阅读说明：本技术 一种生物大分子相互作用的快速检测装置 (Quick detection device of biomacromolecule interaction ) 是由 杨毅红 何怀文 于 2019-11-06 设计创作，主要内容包括：一种生物大分子相互作用的快速检测装置,包括生物大分子相互作用仪、安装座、第一固定组件、散热组件和第二固定组件；生物大分子相互作用仪设置在安装座上；第一固定组件设置在安装座上；散热组件设置在第一固定组件上；第二固定组件设置在散热组件上；安装座设置有竖直段和水平段；竖直段和水平段上设置有镂空腔室；竖直段的镂空腔室内设置有导热件；水平段的镂空腔室内设置有拉动件。本发明利用第一固定组件和第二固定组件配合,对生物大分子相互作用仪进行固定,一方面对设备进行保护,另一方面避免设备在检测时移位；利用导热件和散热组件配合,使得设备快速散热降温,保证了设备工作性能的稳定。(A rapid detection device for biomacromolecule interaction comprises a biomacromolecule interaction instrument, a mounting seat, a first fixing component, a heat dissipation component and a second fixing component; the biomacromolecule interaction instrument is arranged on the mounting seat; the first fixing component is arranged on the mounting seat; the heat dissipation assembly is arranged on the first fixing assembly; the second fixing component is arranged on the heat dissipation component; the mounting seat is provided with a vertical section and a horizontal section; hollow cavities are arranged on the vertical section and the horizontal section; a heat conducting piece is arranged in the hollow cavity chamber of the vertical section; the hollow-out cavity chamber of the horizontal section is internally provided with a pulling piece. The first fixing component and the second fixing component are matched to fix the biomacromolecule interaction instrument, so that the equipment is protected on one hand, and the equipment is prevented from shifting during detection on the other hand; utilize heat-conducting piece and radiator unit cooperation for equipment rapid cooling has guaranteed the stability of equipment working property.)

1. A rapid detection device for biomacromolecule interaction is characterized by comprising a biomacromolecule interaction instrument (1), a mounting seat (2), a first fixing component (3), a heat dissipation component (4) and a second fixing component (5); the biomacromolecule interaction instrument (1) is arranged on the mounting seat (2); a first fixing component (3) for fixing the lower end of the biomacromolecule interaction instrument (1) is arranged on the mounting seat (2); the heat dissipation assembly (4) is arranged on the first fixing assembly (3); the second fixing component (5) for fixing the upper end of the biomacromolecule interaction instrument (1) is arranged on the heat dissipation component (4);

the mounting seat (2) is provided with a vertical section and a horizontal section; hollow cavities which are opened along the left and right directions are arranged on the vertical section and the horizontal section of the mounting seat (2); a heat conducting piece (6) is arranged in the hollow cavity chamber of the vertical section; a pulling piece (27) is arranged in the hollow cavity chamber of the horizontal section;

the first fixing component (3) comprises a first telescopic piece and a fixing plate (9); the two groups of the telescopic pieces are arranged, the two groups of the first telescopic pieces are perpendicular to the vertical section of the mounting seat (2) and are positioned at the left side and the right side of the biomacromolecule interaction instrument (1), and the front ends of the two groups of the first telescopic pieces are connected with the fixing plate (9); the fixing plate (9) is attached to the front end of the biomacromolecule interaction instrument (1);

the heat dissipation component (4) comprises a mounting plate (11) and a heat dissipation piece; the mounting plate (11) is arranged on the first telescopic piece in a sliding mode; the heat dissipation piece is arranged on the mounting plate (11) and supplies air towards the biomacromolecule interaction instrument (1);

the second fixing component (5) comprises a second telescopic piece and a clamping piece (18); one end of the second telescopic piece is connected with the mounting plate (11), and the other end of the second telescopic piece is connected with the clamping piece (18); the clamping piece (18) is clamped with the top end of the biomacromolecule interaction instrument (1).

2. The rapid biomacromolecule interaction detection device as claimed in claim 1, wherein the first telescopic member comprises a fixed rod (7), a movable rod (8) and a return spring (10); the rear end of the fixed rod (7) is connected with the vertical section of the mounting seat (2); the rear end of the movable rod (8) extends into the fixed rod (7) on the corresponding side and is in sliding connection with the fixed rod, and the front end of the movable rod (8) is connected with one end of the fixed plate (9); the reset spring (10) is arranged on the movable rod (8), one end of the reset spring (10) is connected with the fixed rod (7), and the other end of the reset spring is connected with the fixed plate (9).

3. The rapid biomacromolecule interaction detection device as claimed in claim 1, wherein the heat dissipation member comprises a driving motor (12), a main gear (13), an auxiliary gear (14) and a fan (15); the driving motor (12) is arranged on the mounting plate (11); the main gear (13) is in bonding connection with a main shaft of the driving motor (12); the auxiliary gear (14) is connected with the rotating shaft of the fan (15) in a bonding way, and the auxiliary gear (14) is meshed with the main gear (13).

4. A rapid detection device for biomacromolecule interaction according to claim 1, wherein the second telescopic member comprises a rotary sleeve (16) and a threaded rod (17); the rotating sleeve (16) is rotatably arranged on one side of the mounting plate (11) facing the biomacromolecule interaction instrument (1), and an internal thread matched with the threaded rod (17) is arranged on the rotating sleeve (16); one end of the threaded rod (17) is connected with the rotating sleeve (16) in a threaded manner, and the other end is connected with the clamping piece (18).

5. The rapid biological macromolecule interaction detection device as claimed in claim 1, wherein the engaging member (18) is of an L-shaped structure, and a protective pad (19) is disposed on the engaging surface of the engaging member (18).

6. The rapid biomacromolecule interaction detection device as claimed in claim 1, wherein the heat conduction member (6) comprises a heat conduction pipe (20) and a heat conduction sheet (21); the heat conduction pipes (20) and the heat conduction fins (21) are alternately arranged, and the two ends of the heat conduction pipes (20) and the two ends of the heat conduction fins (21) are respectively connected with the front wall and the rear wall of the hollow cavity chamber of the vertical section.

7. The apparatus for rapid detection of biomacromolecule interaction according to claim 6, wherein the heat-conducting sheet (21) is provided with heat-dissipating holes (22).

8. The rapid detection device for biomacromolecule interaction according to claim 1, wherein the pulling member (27) comprises a support rod (24), a moving member (25) and a handle (26); the supporting rod (24) is arranged in the hollow-out cavity chamber of the horizontal section in a sliding manner along the front-back direction; the moving piece (25) is connected with the wall of the hollow cavity of the horizontal section in a sliding way and is connected with the rear end of the supporting rod (24) in a rotating way; the handle (26) is connected with the front end of the support rod (24).

9. The rapid biomacromolecule interaction detection device as claimed in claim 1, wherein the mounting seat (2) is of an L-shaped structure.

10. A rapid detection device for biomacromolecule interaction according to claim 1, characterized in that the bottom end of the mounting seat (2) is provided with a moving wheel (23).

Technical Field

The invention relates to the field of biological detection equipment, in particular to a rapid detection device for biomacromolecule interaction.

Background

The biomacromolecule interaction instrument is a novel biological analysis sensing technology developed based on surface plasma resonance, 3 core parts of the technology are a sensor chip, an SPR optical detection system and a microfluidic cartridge, during experiments, a biomolecule is fixed on the dextran surface of the sensor, molecules interacting with the biomolecule are dissolved on the surface of the chip through which a solution flows, an SPR detector can record a sensing picture according to the change of the whole process of combining and dissociating the molecules in the tracking solution and the molecules on the surface of the chip, dynamics and affinity data are provided, and the BIACORE technology has the advantages of no need of marking, high sensitivity, rapid detection, real-time quantitative test and the like, and is widely used for researching the interaction of the biomolecules such as protein, nucleic acid, polypeptide, small molecular compounds and the like.

The existing biomacromolecule interaction instrument is poor in equipment stability due to lack of fixing and heat dissipation measures, and the reference of detection results is influenced.

In order to solve the above problems, the present application provides a rapid detection device for biomacromolecule interaction.

Disclosure of Invention

Objects of the invention

In order to solve the technical problems in the background art, the invention provides a rapid detection device for biomacromolecule interaction, which utilizes the matching of a first fixing component and a second fixing component to fix a biomacromolecule interaction instrument, so that equipment is protected on one hand, and the equipment is prevented from shifting during detection on the other hand; utilize heat-conducting piece and radiator unit cooperation for equipment rapid cooling has guaranteed the stability of equipment working property.

(II) technical scheme

In order to solve the problems, the invention provides a rapid detection device for biomacromolecule interaction, which comprises a biomacromolecule interaction instrument, a mounting seat, a first fixing component, a heat dissipation component and a second fixing component, wherein the mounting seat is used for fixing a biological macromolecular interaction instrument; the biomacromolecule interaction instrument is arranged on the mounting seat; the first fixing component for fixing the lower end of the biomacromolecule interaction instrument is arranged on the mounting seat; the heat dissipation assembly is arranged on the first fixing assembly; the second fixing component for fixing the upper end of the biomacromolecule interaction instrument is arranged on the heat dissipation component; the mounting seat is provided with a vertical section and a horizontal section; hollow cavities which are opened along the left and right directions are arranged on the vertical section and the horizontal section of the mounting seat; a heat conducting piece is arranged in the hollow cavity chamber of the vertical section; a pulling piece is arranged in the hollow cavity chamber of the horizontal section; the first fixing component comprises a first telescopic piece and a fixing plate; the two groups of the telescopic pieces are arranged, the two groups of the first telescopic pieces are perpendicular to the vertical section of the mounting seat and are positioned on the left side and the right side of the biomacromolecule interaction instrument, and the front ends of the two groups of the first telescopic pieces are connected with the fixing plate; the fixing plate is attached to the front end of the biomacromolecule interaction instrument; the heat dissipation assembly comprises a mounting plate and a heat dissipation piece; the mounting plate is arranged on the first telescopic piece in a sliding mode; the heat dissipation piece is arranged on the mounting plate and supplies air towards the biomacromolecule interaction instrument; the second fixing component comprises a second telescopic piece and a clamping piece; one end of the second telescopic piece is connected with the mounting plate, and the other end of the second telescopic piece is connected with the clamping piece; the clamping piece is clamped with the top end of the biomacromolecule interaction instrument.

Preferably, the first telescopic member comprises a fixed rod, a movable rod and a return spring; the rear end of the fixed rod is connected with the vertical section of the mounting seat; the rear end of the movable rod extends into the fixed rod on the corresponding side and is in sliding connection with the fixed rod, and the front end of the movable rod is connected with one end of the fixed plate; the reset spring is arranged on the movable rod, one end of the reset spring is connected with the fixed rod, and the other end of the reset spring is connected with the fixed plate.

Preferably, the heat sink includes a driving motor, a main gear, an auxiliary gear and a fan; the driving motor is arranged on the mounting plate; the main gear is in bonding connection with a main shaft of the driving motor; the auxiliary gear is connected with the rotating shaft of the fan in a bonding mode, and the auxiliary gear is meshed with the main gear.

Preferably, the second telescopic element comprises a rotating sleeve and a threaded rod; the rotating sleeve is rotatably arranged on one side of the mounting plate, which faces the biomacromolecule interaction instrument, and an internal thread matched with the threaded rod is arranged on the rotating sleeve; one end of the threaded rod is in threaded connection with the rotating sleeve, and the other end of the threaded rod is connected with the clamping piece.

Preferably, the engaging piece has an L-shaped structure, and a protective pad is provided on an engaging surface of the engaging piece.

Preferably, the heat conductive member includes a heat conductive pipe and a heat conductive sheet; the heat conduction pipes and the heat conduction fins are arranged alternately, and the two ends of the heat conduction pipes and the two ends of the heat conduction fins are connected with the front wall and the rear wall of the hollow-out cavity of the vertical section respectively.

Preferably, the heat conducting sheet is provided with heat dissipation holes.

Preferably, the pulling piece comprises a support rod, a moving piece and a handle; the supporting rod is arranged in the hollow-out cavity chamber of the horizontal section in a sliding manner along the front-back direction; the moving piece is connected with the wall of the hollow cavity of the horizontal section in a sliding manner and is rotatably connected with the rear end of the supporting rod; the handle is connected with the front end of the supporting rod.

Preferably, the mounting seat is of an L-shaped structure.

Preferably, the bottom end of the mounting seat is provided with a movable wheel.

The technical scheme of the invention has the following beneficial technical effects:

the first fixing component and the second fixing component are matched to fix the biomacromolecule interaction instrument, so that the equipment is protected on one hand, the service life of the equipment is prolonged, and the equipment is prevented from shifting during detection to reduce the working efficiency and the detection result referential property;

in the invention, the heat conducting piece is matched with the heat radiating assembly, so that the equipment can be quickly cooled, the stability of the working performance of the equipment is ensured, and the reference of the detection result is improved.

Drawings

FIG. 1 is a schematic structural diagram of a rapid detection device for biomacromolecule interaction according to the present invention.

FIG. 2 is a left side view of a rapid biological macromolecule interaction detection device according to the present invention.

FIG. 3 is a schematic structural diagram of a second fixing component in the rapid detecting device for biomacromolecule interaction according to the present invention.

FIG. 4 is a schematic structural diagram of a heat-conducting member in the rapid biological macromolecule interaction detection apparatus according to the present invention.

FIG. 5 is a schematic structural diagram of a heat dissipation assembly in a rapid biological macromolecule interaction detection apparatus according to the present invention.

Reference numerals: 1. a macromolecular interaction instrument; 2. a mounting seat; 3. a first fixed component; 4. a heat dissipating component; 5. a second fixed component; 6. a heat conductive member; 7. fixing the rod; 8. a travel bar; 9. a fixing plate; 10. a return spring; 11. mounting a plate; 12. a drive motor; 13. a main gear; 14. an auxiliary gear; 15. a fan; 16. rotating the sleeve; 17. a threaded rod; 18. a fastener; 19. a protection pad; 20. a heat conducting pipe; 21. a heat conductive sheet; 22. heat dissipation holes; 23. a moving wheel; 24. a support bar; 25. a moving member; 26. a handle; 27. a pulling member.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings in conjunction with the following detailed description. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.

As shown in fig. 1-5, the rapid detection device for biomacromolecule interaction provided by the present invention comprises a biomacromolecule interaction instrument 1, a mounting base 2, a first fixing component 3, a heat dissipation component 4 and a second fixing component 5; the biomacromolecule interaction instrument 1 is arranged on the mounting seat 2; the first fixing component 3 for fixing the lower end of the biomacromolecule interaction instrument 1 is arranged on the mounting seat 2; the heat dissipation assembly 4 is arranged on the first fixing assembly 3; the second fixing component 5 for fixing and fixing the upper end of the biomacromolecule interaction instrument 1 is arranged on the heat dissipation component 4; the mounting seat 2 is provided with a vertical section and a horizontal section; hollow cavities which are opened along the left and right directions are arranged on the vertical section and the horizontal section of the mounting seat 2; a heat conducting piece 6 is arranged in the hollow cavity chamber of the vertical section; a pulling piece 27 is arranged in the hollow cavity chamber of the horizontal section; the first fixed assembly 3 comprises a first telescopic member and a fixed plate 9; the two groups of the telescopic pieces are arranged, the two groups of the first telescopic pieces are perpendicular to the vertical section of the mounting seat 2 and are positioned at the left side and the right side of the biomacromolecule interaction instrument 1, and the front ends of the two groups of the first telescopic pieces are connected with the fixing plate 9; the fixing plate 9 is attached to the front end of the biomacromolecule interaction instrument 1; the radiator block 4 comprises a mounting plate 11 and a radiator element; the mounting plate 11 is arranged on the first telescopic piece in a sliding mode; the heat dissipation piece is arranged on the mounting plate 11 and supplies air towards the biomacromolecule interaction instrument 1; the second fixing assembly 5 comprises a second telescopic member and a clamping member 18; one end of the second telescopic piece is connected with the mounting plate 11, and the other end of the second telescopic piece is connected with the clamping piece 18; the engaging member 18 engages with the distal end of the biomacromolecule interaction apparatus 1.

In an alternative embodiment, the first telescopic member comprises a fixed rod 7, a mobile rod 8 and a return spring 10; the rear end of the fixed rod 7 is connected with the vertical section of the mounting seat 2; the rear end of the movable rod 8 extends into the fixed rod 7 on the corresponding side and is in sliding connection with the fixed rod, and the front end of the movable rod 8 is connected with one end of the fixed plate 9; the return spring 10 is arranged on the movable rod 8, one end of the return spring 10 is connected with the fixed rod 7, and the other end of the return spring is connected with the fixed plate 9.

In an alternative embodiment, the heat sink includes a driving motor 12, a main gear 13, an auxiliary gear 14, and a fan 15; the driving motor 12 is arranged on the mounting plate 11; the main gear 13 is connected with the main shaft of the driving motor 12 in a bonding way; the auxiliary gear 14 is connected with the rotating shaft of the fan 15 in a bonding mode, and the auxiliary gear 14 is meshed with the main gear 13.

In an alternative embodiment, the second telescopic element comprises a rotating sleeve 16 and a threaded rod 17; the rotating sleeve 16 is rotatably arranged on one side of the mounting plate 11 facing the biomacromolecule interaction instrument 1, and an internal thread matched with the threaded rod 17 is arranged on the rotating sleeve 16; one end of the threaded rod 17 is connected with the rotating sleeve 16 in a threaded mode, and the other end of the threaded rod is connected with the clamping piece 18.

In an alternative embodiment, the engaging member 18 is an L-shaped structure, and a protective pad 19 is disposed on the engaging surface of the engaging member 18.

In an alternative embodiment, the heat conductive member 6 includes a heat conductive pipe 20 and a heat conductive sheet 21; the heat conduction pipes 20 and the heat conduction fins 21 are alternately arranged, and two ends of the heat conduction pipes 20 and two ends of the heat conduction fins 21 are respectively connected with the front wall and the rear wall of the hollow cavity of the vertical section.

In an alternative embodiment, the heat-conducting sheet 21 is provided with heat dissipation holes 22.

In an alternative embodiment, the pulling member 27 comprises a support bar 24, a moving member 25 and a handle 26; the supporting rod 24 is arranged in the hollow-out cavity chamber of the horizontal section in a sliding manner along the front-back direction; the moving piece 25 is connected with the wall of the hollow cavity of the horizontal section in a sliding way and is connected with the rear end of the supporting rod 24 in a rotating way; a handle 26 is attached to the front end of the support bar 24.

In an alternative embodiment, the mounting base 2 is of an L-shaped configuration.

In an alternative embodiment, the bottom end of the mounting 2 is provided with a moving wheel 23.

In the invention, before the biomacromolecule interaction instrument 1 is used, the first fixing component 3 and the second fixing component 5 are matched to fix the biomacromolecule interaction instrument 1, so that the equipment is protected on one hand, the service life of the equipment is prolonged, and the equipment is prevented from shifting during detection to cause the reduction of the working efficiency and the detection result reference on the other hand, and the fixing method comprises the following steps: firstly pulling a fixed plate 9, extending a movable rod 8, placing a biomacromolecule interaction instrument 1 on a mounting seat 2, loosening the fixed plate 9, rebounding by a reset spring 10, attaching the rear end of the biomacromolecule interaction instrument 1 to a vertical section of the mounting seat 2, attaching the front end of the biomacromolecule interaction instrument 1 to the fixed plate 9, fixing the lower end of the biomacromolecule interaction instrument 1, then sliding a mounting plate 11 forwards and backwards, adjusting the position of a second fixing component 5, rotating a rotating sleeve 16, extending a threaded rod 17, pushing a clamping piece 18 to clamp the top end edge of the biomacromolecule interaction instrument 1, and fixing the upper end of the biomacromolecule interaction instrument 1;

when using biological macromolecule interaction appearance 1, equipment continuous operation produces the heat, at first utilize heat pipe 20 and conducting strip 21 with partial heat transfer to fretwork cavity room, accelerate thermal giving off, then driving motor 12 drives fan 15 and rotates, towards the 1 air supply of biological macromolecule interaction appearance, accelerate the cooling rate of equipment, finally utilize heat-conducting piece 6 and radiator unit 4 cooperation, make the quick cooling that dispels the heat of equipment, the stability of equipment working property has been guaranteed, the reference nature of testing result has been improved.

It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modification, equivalent replacement, improvement and the like made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. Further, it is intended that the appended claims cover all such variations and modifications as fall within the scope and boundaries of the appended claims or the equivalents of such scope and boundaries.