阅读说明：本技术 一种多通道量子点荧光成像仪 (Multichannel quantum dot fluorescence imager ) 是由 王升启 肖瑞 王东风 荣振 董建 王封 孙美洁 于 2019-10-22 设计创作，主要内容包括：本发明提供了一种多通道量子点荧光成像仪,涉及生物科学研究与医学检验应用技术领域。该多通道量子点荧光成像仪包括壳体以及位于壳体内的旋转座、紫外光源、摄像头和滤光片；旋转座内置于壳体中,用于放置并旋转试纸旋转筒；摄像头和紫外光源均位于试纸旋转筒的周向外侧,且摄像头和紫外光源沿试纸旋转筒的轴线方向间隔设置；摄像头和试纸旋转筒之间设置滤光片。本发明的多通道量子点荧光成像仪,利用旋转座可旋转放置多个试纸条的同时,通过紫外光源、摄像头和滤光片的合理设置获取试纸条受到紫外光线照射后产生的、能够真实反映实验数据的荧光图像信息以供分析,大幅度提高了实验的效率和准确率。(The invention provides a multi-channel quantum dot fluorescence imager, and relates to the technical field of biological science research and medical inspection application. The multi-channel quantum dot fluorescence imager comprises a shell, and a rotating seat, an ultraviolet light source, a camera and an optical filter which are positioned in the shell; the rotary seat is arranged in the shell and used for placing and rotating the test paper rotary cylinder; the camera and the ultraviolet light source are both positioned on the outer side of the circumferential direction of the test paper rotating cylinder, and are arranged at intervals along the axial direction of the test paper rotating cylinder; an optical filter is arranged between the camera and the test paper rotating cylinder. According to the multi-channel quantum dot fluorescence imager, a plurality of test strips can be rotatably placed on the rotary seat, and fluorescence image information which is generated after the test strips are irradiated by ultraviolet light and can truly reflect experimental data is obtained through reasonable arrangement of the ultraviolet light source, the camera and the optical filter for analysis, so that the experimental efficiency and accuracy are greatly improved.)

1. A multi-channel quantum dot fluorescence imager is characterized by comprising a shell (1), a rotating seat (2), an ultraviolet light source (3), a camera (4) and an optical filter (5), wherein the rotating seat (2), the ultraviolet light source (3), the camera (4) and the optical filter (5) are positioned in the shell (1);

the rotary seat (2) is arranged in the shell (1) and used for placing and rotating the test paper rotary cylinder (7);

the camera (4) and the ultraviolet light source (3) are both positioned on the outer side of the test paper rotating cylinder (7) in the circumferential direction, and the camera (4) and the ultraviolet light source (3) are arranged at intervals along the axial direction of the test paper rotating cylinder (7);

the optical filter (5) is arranged between the camera (4) and the test paper rotating cylinder (7).

2. The multi-channel quantum dot fluorescence imager according to claim 1, characterized in that the ultraviolet light source (3) is hinged to the housing (1) with a hinge axis perpendicular to the axis of the test paper rotating cylinder (7); the ultraviolet light source (3) can change the installation angle relative to the shell (1) around the hinge shaft.

3. The multi-channel quantum dot fluorescence imager of claim 1, wherein the camera (4) is movably arranged on the housing (1), and the camera (4) can move along the axial direction of the test paper rotating cylinder (7).

4. The multi-channel quantum dot fluorescence imager of claim 3, characterized in that the camera (4) is mounted inside the housing (1) by a post (6); the length direction of the upright post (6) is parallel to the axial direction of the test paper rotating cylinder (7), the upright post (6) is provided with a guide groove, and the camera (4) is provided with a guide pin corresponding to the guide groove.

5. The multi-channel quantum dot fluorescence imager of claim 1, further comprising a test paper rotating drum (7); the test paper rotating cylinder (7) is arranged on the rotating seat (2).

6. The multi-channel quantum dot fluorescence imager of claim 1, further comprising a reset device (8); the resetting device (8) is arranged at the bottom of the rotating seat (2).

7. The multi-channel quantum dot fluorescence imager of claim 1, further comprising a processor (9); the processor (9) is arranged in the shell (1), and the processor (9) is electrically connected with the camera (4) and the ultraviolet light source (3) respectively.

8. The multi-channel quantum dot fluorescence imager of claim 7, further comprising a battery (10); the battery (10) is arranged in the shell (1) and is electrically connected with the rotating seat (2), the ultraviolet light source (3), the camera (4) and the processor (9).

9. The multi-channel quantum dot fluorescence imager of claim 7, further comprising a display screen (11); the display screen (11) is arranged on the outer side of the shell (1) and is electrically connected with the processor (9).

10. The multi-channel quantum dot fluorescence imager of claim 9, further comprising a printer (12); the printer (12) is arranged in the shell (1) and is electrically connected with the processor (9) and the display screen (11).

Technical Field

The invention relates to the technical field of biological science research and medical examination application, in particular to a multi-channel quantum dot fluorescence imager.

Background

In medical imaging technology, quantum dots serving as semiconductor nano luminescent materials provide great convenience for rapid determination of various analytes.

In the existing quantum dot measurement equipment and method, an ultraviolet light source is usually arranged between a camera and a test strip, and the test strip to be measured is placed in the irradiation range of the ultraviolet light source. Although the equipment and the method avoid a structure using prism refraction, reduce the installation space of detection equipment, easily cause light interference between a camera and an ultraviolet light source, and simultaneously are difficult to reasonably set an optical filter for filtering fluorescence.

Disclosure of Invention

The invention aims to provide a multi-channel quantum dot fluorescence imager which can reasonably arrange an optical filter to reduce light interference and improve the accuracy of measurement, flexibly place a plurality of test strips to realize one-by-one measurement of the test strips at one time and improve the experimental efficiency.

The embodiment of the invention is realized by the following steps:

a multi-channel quantum dot fluorescence imager comprises a shell, and a rotating seat, an ultraviolet light source, a camera and an optical filter which are positioned in the shell; the rotary seat is arranged in the shell and used for placing and rotating the test paper rotary cylinder; the camera and the ultraviolet light source are both positioned on the outer side of the circumferential direction of the test paper rotating cylinder, and are arranged at intervals along the axial direction of the test paper rotating cylinder; the optical filter is arranged between the camera and the test paper rotating cylinder.

By adopting the multi-channel quantum dot fluorescence imager, a plurality of test strips can be placed in front of the ultraviolet light source and the camera in a one-to-one correspondence manner on the test paper rotary drum, and all the test strips are measured one by one at a time by rotating the rotary seat, so that the experimental efficiency is improved. In addition, the camera and the ultraviolet light source are arranged on the outer side of the circumferential direction of the test paper rotating cylinder and are arranged at intervals along the axis direction of the test paper rotating cylinder, so that an optical filter is favorably arranged between the camera and the test paper, the phenomenon that the optical filter blocks emergent rays is avoided, multiple times of invalid refraction of the optical filter on the emergent rays and incident rays is reduced, and the experiment accuracy is improved.

In a preferred embodiment of the present invention, the ultraviolet light source is hinged to the housing, and a hinge axis of the ultraviolet light source is perpendicular to an axis of the test paper rotating cylinder; the ultraviolet light source can change a mounting angle with respect to the housing around the hinge shaft. The technical effects are as follows: the T line position and the C line position of each test strip are different, and the signal intensity displayed by the T line and the signal intensity displayed by the C line are different when different test samples are measured. And the installation angle of the ultraviolet light source is changed, the irradiation angle of emergent light of the ultraviolet light source can be adjusted, and the T line and the C line on the test strip can be accurately corresponding to meet the measurement requirements of different test strips and different samples to be measured.

In a preferred embodiment of the present invention, the camera is movably disposed on the housing, and the camera can move along an axial direction of the test paper rotating cylinder. The technical effects are as follows: in consideration that the different test strips have different T-line positions and C-line positions, the camera can move along the axis direction of the test strip rotating cylinder, the height position of the camera for acquiring the fluorescent signal can be changed, and the measurement requirements of different test strips and different samples to be measured are met.

In a preferred embodiment of the present invention, the camera is mounted in the housing through a pillar; the length direction of the upright column is parallel to the axial direction of the test paper rotating cylinder, a guide groove is formed in the upright column, and a guide pin is arranged on the camera corresponding to the guide groove. The technical effects are as follows: the guide slot and the guide pin structure provide a mechanism for stepless adjustment of the upper position and the lower position of the camera on the stand column, so that the camera can move in the length direction of the guide slot and accurately corresponds to the T line position and the C line position on the test strip. The guide pin can preferably adopt a spring shaft pin to quickly adjust the ascending and descending of the camera. The camera may be attached to the column through a screw hole, and may be fixed to the upper side or the lower side of the column in the same manner.

In the preferred embodiment of the invention, the test paper rotary drum is further included; the test paper rotating cylinder is installed on the rotating seat. The technical effects are as follows: a plurality of test strips are placed on one test strip rotating cylinder, and each time the test strip rotates by one angle, a certain test strip is required to accurately correspond to the ultraviolet light source and the camera.

In the preferred embodiment of the invention, the device also comprises a reset device; the resetting device is arranged at the bottom of the rotating seat. The technical effects are as follows: after all the test paper strips in one test paper rotary cylinder are tested, the rotary seat can be restored to the initial position through the resetting device, and the initial position of the next test paper rotary cylinder can be conveniently determined.

In the preferred embodiment of the invention, the system further comprises a processor; the processor is arranged in the shell and is respectively and electrically connected with the camera and the ultraviolet light source. The technical effects are as follows: the processor is used for controlling the emergent light of the ultraviolet light source and processing and analyzing the fluorescence signal collected by the camera.

In the preferred embodiment of the invention, the device also comprises a battery; the battery is arranged in the shell and is electrically connected with the rotating seat, the ultraviolet light source, the camera and the processor. The technical effects are as follows: the battery can independently provide power for the rotating seat, the ultraviolet light source, the camera and the processor, and the portability of the equipment is improved.

In the preferred embodiment of the invention, the device also comprises a display screen; the display screen is arranged on the outer side of the shell and is electrically connected with the processor. The technical effects are as follows: the processor analyzes and processes the fluorescence emitted by the test strip and then directly displays the fluorescence through the display screen, so that a user can read the test result quickly.

In the preferred embodiment of the invention, the printer is also included; the printer is arranged in the shell and is electrically connected with the processor and the display screen. The technical effects are as follows: the printer can output the analysis result of the processor in real time, and is convenient for storing and sorting the experimental data.

The embodiment of the invention has the beneficial effects that:

according to the multi-channel quantum dot fluorescence imager, a plurality of test strips can be rotatably placed on the rotary seat, and fluorescence image information which is generated after the test strips are irradiated by ultraviolet light and can truly reflect experimental data is obtained through reasonable arrangement of the ultraviolet light source, the camera and the optical filter for analysis, so that the experimental efficiency and accuracy are greatly improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

Fig. 1 is a schematic structural diagram of an external shape of a multi-channel quantum dot fluorescence imager provided in a first embodiment of the invention;

fig. 2 is a schematic view of a first view of the internal structure of a multi-channel quantum dot fluorescence imager according to a first embodiment of the invention;

fig. 3 is a schematic view of a second view of the internal structure of the multi-channel quantum dot fluorescence imager provided by the first embodiment of the invention;

fig. 4 is a schematic structural diagram of an external shape of a multi-channel quantum dot fluorescence imager provided by a fourth embodiment of the invention;

fig. 5 is a schematic view of a first view of an internal structure of a multi-channel quantum dot fluorescence imager according to a fourth embodiment of the invention;

fig. 6 is a schematic view of a second view of the internal structure of a multi-channel quantum dot fluorescence imager according to a fourth embodiment of the invention.

In the figure: 1-a shell; 2-a rotating seat; 3-a source of ultraviolet light; 4-a camera; 5-an optical filter; 6-upright post; 7-test paper rotating cylinder; 8-a resetting device; 9-a processor; 10-a battery; 11-a display screen; 12-printer.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein can be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or the orientations or positional relationships that the products of the present invention are conventionally placed in use, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Some embodiments of the invention are described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.

The first embodiment:

fig. 1 is a schematic structural diagram of an external shape of a multi-channel quantum dot fluorescence imager provided in a first embodiment of the invention; fig. 2 is a schematic view of a first view of the internal structure of a multi-channel quantum dot fluorescence imager according to a first embodiment of the invention; fig. 3 is a schematic view of a second view of the internal structure of the multi-channel quantum dot fluorescence imager according to the first embodiment of the invention.

Referring to fig. 1 to 3, the present embodiment provides a multi-channel quantum dot fluorescence imager, which includes a housing 1, and a rotating base 2, an ultraviolet light source 3, a camera 4, and an optical filter 5 located in the housing 1; the rotary seat 2 is arranged in the shell 1 and used for placing and rotating the test paper rotary cylinder 7; the camera 4 and the ultraviolet light source 3 are both positioned on the circumferential outer side of the test paper rotating cylinder 7, and the camera 4 and the ultraviolet light source 3 are arranged at intervals along the axial direction of the test paper rotating cylinder 7; an optical filter 5 is arranged between the camera 4 and the test paper rotating cylinder 7.

The working principle of the multi-channel quantum dot fluorescence imager is as follows: the ultraviolet light source 3 emits light to the test strip, a sample to be detected on the test strip emits fluorescence under the irradiation of ultraviolet light, the fluorescence enters the camera 4 after being filtered by the optical filter 5, and the detected analyte in the sample to be detected can be rapidly detected through analysis after the fluorescence is captured by the camera 4. Utilize above-mentioned multichannel quantum dot fluorescence imager, can place a plurality of test paper strips in the place ahead of ultraviolet source 3 and camera 4 on test paper revolving drum 7 one-to-one, through rotating roating seat 2, once only survey whole test paper strips one by one, improved the experimental efficiency of equipment. In addition, because camera 4 and ultraviolet source 3 install in the circumference outside of test paper rotary drum 7 and along the axis direction interval setting of test paper rotary drum 7, do benefit to and set up light filter 5 between camera 4 and test paper strip, avoid light filter 5 to the separation of emergent ray also to reduce the many times invalid refraction of light filter 5 to emergent ray and incident ray, improved the experiment accuracy.

Second embodiment:

the present embodiment provides a multi-channel quantum dot fluorescence imager, which is substantially the same as the multi-channel quantum dot fluorescence imager of the first embodiment, and the difference between the two embodiments is that an ultraviolet light source 3 in the multi-channel quantum dot fluorescence imager of the present embodiment is hinged to a housing 1, and a hinge shaft of the ultraviolet light source is perpendicular to an axis of a test paper rotating cylinder 7; the ultraviolet light source 3 can change a mounting angle with respect to the housing 1 about the hinge shaft.

The ultraviolet light source 3 is hinged on the shell 1 and then fixed through a shaft pin, or the ultraviolet light source 3 directly realizes the adjustment of a deflection angle through a meshed gear.

In addition, the ultraviolet light source 3 can also be fixedly installed in the housing 1 to ensure the constancy of the emergent ray angle.

The third embodiment:

the present embodiment provides a multi-channel quantum dot fluorescence imager, which is substantially the same as the multi-channel quantum dot fluorescence imagers of the first and second embodiments, and the difference between the multi-channel quantum dot fluorescence imager of the present embodiment is that a camera 4 is movably disposed in a housing 1, and the camera 4 can move along the axial direction of a test paper rotating cylinder 7.

Wherein, the camera 4 is arranged in the shell 1 through the upright post 6; the length direction of the upright post 6 is parallel to the axial direction of the test paper rotating cylinder 7, the upright post 6 is provided with a guide groove, the length direction of the guide groove is parallel to the axial direction of the test paper rotating cylinder 7, and the camera 4 is provided with a guide pin corresponding to the guide groove.

The guide pin is preferably a spring pin to quickly adjust the ascending and descending of the camera 4.

The camera 4 may be attached to the column 6 by screw holes, and may be fixed to the upper side or the lower side of the column 6 in the same manner.

The fourth embodiment:

fig. 4 is a schematic structural diagram of an external shape of a multi-channel quantum dot fluorescence imager provided by a fourth embodiment of the invention; fig. 5 is a schematic view of a first view of an internal structure of a multi-channel quantum dot fluorescence imager according to a fourth embodiment of the invention; fig. 6 is a schematic view of a second view of the internal structure of a multi-channel quantum dot fluorescence imager according to a fourth embodiment of the invention. Referring to fig. 4, 5 and 6, the present embodiment provides a multi-channel quantum dot fluorescence imager, which is substantially the same as the multi-channel quantum dot fluorescence imagers of the first, second and third embodiments, and the difference between the multi-channel quantum dot fluorescence imager of the present embodiment further includes a test paper rotating cylinder 7; the test paper rotary cylinder 7 is arranged on the rotary seat 2.

In addition, on the basis of any of the above embodiments, as shown in fig. 2, 3, 5 and 6, the device further comprises a resetting device 8; the resetting device 8 is arranged at the bottom of the rotating base 2.

On the basis of any of the above embodiments, as shown in fig. 2, 3, 5 and 6, the system further comprises a processor 9; the processor 9 is arranged in the shell 1, and the processor 9 is respectively electrically connected with the camera 4 and the ultraviolet light source 3. The processor 9 can be installed by a vertical plate erected in the housing 1, wherein the vertical plate is provided with air holes to improve the heat dissipation effect of the processor 9.

On the basis of any of the above embodiments, as shown in fig. 2, 3, 5 and 6, the battery pack further comprises a battery 10; the battery 10 is disposed in the housing 1 and is electrically connected to the rotary base 2, the ultraviolet light source 3, the camera 4, and the processor 9. Preferably, the battery 10 should be a rechargeable lithium battery 10 to meet the portability requirements of the device.

Further, as shown in fig. 1 and fig. 2, the display device further includes a display screen 11; the display screen 11 is disposed outside the housing 1 and is electrically connected to the processor 9. Preferably, the display screen 11 is arranged at the outer side of the top of the shell 1, so that the observation is convenient. Moreover, the display screen 11 is preferably a touch display screen 11, so as to be convenient for a user to operate manually.

Further, as shown in fig. 2, 3, 5, and 6, a printer 12 is further included; the printer 12 is built into the housing 1 and is electrically connected to the processor 9 and the display screen 11.

The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.