阅读说明：本技术 一种综合抗衰老眼霜及其制备方法 (Comprehensive anti-aging eye cream and preparation method thereof ) 是由 母玉敏 李永生 汪源 邓茂萍 于 2019-11-05 设计创作，主要内容包括：本发明公开了一种综合抗衰老眼霜,按照质量份数,其组成包括：金纽扣花提取物水醇剂3.00～6.00份、微囊包裹活性成分2.00～5.00份、二裂酵母发酵产物溶胞物1.00～3.50份。该产品采用微囊包裹活性成分为微胶囊包裹的大分子透明质酸钠,有效物能渗透表皮层10μm深度,并能缓释营养物；在抗皱测试中显示,该产品具有即时祛皱,在300人使用的测试中,连续使用一月后,眼皱纹可减少25％。其制备步骤包括：1)配置水相、2)配置油相、3)将水相加入油相中,均质,然后加入剩余物质,混合均匀得到综合抗衰老眼霜。该产品的制备过程采用转相乳化法,形成的乳粒在1.0～3.0μm之间,相比于传统乳化法,得到的膏体更细腻且保湿效果更好。(The invention discloses a comprehensive anti-aging eye cream which comprises the following components in parts by weight: 3.00-6.00 parts of a gold button flower extract hydroalcoholic agent, 2.00-5.00 parts of a microcapsule-coated active ingredient and 1.00-3.50 parts of a schizosaccharomyces cerevisiae fermentation product lysate. The product adopts microcapsule-coated active ingredient as macromolecular sodium hyaluronate coated by microcapsule, and effective substance can penetrate into epidermal layer to 10 μm depth and slowly release nutrients; the product was shown to have immediate wrinkle removal in the anti-wrinkle test, and eye wrinkles were reduced by 25% after one month of continuous use in the test of 300 people use. The preparation method comprises the following steps: 1) preparing a water phase, 2) preparing an oil phase, 3) adding the water phase into the oil phase, homogenizing, then adding the rest substances, and uniformly mixing to obtain the comprehensive anti-aging eye cream. The preparation process of the product adopts a phase inversion emulsification method, the formed emulsion particles are 1.0-3.0 mu m, and compared with the traditional emulsification method, the obtained paste is finer and smoother and has better moisturizing effect.)

1. The comprehensive anti-aging eye cream comprises the following components in parts by weight:

the aqueous alcohol agent of the extract of the gold button flower: 3.00-6.00 parts;

microencapsulation of active ingredients: 2.00-5.00 parts;

split yeast fermentation lysate: 1.00-3.50 parts;

the aqueous alcohol agent of the extract of the golden buttonholing comprises the following components in parts by weight: water: 25-50 parts of ethanol: 50-75 parts of a gold button flower extract: 5-10 parts;

the microcapsule wraps active ingredients, and the microcapsule comprises the following components in parts by weight: water: 50-65 parts of sucrose palmitate: 10-25 parts of tocopherol acetate: 5-10 parts of glycerol linoleate: 5-10 parts of sodium hyaluronate: 0.1 to 0.2 portion.

2. The comprehensive anti-aging eye cream of claim 1, wherein: the comprehensive anti-aging eye cream comprises the following components: the extract of the golden button flower is hydroalcoholic agent, the active ingredients are encapsulated by microcapsules, and the lysate of the fermentation product of the yeast is split; the mass ratio of the gold buttonholing extract hydroalcoholic agent to the microcapsule coated active ingredient to the secondary fission yeast fermentation product lysate is 5: 3: 2;

the aqueous alcohol agent of the extract of the golden buttonholing comprises the following components in parts by weight: water: 27 parts of ethanol: 65 parts of a gold button flower extract: 8 parts of a mixture;

the microcapsule wraps active ingredients, and the microcapsule comprises the following components in parts by weight: water: 61.85 parts, sucrose palmitate: 20 parts, tocopherol acetate: 10 parts, glycerol linoleate: 8 parts, sodium hyaluronate: 0.15 part.

3. The comprehensive anti-aging eye cream of claim 1, wherein: the comprehensive anti-aging eye cream comprises the following components in parts by weight:

the liposome emulsifier comprises the following components in parts by weight: hydrogenated soft phospholipid: 58 parts and myristic acid: 3 parts of stearic acid: 8 parts, behenic acid: 15 parts, stearyl alcohol: 8 parts, behenyl alcohol: 8 parts of a mixture;

the fat-endowing active ingredients comprise the following components in parts by mass: jojoba esters: 50-75 parts of green wattle flower wax: 25-50 parts of sunflower seed wax: 1-5 parts of polyglycerol-3: 1-5 parts;

the anticorrosive compound comprises the following components in parts by weight: caprylyl hydroximic acid: 5-8 parts of 1, 3-propylene glycol: 60-70 parts of 1, 2-hexanediol: 30-40 parts of a binder;

the rheology adjusting active component comprises the following components in parts by weight: sodium acrylate/sodium acryloyldimethyl taurate copolymer: 20-30 parts of isohexadecane: 20-40 parts of polysorbate-80: 30-50 parts of a solvent;

the crocus sativus extract hydroalcoholic agent comprises the following components in parts by weight: water: 75-80 parts of propylene glycol: 12-17 parts of crocus sativus extract: 5-10 parts;

the compound essential oil comprises the following components in parts by weight: butter oil: 18-22 parts of rosewood oil: 28-32 parts of geranium oil: 48-52 parts.

4. The comprehensive anti-aging eye cream of claim 3, wherein: the comprehensive anti-aging eye cream comprises the following components in parts by weight:

5. the comprehensive anti-aging eye cream according to claim 3 or 4, wherein: the fat-endowing active ingredients comprise the following components in parts by mass: jojoba esters: 60 parts of green wattle flower wax: 30 parts of sunflower seed wax: 5 parts of polyglycerol-3: 5 parts of the raw materials.

6. The comprehensive anti-aging eye cream according to claim 3 or 4, wherein: the anticorrosive compound comprises the following components in parts by weight: caprylyl hydroximic acid: 5 parts of 1, 3-propylene glycol: 65 parts of 1, 2-hexanediol: 30 parts of.

7. The comprehensive anti-aging eye cream according to claim 3 or 4, wherein: the rheology adjusting active component comprises the following components in parts by weight: sodium acrylate/sodium acryloyldimethyl taurate copolymer: 25 parts of isohexadecane: 30 parts, polysorbate-80: 45 parts of (1); the crocus sativus extract hydroalcoholic agent comprises the following components in parts by weight: water: 77 parts, propylene glycol: 15 parts, saffron extract: 8 parts.

8. The comprehensive anti-aging eye cream according to claim 3 or 4, wherein: the compound essential oil comprises the following components in parts by weight: butter oil: 20 parts of rosewood oil: 30 parts of geranium oil: 50 parts of the raw materials.

9. A comprehensive anti-aging eye cream according to any one of claims 1 to 4, characterized in that: the lysate of the yeast fermentation product of the second split is anti-aging active substances extracted from the lysate of the probiotics of the bifidobacteria; the particle size of the emulsion particles of the comprehensive anti-aging eye cream is 1.0-3.0 mu m.

10. The method for preparing the comprehensive anti-aging eye cream of claims 1-9, which comprises the following steps:

1) reserving 30-40 Wt.% of water, mixing the rest of water with the acrylate copolymer, the glycerol, the propylene glycol, the hyaluronic acid, the allantoin and the disodium ethylene diamine tetraacetate, and heating to 85-95 ℃ to obtain a water phase;

2) uniformly mixing a liposome emulsifier, isononyl isononanoate, simethicone, tocopherol acetate, vitamin E, an active fat-imparting component, glyceryl monostearate, glyceryl stearate citrate, phytosterol isostearate and cyclopentadimethylsiloxane, and heating to 80-85 ℃ to obtain an oil phase;

3) adding the water phase obtained in the step 1) into the oil phase obtained in the step 2) under stirring, homogenizing for at least 10min, then adding the rest 30-40 Wt.% of water, carrying out phase inversion, keeping the temperature at 80-85 ℃ for 20-30 min, cooling, adding p-hydroxyacetophenone, the antiseptic compound, the uniformly mixed squalane and the rheology adjusting active ingredient when the temperature is reduced to 65 +/-2 ℃, stirring uniformly, adding a KOH aqueous solution, stirring uniformly and continuously cooling; cooling to 45 deg.C, adding flos Trollii extract hydroalcoholic agent, microcapsule coated active ingredient, yeast lysate, stigma croci Sativi extract hydroalcoholic agent, and compound essential oil, and mixing well to obtain the final product.

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to anti-aging eye cream and a preparation method thereof.

Background

The eye cream is a cosmetic which can relieve the problems of black eye, under-eye puffiness, fishtail lines, fat particles and the like caused by ultraviolet irradiation, long-time computer radiation, bad living habits and the like. The use of the eye cream can relieve the problems so as to achieve the state of tight, fine and elastic eye skin.

Eye creams are generally classified into the following 4 types: 1) moisturizing eye cream; the eye cream contains more moisturizing components, has strong moisturizing function, and is suitable for dry autumn and winter; 2) firming eye cream: the eye cream is rich in nourishing components, and oily components are higher than those of moistening type eye cream, so that the eye cream is suitable for people with dark eye circles and remarkable skin aging phenomena and extremely dry skin; 3) anti-aging eye cream: the product has the advantages of wrinkle resistance, and suitability for summer and computer operators; 4) anti-allergy eye cream: is suitable for people with sensitive skin.

The anti-aging eye cream on the market has short moisturizing time, poor skin permeability and poor absorption effectiveness, so the anti-aging effect of the eye cream is not obvious. In addition, cream on the market cannot avoid the addition of preservatives in order to guarantee the storage period of products, the preservatives can bring certain stimulation to the skin of users, the stimulation is particularly obvious to people with sensitive skin, and the using effect of the products is influenced.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: provides the comprehensive anti-aging eye cream which has strong permeability, can effectively preserve moisture, obviously remove wrinkles and has no traditional preservative.

In order to solve the problems, the technical scheme is as follows: the comprehensive anti-aging eye cream comprises the following components in parts by weight:

the aqueous alcohol agent of the extract of the gold button flower: 3.00-6.00 parts;

microencapsulation of active ingredients: 2.00-5.00 parts;

split yeast fermentation lysate: 1.00-3.50 parts;

the aqueous alcohol agent of the extract of the golden buttonholing comprises the following components in parts by weight: water: 25-50 parts of ethanol: 50-75 parts of a gold button flower extract: 5-10 parts; the microcapsule wraps active ingredients, and the microcapsule comprises the following components in parts by weight: water: 50-65 parts of sucrose palmitate: 10-25 parts of tocopherol acetate: 5-10 parts of glycerol linoleate: 5-10 parts of sodium hyaluronate: 0.1-0.2 parts;

the lysate of the yeast fermentation product is an anti-aging active substance extracted from the lysate of the bifidobacterium probiotics, and can promote cell repair, resist skin aging and ensure skin activity. Meanwhile, microcapsule-coated active ingredients are adopted as macromolecular sodium hyaluronate coated by microcapsules, and the penetration depth is verified through experiments: after the artificial skin was treated with a fluorescent probe (fluorescein laurate) encapsulated in a microcapsule of the active ingredient for 12 hours, the markers were detected by Raman spectroscopy. The experimental result shows that the macromolecular sodium hyaluronate with the microcapsule-coated active ingredient coated by the microcapsule can penetrate into the 10-micron depth of the skin epidermal layer, and then the sodium hyaluronate is slowly released in a long-acting manner to fill wrinkles, so that the double-effect anti-aging effect is achieved. In addition, the product also combines the effects of the aqueous alcohol agent of the extract of the golden buttonholing flower for instantly relaxing muscles and removing wrinkles in time, so that the product has visual and obvious effect on the using effect.

The comprehensive anti-aging eye cream preferably comprises the following components: the mass ratio of the aureobasidium extract hydroalcoholic agent, the microcapsule coated active ingredient and the secondary cracking yeast fermentation product lysate to the aureobasidium extract hydroalcoholic agent to the microcapsule coated active ingredient to the secondary cracking yeast fermentation product lysate is 5: 3: 2;

further preferably, the aqueous alcoholic agent of the extract of the gold buttonholing comprises the following components in parts by mass: water: 27 parts of ethanol: 65 parts of a gold button flower extract: 8 parts of a mixture;

further preferably, the microcapsule wraps active ingredients, and the microcapsule comprises the following components in parts by weight: water: 61.85 parts, sucrose palmitate: 20 parts, tocopherol acetate: 10 parts, glycerol linoleate: 8 parts, sodium hyaluronate: 0.15 part.

Figures 1-3 show wrinkle removing effects of flos Trollii extract hydroalcoholic agent, microcapsule coated active ingredient, and secondary fission yeast fermentation product lysate. The wrinkle-removing effect of the three raw materials has optimal values, and the later wrinkle-removing effect curve tends to be gentle, namely the consumption of the three raw materials is increased after the three raw materials reach a certain amount, and the improvement of the wrinkle-removing effect is not obvious. The effective proportion of the wrinkle-removing raw materials is further screened, and the proportion of three effective components of the gold buttonholing extract hydroalcoholic agent, the microcapsule coating active component and the secondary cracking yeast fermentation product lysate is finally determined; the three components have synergistic effect, and the optimal effect of removing eye wrinkles is achieved.

In use, the golden button flower extract hydroalcoholic agent, the micro-capsule wrapping active ingredient and the secondary cracking yeast fermentation product lysate have a synergistic effect: the lysate of the two-row yeast fermentation product promotes the absorption and utilization of the active ingredients encapsulated by the microcapsules while repairing the damaged skin; furthermore, the skin activity is enhanced, so that the effect of the aqueous alcohol agent of the extract of the inula flower is more obvious.

The optimal proportion is screened out through experiments, the three raw materials are three factors, three levels are respectively adopted, the following orthogonal test is designed, and the optimal proportion of the three raw materials is obtained:

TABLE 1 orthogonal test design Table

In Table 1, A represents the extract hydroalcoholic agent of the extract of the gold button flower, B represents the encapsulated active ingredient of the microcapsule, and C represents the lysate of the fermentation product of the yeast schizosaccharomyces; y represents the wrinkle removal value.

Orthogonal tests of contents of three effective components, namely the water alcohol agent of the extract of the golden button flower, the microcapsule encapsulated active component and the lysate of the fermentation product of the second-cracking yeast are carried out according to the table:

TABLE 2 orthogonal experimental data processing of three active principles

Analysis of the very poor delta values:

δ₁₁＝6.67-7.63＝-0.96 δ₂₁＝8.07-7.63＝0.44 δ₃₁＝8.17-7.63＝0.54 T₁＝0.54-(-0.96)＝1.5；

δ₁₂＝6.9-7.63＝-0.73 δ₂₂＝8.27-7.63＝0.64 δ₃₂＝7.73-7.63＝0.1 T₂＝0.64-(-0.73)＝1.37；

δ₁₃＝7.67-7.63＝0.03 δ₂₃＝7.83-7.63＝0.2 δ₃₃＝7.4-7.63＝0.23 T₃＝0.23-0.03＝0.2；

from the above, δ₃₁＞δ₂₁＞δ₁₁；δ₂₂＞δ₃₂＞δ₁₂；δ₃₃＞δ₂₃＞δ₁₃(ii) a Therefore, according to the size of the range delta value, the combination of the corresponding factor levels is determined as follows: a. the₃B₂C₃The optimal wrinkle removing effect is the combination of the water-alcohol agent content of the extract of the golden button flower, the active ingredient content of the microcapsule package and the lysate content of the yeast fermentation product of the second crack of 5: 3: 2.

In order to further enhance the performance of the comprehensive anti-aging eye cream, the comprehensive anti-aging eye cream preferably comprises the following components in parts by weight:

the liposome emulsifier comprises the following components in parts by weight: 58 parts of hydrogenated soft phospholipid, 3 parts of myristic acid, 8 parts of stearic acid, 15 parts of behenic acid, 8 parts of stearyl alcohol and 8 parts of behenyl alcohol; it can spontaneously form liposome in emulsion state, and encapsulate phytosterol isostearate and other nutritional components with repairing and antiinflammatory effects in the liposome during emulsification process, so as to improve the permeability of nutritional substances in skin. It is noted that the liposome emulsifier component is not less than 3.5 parts, otherwise the phase inversion fails, and a stable oil-in-water paste cannot be obtained; however, when the amount is more than 5 parts, a sticky feeling is brought.

The fat-endowing active ingredients comprise the following components in parts by mass: jojoba esters: 50-75 parts of cercis chinensis (Acacia DECURRENS) flower wax: 25-50 parts of sunflower (Helianthus ANNUUS) seed wax: 1-5 parts of polyglycerol-3: 1-5 parts.

The anticorrosive compound comprises the following components in parts by weight: caprylyl hydroximic acid: 5-8 parts of 1, 3-propylene glycol: 60-70 parts of 1, 2-hexanediol: 30-40 parts of a binder; the product does not use the traditional preservative, and the conventional preservative system is replaced by the compound with the preservative effect, so that the product does not contain formaldehyde releaser and parabens, the skin is safe and mild, and the product passes the preservative inspection. When the anti-corrosion compound is less than 0.3 part, the anti-corrosion test is not successful, and when the anti-corrosion compound is more than 0.8 part, stimulation is brought to a user.

The rheology adjusting active component comprises the following components in parts by weight: sodium acrylate/sodium acryloyldimethyl taurate copolymer: 20-30 parts of isohexadecane: 20-40 parts of polysorbate-80: 30-50 parts.

The crocus sativus extract hydroalcoholic agent comprises the following components in parts by weight: water: 75-80 parts of propylene glycol: 12-17 parts of CROCUS SATIVUS (CROCUS SATIVUS) extract: 5-10 parts.

The compound essential oil comprises the following components in parts by weight: butter oil: 18-22 parts of rosewood oil: 28-32 parts of geranium oil: 48-52 parts, the blending is reasonable according to the opsonization, so that the anxiety of the user is relieved and the mood of the user is relieved in the using process.

The process adopts a phase inversion emulsification method, the particle size of the formed emulsion particles is 1.0-3.0 mu m, and compared with the traditional emulsification method, the obtained ointment is finer and has better moisturizing effect.

Further preferably, the comprehensive anti-aging eye cream comprises the following components in parts by weight:

preferably, the fat-endowing active ingredients comprise the following components in parts by weight: jojoba esters: 60 parts of green wattle flower wax: 30 parts of sunflower seed wax: 5 parts of polyglycerol-3: 5 parts of the raw materials.

Further preferably, the anticorrosive compound comprises the following components in parts by weight: caprylyl hydroximic acid: 5 parts of 1, 3-propylene glycol: 65 parts of 1, 2-hexanediol: 30 parts of.

Further preferably, the rheology adjusting active ingredient comprises the following components in parts by weight: sodium acrylate/sodium acryloyldimethyl taurate copolymer: 25 parts of isohexadecane: 30 parts, polysorbate-80: 45 parts of the raw materials.

Further preferably, the crocus sativus extract hydroalcoholic agent comprises the following components in parts by weight: water: 77 parts, propylene glycol: 15 parts, saffron extract: 8 parts.

Further preferably, the compound essential oil comprises the following components in parts by weight: butter oil: 20 parts of rosewood oil: 30 parts of geranium oil: 50 parts of the raw materials.

The second technical problem to be solved by the invention is: provides a preparation method of comprehensive anti-aging eye cream.

In order to solve the second technical problem, the adopted technical scheme is as follows: a preparation method of the comprehensive anti-aging eye cream comprises the following steps:

1) taking 30-40 Wt.% of water, mixing the rest water with an acrylate copolymer (Carbopol Ultrez21), glycerol, propylene glycol, Hyaluronic Acid (HA), allantoin and disodium ethylene diamine tetraacetate (EDTA-2Na) in a water phase pot, and heating to 85-95 ℃ to obtain a water phase;

2) uniformly mixing a liposome emulsifier, isononyl isononanoate (SALACOS 99), dimethyl silicone oil (QP1-9140350cs), tocopherol acetate, Vitamin E (VE), an active fat-imparting component, glyceryl monostearate, glyceryl stearate citrate, phytosterol isostearate and cyclopentadimethylsiloxane (PMX-245) in an emulsifying pot, and heating to 80-85 ℃ to obtain an oil phase;

3) adding the water phase obtained in the step 1) into the oil phase obtained in the step 2) under stirring, homogenizing for 10min, adding the rest 30-40 Wt.% of water, carrying out phase inversion, keeping the temperature at 80-85 ℃ for 20-30 min, cooling, adding p-hydroxyacetophenone, the antiseptic compound, the uniformly mixed squalane and the rheology adjusting active ingredient when the temperature is reduced to 65 +/-2 ℃, stirring uniformly, adding a KOH aqueous solution, stirring uniformly and continuously cooling; cooling to 45 deg.C, adding flos Trollii extract hydroalcoholic agent, microcapsule coated active ingredient, yeast lysate, stigma croci Sativi extract hydroalcoholic agent, and compound essential oil, and mixing well to obtain the final product.

Wherein, the potassium hydroxide is added after being completely dissolved by water in advance.

Has the advantages that: the product adopts microcapsule-coated active ingredient as macromolecular sodium hyaluronate coated by microcapsule, and effective substance can penetrate into epidermal layer to 10 μm depth and slowly release nutrients; the product was shown to have immediate wrinkle removal in the anti-wrinkle test, and eye wrinkles were reduced by 25% after one month of continuous use in the test of 300 people use.

Because of the absorption effectiveness, the anti-aging effect of eye cream on the market is not obvious, and the product adopts liposome emulsifier combined with microcapsule-coated active ingredient microcapsule-coated raw materials to accelerate the absorption of the eye cream. Trial data showed that 80% of the population considered to be readily absorbed.

The product increases the dimension of anti-aging, and combines the factors of ultraviolet protection, liposome permeation of nutrient substances and slow release of sodium hyaluronate to improve the anti-aging effect to a certain extent. The test result shows that the wrinkle removing effect is improved by 15 percent compared with the products on the market.

The cream on the market mostly can not avoid the stimulation brought by the preservative, the product adopts a non-traditional preservative system, and the product is ensured not to contain formaldehyde releaser and parabens, so that the product is safe and mild to the skin, and passes the preservative inspection.

The preparation process of the product adopts a phase inversion emulsification method, the formed emulsion particles are 1.0-3.0 mu m, and compared with the traditional emulsification method, the obtained paste is finer and smoother and has better moisturizing effect. The phase inversion emulsification method of the product can be finished without special equipment, and the industrial scale production is easy to realize.

Drawings

FIG. 1. wrinkle removing effect of aqueous alcoholic agent of extract of gold buttonholing;

FIG. 2 illustrates the wrinkle-removing effect of microencapsulation of active ingredients;

FIG. 3. wrinkle removal effect of split yeast fermentation lysate;

FIG. 4 is a photograph of a right eye wrinkle detection test before and after the subject uses the comprehensive anti-aging eye cream;

FIG. 5 is a photograph of the test for detecting wrinkles on the left eye before and after the application of the comprehensive anti-aging eye cream to the subject.

Detailed Description

The present application is further illustrated by the following examples, which are not intended to limit the invention thereto.

The preparation method of the comprehensive anti-aging eye cream comprises the following steps:

1) taking 30-40 Wt.% of water, mixing the rest water with an acrylate copolymer (Carbopol Ultrez21), glycerol, propylene glycol, Hyaluronic Acid (HA), allantoin and disodium ethylene diamine tetraacetate (EDTA-2Na) in a water phase pot, and heating to 85-95 ℃ to obtain a water phase;

2) uniformly mixing a liposome emulsifier, isononyl isononanoate (SALACOS 99), dimethyl silicone oil (QP1-9140350cs), tocopherol acetate, Vitamin E (VE), an active fat-imparting component, glyceryl monostearate, glyceryl stearate citrate, phytosterol isostearate and cyclopentadimethylsiloxane (PMX-245) in an emulsifying pot, and heating to 80-85 ℃ to obtain an oil phase;

3) adding the water phase obtained in the step 1) into the oil phase obtained in the step 2) under stirring, homogenizing for 10min, adding the rest 30-40 Wt.% of water, carrying out phase inversion, keeping the temperature at 80-85 ℃ for 20-30 min, cooling, adding p-hydroxyacetophenone, the antiseptic compound, the uniformly mixed squalane and the rheology adjusting active ingredient when the temperature is reduced to 65 +/-2 ℃, stirring uniformly, adding a KOH aqueous solution, stirring uniformly and continuously cooling; cooling to 45 deg.C, adding flos Trollii extract hydroalcoholic agent, microcapsule coated active ingredient, yeast lysate, stigma croci Sativi extract hydroalcoholic agent, and compound essential oil, and mixing well to obtain the final product.