Carousel formula ally oneself with more and examine device and system
阅读说明：本技术 一种转盘式的多联检装置以及系统 (Carousel formula ally oneself with more and examine device and system ) 是由 王东 李泉 于 2019-10-11 设计创作，主要内容包括：本发明属于微流控芯片发光免疫检测技术领域,尤其涉及一种转盘式的多联检装置以及系统。多联检装置包括：至少一个磁微粒发光微流控芯片,磁微粒发光微流控芯片包括芯片本体,芯片本体上设有加样部；转盘,转盘上设有供样本加入的加样池以及多个分别与加样池连通的输样通道,各个输样通道相互独立设置,并且各个输样通道分别与对应的加样部相互连接,输样通道的至少一端设有堵盖。当转盘转动时,转盘上的加样池中的样本会由于离心力均匀分离到各个输样通道中,并从输样通道流向加样部,如此可一次性在加样池中加入较多供检测的样本,再分别将样本同时流向各个磁微粒发光微流控芯片,无需人工一一手动操作,大大提高了检测效率。(The invention belongs to the technical field of micro-fluidic chip luminescence immunoassay, and particularly relates to a rotating disc type multi-gang detection device and a rotating disc type multi-gang detection system. The multi-joint inspection device comprises: the magnetic particle light-emitting micro-fluidic chip comprises a chip body, wherein a sample adding part is arranged on the chip body; the carousel is equipped with the application of sample pond that supplies the sample to add and a plurality of defeated appearance passageway that communicates with the application of sample pond respectively on the carousel, and each is defeated appearance passageway mutual independence sets up to each is defeated appearance passageway and is mutually connected mutually with the application of sample portion that corresponds respectively, and the at least one end of defeated appearance passageway is equipped with the blanking cover. When the carousel rotated, the sample in the application of sample pond on the carousel can be because centrifugal force evenly separated each defeated appearance passageway to from defeated appearance passageway flow direction application of sample portion, so can once only add more samples that supply to detect in the application of sample pond, flow to each magnetic particle luminescence micro-fluidic chip with the sample simultaneously again respectively, need not artifical manual operation one by one, improved detection efficiency greatly.)
1. The utility model provides a carousel formula ally oneself with examines device more which characterized in that, the many allies oneself with examines the device and include:
the magnetic particle light-emitting micro-fluidic chip comprises a chip body, wherein a sample adding part is arranged on the chip body;
the carousel, be equipped with on the carousel supply the sample loading pond that the sample added and a plurality of respectively with the defeated appearance passageway of sample loading pond intercommunication, each defeated appearance passageway mutual independence sets up to each defeated appearance passageway interconnects mutually with the sample loading portion that corresponds respectively, the at least one end of defeated appearance passageway is equipped with the blanking cover.
2. The multi-gang inspection apparatus of claim 1, further comprising:
and the connection area is provided with a connection channel which is respectively communicated with the sample adding part and the sample conveying channel.
3. A multi-gang inspection apparatus as claimed in claim 2, wherein the turntable is integrally provided with the docking area.
4. The multi-gang inspection device as claimed in claim 2, wherein a buffer pool is provided on the docking area, and the width of the buffer pool is greater than the width of the docking channel.
5. The multi-gang inspection device of claim 2, wherein a first side of the docking area extends toward a second side and is disposed with a gradually decreasing width, the first side being disposed adjacent to the chip body.
6. The multi-test device as claimed in claim 2, wherein said docking channel has a sharp portion at an end thereof adjacent to said sample loading portion.
7. The multi-test device as claimed in claim 1, wherein the carousel is configured as a circle, the sample loading wells are configured as a circle having a smaller diameter than the carousel, and the sample loading channels are disposed between an outer wall of the carousel and an outer wall of the sample loading wells.
8. The utility model provides a many joint inspection systems of carousel formula which characterized in that, many joint inspection systems include:
a multiple inspection apparatus as claimed in any one of claims 1 to 7;
the driving device is used for driving the turntable to rotate;
under the drive of the driving device, the sample feeding pool of the turntable separates the samples to each sample feeding channel, and the samples enter the sample feeding part from the sample feeding channels.
9. The multi-gang inspection system of claim 8, wherein the driving means is a rotary motor.
Technical Field
The invention belongs to the technical field of micro-fluidic chip luminescence immunoassay, and particularly relates to a rotating disc type multi-gang detection device and a rotating disc type multi-gang detection system.
Background
Currently, there are two major trends In Vitro Diagnostics (IVD): one is automatic and integrated, namely, the high-precision disease analysis and diagnosis is realized by utilizing full-automatic and high-sensitivity large-scale instruments and equipment of a central laboratory matched with a large-scale hospital; the other type of miniaturization and bedside miniaturization is realized, namely, the rapid analysis and diagnosis on site is realized through handheld small simple equipment. However, small hospitals are not capital intensive, have a small sample size, and are not suitable for purchasing expensive large equipment. Therefore, most of the rapid detection equipment adopted by hospitals at the present stage mainly comprises test strips and corollary equipment thereof, but the test strips can only realize qualitative or semi-quantitative detection, and have the advantages of low detection sensitivity, poor specificity, poor repeatability and obvious interference. Due to the fact that China has a large population, aging is aggravated, the disease incidence is increased sharply, and dependence on large hospitals is overwhelmed. Therefore, the development of a rapid detection method and equipment which are simple and convenient to operate, high in sensitivity, good in repeatability and accurate in quantification becomes urgent.
The micro-fluidic chip technology integrates basic operation units of sample preparation, reaction, separation, detection and the like in the biological, chemical and medical analysis process into a micron-scale chip, and automatically completes the whole analysis process. Due to its great potential in the fields of biology, chemistry, medicine, etc., it has been developed into a research field with multiple interdisciplinary disciplines of biology, chemistry, medicine, fluid, material, machinery, etc., and is applied to the fields of biomedical research, biochemical detection, judicial appraisal, etc. The prior microfluidic chip needs to perform an operation before performing luminescence immunoassay, that is, adding a sample into the microfluidic chip. However, the existing sample adding method only leads the samples into each microfluidic chip one by one manually or mechanically and automatically. When the number of samples is large and the joint inspection is required to be simultaneously realized by a plurality of micro-fluidic chips, if the samples are still respectively introduced into the corresponding micro-fluidic chips one by one, and then the detection is carried out by one pair of micro-fluidic chips, the detection efficiency is low, and the purpose of simultaneously carrying out the sample adding detection on a large scale cannot be achieved.
Disclosure of Invention
The embodiment of the invention provides a rotating disc type multi-link detection device and system, and aims to solve the problem of low efficiency caused by the fact that existing samples need to be added into micro-fluidic chips one by one and the micro-fluidic chips are detected respectively.
The embodiment of the invention is realized in such a way, and provides a rotating disc type multi-joint inspection device, which comprises: the magnetic particle light-emitting micro-fluidic chip comprises a chip body, wherein a sample adding part is arranged on the chip body; the carousel, be equipped with on the carousel supply the sample loading pond that the sample added and a plurality of respectively with the defeated appearance passageway of sample loading pond intercommunication, each defeated appearance passageway mutual independence sets up to each defeated appearance passageway interconnects mutually with the sample loading portion that corresponds respectively, the at least one end of defeated appearance passageway is equipped with the blanking cover.
Still further, the multi-joint inspection device further comprises: and the connection area is provided with a connection channel which is respectively communicated with the sample adding part and the sample conveying channel.
Still further, the carousel is provided integrally with the docking area.
Furthermore, a buffer pool is arranged on the connection area, and the width of the buffer pool is larger than that of the connection channel.
Still further, a first side of the docking area extends toward a second side and is disposed with a gradually decreasing width, and the first side is disposed adjacent to the chip body.
Furthermore, the connection channel is provided with a sharp part at one end close to the sample adding part.
Furthermore, the turntable is circular, the sample adding pool is circular with a smaller diameter than the turntable, and the sample conveying channel is arranged between the outer wall of the turntable and the outer wall of the sample adding pool.
The invention also provides a rotating disc type multi-link inspection system, which comprises: the multi-gang inspection device is described above; the driving device is used for driving the turntable to rotate; under the drive of the driving device, the sample feeding pool of the turntable separates the samples to each sample feeding channel, and the samples enter the sample feeding part from the sample feeding channels.
Further, the driving device is a rotating motor.
The invention has the advantages that the invention provides a turntable type multi-joint detection device and a system, the device is provided with a turntable and at least one magnetic particle luminous micro-fluidic chip connected with the turntable, a sample conveying channel on the turntable is connected with a sample adding part on the magnetic particle luminous micro-fluidic chip, when the turntable rotates, a sample in a sample adding pool on the turntable can be uniformly separated into each sample conveying channel due to centrifugal force and flows to the sample adding part from the sample conveying channel, thus more samples for detection can be added into the sample adding pool at one time, then the samples flow to each magnetic particle luminous micro-fluidic chip simultaneously without manual operation, each magnetic particle luminous micro-fluidic chip is also arranged on the turntable together, the aim of joint detection of a plurality of magnetic particle luminous micro-fluidic chips can be realized, the detection efficiency is greatly improved, and the sample conveying channel is provided with a blocking cover, when the corresponding position of the sample conveying channel is not connected with the magnetic particle luminous micro-fluidic chip, the blocking cover can seal the sample conveying channel, so that the loss of the sample is avoided.
Drawings
Fig. 1 is a schematic diagram of a multi-gang inspection apparatus provided by an embodiment of the present invention;
FIG. 2 is a schematic diagram of a turntable provided by an embodiment of the present invention;
fig. 3 is a schematic diagram of a magnetic particle light-emitting microfluidic chip according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Compared with the prior art, the invention discloses a rotating disc type multi-joint detection device and a rotating disc type multi-joint detection system, which are provided with a rotating disc 2 and at least one magnetic particle luminous