阅读说明：本技术 一种表面抗菌材料 (Surface antibacterial material ) 是由 李海平 于 2018-06-20 设计创作，主要内容包括：本发明涉及抗菌材料技术领域,特别涉及一种表面抗菌材料；本发明的表面抗菌材料以层或者层的成分存在；本发明的表面抗菌材料将具有熬的成本效益率和良好的加工性质；而且,当该活性物质不但在其纳米级粒子形式下具有抗菌作用,而且在其非可吸入粒子形式和其紧密集合形式下也具有抗菌作用时,这是有利的。(The invention relates to the technical field of antibacterial materials, in particular to a surface antibacterial material; the surface antimicrobial material of the present invention is present as a layer or as a component of a layer; the surface antibacterial material has the advantages of decocting cost benefit rate and good processing property; furthermore, it is advantageous when the active substance has an antibacterial effect not only in its nanoscale particle form, but also in its non-inhalable particle form and its closely-packed form.)

1. A surface antimicrobial material, characterized by: the material is present as a layer or as a component of a layer.

2. A surface antimicrobial material according to claim 1, characterized in that: the antimicrobial material has a solubility in aqueous media of less than 0.1 moles/liter.

3. A surface antimicrobial material according to claim 1, characterized in that: the antimicrobial material is present in a dense form.

4. A surface antimicrobial material according to claim 1, characterized in that: the antimicrobial material is present in a porous form.

5. A surface antimicrobial material according to claim 1, characterized in that: the antimicrobial material is present in the layer as island-like, substantially non-connected aggregates.

6. A surface antimicrobial material according to claim 1, characterized in that: the layer is deposited by electron beam evaporation, chemical vapour deposition, electrophoresis, slurry techniques, sol-gel techniques or plasma spraying.

7. A surface antimicrobial material according to claim 1, characterized in that: the antimicrobial material is present as a composite material in combination with one or more materials.

Technical Field

The invention relates to the technical field of antibacterial materials, in particular to a surface antibacterial material.

Background

Microorganisms such as bacteria and fungi are ubiquitous in our living space and vice versa on most different types of surfaces. Many microorganisms are pathogens, and thus their spread and/or control plays a particular role in public health and hygiene, and if such microorganisms enter our body, they may cause life-threatening infections, which become nosocomial if someone infects such infections in a hospital.

It is estimated that several billion euros are spent each year worldwide to eliminate losses caused by nosocomial infections, and therefore, control of pathogenic microorganisms plays a special role in public health and hygiene.

In addition to blocking and/or killing unwanted microorganisms by antibiotics, for example, it is increasingly important to prevent mistakes, such as creating a spatial debate that is not suitable for the survival of microorganisms. Of these precautions, the use of silver as an additive to mailing and inorganic materials has rapidly become important over the past few years. Here, the anion interferes with an important function of the microorganism. At present, it stems from the hypothesis: anions block enzymes and prevent their important transport functions in the cell, additional effects include compromising the structural strength of the cell and/or also disrupting membrane structure. These effects can lead to cell damage and/or cell death. Silver also has a broad spectrum of activity against multiple resistant microorganisms. A small geisha is sufficient to achieve long-term effects; this becomes a microbial effect. In some cases some organic compounds are also added to enhance the effectiveness of the silver, and it is often important that a sufficient amount of silver ions is present. Therefore, a nano-sized silver powder, so-called nano-silver, is used to realize a large ion surface.

Silver has no toxic side effect within the dosage range of silver. Only a highly increased accumulation of silver in the body may lead to poisoning, an irreversible grey-tone discoloration of the skin and mucous membranes. In addition, increased silver concentrations can cause dysgeusia, dysosmia, and annoying convulsions; it must also be mentioned that, overall, the interaction between nanoscale examples and human tissue has not yet been fully studied. Extensive research planning has only begun in the recent past. For many applications, the antimicrobial effect of silver is insufficient. In addition to this, silver chloride formation also occurs. The main disadvantage of using nanosilver is the unsatisfactory cost situation. On the one hand, this is due to the high price of silver, and on the other hand, the treatment of river pudendum into nanoparticles is time consuming and expensive. Additional problems arise in the processing of nanosilver due to the formation of agglomerates, aggregates and clusters. Due to this problem, the active surface is reduced, and as a result of further action, the antibacterial action is reduced. To prevent this problem, nano-silver is deposited on, for example, TiO₂On the surface of the carrier, which in turn increases the production costs.

For many applications, in addition to a sufficient antibacterial effect, it is also required that the active substance does not have any cytotoxicity and thrombogenicity and is generally biocompatible; many Mars materials do not possess these properties due to their high cytotoxicity and lack of biocompatibility.

Disclosure of Invention

In order to overcome the above-mentioned disadvantages, the present invention aims to provide a surface antibacterial material having an antibacterial effect.

The technical scheme for solving the technical problem is as follows:

a surface antimicrobial material, wherein: the material is present as a layer or as a component of a layer.

As an improvement of the invention: the antimicrobial material has a solubility in aqueous media of less than 0.1 moles/liter.

As a further improvement of the invention: the antimicrobial material is present in a dense form.

As a further improvement of the invention: the antimicrobial material is present in a porous form.

As a further improvement of the invention: the antimicrobial material is present in the layer as island-like, substantially non-connected aggregates.

As a further improvement of the invention: the layer is deposited by electron beam evaporation, chemical vapour deposition, electrophoresis, slurry techniques, sol-gel techniques or plasma spraying.

As a further improvement of the invention: the antimicrobial material is present as a composite material in combination with one or more materials.

After adopting the technical scheme, compared with the prior art, the invention has the following beneficial effects: the surface antibacterial material has the advantages of decocting cost benefit rate and good processing property; furthermore, it is advantageous when the active substance has an antibacterial effect not only in its nanoscale particle form, but also in its non-inhalable particle form and its closely-packed form.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

A surface antimicrobial material of the present invention is present in a layer or a component of a layer.

The surface antimicrobial material has a solubility in aqueous media of less than 0.1 moles/liter.

The surface antimicrobial material is present in a dense form.

The surface antimicrobial material is present in a porous form.

The surface antimicrobial material is present in the layer as island-like, substantially non-connected aggregates.

The layer is deposited by electron beam evaporation, chemical vapour deposition, electrophoresis, slurry techniques, sol-gel techniques or plasma spraying.

The surface antimicrobial material is present as a composite material in combination with one or more materials.

Here, it can be seen that all substances based on tungsten and aluminum at least equal or partially clearly exceed your antibacterial action in the compact form in terms of their antibacterial action. Samples that include silver or copper in addition to aluminum or sample cups that contain silver or copper in addition to tungsten surprisingly prove particularly effective; polymeric matrix composite materials containing aluminum cyanide or tungsten oxide have also been evaluated as having good antimicrobial action.

The effect of the titanium-based comparative sample must also be evaluated as negative.

Tests of polymer matrix materials have shown that the effect can be controlled by the amount and example size of molybdenum powder added; the finer the molybdenum powder, the higher its effect. Here, the molybdenum oxide powder has a higher antibacterial effect than the molybdenum metal powder. Furthermore, preliminary tests on cytotoxicity were also conducted, and it became apparent that all the materials containing copper had cytotoxicity, and that preliminary tests on thrombogenicity were also conducted, and that tungsten alloys containing silver had higher thrombogenicity than molybdenum alloys containing silver. However, it must be noted restrictively that the surface quality also influences the result.

Experiments with water soluble molybdenum and tungsten salts were also performed to determine the mechanism of action. For this purpose, sodium molybdate and sodium tungstate were embedded in the plastic mechanism and the first experiment described above was carried out to determine their antibacterial action.

Here, no decrease in the pH of the physiological saline occurred, and the sample was not antibacterial. Then, the content of dissolved components in the salt solution was measured after an age hardening time of 24 hours. As expected, this value was high for the hydrorony compound.

It is known from the literature that silver exerts an antibacterial effect through the formation of anions. This effect increases with anion concentration; however, for molybdenum and tungsten, it is not possible to determine any dependence of the antibacterial action on the contents of molybdenum and tungsten in physiological saline. Therefore, it must stem from the fact that molybdenum and tungsten do not have sparks per se. Therefore, the pH of the physiological saline was measured after the end of the experiment. For materials without any antimicrobial effect, the PH is medium at a large scale, and pure silver likewise does not cause any reduction in PH.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.