and the solvent move into the dam forming part 200 connected to the inlet 100. The packing 400 is filled in the rear of the dam 210 in the dam forming part 200, and the solvent is discharged through the outlet 300 connected to the dam forming part 200 via the side surface of the dam 210.

The dam forming part 200 of the micro-device for solid phase extraction 10 according to the present invention has a cylindrical shape (or a disk shape having a predetermined length) with a circular cross section. The dam forming part 200 includes a dam 210 at the outlet 300 side. The dam 210 also has a disk shape with a circular cross section. With respect to both ends of the dam forming part having the cylindrical shape, an end of the dam forming part 200 connected to the inlet 100 is referred to as a first end 220, and an end of the dam forming part 200 connected to the outlet 300 is referred to as a second end 230. The dam 210 is located near the second end 230 of the dam formation 200, and the dam 210 is located at a predetermined distance from the second end 230 so that the solvent can flow toward the outlet 300. However, the present invention is not limited to the above. For example, the dam 210 may be made of a porous plate having holes with a size smaller than that of the packing 400 or a mesh structure that does not allow the packing 400 to pass through. In this case, the solvent may flow to the outlet 300 through the dam 210 and the side surface of the dam 210.

The second end 230 protrudes toward the outlet 300 and may have, for example, a conical shape as shown in fig. 1a to minimize resistance due to the second end 230 when the solvent passing through the dam 210 moves toward the outlet 300 in the dam forming part 200. The dam 210 may have a disk shape as described above, but as shown in fig. 1a, the front portion of the dam 210 may also have a conical shape, as well as the second end 230 having a conical shape.

In addition, as shown in fig. 1a, in the case where the diameter of the dam forming part 200 is equal to that of the dam 210, a protrusion 240 is further provided, and in the protrusion 240, a side surface around a portion of the dam forming part 200 where the dam 210 is located further protrudes, so that the protrusion 240 allows the solvent to move between the side surface of the dam 210 and the inner surface of the dam forming part 200. In this case, the diameter of the second end 230 of the dam forming part 200 may be greater than the diameter of the first end 220 of the dam forming part 200. As shown by the flow lines of the solvent in fig. 1a, the solvent may pass between the packing 400, pass through the protrusion 240 of the dam forming part 200, and pass through the space between the second end 230 of the dam forming part 200 and the dam 210, and then move toward the outlet 300.

The solvent inlet 250 has a width smaller than the diameter of the packing 400, and the solvent inlet 250 is an inlet of a space for the solvent to flow between the side surface of the dam 210 and the inner surface of the dam forming part 200.

Fig. 3 is a front view of a micro-device for solid phase extraction 10' according to another embodiment of the present invention, in which the micro-device for solid phase extraction of fig. 1a is partially modified. As shown in fig. 3, if the diameter of the dam 210 ' is smaller than that of the dam formation 200 ', the solvent may pass through the side surface of the dam 210 ', and thus, the dam formation may not require the protrusion. In this case, the width of the solvent inlet 250 ' (which is an inlet of a space for the solvent to flow between the side surface of the dam 210 ' and the inner surface of the dam forming part 200 ') is smaller than the diameter of the filler 400.

Referring again to fig. 1a, as described above, the inlet 100 and the outlet 300 may be connected to the dam formation 200 and formed integrally with the dam formation 200. For example, each of the inlet 100 and the outlet 300 may have a long cylindrical shape. In addition, each of the inlet 100 and the outlet 300 may be located on the same line with respect to a central axis in a length direction of the dam formation 200. Each of the inlet 100 and the outlet 300 has a diameter smaller than that of the dam formation 200.

For example, the size of the micro-device for solid phase extraction 10 is as shown in fig. 1b, the diameter of the micro-device for solid phase extraction 10 (i.e., the diameter of the micro-device 10 including the protrusion 240 of the dam formation part 200) may be 25mm to 32mm, and the total length of the micro-device for solid phase extraction 10 (i.e., the total length of the micro-device including the inlet 100, the dam formation part 200, and the outlet 300) may be about 10.3mm to 10.45mm, and in one embodiment may be about 10 mm. The diameter of the filler 400 may be 35 to 60 μm. The diameter of the inlet 100 may be 0.5mm to 10mm and the length of the inlet 100 may be about 5 mm. The diameter of the outlet 300 may be 0.5mm to 10mm and the length of the outlet 300 may be about 5 mm. The length from the first end 220 of the dam forming part 200 to the rear of the dam 210 (i.e., the length of the region that may be filled with the filler 400) may be 0.2mm to 0.3 mm. The length from the rear of the dam 210 to the second end 230 may be 100 μm to 150 μm. The length of the dam 210 may be 30 μm to 35 μm. The width of the solvent inlet 250 of the protrusion 240 may be 30 to 35 μm to prevent the filler 400 from passing through. The dimensions shown in fig. 1b are for example only, the present invention is not limited thereto, and various modifications and changes may be made according to various environments in which the present invention is implemented.

The packing 400 in the dam forming part 200 is blocked by the dam 210 and cannot be discharged toward the outlet 300, and thus the packing 400 may be filled in the rear of the dam 210. As shown in fig. 2, the packing 400 may be filled in a disc shape at the rear of the dam 210 according to the flow of the solvent. The filling shape of the filler 400 is shown as 200a in fig. 2.

According to the present invention, since the packing 400 generates a similar pressure difference at the same packing distance from the central axis in the longitudinal direction of the dam forming portion 200, a uniform flow distribution of the solvent can be achieved in the micro-device for solid phase extraction 10. Therefore, the dam forming part 200 and the dam 210 are designed to be radially symmetrical (cylindrical) from the central axis so that the packing 400 is filled at the same distance. Therefore, as shown in fig. 2, the region 200a filled with the packing 400 has a disc shape, and the inlet 100 and the outlet 300 are located on the central axis. That is, each of the dam forming part 200 and the dam 210 has a circular cross section perpendicular to a central axis in a direction extending along the inlet 100. In the dam forming portion 200, the filler 400 is filled in a disc shape with respect to the central axis. In this way, when the cross-section is circular, the packing 400 is formed in the same distribution from the central axis of the micro-device for solid phase extraction 10 in the fluid flow direction, thereby eliminating unnecessary volume of the micro-device for solid phase extraction 10 and maximizing the solid phase extraction efficiency.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. It is therefore to be understood that the above embodiments are illustrative in all respects and not restrictive. Furthermore, the scope of the invention is defined by the appended claims rather than the foregoing detailed description. In addition, all changes or modifications derived from the meaning and scope of the claims and equivalents thereof should be construed as being included in the scope of the present invention.

[ description of symbols ]

10 micro device for solid phase extraction

100 inlet 200 dam forming part

210 dam 220 first end

230, second end 240, projection

250 solvent inlet 300 outlet

400 parts of filler