Composition for repairing skin barrier and preparation method and application thereof
阅读说明：本技术 一种修复皮肤屏障的组合物及其制备方法与应用 (Composition for repairing skin barrier and preparation method and application thereof ) 是由 李吉 谢红付 王乾 于 2019-10-25 设计创作，主要内容包括：本发明涉及生物医药及个人护理品技术领域,尤其涉及一种修复皮肤屏障的组合物及其制备方法与应用。本发明提供的组合物由钙离子化合物、神经酰胺、胆固醇、氢化卵磷脂、甜菜碱组成。本发明用于修护皮肤屏障,各组分之间起到显著的协同作用,不仅能有效的补充和促进皮肤细胞间脂质的合成,还能修复已受损肌肤,重建肌肤屏障。同时,本发明提供了上述皮肤屏障修复组合物的有效制备方法。此组合物对敏感性皮肤、特应性皮炎等亚健康皮肤有明显的缓解和治疗作用。(The invention relates to the technical field of biological medicines and personal care products, in particular to a composition for repairing a skin barrier and a preparation method and application thereof. The composition provided by the invention comprises a calcium ion compound, ceramide, cholesterol, hydrogenated lecithin and betaine. The skin repairing agent is used for repairing skin barriers, has a remarkable synergistic effect among components, can effectively supplement and promote the synthesis of lipid among skin cells, and can repair damaged skin and rebuild skin barriers. Meanwhile, the present invention provides an efficient preparation method of the above skin barrier repair composition. The composition has obvious relieving and treating effects on sensitive skin, sub-health skin such as atopic dermatitis, etc.)
1. A composition comprises calcium ion compound, ceramide, cholesterol, hydrogenated lecithin, betaine, polyol, octyl dodecanol and water.
2. The composition according to claim 1, which is characterized by comprising the following components in percentage by mass:
3. the composition according to claim 2, which is characterized by comprising the following components in percentage by mass:
4. the composition according to any one of claims 1 to 3,
the calcium ion compound is at least one selected from calcium chloride, calcium pyrrolidone carboxylate, calcium gluconate, EDTA disodium calcium, calcium aspartate and yeast/calcium fermentation product;
the ceramide is selected from at least one of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6 II, ceramide 7, ceramide 8, ceramide 9 and ceramide-like;
the polyalcohol is at least one of glycerol, propylene glycol, butanediol, pentanediol, hexanediol, dipropylene glycol, methyl propanediol and PEG-8.
5. A process for preparing a composition as claimed in any one of claims 1 to 4, comprising:
mixing ceramide, cholesterol, hydrogenated lecithin and octyldodecanol at 80-90 ℃, stirring at 100rpm to obtain an oil phase
Mixing a calcium ion compound, betaine, polyhydric alcohol and water at 80-90 ℃, and stirring at 100rpm to prepare a water phase;
mixing the oil phase and the water phase, and homogenizing at high speed and high pressure to obtain the composition.
6. The preparation method according to claim 5, wherein the parameters of the high-speed high-pressure homogenization are as follows: 1300 bar.
7. Use of a composition according to any one of claims 1 to 4 or a composition prepared by a preparation process according to any one of claims 5 to 6 for the preparation of a water-replenishing and/or moisturizing cosmetic and/or pharmaceutical product.
8. A cosmetic and/or pharmaceutical product comprising the composition according to any one of claims 1 to 4 or the composition prepared by the preparation method according to any one of claims 5 to 6.
Technical Field
The invention relates to the technical field of biological medicines and personal care products, in particular to a composition for repairing a skin barrier and a preparation method and application thereof.
Background
The skin barrier in a narrow sense refers to a 'brick wall structure' of a sebum membrane and a cuticle, wherein the 'brick wall structure' of the cuticle is a composite structure composed of protein, lipid and the like, so that the skin barrier not only effectively prevents water from losing from the inside, but also provides a protective barrier for external stimulation and pathogens, protects the skin from being influenced by external substances, and has a great effect on maintaining the health of the skin. The healthy epidermal barrier mainly comprises: good keratinocytes, intact lipid layers and a well-defined bilayer structure of the lipid matrix. However, improper use of environment, diet and skin care products can easily cause damage to skin barrier, especially, water loss is too fast, and external toxic and harmful substances can easily invade human body to cause phenomena of dry, sensitive, inflammatory, aging and the like of skin.
Research shows that stratum corneum intercellular lipid plays an important role in maintaining the intact skin barrier, and meanwhile, ceramide is the main component of the stratum corneum intercellular lipid, accounts for 40-50% of the stratum corneum lipid, and plays an important role in maintaining the ordered arrangement of intercellular lipid and the healthy function of the skin barrier. Problem skin and sub-healthy skin with age, the loss of ceramide is accelerated, so it is important to develop skin care products that effectively supplement ceramide and promote the ordered arrangement of intercellular lipids.
From the perspective of cell biology, in order to adapt to complex environmental changes, a signal molecule capable of transmitting external stimuli to internal metabolic reactions is required, and calcium ions are one of important signal molecules in the human body. Calcium ions exist inside and outside the cell, the charged ions cannot freely pass through the cell membrane but need ion channel proteins on the cell membrane to transport, and external stimulation can adjust the ion concentration in the cell by applying opening and closing of the channel to influence the physiological activity of the cell. In normal skin epidermis, the concentration of calcium ions is not uniform, but has a specific concentration gradient, i.e. gradually decreases from the stratum corneum towards the basal layer. It has been found that high concentrations of calcium ions can promote keratinocyte differentiation, stratification and keratin formation. Calcium ions can repair skin barriers from inside to outside by influencing the integrity of cornification envelopes, the synthesis of structural lipids and skin surface lipids and the synthesis of natural moisturizing factors, so that the autonomous repair of the body cannot be realized by the participation of the calcium ions. The breakdown of the skin barrier means that the transdermal water (TEWL) value increases dramatically and water is largely lost, causing a rapid decrease in the extracellular calcium ion concentration in the epidermis. Therefore, proper calcium ion supplementation is also particularly important for sub-healthy skin and problem skin. Meanwhile, for skin with undamaged barrier, the function of the barrier can be obviously enhanced by enhancing the calcium ion gradient among epidermal cells.
The current cosmetics are more focused on repairing the sebum membrane of the skin. The invention has obvious effect on repairing the 'brick wall structure' of the cuticle besides repairing the skin sebum membrane.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a composition for repairing skin barrier, and a preparation method and an application thereof, wherein the composition of the present invention has a significant effect on enhancing and repairing skin barrier functions of healthy skin, sub-healthy skin, atopic dermatitis, and other problems.
The composition provided by the invention comprises a calcium ion compound, ceramide, cholesterol, hydrogenated lecithin, betaine, polyhydric alcohol, octyl dodecanol and water.
In the embodiment of the invention, the composition consists of the following components in percentage by mass:
in some embodiments, the preferred composition consists of the following components in parts by mass:
in the composition of the present invention:
the calcium ion compound is at least one selected from calcium chloride, calcium pyrrolidone carboxylate, calcium gluconate, EDTA disodium calcium, calcium aspartate and yeast/calcium fermentation product;
the ceramide is selected from at least one of ceramide 1,
the polyalcohol is at least one of glycerol, propylene glycol, butanediol, pentanediol, hexanediol, dipropylene glycol, methyl propanediol and PEG-8.
In some embodiments, in the composition:
the calcium ion compound is calcium chloride or calcium gluconate;
the ceramide is ceramide 1, ceramide 3 and
the polyalcohol is glycerol and butanediol, or butanediol and propylene glycol, or glycerol and propylene glycol.
In one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, and betaine. Wherein the ceramide is ceramide 3; the polyhydric alcohol is glycerol and propylene glycol. The mass ratio of the glycerol to the propylene glycol is 1: 1.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition is comprised of water, calcium ion compound, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, betaine. Wherein the calcium ion compound is calcium chloride, and the polyalcohol is glycerol and propylene glycol. The mass ratio of the glycerol to the propylene glycol is 1: 1.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, calcium ion compound, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, betaine. Wherein the ceramide is ceramide 3; the calcium ion compound is calcium chloride. The polyhydric alcohol is glycerol and propylene glycol. The mass ratio of the glycerol to the propylene glycol is 1: 1.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, and betaine. Wherein, ceramide is ceramide 1; the polyhydric alcohols are glycerol and butanediol. The mass ratio of the glycerol to the butanediol is 1: 2.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and hydrogenated lecithin, cholesterol, octyldodecanol, a polyol, calcium ions, and betaine. Wherein the calcium ion is derived from calcium chloride; the polyhydric alcohols are glycerol and butanediol. The mass ratio of the glycerol to the butanediol is 1: 2.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, calcium ion, and betaine. Wherein, ceramide is ceramide 1, and calcium ion is derived from calcium chloride; the polyhydric alcohols are glycerol and butanediol. The mass ratio of the glycerol to the butanediol is 1: 2.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, and betaine. Wherein the ceramide is
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and hydrogenated lecithin, cholesterol, octyldodecanol, a polyol, a calcium ion compound, and betaine. Wherein the polyhydric alcohol is butanediol and propylene glycol; the mass ratio of the propylene glycol to the butanediol is 3: 5. the calcium ion compound is derived from calcium gluconate.
In this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, a polyol, a calcium ion compound, and betaine. Wherein the ceramide is
In this example, the composition consists of the following components in mass fraction:
the composition provided by the invention comprises a calcium ion compound, ceramide, cholesterol, hydrogenated lecithin and betaine. The composition is used for repairing skin barriers, has a remarkable synergistic effect among components, can effectively supplement and promote the synthesis of lipid among skin cells, and can repair damaged skin and rebuild skin barriers. Meanwhile, the present invention provides an efficient preparation method of the above skin barrier repair composition. The composition has obvious relieving and treating effects on sensitive skin, sub-health skin such as atopic dermatitis, etc.
The preparation method of the composition comprises the following steps:
mixing ceramide, cholesterol, hydrogenated lecithin and octyldodecanol at 80-90 ℃, and stirring at 100rpm to prepare an oil phase;
mixing a calcium ion compound, betaine, polyhydric alcohol and water at 80-90 ℃, and stirring at 100rpm to prepare a water phase;
mixing the oil phase and the water phase, and homogenizing at high speed and high pressure to obtain the composition.
And cooling the homogenized composition to room temperature, wherein the room temperature is 18-30 ℃.
In some embodiments, the parameters of the high-speed high-pressure homogenization are: homogenizing under 1300bar pressure for 3 times. The resulting composition is a translucent or milky white body.
The composition or the composition prepared by the preparation method of the invention is applied to the preparation of water-replenishing and/or moisturizing cosmetics and/or medicines.
The composition or the composition prepared by the preparation method of the invention is applied to preparing cosmetics and/or medicines for repairing skin barriers.
The invention also provides a cosmetic and/or pharmaceutical product comprising the composition of the invention or the composition prepared by the preparation method of the invention.
The cosmetic of the present invention is a product which is applied to any part of the surface of the human body (skin, hair, nails, lips, etc.) by smearing, sprinkling, spraying or the like, so as to achieve the purposes of cleaning, perfuming, changing the appearance, correcting the odor of the human body, maintaining and keeping a good state. The cosmetic of the present invention refers to a cosmetic to be applied to the skin. The cosmetic and/or pharmaceutical preparation can be in the form of cream, lotion, cosmetic water, gel, facial mask, and spray.
In some embodiments, the cosmetic is in the form of a lotion, wherein the composition is present in an amount of 1% by weight.
The invention also provides a method for repairing a skin barrier by topically applying the cosmetic or pharmaceutical composition of the invention. The external application is smearing, spraying or pasting.
The composition provided by the invention comprises intercellular endogenous lipid such as ceramide and cholesterol, calcium ion compounds and the like, and experiments show that the two can play a good synergistic effect. Not only supplements intercellular lipid lost due to barrier damage, but also plays a good role in self-repairing of the skin barrier by adjusting the concentration of calcium ions. Has obvious effect on strengthening and repairing the barrier function of healthy skin, sub-healthy skin, atopic dermatitis and other problems.
The composition of the present invention has at least the following beneficial effects:
(1) the pH value of the skin barrier repair composition is 5-7.5, so that the skin barrier can be quickly repaired, the natural moisturizing factors and lipid structures are quickly and orderly arranged, external stimulation is resisted, and the problem skin is repaired. (2) The product has good appearance and texture, and has good appearance and moisture retention. (3) The product has excellent high and low temperature stability and certain consistency, and meets good user experience.
Drawings
FIG. 1 shows the average particle size distribution of the composition;
Detailed Description
The invention provides a composition for repairing skin barrier, a preparation method and application thereof, and a person skilled in the art can appropriately modify process parameters for realization by referring to the content. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The test materials adopted by the invention are all common commercial products and can be purchased in the market.
The invention is further illustrated by the following examples:
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