阅读说明：本技术 一种多奈哌齐双羟萘酸盐新的制备方法 (Novel preparation method of donepezil pamoate ) 是由 许炜 陈茜 顾虹 于 2018-06-05 设计创作，主要内容包括：本发明公开了一种多奈哌齐双羟萘酸盐(1-苄基-4-[(5,6-二甲氧基茚满酮-2-基)甲基]哌啶双羟萘酸盐)新的制备方法,采用所述方法制得的多奈哌齐双羟萘酸盐纯度高,具有良好的流动性。(The invention discloses a novel preparation method of donepezil pamoate (1-benzyl-4- [ (5, 6-dimethoxy indanone-2-yl) methyl ] piperidine pamoate).)

A preparation method of a crystal form A of a compound shown in a formula I is characterized in that the compound shown in the formula I is dissolved in an organic solvent, and another solvent is dripped to separate out the compound shown in the formula I, so that the crystal form A of the compound shown in the formula I is obtained.

The method according to claim 1, wherein the reaction solvent is selected from the group consisting of alcohols, ethers, esters, ketones, nitriles, alkanes, and water.

The method of claim 1, wherein the reaction solvent is selected from the group consisting of ketones.

The method of claim 1, wherein the reaction solvent is acetone.

The method according to claim 1, wherein the dissolution temperature is 0 to 50 ℃.

The method according to claim 1, wherein the dissolution temperature is 15 to 30 ℃.

The method according to claim 1, wherein the dropwise addition solvent is selected from one or a combination of alcohols, ethers, esters, ketones, nitriles, alkanes and water.

The process according to claim 1, wherein the dropwise addition solvent is water.

The production process according to claim 1, wherein the temperature at the time of dropping the solvent is 0 to 50 ℃.

The production process according to claim 1, wherein the temperature at the time of dropping the solvent is 15 to 30 ℃.