阅读说明：本技术 一种可步进的给药装置 (Stepping drug administration device ) 是由 吕丹 詹阳 孙语遥 欧阳雨林 于 2019-10-12 设计创作，主要内容包括：本发明提出一种可步进的给药装置,包括：承载组件,给药导管、线管、螺纹杆、螺母、信号记录器和连接杆；其中,螺纹杆的中部套接有螺母,螺纹杆的下端接触承载组件的下部内壁,螺纹杆的上端穿透承载组件的上部,螺纹杆的上端设置有驱动结构；承载组件内还设置有用于限制螺母转动的限位件,以当螺纹杆转动时,实现螺母的上下移动；以当螺母上下移动时,带动给药导管上下移动。通过该装置,可以实现给药导管的步进,从而可以给更大的区域进行给药操作,且本方案中在给药导管附加有用于检测神经元信号的电极丝,以此实现了给药与信号检测的一体化,且可以有针对性的检测给药的区域,信号的获取更及时也更有针对性,从而使得获取到的信号更准确。(The invention provides a steppable drug delivery device, comprising: the drug delivery device comprises a bearing assembly, a drug delivery catheter, a line pipe, a threaded rod, a nut, a signal recorder and a connecting rod; the middle part of the threaded rod is sleeved with a nut, the lower end of the threaded rod is contacted with the inner wall of the lower part of the bearing component, the upper end of the threaded rod penetrates through the upper part of the bearing component, and the upper end of the threaded rod is provided with a driving structure; a limiting part for limiting the rotation of the nut is further arranged in the bearing assembly, so that the nut can move up and down when the threaded rod rotates; when the nut moves up and down, the administration catheter is driven to move up and down. Through the device, can realize the step-by-step of pipe of dosing to can give bigger region and dose the operation, and in this scheme in the pipe of dosing add have be used for detecting the wire electrode of neuron signal, with this integration of having realized dosing and signal detection, and can have corresponding detection area of dosing, the acquisition of signal is more timely also more corresponding, thereby makes the signal of acquireing more accurate.)

1. A steppable drug delivery device comprising: the device comprises a bearing component, a drug delivery catheter connected with the bearing component, a plurality of wire tubes, a threaded rod, a nut matched with the threaded rod, a signal recorder for recording neuron signals and a connecting rod for connecting an external stereotaxic apparatus;

the middle part of the threaded rod is sleeved with a nut, the lower end of the threaded rod is contacted with the inner wall of the lower part of the bearing component, the upper end of the threaded rod penetrates through the upper part of the bearing component, and the upper end of the threaded rod is provided with a driving structure; a limiting part for limiting the rotation of the nut is further arranged in the bearing assembly, so that when the threaded rod rotates, the nut can move up and down;

the outer wall of the administration catheter is fixedly connected with a plurality of wire pipes in a parallel mode; one or more wire tubes are internally provided with wire electrodes for detecting and transmitting neuron signals; the electrode wire is connected with the signal recorder; the nut is fixedly connected with the administration catheter, so that the administration catheter is driven to move up and down when the nut moves up and down.

2. The step-able drug delivery device of claim 1, wherein the carrier assembly comprises: a first supporting plate positioned at the upper end, a second supporting plate positioned at the lower end and an upright post; wherein the content of the first and second substances,

the first supporting plate and the second supporting plate are respectively provided with a guide pipe connecting hole, a rod connecting hole and an upright post connecting hole;

the drug delivery catheter fixedly connected with the plurality of wire pipes respectively penetrates through the catheter connecting holes in the first supporting plate and the second supporting plate to realize connection with the bearing component; the connecting rods respectively penetrate through the rod connecting holes in the first supporting plate and the second supporting plate to be fixedly connected with the bearing assembly; the upright posts respectively penetrate through upright post connecting holes in the first supporting plate and the second supporting plate to be fixedly connected with the bearing assembly;

the first supporting plate is also provided with a driving hole for accommodating the threaded rod; a groove is formed in the second supporting plate;

the nut is arranged between the first supporting plate and the second supporting plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;

the lower end of the threaded rod penetrates through the driving hole and is sleeved with the threads until the lower end of the threaded rod contacts the bottom of the groove.

3. The step-able drug delivery device of claim 2, wherein the post is provided in plurality; the number of the upright post connecting holes is equal to or greater than that of the upright posts.

4. The step-able drug delivery device of claim 1, wherein the carrier assembly comprises: a first supporting plate positioned at the upper end, a second supporting plate positioned at the lower end, a third supporting plate positioned in the middle and an upright post; wherein the content of the first and second substances,

the first support plate, the second support plate and the third support plate are all provided with a conduit connecting hole, a rod connecting hole and an upright post connecting hole;

the drug delivery catheter fixedly connected with the plurality of wire pipes respectively penetrates through the catheter connecting holes in the first support plate, the second support plate and the third support plate to be connected with the bearing component;

the connecting rod respectively penetrates through the rod connecting holes in the first supporting plate, the second supporting plate and the third supporting plate to be fixedly connected with the bearing assembly;

the upright post respectively penetrates through upright post connecting holes in the first supporting plate, the second supporting plate and the third supporting plate to realize the fixed connection with the bearing component;

the first supporting plate and the third supporting plate are provided with driving holes for accommodating the threaded rods;

the nut is arranged between the first supporting plate and the third supporting plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;

the threaded rod penetrates through the driving holes in the first supporting plate and the third supporting plate respectively, the lower end of the threaded rod is blocked by the second supporting plate, and the nut is sleeved on the threaded rod in the area between the first supporting plate and the third supporting plate.

5. A stepped drug delivery device according to claim 4, wherein the threaded rod is further provided at its lower end with a head; wherein the head has a cross-sectional area greater than the cross-sectional area of the threaded portion of the threaded shank.

6. The stepwise drug delivery device of claim 4, wherein said nut is in the shape of a polygon, said posts are square, and said stop comprises one or more of said posts.

7. The step-able drug delivery device of claim 1, wherein the drive structure comprises: a screw cross slot or a screw straight slot.

8. A step-able drug delivery device as in claim 1, wherein said signal recorder is adhesively secured to said carrier assembly; the administration catheter fixedly connected with the plurality of line pipes is fixedly connected with the nut in a bonding mode.

9. The step-able drug delivery device of claim 1, wherein the conduit is a silicon tube.

10. A step-able drug delivery device as in claim 1, wherein the connection between the wire electrode and the signal recorder is encapsulated by silver paint.

Technical Field

The invention relates to the field of biomedical experimental devices, in particular to a stepping drug delivery device.

Background

In biological experiments, the administration methods of experimental animals are various, such as intraperitoneal injection, intravenous injection, intragastric administration and the like. However, for the study of the brain nerve and brain diseases, the above administration mode has serious disadvantages:

firstly, some medicines can not penetrate blood brain barrier and can not achieve the expected effect;

secondly, the dosage is small, and is generally several microliters or even less.

The conventional administration mode for experimental animals is limited in terms of the treatment of cranial nerves and brain diseases.

For this reason, there has been developed a central nervous system administration method, which is mostly used for the reaction of the target nucleus or brain region to the drug, and the currently internationally recognized intracerebral acute and chronic micro-administration method for experimental animals is the pre-embedded catheter method: in the specific method, a pipeline (conduit) with an inner core and a proper diameter and length is embedded in a target brain area or nucleus at the position of a stereotaxic apparatus, the exposed part of the pipeline is fixed on the surface of a skull by dental cement and small screws, in addition, after the drug administration, the signal of a neuron is detected and recorded, and the change of the electrical signal of the neuron is recorded through the brain drug administration so as to prove the drug effect or observe the behavioral change after the drug administration.

However, in this way, since the catheter is fixed, the administration can be performed only for a fixed position, and one such device cannot perform the administration for a plurality of positions, and cannot perform the administration for more comprehensive positions; and the current mode occupies too much volume, and a microelectrode array for signal recording cannot be embedded after a catheter is embedded in the brain, so that accurate recording of the electrical signal of the neuron after acute administration cannot be realized.

Thus, there is a need for a better drug delivery device.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a stepping drug delivery device, through which the stepping of a drug delivery catheter can be realized, so that the drug delivery operation can be carried out on a larger area, in addition, in the scheme, the drug delivery catheter is additionally provided with an electrode wire for detecting neuron signals, so that the integration of drug delivery and signal detection is realized, the drug delivery area can be detected in a targeted manner, the acquisition of the signals is more timely and more targeted, and the acquired signals are more accurate.

Specifically, the present invention proposes the following specific examples:

the embodiment of the invention provides a stepping drug delivery device, which comprises: the device comprises a bearing component, a drug delivery catheter connected with the bearing component, a plurality of wire tubes, a threaded rod, a nut matched with the threaded rod, a signal recorder for recording neuron signals and a connecting rod for connecting an external stereotaxic apparatus;

the middle part of the threaded rod is sleeved with a nut, the lower end of the threaded rod is contacted with the inner wall of the lower part of the bearing component, the upper end of the threaded rod penetrates through the upper part of the bearing component, and the upper end of the threaded rod is provided with a driving structure; a limiting part for limiting the rotation of the nut is further arranged in the bearing assembly, so that when the threaded rod rotates, the nut can move up and down;

the outer wall of the administration catheter is fixedly connected with a plurality of wire pipes in a parallel mode; one or more wire tubes are internally provided with wire electrodes for detecting and transmitting neuron signals; the electrode wire is connected with the signal recorder; the nut is fixedly connected with the administration catheter, so that the administration catheter is driven to move up and down when the nut moves up and down.

In a specific embodiment, the carrier assembly includes: a first supporting plate positioned at the upper end, a second supporting plate positioned at the lower end and an upright post; wherein the content of the first and second substances,

the first supporting plate and the second supporting plate are respectively provided with a guide pipe connecting hole, a rod connecting hole and an upright post connecting hole;

the drug delivery catheter fixedly connected with the plurality of wire pipes respectively penetrates through the catheter connecting holes in the first supporting plate and the second supporting plate to realize connection with the bearing component; the connecting rods respectively penetrate through the rod connecting holes in the first supporting plate and the second supporting plate to be fixedly connected with the bearing assembly; the upright posts respectively penetrate through upright post connecting holes in the first supporting plate and the second supporting plate to be fixedly connected with the bearing assembly;

the first supporting plate is also provided with a driving hole for accommodating the threaded rod; a groove is formed in the second supporting plate;

the nut is arranged between the first supporting plate and the second supporting plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;

the lower end of the threaded rod penetrates through the driving hole and is sleeved with the threads until the lower end of the threaded rod contacts the bottom of the groove.

In a specific embodiment, the upright post is provided with a plurality of upright posts; the number of the upright post connecting holes is equal to or greater than that of the upright posts.

In a specific embodiment, the carrier assembly includes: a first supporting plate positioned at the upper end, a second supporting plate positioned at the lower end, a third supporting plate positioned in the middle and an upright post; wherein the content of the first and second substances,

the first support plate, the second support plate and the third support plate are all provided with a conduit connecting hole, a rod connecting hole and an upright post connecting hole;

the drug delivery catheter fixedly connected with the plurality of wire pipes respectively penetrates through the catheter connecting holes in the first support plate, the second support plate and the third support plate to be connected with the bearing component;

the connecting rod respectively penetrates through the rod connecting holes in the first supporting plate, the second supporting plate and the third supporting plate to be fixedly connected with the bearing assembly;

the upright post respectively penetrates through upright post connecting holes in the first supporting plate, the second supporting plate and the third supporting plate to realize the fixed connection with the bearing component;

the first supporting plate and the third supporting plate are provided with driving holes for accommodating the threaded rods;

the nut is arranged between the first supporting plate and the third supporting plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;

the threaded rod penetrates through the driving holes in the first supporting plate and the third supporting plate respectively, the lower end of the threaded rod is blocked by the second supporting plate, and the nut is sleeved on the threaded rod in the area between the first supporting plate and the third supporting plate.

In a specific embodiment, the lower end of the threaded rod is also provided with a head; wherein the head has a cross-sectional area greater than the cross-sectional area of the threaded portion of the threaded shank.

In a specific embodiment, the nut is in a polygonal shape, the pillar is square, and the limiting member includes one or more of the pillars.

In a specific embodiment, the driving structure comprises: a screw cross slot or a screw straight slot.

In a particular embodiment, the signal recorder is adhesively secured to the carrier assembly; the administration catheter fixedly connected with the plurality of line pipes is fixedly connected with the nut in a bonding mode.

In a specific embodiment, the conduit is a silicon conduit.

In a specific embodiment, the connection part of the electrode wire and the signal recorder is packaged in a mode of coating silver paint.

Therefore, the stepping drug delivery device can realize the stepping of the drug delivery catheter through the device, so that drug delivery operation can be performed in a larger area, in addition, the drug delivery catheter is additionally provided with the wire electrode for detecting neuron signals, the integration of drug delivery and signal detection is realized, the drug delivery area can be detected in a targeted manner, the acquisition of the signals is more timely and more targeted, and the acquired signals are more accurate.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

FIG. 1 is a schematic view of a step-able drug delivery device according to an embodiment of the present invention;

FIG. 2 is a schematic view of a step-able drug delivery device according to an embodiment of the present invention;

FIG. 3 is a schematic diagram of an exploded view of a step-able drug delivery device according to an embodiment of the present invention;

FIG. 4 is a schematic view of the structure of a drug delivery catheter, a wire conduit and a wire electrode of a step-by-step drug delivery device according to an embodiment of the present invention;

FIG. 5 is a schematic view of a threaded rod and nut of a step-able drug delivery device according to an embodiment of the present invention;

fig. 6 is a schematic structural diagram of a signal recorder in a step-able drug delivery device according to an embodiment of the present invention.

Illustration of the drawings:

1-a carrier assembly; 11-a first support plate; 12-a third support plate; 13-a second support plate; 14-upright post; 2-a drug delivery catheter; 3-a line pipe;

4-a threaded rod; 41-a drive structure;

5-a nut;

6-a signal recorder; 7-a connecting rod; 8-electrode wire.

Detailed Description

Various embodiments of the present disclosure will be described more fully hereinafter. The present disclosure is capable of various embodiments and of modifications and variations therein. However, it should be understood that: there is no intention to limit the various embodiments of the disclosure to the specific embodiments disclosed herein, but rather, the disclosure is to cover all modifications, equivalents, and/or alternatives falling within the spirit and scope of the various embodiments of the disclosure.

The terminology used in the various embodiments of the present disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the various embodiments of the present disclosure. As used herein, the singular forms are intended to include the plural forms as well, unless the context clearly indicates otherwise. Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the various embodiments of the present disclosure belong. The terms (such as those defined in commonly used dictionaries) should be interpreted as having a meaning that is consistent with their contextual meaning in the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined in various embodiments of the present disclosure.