阅读说明：本技术 清洁组合物，其制造方法和使用 (Cleaning compositions, methods of manufacture and uses thereof ) 是由 沃尔特·霍金斯 莎伦·W·雷诺兹 詹姆斯·W·利拉德 河清 哈里·迈克尔·琼斯 于 2017-09-06 设计创作，主要内容包括：一种用于配制清洁组合物的方法包括以下步骤：用涂布剂涂布颗粒状吸收性材料以制备涂布的吸收性材料并将该涂布的吸收性材料与卫生剂混合,其中所述涂布的吸收性材料吸收所述卫生剂以形成清洁组合物。得到的清洁组合物可用于清理病原体或危害物质。所述清洁组合物还可以用作公共区域的可液化干性清洁粉末以便响应体液事件。公开了一种在高表面积固体上的无毒生物静态膜的涂布方法。(A method for formulating a cleaning composition comprising the steps of: coating a particulate absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitary agent, wherein the coated absorbent material absorbs the sanitary agent to form a cleaning composition. The resulting cleaning composition can be used to clean pathogens or hazardous materials. The cleaning composition may also be used as a liquefiable dry cleaning powder in public areas to respond to bodily fluid events. A method of coating a non-toxic biostatic membrane on a high surface area solid is disclosed.)

1. A method of formulating a cleaning composition comprising the steps of:

(a) grinding an absorbent material to produce a particulate absorbent material, wherein the particulate absorbent material is selected from the group consisting of ceramic minerals, zeolites, activated carbon, fumed silica, processing clays, cellulose absorbents, fibrous absorbents, and combinations thereof;

(b) coating the particulate absorbent material with a biocide to produce a coated absorbent material, wherein the biocide is applied to the particulate absorbent material by vapor deposition, by pressure droplet spraying, or by a fuming or atomizing nozzle to form a surface-bound film on the particulate absorbent material, and wherein the biocide is selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, vapor phase metal hydroxides, silver solutions, copper solutions, and combinations thereof;

(c) mixing the coated absorbent material with a sanitizing agent to cause the coated absorbent material to absorb the sanitizing agent to form the cleaning composition, wherein the sanitizing agent is selected from the group consisting of a chlorine bleach solution, a hydrogen peroxide solution, peracetic acid, a quaternary amine solution, an alcohol solution, and combinations thereof; and

(d) adding to the cleaning composition a modifier selected from the group consisting of a viscosity increasing agent, a thickener, a gum, an absorbent polymer, a carboxymethyl cellulose (CMC) -derived polymer, a Hierarchical Porous Carbon (HPC) -derived polymer, or a combination thereof,

wherein the cleaning composition comprises 25-30% (w/w) of the particulate absorbent material, 0.5-3.5 wt% of the biocide, 0.1-10 wt% of the hygiene agent and 0.1-5 wt% of the modifying agent.

2. The method of claim 1, wherein the particulate absorbent material is a ceramic mineral or a zeolite.

3. The method of claim 1, wherein the cleaning composition is formulated to absorb liquid at a liquid loading that is increased by 25-30% by volume or 200-300% by mass.

4. A method of formulating a cleaning composition comprising the steps of:

(a) grinding an absorbent material to produce a particulate absorbent material;

(b) coating the particulate absorbent material with a biocide to produce a coated absorbent material;

(c) mixing the coated absorbent material with a sanitary agent, allowing the coated absorbent material to absorb the sanitary agent to form the cleaning composition; and

(d) adding to the cleaning composition a modifier selected from the group consisting of a viscosity increasing agent, a thickener, a gum, an absorbent polymer, a carboxymethyl cellulose (CMC) -derived polymer, a Hierarchical Porous Carbon (HPC) -derived polymer, or a combination thereof,

wherein the particulate absorbent material comprises 25-30% (w/w) of the cleaning composition.

5. The method of claim 4, wherein the biocide is selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, vapor phase metal hydroxides, silver solutions, copper solutions, and combinations thereof.

6. The method of claim 4, wherein the biocide is a liquid phase biocide.

7. The method of claim 6, wherein the liquid-phase biocide comprises one or more members selected from the group consisting of chlorine bleach solutions, hydrogen peroxide solutions, peracetic acid, quaternary amine solutions, alcohol solutions, periodine solutions, dimethylbenzyl ammonium chloride, dimethylethylbenzyl ammonium chloride, and mixtures thereof.

8. A method as claimed in claim 4 wherein the biocide is applied to the particulate absorbent material by vapour deposition, by pressure droplet spraying or by a fuming or atomising nozzle.

9. The method of claim 4, wherein the biocide forms a surface adhesion film on the particulate absorbent material.

10. The method of claim 4, wherein the biocide comprises 0.5-3.5% (w/w) of the cleaning composition.

11. The method of claim 4, wherein the particulate absorbent material is selected from the group consisting of ceramic minerals, zeolites, activated carbon, fumed silica, processing clays, cellulose absorbents, fibrous absorbents, and combinations thereof.

12. The method of claim 4, wherein the particulate absorbent material comprises a ceramic material.

13. The method of claim 4, wherein the particulate absorbent material comprises a zeolite.

14. The method of claim 4, wherein the particulate absorbent material has a surface area to mass ratio of 1,000m²More than g.

15. The method of claim 4Wherein the particulate absorbent material has a surface area/volume ratio of 1,000m²More than ml.

16. The method of claim 4, wherein the sanitizing agent is selected from the group consisting of chlorine bleach solutions, hydrogen peroxide solutions, peracetic acid, quaternary amine solutions, alcohol solutions, and combinations thereof.

17. The method of claim 4, wherein the sanitizing agent comprises 0.1 to 10% (w/w) of the cleaning composition.

18. The method of claim 4, wherein the modifying agent comprises a thickener, a gum, an absorbent polymer, or a combination thereof.

19. The method of claim 4, wherein the modifying agent comprises a carboxymethyl cellulose (CMC) -derived polymer and/or a Hierarchical Porous Carbon (HPC) -derived polymer.

20. The method of claim 4, wherein the modifying agent is a tackifier.

21. The method of claim 4, wherein the modifier comprises 0.1-5% (w/w) of the final product.

22. The method of claim 4, wherein the cleaning composition is formulated to absorb liquid at a liquid loading of 25-30% by volume or 200-300% by mass increase.

23. A method of using a cleaning composition comprising:

applying an effective amount of the cleaning composition of claim 1 to a surface in need of cleaning to form a treated surface; and

removing the cleaning composition.

24. The method of claim 23, further comprising the step of rinsing the treated surface with a liquid or wiping the surface with a wiping material after removing the cleaning composition.

25. The method of claim 23, wherein the cleaning composition is removed after treating the surface for a period of time from 30 seconds to 30 minutes.

26. The method of claim 23, wherein the surface to be cleaned is in a public area.

27. The method of claim 23, wherein the surface to be cleaned comprises biohazard leakage.

Technical Field

The present application relates generally to a cleaning composition and method, and in particular, to a cleaning composition and method for cleaning surfaces, such as disinfecting or removing biohazard materials from public areas.

Background

Typically, over the years, various types of disinfectants have been used in various industries, including the pharmaceutical and medical industries, as alternatives to heat disinfection, radiation disinfection, or other less desirable techniques. Disinfectants provide a safer, more economical and/or convenient means of eliminating potentially harmful germs, viruses, fungi and bacteria. However, the inherent strength of chemical disinfectants sometimes results in effectiveness and cost that exceed safety. Therefore, the user must be very careful as to the nature of the chemical sterilant used and strict guidelines are available for all chemical sterilant compositions.

Disclosure of Invention

One aspect of the present application relates to a method of formulating a cleaning composition comprising the steps of: coating a particulate absorbent material with a coating agent to produce a coated absorbent material; mixing the coated absorbent material with a sanitary agent, wherein the coated absorbent material absorbs the sanitary agent to form a cleaning composition.

Another aspect of the present application relates to a cleaning composition comprising a particulate absorbent material coated with a biocide; and a sanitary agent absorbed in the particulate absorbent material.

Another aspect of the present application relates to a method for preventing and/or decontaminating a surface from pathogens comprising: applying an effective amount of a cleaning composition to the surface, wherein the cleaning composition comprises a particulate absorbent material coated with a biocide; and a sanitary agent absorbed in the particulate absorbent material. In one embodiment, the pathogen is a virus or a bacterium.

Furthermore, another aspect of the present application relates to a hygiene method comprising the steps of: applying an effective amount of a cleaning composition to a surface in need of hygiene, the cleaning composition comprising a particulate absorbent material coated with a biocide; and a sanitary agent absorbed in the particulate absorbent material; and removing the cleaning composition after a period of time.

Another aspect of the present application relates to a cleaning assembly comprising a cleaning composition comprising a particulate absorbent material coated with a biocide; and instructions for absorbing the hygienic agent in the particulate absorbent material to a surface in need of hygiene and how to use the cleaning composition.

Another aspect of the present application is a specific method of coating a non-toxic biostatic membrane onto a high surface area solid, such as a particulate absorbent material.

These and other aspects and embodiments of the present application will be better understood with reference to the following detailed description when considered in conjunction with the accompanying drawings and claims.

Detailed Description

Aspects of the present application, including methods, materials, and examples, are described in connection with exemplary embodiments, which are not limiting, and the scope of the present application is intended to cover all equivalents, alternatives, and modifications, which are either commonly known or incorporated herein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. Those of skill in the art will recognize many techniques and materials similar or equivalent to those described herein, which may be used in the practice of the aspects and embodiments of the present application. The described aspects and embodiments of the present application are not limited to the described methods and materials.

As used in this specification and the appended claims, the singular forms "a", "an", and "the" include plural referents unless the content clearly dictates otherwise.

Ranges can be expressed herein as from "about" one particular value, and/or to "about" another particular value. When such a range is expressed, another embodiment includes from the one particular value and/or to the other particular value. Similarly, when values are expressed as approximations, by use of the antecedent "about," it will be understood that the particular value forms another embodiment. It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint. It will also be understood that a number of values are disclosed herein, and that each value is also disclosed herein as "about" that particular value, in addition to the value itself. For example, if the value "10" is disclosed, then "about 10" is also disclosed. It is also understood that when a value is disclosed that is "less than or equal to" the value, possible ranges between "greater than or equal to the value" and the value are also disclosed, as appropriately understood by those skilled in the art. For example, if the value "10" is disclosed, then "less than or equal to 10" and "greater than or equal to 10" are also disclosed.

The present application describes a novel, effective and low cost cleaning composition that can be used to quickly and safely clean biohazard spills (vomit/urine/blood and feces) from surfaces in the hospital, emergency care facility, medical room, nursing home, prison, school and hospitality industries. The method and formulation are also well suited for use with highly dangerous spills common in these environments, such as spills of chemotherapeutic drugs.

Manufacturing method

One aspect of the present application relates to a method of making a cleaning composition. The method comprises the following steps: coating a particulate absorbent material with a coating agent to produce a coated absorbent material; mixing the coated absorbent material with a sanitary agent, wherein the coated absorbent material absorbs the sanitary agent to form a coated and absorbed absorbent material. In some embodiments, the method further comprises the step of grinding the absorbent material to produce a particulate absorbent material for use in the coating step. In other embodiments, the method further comprises the step of adding one or more modifying agents to the coated and absorbed absorbent material in an amount sufficient to achieve the desired physical properties (e.g., dustless and clumpy, ease of pickup, liquid loading capacity, etc.).

The cleaning compositions are useful for eradicating, eliminating, inactivating, inhibiting the activity of, or reducing the number of pathogens on a surface. The cleaning compositions are particularly useful for cleaning biohazard spills such as vomit, urine, blood and feces in hospitals, emergency care facilities, medical rooms, nursing homes, prisons, schools and the hospitality industry. The cleaning compositions of the present application are also ideally suited for cleaning of commonly found, highly dangerous spills in these environments, such as spills of chemotherapeutic drugs.

Particulate absorbent material

The particulate absorbent material may be any solid material having the desired surface area, granulation, and absorption characteristics. As used herein, the term "absorbent" or "sorbent" is understood to mean a material capable of taking up and holding aqueous fluids. Suitable particulate absorbent materials include, but are not limited to, expanded and optimized ceramic minerals such as perlite and vermiculiteZeolite, activated carbon, cellulose absorbent and fibrous absorbent. In some embodiments, the particulate absorbent material comprises activated carbon, fumed silica, fine perlite, zeolite, processed clay, or combinations thereof. The adsorbent/absorbent will exhibit caking or matting properties (mechanical properties) for optimum performance and good dust removal. The particulate absorbent material preferably has a surface area to mass ratio or a surface area to volume ratio. In some embodiments, the particulate absorbent material has a surface area to mass ratio within the following range: 100-10,000m²/g，100-9,000m²/g，100-8,000m²/g，300-8,000m²/g，1,000-8,000m²/g，2,000-8,000m²/g，3,000-8,000m²/g，4,000-8,000m²/g，5,000-8,000m²/g，6,000-8,000m²/g，7,000-8,000m²/g，100-7,000m²/g，300-7,000m²/g，1,000-7,000m²/g，2,000-7,000m²/g，3,000-7,000m²/g，4,000-7,000m²/g，5,000-7,000m²/g，6,000-7,000m²/g，100-6,000m²/g，300-6,000m²/g，1,000-6,000m²/g，2,000-6,000m²/g，3,000-6,000m²/g，4,000-6,000m²/g，5,000-6,000m²/g，100-4,000m²/g，300-4,000m²/g，1,000-4,000m²/g，2,000-4,000m²/g，3,000-4,000m²/g，100-3,000m²/g，300-3,000m²/g，1,000-3,000m²/g，2,000-3,000m²/g，100-2,000m²/g，300-2,000m²(ii)/g or 1,000-2,000m²/g。

In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 10,000m²(ii) in terms of/g. In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 9,000m²(ii) in terms of/g. In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 8,000m²(ii) in terms of/g. In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 7,000m²(ii) in terms of/g. In some casesIn an embodiment, the particulate absorbent material has a surface area to mass ratio of up to 6,000m²/g。

In some embodiments, the particulate absorbent material has a surface area to mass ratio of 100m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 300m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 1,000m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 2,000m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 3,000m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 4,000m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 5,000m²(ii) a/g or greater.

In some embodiments, the particulate absorbent material has a surface area/mass ratio of 1000-²/g。

In some embodiments, the particulate absorbent material comprises a ceramic mineral.

In some embodiments, the particulate absorbent material comprises perlite and/or vermiculite.

In some embodiments, the particulate absorbent material has a surface area to volume ratio in the following range: 100-5,000m²/ml，300-5,000m²/ml，1,000-5,000m²/ml，2,000-5,000m²/ml，3,000-5,000m²/ml，4,000-5,000m²/ml，100-4,000m²/ml，300-4,000m²/ml，1,000-4,000m²/ml，2,000-54,000m²/ml，3,000-4,000m²/ml，100-3,000m²/ml，300-3,000m²/ml，1,000-3,000m²/ml，2,000-3,000m²/ml，100-2,000m²/ml，300-2,000m²/ml or 1,000-2,000m²/ml。

In some embodiments, the particulate absorbent material has a surface area to volume ratio of up to 5,000m²And/ml. In some casesIn embodiments, the particulate absorbent material has a surface area to volume ratio of up to 4,000m²And/ml. In some embodiments, the particulate absorbent material has a surface area to volume ratio of up to 3,000m²/ml。

In some embodiments, the particulate absorbent material has a surface area to volume ratio of 100m²A/ml or greater. In some embodiments, the particulate absorbent material has a surface area to volume ratio of 300m²A/ml or greater. In some embodiments, the particulate absorbent material has a surface area to volume ratio of 1,000m²A/ml or greater. In some embodiments, the particulate absorbent material has a surface area to volume ratio of 2,000m²A/ml or greater. In some embodiments, the surface area to volume ratio of the particulate absorbent material ranges from 1000-²/ml。

As used herein, the term "ceramics" may refer to a mixture of non-metallic elements having a general hardness, compressive strength, modulus of elasticity, thermal expansion, and density. Exemplary ceramics include, but are not limited to, materials for ceramic ware (potery), bricks, tiles, cement, and glass, barium titanate, strontium titanate, bismuth strontium calcium copper oxide, boron nitride, ceramics, ferrites, lead zirconate titanate, magnesium diboride, porcelain (porcelain), sialon (sialon), silicon carbide, silicon nitride, steatite, titanium carbide, uranium oxide, yttrium barium copper oxide, zinc oxide, zirconium dioxide, and partially stabilized zirconium oxide. The ceramic may be an oxide (alumina, beryllia, ceria, zirconia), a non-oxide (carbide, boride, nitride, suicide) or a composite (a combination of oxide and non-oxide).

Perlite is a naturally occurring form of obsidian characterized by spherulites formed by the cracking of volcanic glass during cooling. Perlite generally comprises a mixture of silica, alumina, sodium oxide, potassium oxide, iron oxide, magnesium oxide, and calcium oxide. Potential alternatives to perlite include, but are not limited to, diatomaceous earth, expanded clay, shale, pumice, slag, or vermiculite. Vermiculite is a naturally occurring hydrous phyllosilicate material, which is a 2:1 clay.

As used herein, the term "zeolite" may refer to any of a number of minerals of hydrated aluminosilicates containing sodium, potassium, calcium and barium. Zeolites may occur naturally or may be synthesized artificially. Exemplary zeolites include, but are not limited to, analcime, chabazite, clinoptilolite, heulandite, natrolite, phillipsite, and stilbite.

As used herein, the term "activated carbon" may refer to a form of carbon that is processed to have small, low volume pores that increase the surface area available for adsorption or chemical reactions. A synonym for activated carbon (activated carbon) is activated charcoal (activated charcoal).

As used herein, the term "cellulose absorbent" may refer to cellulose and cellulose derivatives that may provide structure, volume, water holding capacity, and fluid channels in a wide range of sizes.

As used herein, the term "fibrous absorbent" refers to a fibrous structure having high void volume, hydrophilic properties, and wet resiliency. Examples of fibrous absorbents include, but are not limited to, cotton fiber-based absorbents, cereal fiber-based absorbents, and hemp-based absorbents.

In some embodiments, the particulate absorbent material comprises 10-70% (w/w), 10-60% (w/w), 10-50% (w/w), 10-40% (w/w), 10-30% (w/w), 10-20% (w/w), 20-70% (w/w), 20-60% (w/w), 20-50% (w/w), 20-40% (w/w), 20-30% (w/w), 30-70% (w/w), 30-60% (w/w), 30-50% (w/w), 30-40% (w/w), 40-70% (w/w), 40-60% (w/w), 40-50% (w/w), 50-70% (w/w), 50-70% (w/w) or 60-70% (w/w). In some embodiments, the particulate absorbent material comprises 25-30% (w/w) of the final product. In some embodiments, the particulate absorbent material comprises about 27% (w/w) of the final product.

Coating agent

The coating agent can be any biocide that is capable of forming a coating on the surface of the particulate absorbent material of the present application. In some embodiments, the coating agent contains one or more agents selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, fumed metal hydroxides, silver solutions, copper solutions, and combinations thereof.

In some embodiments, the coating agent is a biocide that forms a surface-bound film on the particulate absorbent material. The static surface-bound biocide film deactivates or inhibits pathogens that come into contact with the cleaning composition of the present invention for a long period of time, thus ensuring the effectiveness of the cleaning effect for a long period of time. In some embodiments, the coating agent is applied to the particulate absorbent material by vapor deposition. In some embodiments, the vapor deposition is performed by thermally heating the coating agent and the particulate absorber.

In some embodiments, the coating agent is applied to the particulate absorbent material by a pressurized droplet spray.

In some embodiments, the coating agent is applied to the particulate absorbent material through a fuming or atomizing nozzle.

In some embodiments, the coating agent is applied to the particulate absorbent material by a deposition technique commonly used for metal plating.

As used herein, the term "biocide" refers to any material that destroys, inactivates, eliminates, prevents, inhibits the growth of, or otherwise renders harmless pathogens or microorganisms and/or prevents their destruction or infection. Examples of biocides include, but are not limited to, silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, vapor phase metal hydroxides, silver and its salts or solutions, copper and its salts or solutions, formaldehyde; bronopol; chlorocresol; peracetic acid; p-chlorocresol; biphenyl-2-ol; hexa-2, 4-dienoic acid/ascorbic acid (scorbutic acid); glutaraldehyde; chlorobenzophenol (clorofen); 2-phenoxyethanol; cetylpyridinium chloride; sodium chloramine-T; sodium o-phenylphenol; a phthalaldehyde; n- (3-aminopropyl) -N-dodecylpropane-1, 3-diamine; trichloroxin sodium; sodium dichloroisocyanurate dihydrate; didecyl dimethyl ammonium chloride; iodine; sodium hypochlorite; hydrogen peroxide; calcium hypochlorite; silver chloride; lignin; 2, 2-dibromo-2-cyanoacetamide; p-chloro-m-cresol sodium; d-gluconic acid mixture with N, N' -bis (4-chlorophenyl) -3, 12-diimino-2, 4,11, 13-tetraazatetradecanediamidine (2: 1); (E, E) -hex-2, 4-dienoic acid potassium salt; quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl-chloride; benzyl-C12-16-alkyldimethyl-chloride; di-C8-10-alkyldimethyl-chloride; bis (peroxymonosulfate) -pentapotassium bis (sulfate); benzyl-C12-14-alkyldimethyl-chloride; c12-14-alkyl [ (ethylphenyl) methyl ] dimethyl-chloride; [2- [ [2- [ (2-carboxyethyl) (2-hydroxyethyl) -amino ] ethyl ] amino ] -2-oxoethyl ] -cocoalkyldimethylhydroxide, inner salt; a reaction product from: glutamic acid and N- (C12-14-alkyl) -propanediamine; 6- (phthalimido) peroxycaproic acid; silver sodium hydrogen zirconium phosphate; poly (hexamethylene diamine guanidine chloride); polyhexamethylene biguanide; an oligo (2- (2-ethoxy) ethoxyethylguanidinium chloride) polymer; amine, n-C10-16-alkyltrimethylene di-, the reaction product from chloroacetic acid; quaternary ammonium iodides; benzylalkyldimethyl (C8-C22 alkyl, saturated and unsaturated, and tallow alkyl, cocoalkyl and soya alkyl), chloride, bromide or hydroxide)/BKC; dialkyl dimethyl (C6-C18 alkyl, saturated and unsaturated, and tallow alkyl, coco alkyl and soya alkyl) chloride, bromide or methylsulfate)/DDAC; 2-butanone, peroxide; boric acid; disodium octaborate tetrahydrate; triclosan; tea tree (melaleuca alternifolia), extract/Australian tea tree oil; sulfur dioxide; sodium bisulfite; disodium bisulfite; sodium sulfite; potassium sulfite; dipotassium disulfite; 1- [ [2- (2, 4-di-chlorophenyl) -4-propyl-1, 3-dioxolan-2-yl ] methyl ] -1H-1,2, 4-triazole/propiconazole; triclocarban; dodecyl guanidine monohydrochloride; silver zinc aluminoborophosphate glass/glass oxide, silver and zinc containing; sodium aluminum silicate silver zinc complex/silver zinc zeolite plant protectant; sodium benzoate; disodium tetraborate, anhydrous; a mixture of cis and trans p-menthane-3, 8-diol/p-menthyl-3, 8-diol (citriodiol); mesiramine ethosulfate; amine, C10-16-alkyldimethyl-, N-oxide; calcium di-hexa-2, 4-dienoate; sodium bicarbonate; benzalkonium chloride; benzethonium chloride; a salt of ammonium bromide; polyvinylpyrrolidone-iodine; silver nitrate; n, N' - (decan-1, 10-diylbis-1 (4H) -pyridinyl-4-ylidene) bis (octylammonium) dichloride; 2,4,8, 10-tetra (tert-butyl) -6-hydroxy-12H-dibenzo [ d, g ] [1,3,2] dioxaphosphorinane-6-oxide, sodium salt.

As used herein, the term "silane" refers to compounds having four substituents on silicon, including organosilicon compounds. Exemplary silanes include, but are not limited to, trichlorosilane (SiHCl)₃) Tetramethylsilane (Si (CH)₃)₄) And tetraethoxysilane (Si (OC)₂H₅)₄)。

As used herein, the term "siloxane" refers to a compound containing functional groups with Si-O-Ai linkages in silicone chemistry. Exemplary silicones include, but are not limited to, polydimethylsiloxane or cyclomethicone.

As used herein, the term "pathogen" includes, but is not limited to, viruses, bacteria, yeasts, protozoa, or other pathogenic microorganisms. The following describes definitions and descriptions of pathogens that may be eliminated, killed, inactivated or inhibited by application of the cleaning compositions of the present application. The ordinarily skilled artisan will appreciate that the pathogens described herein are non-limiting. In some embodiments, the biocide and/or cleaning compositions of the present application may be directed against a family of key pathogens such as norovirus, HIV, MRSA, clostridium difficile (c.diff.), hepatitis virus, ebola (ebola), various GI-related viruses, or targeted bioterrorism agents, among others, which are defined and described below.

Examples of viruses include, but are not limited to, influenza virus, herpes virus, poliovirus, norovirus, gastrointestinal-related (GI-related) virus, and retrovirus. Examples of viruses include, but are not limited to, human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2), human T cell lymphotropic virus type I and type II (HTLV-I and HTLV-II), hepatitis A virus, Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Hepatitis D Virus (HDV), Hepatitis E Virus (HEV), Hepatitis G Virus (HGV), parvovirus B19 virus, Transfusion Transmitted Virus (TTV), Epstein-Barr virus, human cytomegalovirus type 1 (HCMV-1), human herpes virus type 6 (HHV-6), human herpes virus type 7 (HHV-7), human herpes virus type 8 (HHV-8), influenza A virus (including subtypes H1N1 and H5N1), influenza B virus, human interplasma pneumovirus, Severe Acute Respiratory Syndrome (SARS) coronavirus, SARS virus, HIV-V, HIV-II, HIV-IV-II, HIV-type I-II, HIV-, Hantavirus, and RNA viruses from: arenaviridae (such as Lassa Fever Virus (LFV)), pneumoviridae (such as human metapneumovirus), filoviridae (e.g., ebola virus (EBOV), marburg virus (MBGV), and zika virus); bunyaviridae (e.g., Rift Valley Fever Virus (RVFV), crimean-congo hemorrhagic fever virus (CCHFV), and hantaviruses); the Flaviviridae family (West Nile Virus (WNV), dengue Virus (DENV), Yellow Fever Virus (YFV), GB Virus C (GBV-C; formerly Hepatitis G Virus (HGV)), the rotaviridae family (e.g., rotavirus), human T cell lymphotropic viruses (HTLV) types I and II (HTLV-I and HTLV-II), parvovirus B19 virus, Transfusion Transmitted Viruses (TTV); measles virus; rotaviruses, including types A, B, C, D and E; Human Papilloma Virus (HPV) and its various serotypes, as well as other various RNA viruses.

Examples of microorganisms that cause gastroenteritis in humans and animals include viruses, bacteria, parasites and fungi. The virus causes about 7% of infectious diarrhea. Viral infections causing gastroenteritis may be attributed to rotavirus, adenovirus, norovirus, astrovirus and coronavirus. Bacterial infections that cause gastroenteritis can be caused by Campylobacter (Campylobacter), Escherichia coli (Escherichia coli), Salmonella (Salmonella), Shigella (Shigella), Staphylococcus aureus (Staphylococcus aureus) and Clostridium (Clostridium) species. Protozoan infections leading to gastroenteritis may be the result of Giardia (Giardia), Entamoeba (Entamoeba) and Cryptosporidium (Cryptosporidium) species.

As used herein, the term "bacterium" shall refer to a member of a large number of unicellular microorganisms that have cell walls but lack organelles and organized nuclei. Synonyms for bacteria include the terms "microorganisms", "germs", "bacilli", "pathogens" and "prokaryotes". Exemplary bacteria include, but are not limited to, Mycobacterium species (Mycobacterium species), including Mycobacterium tuberculosis (m.tuberculosis); staphylococcus aureus species (Staphylococcus species), including Staphylococcus epidermidis (s. epidermidis), Staphylococcus aureus (s. aureus), and methicillin-resistant Staphylococcus aureus (methicillin-resistant s. aureus); streptococcus species (Streptococcus species) including Streptococcus pneumoniae (s.pneumoniae), Streptococcus pyogenes (s.pyogenenes), Streptococcus mutans (s.mutans), Streptococcus agalactiae (s.agalactiae), Streptococcus equi (s.equi), Streptococcus canis (s.canis), Streptococcus bovis (s.bovis), Streptococcus equi (s.equi), Streptococcus anginosus (s.anginosus), Streptococcus sanguinis (s.sanguinis), Streptococcus salivarius (s.salivarius), Streptococcus mitis (s.mitis); other pathogenic streptococcus species, including Enterococcus species (Enterococcus species), such as Enterococcus faecalis (e.faecalis) and Enterococcus faecium (e.faecalis); haemophilus influenzae (Haemophilus influenzae), Pseudomonas species (Pseudomonas species), including Pseudomonas aeruginosa (p. aeruginosa), Pseudomonas pseudomelioidea (p. Pseudomonas pseudomelitensis), and Pseudomonas farinosa (p. mellei); salmonella species (salmonella) including salmonella enterocolitica (s.enterocolitica), salmonella typhimurium (s.typhimurium), salmonella enteritidis (s.enteritidis), salmonella bangolgi (s.bongori), and salmonella choleraesuis (s.choleraesuis); shigella species (Shigella species) including Shigella flexneri (s.flexneri), Shigella sonnei (s.sonnei), Shigella dysenteriae (s.dysenteriae) and Shigella boydii (s.boydii); brucella species (Brucella species) including Brucella melitensis (b.melitensis), Brucella suis (b.suis), Brucella bovis (b.abortus) and Brucella pertussis (b.pertussis); neisseria species (Neisseria species), including Neisseria meningitidis (n.meningitidis) and Neisseria gonorrhoeae (n.gonorrhoeae); escherichia coli (Escherichia coli), including enterotoxigenic e.coli (ETEC); vibrio cholerae (Vibrio cholerae), Helicobacter pylori (Helicobacter pylori), Chlamydia trachomatis (Chlamydia trachomatis), clostridium difficile (clostridium difficile), cryptococcus neoformans (cryptococcus organogens), moraxella species (moraxella species), including moraxella catarrhalis (m.catarrhalis), campylobacter species (campylobacter), including campylobacter jejuni (c.jejuni); corynebacterium species (Corynebacterium species) including Corynebacterium diphtheriae (c.diphtheria), Corynebacterium ulcerans (c.ulcerans), Corynebacterium pseudotuberculosis (c.pseudotubercuberculosis), Corynebacterium pseudodiphtheriae (c.pseudodiphtheria), haemophilus urealyticum (c.urealyticum), clostridium hemolyticus (c.haemolyticum), Corynebacterium equi (c.equi); listeria monocytogenes (Listeria monocytogenes), Agrobacterium stellatous (Nocardia asteroides), Bacteroides (Bacteroides species), Actinomycetes (Actinomycetes species), Treponema pallidum (Treponema pallidum), Leptospira sp.pneumoniae (Klebsiella pneumoniae); proteus species (Proteus sp.), including Proteus vulgaris (Proteus vulgaris); serratia species (Serratia species), Acinetobacter species (Acinetobacter), Yersinia species (Yersinia species), including plague bacillus (y.pestis) and pseudotuberculosis bacillus (y.pseudotuberculosis); francisella tularensis (Francisella tularensis), Enterobacter species (Enterobacter species), Bacteroides species (Bacteriodes species), Legionella species (Legionella species), Borrelia burgdorferi (Borrelia burgdorferi), and the like.

As used herein, the term "MRSA" may refer to the gram-positive bacterium methicillin-resistant staphylococcus aureus (MRSA). The term MRSA includes any strain of staphylococcus aureus produced by horizontal gene transfer and natural selection that is multi-resistant to beta-lactam antibiotics.

As used herein, the term "c.diff" refers to a gram-positive spore forming bacterium, known as Clostridium difficile (Clostridium difficile), or c.difficile, or c.diff or sometimes CDF/CDF. Difficile Infection (CDI) is a symptomatic infection caused by this bacterium, which can cause clostridium difficile-associated diarrhea or clostridium difficile colitis.

As used herein, the term "fungus" may refer to any member of saprophytic and parasitic sporulating eukaryotic, generally filamentous organisms (originally classified as chlorophyll-deficient plants) including molds, rusts, molds, gramineae (smut), mushrooms and yeasts. Exemplary fungi include, but are not limited to, Aspergillus species (Aspergillus species), Dermatophytes (Dermatophytes), dermatitidis (blatomyces dermatitididis), candida species (candida species), including candida albicans (c.albicans) and kluyveromyces (c.krusei); malassezia furfur (Malassezia furfur), Malassezia furfur (exophia wereckii), trichophyton holtzeri (piedra hirrtatia), trichophyton bailii (trichosporium beijersei), pseudallescheria (pseudohalibium boscheni), Pneumocystis yei (Pneumocystis jirov), mycobacterium grisea (Madurella grisea), Histoplasma capsulatum (Histoplasma capsulatum), Trichosporon scheriam (sporotrichinos scheniii), Histoplasma capsulatum (Histoplasma capsulatum), species (Tinea specularis including Tinea versicolor (t. versicolor), Tinea pedis (t.peyer), Tinea unguium (t. gunnii), Tinea cruris (t.guncia), Tinea capitis (t.barbarum), Tinea capitis (t.barnacrum); trichophyton species (Trichophyton species) including Trichophyton rubrum (t.rubrum), Trichophyton interdigitatum (t.intercropple), Trichophyton tonsurans (t.times), Trichophyton purpureum (t.villosum), Trichophyton erythraeum (t.yaoundei), Trichophyton schoenleini, Trichophyton maculon (t.megrini), Trichophyton sudanense (t.soudanense), Trichophyton equi (t.equinum), Trichophyton mentagrophytes (t.erinaceic) and Trichophyton verruciformis (t.verrucosum); mycoplasma genitalium (Mycoplasma genilia); microsporum species (Microsporum species) include Microsporum audorenii (m.audouini), m.ferrugineum, Microsporum canis (m.canis), m.nanum, m.distortum, Microsporum gypseum (m.gypseum), m.fulvum, and the like.

As used herein, the term "protozoa" may refer to any member of a variety of eukaryotes that are predominantly single-celled, exist alone or aggregate into colonies, are typically non-photosynthetic, and are further classified as phyla typically according to their ability and manner of movement (pseudopodia, flagella, or cilia). Exemplary protozoa include, but are not limited to, Plasmodium species (Plasmodium species), including Plasmodium falciparum (p.falciparum), Plasmodium vivax (p.vivax), Plasmodium ovale (p.ovale), andplasmodium malariae (p. malariae)(ii) a Leishmania species (Leishmania species) including Leishmania major (L.major), Leishmania tropica (L.tropi)ca), Leishmania donovani (L.donovani), Leishmania infantis (L.infantum), Leishmania chekiangensis (L.chagasi), Leishmania mexicana (L.mexicana), Leishmania panama (L.panamensis), Leishmania braziliensis (L.brasziliensis) and Leishmania guianensis (L.guyensi); cryptosporidium (Cryptosporidium), Isospora beijerinckii (Isospora belli), Toxoplasma gondii (Toxoplasma gondii), Trichomonas vaginalis (Trichomonas vagianais) and Cyclosporium species (Cyclosporium species).

As used herein, the term "targeted bioterrorism agent" includes, but is not limited to, anthrax (Bacillus anthracis), botulism (Clostridium botulinum toxin), plague (Yersinia pestis), smallpox (Variola virus), tularemia (Franciscella tularensis), and viral hemorrhagic fever (arenaviruses), bunyavirus (bunyaviruses), filoviruses (filoviruses), and arenaviruses (arenaviruses), or other class CDC a agents. Brucella (Brucella species), Clostridium perfringens (Clostridium perfringens), Salmonella species (Salmonella species), Escherichia coli (Escherichia coli) and Shigella species (Shigella species), Pseudomonas farci (Burkholderia mallei), Pseudomonas pseudomallei (Burkholderia pseudomallei), Chlamydia psittaci (Chlamydia psittaci), Burnather Kokstro (Coxiella brunetti), Ricinus communis (Ricinus communis), Rickettsia prowakii (Rickettsia rapiakii), Vibrio cholera (Vibrio cholera) and Cryptosporidium (Cryptosporidium parum), and alphaviruses such as Venezuelan encephalitis (Western encephalitis), Western encephalitis, and other western encephalitis viruses (European encephalitis B). Newly emerging infectious disease agents, such as Nipah virus (Nipah virus), hantavirus (hantavirus) and other CDC class C agents.

In some embodiments, the coating agent is added in an amount of 0.1 to 10% (w/w), 0.1 to 5% (w/w), 0.1 to 2% (w/w), 0.1 to 1% (w/w), 0.1 to 0.5% (w/w), 0.3 to 10% (w/w), 0.3 to 5% (w/w), 0.3 to 2% (w/w), 0.3 to 1% (w/w), 1 to 10% (w/w), 1 to 5% (w/w), 1 to 2% (w/w), 3 to 10% (w/w), or 3 to 5% (w/w) of the final product.

In some embodiments, the coating agent is added in an amount of 0.5 to 3.5% (w/w) or 1 to 3% (w/w) of the final product. In some embodiments, the coating agent is added in an amount of about 2% (w/w) of the final product.

Sanitary agent

The sanitary agent can be any agent having biocidal activity and can be absorbed by the coated particulate absorbent of the present application. The sanitary agents contain active substances designed to destroy, inhibit, reduce the activity of, inhibit the growth of, or otherwise render harmless harmful to the pests or toxic chemicals. In some embodiments, the hygienic agent is a liquid phase agent. In some embodiments, the hygiene agent is a liquid phase biocide. In some embodiments, the hygienic agent is a liquid phase chemical that inactivates or removes toxic chemicals, such as chemotherapeutic drugs. In some embodiments, a liquid phase biocide is added at the site of application to provide chemical disinfection for immediate response.

Examples of liquid phase biocides include, but are not limited to, chlorine bleach solutions, hydrogen peroxide solutions, peracetic acid, quaternary amine solutions, alcohol solutions, periodine solutions, dimethylbenzyl ammonium chloride, dimethylethylbenzyl ammonium chloride, and mixtures thereof.

Examples of liquid phase chemicals that can be used to inactivate or remove toxic chemicals include, but are not limited to, anionic surfactants such as soaps, sulfonates, and sulfates. In some embodiments, a large amount of water is used to dilute toxic chemicals.

In some embodiments, the hygienic agent is added in an amount of 0.1 to 10% (w/w), 0.1 to 3% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 10% (w/w), 0.3 to 3% (w/w), 0.3 to 1% (w/w), 1 to 10% (w/w), 1 to 3% (w/w), or 3 to 10% (w/w) of the final product.

In some embodiments, the hygiene agent comprises dimethylbenzyl ammonium chloride or dimethylethylbenzylammonium chloride. In some embodiments, the hygiene agent comprises dimethylbenzyl ammonium chloride or a mixture of dimethylethylbenzylammonium chlorides. In some embodiments, the hygiene agent is a 1:1 mixture of dimethylbenzyl ammonium chloride or dimethylethylbenzylammonium chloride.

In some embodiments, the hygienic agent is a quaternary amine and is added in an amount of 0.3 to 3% (w/w), 0.5 to 2% (w/w), or 0.5 to 1.5% (w/w) of the final product. In some embodiments, the hygienic agent is a quaternary amine and is added in an amount of about 1% (w/w) of the final product.

Modifying agent

In the final product, the modifier is added to the coated particulate absorbent or both the absorbed and coated particulate absorbent in an amount to achieve the desired physical properties (e.g., dustless and clumpy, ease of pickup, liquid loading capacity, etc.). Examples of modifiers include, but are not limited to, thickeners, gums (gum), absorbent polymers, viscosifiers, and combinations thereof.

As used herein, the term "thickener" may include any material known or otherwise effective to provide suspending, gelling, viscosifying, solidifying, or thickening properties to a composition, or otherwise provide structure in the form of a final product. These thickeners may include gelling agents, polymeric or non-polymeric agents, inorganic thickeners or viscosifiers. The amount and type of thickener can vary depending on the desired characteristics of the final product.

As used herein, the term "tackifier" refers to polymeric adhesives that increase the tack, i.e., the inherent tack or self-tack, of the composition such that they adhere firmly to a surface under light pressure for a short period of time. Examples of suitable tackifiers include highly flexible resins such as, but not limited to, homopolymers of alkyl (meth) acrylates, especially alkyl acrylates, for example poly (isobutyl acrylate) or poly (2-ethylhexyl acrylate), such as linear polyesters which are customarily used for coil coating, linear difunctional oligomers based on polycarbonate diols or polyester diols, which can be cured with actinic radiation, have a number average molecular weight of more than 2000, in particular 3000-4000, are linear vinyl ether homopolymers or copolymers based on ethyl, propyl, isobutyl, butyl and/or 2-ethylhexyl vinyl ether, or are non-reactive urethane urea oligomers, it is prepared from bis (4, 4-isocyanatophenyl) methane, N-dimethylethanolamine or a diol such as propylene glycol, hexylene glycol or dimethylpentylene glycol.

In some embodiments, the modifying agent comprises a polymeric substance that absorbs a liquid (preferably water), swells, and eventually converts to a viscous true or colloidal solution.

In some embodiments, the modifier comprises one or more silicone gums. As used herein, the term "silicone gum" refers to a silicone polymer having a degree of polymerization sufficient to provide a silicone having a gum-like structure. In some cases, the silicone polymer forming the gel may be crosslinked.

In some embodiments, the modifying agent comprises a polymer. As used herein, examples of polymers include, but are not limited to, natural and synthetic polymers, such as polyacrylamide (ACAM) and carboxymethylcellulose.

In some embodiments, the polymers of the present application include, but are not limited to, polyacrylates, such as sodium polyacrylate, and carboxymethylcellulose.

In some embodiments, the modifying agent comprises one or more superabsorbent polymers. The term "superabsorbent polymer" is understood to mean a hydrophilic polymeric structure capable of absorbing water or aqueous salt solutions with more than 10g of pure water/salt water/gram of dry material (>10 g/g). Examples of superabsorbent polymers include, but are not limited to, sodium polyacrylate and carboxymethylcellulose.

In some embodiments, the one or more modifying agents further comprise one or more additives selected from the group comprising denaturants, colorants, odor correctors, and/or pH adjusters.

In some embodiments, the one or more modifiers are added in an amount of 0.1 to 5% (w/w), 0.1 to 2% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 5% (w/w), 0.3 to 2% (w/w), 0.3 to 1% (w/w), 1 to 5% (w/w), 1 to 2% (w/w), or 2 to 5% (w/w) of the final product.

Cleaning composition

Another aspect of the present application relates to a cleaning composition. The cleaning composition contains a particulate absorbent material coated with a coating agent. Examples of the coating agent have been described above. In some embodiments, the coating agent contains a biocide. In some embodiments, the biocide comprises an agent selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, gas phase metal hydroxides, silver and silver salts, copper and copper salts. In some embodiments, the biocide forms a static film on the surface of the particulate absorbent material. In some embodiments, the particulate absorbent material comprises activated carbon, fumed silica, fine perlite, zeolite, processed clay, or combinations thereof. In some embodiments, the coating agent comprises 0.1 to 5% (w/w), 0.1 to 2% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 5% (w/w), 0.3 to 2% (w/w), 0.3 to 1% (w/w), 1 to 5% (w/w), 1 to 2% (w/w), or 2 to 5% (w/w) of the cleaning composition.

In some embodiments, the particulate absorbent material comprises a ceramic mineral. In some embodiments, the particulate absorbent material comprises perlite and/or vermiculite. In some embodiments, the particulate absorbent material has a surface area to mass ratio within the following range: 100-10,000m²/g，100-9,000m²/g，100-8,000m²/g，300-8,000m²/g，1,000-8,000m²/g，2,000-8,000m²/g，3,000-8,000m²/g，4,000-8,000m²/g，5,000-8,000m²/g，6,000-8,000m²/g，7,000-8,000m²/g，100-7,000m²/g，300-7,000m²/g，1,000-7,000m²/g，2,000-7,000m²/g，3,000-7,000m²/g，4,000-7,000m²/g，5,000-7,000m²/g，6,000-7,000m²/g，100-6,000m²/g，300-6,000m²/g，1,000-6,000m²/g，2,000-6,000m²/g，3,000-6,000m²/g，4,000-6,000m²/g，5,000-6,000m²/g，100-4,000m²/g，300-4,000m²/g，1,000-4,000m²/g，2,000-4,000m²/g，3,000-4,000m²/g，100-3,000m²/g，300-3,000m²/g，1,000-3,000m²/g，2,000-3,000m²/g，100-2,000m²/g，300-2,000m²(ii)/g, or 1,000-2,000m²/g。

In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 10,000m²(ii) in terms of/g. In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 9,000m²(ii) in terms of/g. In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 8,000m²(ii) in terms of/g. In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 7,000m²(ii) in terms of/g. In some embodiments, the particulate absorbent material has a surface area to mass ratio of up to 6,000m²/g。

In some embodiments, the particulate absorbent material has a surface area to mass ratio of 100m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 300m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 1,000m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 2,000m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 3,000m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 4,000m²(ii) a/g or greater. In some embodiments, the particulate absorbent material has a surface area to mass ratio of 5,000m²(ii) a/g or greater.

In some embodiments, the particulate absorbent material has a surface area to mass ratio of 1000-²In the range of/g.

In some embodiments, the particulate absorbent material has a surface area to volume ratio within the following range: 100-5,000m²/ml，300-5,000m²/ml，1,000-5,000m²/ml，2,000-5,000m²/ml，3,000-5,000m²/ml，4,000-5,000m²/ml，100-4,000m²/ml，300-4,000m²/ml，1,000-4,000m²/ml，2,000-54,000m²/ml，3,000-4,000m²/ml，100-3,000m²/ml，300-3,000m²/ml，1,000-3,000m²/ml，2,000-3,000m²/ml，100-2,000m²/ml，300-2,000m²/ml, or 1,000-²/ml。

In some embodiments, the particulate absorbent material has a surface area to volume ratio of up to 5,000m²And/ml. In some embodiments, the particulate absorbent material has a surface area to volume ratio of up to 4,000m²And/ml. In some embodiments, the particulate absorbent material has a surface area to volume ratio of up to 3,000m²/ml。

In some embodiments, the particulate absorbent material has a surface area to volume ratio of 100m²A/ml or greater. In some embodiments, the particulate absorbent material has a surface area to volume ratio of 300m²A/ml or greater. In some embodiments, the particulate absorbent material has a surface area to volume ratio of 1,000m²A/ml or greater. In some embodiments, the particulate absorbent material has a surface area to volume ratio of 2,000m²A/ml or greater. In some embodiments, the particulate absorbent material has a surface area/volume ratio of 1000-²In the range of/ml.

In some embodiments, the particulate absorbent material comprises 10-70% (w/w), 10-60% (w/w), 10-50% (w/w), 10-40% (w/w), 10-30% (w/w), 10-20% (w/w), 20-70% (w/w), 20-60% (w/w), 20-50% (w/w), 20-40% (w/w), 20-30% (w/w), 30-70% (w/w), 30-60% (w/w), 30-50% (w/w), 30-40% (w/w), 40-70% (w/w), 40-60% (w/w), 40-50% (w/w), 50-70% (w/w), 50-70% (w/w) or 60-70% (w/w). In some embodiments, the particulate absorbent material comprises 25-30% (w/w) of the final product. In some embodiments, the particulate absorbent material comprises about 27% (w/w) of the cleaning composition.

In some embodiments, the cleaning composition further comprises a hygiene agent absorbed in the coated particulate absorbent material. Examples of sanitary agents have been described above.

In some embodiments, the sanitary agent comprises an active substance designed to destroy, inhibit, reduce the activity of, inhibit the growth of, or otherwise render harmless a pest or toxic chemical. In some embodiments, the hygienic agent is a liquid phase agent. In some embodiments, the hygiene agent is a liquid phase biocide. In some embodiments, the hygienic agent is a liquid phase chemical that inactivates toxic chemicals, such as chemotherapeutic drugs.

Examples of liquid phase biocides include, but are not limited to, chlorine bleach solutions, hydrogen peroxide solutions, peracetic acid, quaternary amine solutions, periodine, alcohol solutions, dimethylbenzyl ammonium chloride, dimethylethylbenzyl ammonium chloride, and mixtures thereof.

Examples of liquid phase chemicals that can be used to inactivate or remove toxic chemicals include, but are not limited to, anionic surfactants such as soaps, sulfonates, and sulfates. In some embodiments, a large amount of water is used to dilute toxic chemicals.

In some embodiments, the hygienic agent comprises 0.1 to 10% (w/w), 0.1 to 3% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 10% (w/w), 0.3 to 3% (w/w), 0.3 to 1% (w/w), 1 to 10% (w/w), 1 to 3% (w/w), or 3 to 10% (w/w) of the cleansing composition.

In some embodiments, the hygiene agent comprises dimethylbenzyl ammonium chloride or dimethylethylbenzylammonium chloride. In some embodiments, the hygiene agent comprises dimethylbenzyl ammonium chloride or a mixture of dimethylethylbenzylammonium chlorides. In some embodiments, the hygiene agent is a 1:1 mixture of dimethylbenzyl ammonium chloride or dimethylethylbenzylammonium chloride.

In some embodiments, the cleaning composition further comprises one or more modifying agents. Examples of sanitary agents have been described above. In some embodiments, the modifying agent comprises a thickener, a tackifier, a gum, an absorbent polymer, or a combination thereof. In some embodiments, the one or more modifying agents comprise a carboxymethyl cellulose (CMC) -derived polymer and/or a Hierarchical Porous Carbon (HPC) -derived polymer.

In some embodiments, the one or more modifying agents further comprise one or more additives selected from the group comprising denaturants, colorants, odor correctors, and/or pH adjusters.

In some embodiments, the one or more modifying agents comprise 0.1 to 5% (w/w), 0.1 to 2% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 5% (w/w), 0.3 to 2% (w/w), 0.3 to 1% (w/w), 1 to 5% (w/w), 1 to 2% (w/w), or 2 to 5% (w/w) of the cleaning composition.

In some embodiments, the liquid loading capacity of the cleaning composition is in the following range: 10-50 vol%, 15-45 vol%, 20-40 vol%, 25-35 vol% or 25-30 vol%. In other embodiments, the liquid loading capacity of the cleaning composition is 100-400 mass% increase, 150-350 mass% increase, or 200-300 mass% increase. In some embodiments, the cleaning compositions of the present application are capable of absorbing liquid at 25-30% by volume or 200-300% mass increase.

Application method

Another aspect of the present application relates to methods of using the cleaning compositions of the present application. The method comprises the following steps: an effective amount of the cleaning composition of the present application is applied to a surface in need of cleaning and the cleaning composition is removed after a certain period of time.

In some embodiments, the time period is 30 seconds to 30 minutes. In some embodiments, the time period is 1 to 30 minutes, 1 to 20 minutes, 1 to 10 minutes, 2 to 30 minutes, 2 to 20 minutes, 2 to 10 minutes, 5 to 30 minutes, 5 to 20 minutes, and 5 to 10 minutes.

In some embodiments, the surface in need of cleaning comprises biohazard leakage. In some embodiments, the biohazard leak is vomit, urine, blood, stool, and/or a chemotherapeutic agent. In some embodiments, the surface to be cleaned is a surface in a public area and needs to be treated to prevent or reduce cross-contamination or infection. As used herein, the term "public area" includes, but is not limited to, hospitals, medical rooms, emergency care facilities, nursing homes, prisons and related correction facilities, schools, buses, airplanes, airports, bars, restaurants, hotels, amusement parks, any large housing facility, veterinary facilities, and drug development facilities. In some embodiments, the public area is located in a hotel.

In some embodiments, the method further comprises the steps of: after removal of the cleaning composition, the treated surface is washed with a liquid or wiped with a wiping material such as a paper towel or a mop.

Another aspect of the present application relates to a method of disinfecting an affected area to prevent or reduce the spread of pathogens, such as viruses and bacteria. The method comprises the following steps: applying an effective amount of a cleaning composition of the present application to the affected area and removing the cleaning composition after a period of time, wherein the cleaning composition comprises a particulate absorbent material coated with a static surface-bound film of a biocide selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, gas phase metal hydroxides, silver and silver salts, copper and copper salts. In some embodiments, the cleaning composition further comprises a sanitizing agent selected from the group consisting of a chlorine bleach solution, a hydrogen peroxide solution, peracetic acid, a quaternary amine solution, and an alcohol solution. In some embodiments, the sanitary agent is added to the cleaning composition immediately prior to application to the affected area.

In some embodiments, the cleaning compositions of the present application are multi-phase products that can kill microorganisms by a number of different mechanisms. In one embodiment, the composition is a doped particulate ceramic disinfectant that combines a surface area static disinfectant or biocide coating with a chemical phase primary disinfectant or biocide absorbed in the ceramic particles. As used herein, the term "disinfectant" describes the compositions and formulations described herein for the elimination of pathogens from surfaces. As used herein, the term "disinfect" may refer to the elimination of many or all pathogens on the surface to which the disinfectant is applied.

In some embodiments, the cleaning compositions of the present application are surface area solid phase disinfectants that in combination with superabsorbent polymers allow for an increase in the liquid loading of the available liquid (e.g., 25-30 vol%/200-300 mass increase%) to impart chemical disinfection, deodorizing chemicals or coverage effects on the affected area to reduce the diffusion of microorganisms into the open air.

In some embodiments, the cleaning compositions of the present application are high surface area solid phase disinfectants with the addition of an adhesion promoter, so that it coats the biohazard and forms a coating that greatly reduces the release of airborne pathogens.

The following examples are provided by way of illustration of certain embodiments of aspects of the present application. These examples should not be construed as limiting the scope of the application.

Assembly

Another aspect of the present application relates to a cleaning assembly. The assembly may be used to clean hazardous materials such as vomit, urine, blood, feces, and/or spills of chemotherapeutic agents, or to disinfect surfaces. In some embodiments, the component comprises the cleaning composition of the present application and instructions on how to use the cleaning composition.

In some embodiments, the component further comprises a copy of Occupational Safety and Health Administration (OSHA) guidelines. In some embodiments, the assembly further comprises one or more of the following items: biohazard bags, gloves, ties, antimicrobial hand wipes, antiseptic wipes, shovels/scrapers.

The cleaning assembly can be conveniently placed in a location that is quickly reached by all caregivers. For example, all patient rooms and chemotherapy rooms, life saving boxes & carts, emergency carts, cafeterias, environmental service cabinets, and in or near emergency cases, etc.