阅读说明：本技术 用于医疗装置的涂层 (Coating for medical devices ) 是由 U·谢德勒 C·海泽 T·蒂勒 H·亨克斯 H·蒙斯塔特 R·汉内斯 T·伦茨-哈比安 于 2018-05-17 设计创作，主要内容包括：本发明涉及一种医疗装置,其包括具有涂层的至少一个基底,其中所述涂层包括位于所述基底上的功能层,其中所述功能层包含至少一种糖醇并且通过所述糖醇的官能化直接或间接地结合至所述基底。可选地,功能层也可包括其它糖类,在这样的情况下,糖类仅在与基底结合时发生聚合是至关重要的。本发明的医疗装置表现出降低的血小板粘附和聚集。(The present invention relates to a medical device comprising at least one substrate having a coating, wherein the coating comprises a functional layer on the substrate, wherein the functional layer comprises at least one sugar alcohol and is directly or indirectly bound to the substrate by functionalization of the sugar alcohol. Alternatively, the functional layer may also comprise other saccharides, in which case it is essential that the saccharides only polymerize when bound to the substrate. The medical devices of the present invention exhibit reduced platelet adhesion and aggregation.)

1. A medical device comprising at least one substrate provided with a coating, wherein the coating comprises a functional layer, characterized in that:

the functional layer comprises at least one sugar alcohol and is directly or indirectly bound to the substrate by means of functionalization of the sugar alcohol.

2. The medical device of claim 1, wherein: the coating includes a carrier layer on the substrate and containing an adhesion promoter, wherein the functional layer is bonded to the carrier layer.

3. The medical device of claim 2, wherein: the bonding of the adhesion promoter to the substrate and/or the bonding of the functional layer to the carrier layer is covalent bonding.

4. The medical device of claim 2 or 3, wherein: the adhesion promoter comprises a silicon compound, in particular a silane compound.

5. The medical device according to any one of claims 1 to 4, wherein: sugar alcohols of said functional layer in unfunctionalized, oxidized or dehydrated form includeAt least one molecule of formula C₆H₁₄O₆Sugar alcohol and/or a derivative thereof.

6. The medical device of any one of the preceding claims, wherein: the sugar alcohol of the functional layer in a form not bound to the carrier layer or the substrate is functionalized via at least one reactive multiple bond, in particular a double bond.

7. The medical device of claim 6, wherein: the reactive double bond is a component of the (meth) acrylic group.

8. The medical device of any one of the preceding claims, wherein: the sugar alcohols of the functional layer are at least partially oligomerized or polymerized with each other.

9. A medical device comprising at least one substrate provided with a coating, wherein the coating comprises a functional layer, characterized in that:

the functional layer comprises at least one monosaccharide, wherein the monosaccharide can be directly or indirectly attached to the substrate by functionalization of the monosaccharide, and oligomerization or polymerization thereof occurs only after binding to the substrate.

10. The medical device of claim 9, wherein: the coating includes a carrier layer on the substrate and containing an adhesion promoter, wherein the functional layer is bonded to the carrier layer.

11. The medical device of claim 10, wherein: the bonding of the adhesion promoter to the substrate and/or the bonding of the functional layer to the carrier layer is covalent bonding.

12. The medical device of claim 10 or 11, wherein: the adhesion promoter comprises a silicon compound, in particular a silane compound.

13. The medical device according to any one of claims 9 to 12, wherein: said monosaccharide of said functional layer in its non-functionalized form comprises a sugar alcohol and/or a derivative thereof.

14. The medical device of claim 13, wherein: the sugar alcohol of said functional layer in its unfunctionalized, oxidized or dehydrated form comprises at least one molecule of formula C₆H₁₄O₆Sugar alcohol and/or a derivative thereof.

15. The medical device according to any one of claims 9 to 14, wherein: the monosaccharide of the functional layer in a form not bound to the carrier layer or the substrate is functionalized via at least one reactive multiple bond, in particular a double bond.

16. The medical device of claim 15, wherein: the reactive double bond is a component of the (meth) acrylic group.

17. The medical device of any one of claims 9-16, wherein: the monosaccharides of the functional layer are at least partially oligomerized or polymerized with each other.

18. The medical device of any one of the preceding claims, wherein: the substrate comprises at least one metal selected from the group comprising: nickel, titanium, platinum, iridium, gold, cobalt, chromium, aluminum, iron, and/or alloys thereof.

19. The medical device of any one of claims 1-17, wherein: the substrate comprises at least one plastic material selected from the group comprising: polyamides (PA), Polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), Polylactide (PLA), polyesters, polyethers, polyurethanes, polyolefins, and related block copolymers.

20. The medical device of any one of the preceding claims, wherein: the medical device is a medical device for intravascular application.

21. The medical device of any one of the preceding claims, wherein: the medical device is a medical device for neurovascular applications.

22. The medical device of any one of the preceding claims, wherein: the medical device is a medical device for cardiovascular applications.