阅读说明：本技术 血管生理参数测量方法、设备、计算机设备和存储介质 (method and device for measuring blood vessel physiological parameters, computer device and storage medium ) 是由 曹艳平 郑阳 李国洋 江宇轩 于 2019-08-26 设计创作，主要内容包括：本申请涉及血管生理参数测量方法、设备、计算机设备和存储介质。所述方法包括：获取待测量血管在不受载荷时的第一参考超声图像序列,以及待测量血管受预设载荷时的至少一组超声图像序列,并进行排序得到心动周期内的目标第一参考超声图像序列和至少一组目标超声图像序列；根据目标第一参考超声图像序列和至少一组目标超声图像序列,得到位移场序列组；将预设载荷输入预设待测量血管有限元模型进行模拟并位移场序列组进行匹配,得到心动周期血压变化波形,以及血管弹性模量与心动周期血压关系。本方法能够同时得到心动周期的血压变化波形和血管弹性模量,提高了血管生理参数测量的效率。(the application relates to a method, a device, a computer device and a storage medium for measuring a physiological parameter of a blood vessel. The method comprises the following steps: acquiring a first reference ultrasonic image sequence of a vessel to be measured when the vessel to be measured is not loaded and at least one group of ultrasonic image sequences of the vessel to be measured when the vessel to be measured is loaded in a preset mode, and sequencing the first reference ultrasonic image sequence and the at least one group of target ultrasonic image sequences to obtain a target first reference ultrasonic image sequence and at least one group of target ultrasonic image sequences in a cardiac cycle; obtaining a displacement field sequence group according to the target first reference ultrasonic image sequence and at least one group of target ultrasonic image sequences; inputting the preset load into a preset finite element model of the blood vessel to be measured, simulating, and matching a displacement field sequence group to obtain a heart cycle blood pressure change waveform and a relationship between the elastic modulus of the blood vessel and the heart cycle blood pressure. The method can simultaneously obtain the blood pressure change waveform of the cardiac cycle and the elastic modulus of the blood vessel, and improves the efficiency of measuring the physiological parameters of the blood vessel.)

1. a method for measuring a physiological parameter of a blood vessel, the method comprising:

Acquiring a first reference ultrasonic image sequence of a vessel to be measured when the vessel to be measured is not loaded and at least one group of ultrasonic image sequences of the vessel to be measured when the vessel to be measured is loaded in a preset manner, wherein each ultrasonic image sequence corresponds to a preset load;

Sequencing the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences respectively to obtain a target first reference ultrasonic image sequence and at least one group of target ultrasonic image sequences in a cardiac cycle;

Obtaining a displacement field sequence group according to the target first reference ultrasonic image sequence and the at least one group of target ultrasonic image sequences;

Inputting the preset load into a preset finite element model of the blood vessel to be measured for simulation to obtain a blood vessel deformation under the preset load, and matching the blood vessel deformation with the displacement field sequence group to obtain a cardiac cycle blood pressure change waveform and a relationship between a blood vessel elastic modulus and a cardiac cycle blood pressure.

2. The method according to claim 1, characterized in that the step of inputting the preset load into a preset finite element model of the blood vessel to be measured for simulation comprises the steps of obtaining the deformation of the blood vessel under the preset load;

Acquiring a second reference ultrasonic image sequence when the vessel to be measured is subjected to initial loading;

Acquiring the pressing depth according to the first reference ultrasonic image sequence and the second reference ultrasonic image sequence;

inputting the pressing depth and the initial load into a preset contact mechanical model to obtain the elastic modulus of the surrounding tissue of the blood vessel to be measured;

And establishing the finite element model of the preset blood vessel to be measured according to the elastic modulus of the surrounding tissue and the target first reference ultrasonic image sequence.

3. the method of claim 2, wherein establishing the preset finite element model of the vessel to be measured according to the elastic modulus of the surrounding tissue and the target first reference ultrasound image sequence comprises:

Identifying the distance from a blood vessel to the skin surface, the blood vessel thickness and the blood vessel outer diameter according to one frame of image of the target first reference ultrasonic image sequence;

establishing a circumferential finite element model according to the distance between the blood vessel and the skin surface, the blood vessel thickness, the blood vessel outer diameter, the elastic modulus of the surrounding tissues and a preset circumferential simplified model; establishing an axial finite element model according to the distance between the blood vessel and the skin surface, the thickness of the blood vessel, the outer diameter of the blood vessel, the elastic modulus of the surrounding tissues and a preset axial simplified model;

And integrating to obtain the preset blood vessel finite element model to be measured according to the annular finite element model and the axial finite element model.

4. The method of claim 1, wherein acquiring the first reference ultrasound image sequence of the vessel to be measured when not under load and the at least one set of ultrasound image sequences of the vessel to be measured under a predetermined load further comprises:

identifying a vessel diameter in the first reference ultrasound image sequence and the at least one set of ultrasound image sequences;

And judging whether the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences contain a complete cardiac cycle or not according to the vessel diameter, and if not, re-acquiring the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences.

5. the method of claim 4, wherein the sorting the first reference ultrasound image sequence and the at least one group of ultrasound image sequences, respectively, to obtain a target first reference ultrasound image sequence and at least one group of target ultrasound image sequences in a cardiac cycle comprises:

respectively taking images corresponding to the blood vessel diameter reaching the local maximum for the first time in the first reference ultrasonic image sequence and each ultrasonic image sequence as first frames of the target first reference ultrasonic image sequence and each target ultrasonic image sequence;

respectively taking the previous frame image of the first reference ultrasonic image sequence and each ultrasonic image sequence when the blood vessel diameter reaches the local maximum for the second time as the last frame of the target first reference ultrasonic image sequence and each target ultrasonic image sequence;

And adjusting the frame number of each target ultrasonic image sequence to be the same as the frame number of the target first reference ultrasonic image sequence according to the first frame and the last frame.

6. The method of claim 5, wherein from the target first reference ultrasound image sequence and the at least one target ultrasound image sequence, a set of displacement field sequences is derived:

Calculating pixel point displacement of frames corresponding to each target ultrasonic image sequence and the target first reference ultrasonic image sequence to obtain a first displacement field sequence corresponding to each target ultrasonic image sequence;

Calculating pixel point displacement of each frame of image and the first frame of image in each target ultrasonic image sequence to obtain a second displacement field sequence corresponding to each target ultrasonic image sequence;

will be provided with

and combining the first displacement field sequence and the second displacement field sequence to obtain the displacement field sequence group.

7. the method of claim 6, wherein inputting the preset load into a preset finite element model of the blood vessel to be measured for simulation to obtain a blood vessel deformation amount under the preset load, matching the blood vessel deformation amount with the displacement field sequence group to obtain a blood pressure variation waveform of a cardiac cycle, and obtaining a relationship between a blood elastic modulus and the blood pressure of the cardiac cycle comprises:

Obtaining a high pressure value and a low pressure value of the blood vessel to be measured by adopting an oscillometric method;

Determining high-pressure vessel deformation according to a first frame of each first displacement field sequence, and simulating the high-pressure vessel deformation by using the preset vessel finite element model to be measured to obtain the high-pressure vessel elastic modulus corresponding to each first displacement field sequence;

Determining the deformation of a low-pressure blood vessel according to the last frame of each first displacement field sequence, and simulating the deformation of the low-pressure blood vessel by using the preset finite element model of the blood vessel to be measured to obtain the elastic modulus of the low-pressure blood vessel corresponding to each first displacement field sequence;

And substituting the high pressure value, the low pressure value, the high pressure vessel elastic modulus corresponding to each first displacement field sequence and the low pressure vessel elastic modulus corresponding to each first displacement field sequence into a nonlinear constitutive model to perform fitting to obtain a fitting result, determining a vessel material parameter according to the fitting result, and obtaining the relationship between the vessel elastic modulus corresponding to each preset load and the cardiac cycle blood pressure by using the vessel material parameter.

8. the method of claim 7, further comprising:

determining the blood vessel deformation of each frame of image according to each second displacement field sequence;

Simulating the blood vessel deformation of each frame of image by using the blood vessel material parameters and the preset blood vessel finite element model to be measured to obtain the blood pressure change waveform of each second displacement field sequence;

and taking the weighted average value of the blood pressure change waveform of each second displacement field sequence as the heart cycle blood pressure change waveform of the blood vessel to be measured.

9. The method according to claim 6, wherein the preset load is input into a preset finite element model of the blood vessel to be measured for simulation to obtain a blood vessel deformation amount under the preset load, the blood vessel deformation amount is matched with the displacement field sequence group to obtain a blood pressure change waveform of a cardiac cycle, and the relationship between the elastic modulus of the blood vessel and the blood pressure of the cardiac cycle comprises;

obtaining the blood vessel deformation amount of the same blood pressure under the corresponding preset load according to the images of the same frame in each first displacement field sequence;

and simulating the blood vessel deformation of the same blood pressure by using the preset blood vessel finite element model to be measured, and obtaining the variation waveform of the blood pressure in the cardiac cycle and the relationship between the elastic modulus of the blood vessel and the blood pressure in the cardiac cycle by adopting an optimal approximation method.

10. A vascular physiological parameter measurement device, characterized in that the device comprises:

The device comprises an image sequence acquisition module, a load detection module and a load detection module, wherein the image sequence acquisition module is used for acquiring a first reference ultrasonic image sequence of a vessel to be measured when the vessel to be measured is not loaded and at least one group of ultrasonic image sequences of the vessel to be measured when the vessel to be measured is loaded in a preset mode, and each ultrasonic image sequence corresponds to a preset load;

An image sequence processing module, configured to sort the first reference ultrasound image sequence and the at least one group of ultrasound image sequences, respectively, to obtain a target first reference ultrasound image sequence and at least one group of target ultrasound image sequences in a cardiac cycle;

A displacement field determination module, configured to obtain a displacement field sequence group according to the target first reference ultrasound image sequence and the at least one group of target ultrasound image sequences;

and the vessel physiological parameter determining unit is used for inputting the preset load into a preset finite element model of the vessel to be measured for simulation to obtain a vessel deformation under the preset load, and is also used for matching the vessel deformation with the displacement field sequence group to obtain a cardiac cycle blood pressure change waveform of the vessel to be measured and a relationship between a vessel elastic modulus and a cardiac cycle blood pressure.

11. A computer device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, characterized in that the steps of the method of any of claims 1 to 9 are implemented when the computer program is executed by the processor.

12. a computer-readable storage medium, on which a computer program is stored, which, when being executed by a processor, carries out the steps of the method of any one of claims 1 to 9.

13. a vascular physiological parameter measurement device, the device comprising: the device comprises a force sensor, an ultrasonic probe and a loading head;

The force sensor is arranged on the ultrasonic probe, and the loading head is detachably connected with the ultrasonic probe;

The loading head is used for applying load to the skin surface of a measured person during measurement, and the force sensor is used for measuring the load value applied to the skin surface of the measured person.

14. The apparatus of claim 13, further comprising a connection assembly by which the loading head is removably connected to the ultrasound probe, the connection assembly comprising: a clamping groove and a connecting rod;

The clamping groove is of a hollow structure and is arranged at the measuring end of the ultrasonic probe, one end of the connecting rod is fixedly connected with the clamping groove, and the other end of the connecting rod is connected with the loading head.

15. The apparatus of claim 13, wherein the loading head is one of a cuboid, a sphere, a hemisphere, and a cylinder in shape.

16. a data acquisition method based on the vascular physiological parameter measuring device is characterized by comprising the following steps:

selecting the skin surface of a measured person as a measuring area, placing a loading head in the measuring area, and measuring an ultrasonic image sequence when the ultrasonic probe is not loaded;

applying a load to the measurement region by the ultrasonic probe, and acquiring an ultrasonic image sequence of the measurement region again by the ultrasonic probe;

Adjusting the size of the applied load, and collecting an ultrasonic image sequence under the current load for multiple times;

And taking the ultrasonic image sequence when the ultrasonic probe is not loaded and the ultrasonic image sequence when the ultrasonic probe is loaded differently as acquisition data.

17. The data acquisition method according to claim 16, wherein the applying a load to the measurement region by the ultrasonic probe and re-acquiring an ultrasonic image sequence of the measurement region by the ultrasonic probe includes:

removing the loading head, placing the ultrasonic probe on the measurement region, contacting the ultrasonic probe with the skin surface of the measurement region, and acquiring an ultrasonic image sequence of the measurement region through the ultrasonic probe.

18. the data acquisition method according to claim 16, wherein the applying a load to the measurement region by the ultrasonic probe and re-acquiring an ultrasonic image sequence of the measurement region by the ultrasonic probe includes:

and replacing the loading head, placing the replaced loading head in the measurement area, and applying the load to the measurement area through the replaced loading head, wherein the surface area of the replaced loading head is larger than that of the loading head.

Technical Field

the present application relates to the field of blood vessel characteristic research, and in particular, to a method, device, computer device, and storage medium for measuring a blood vessel physiological parameter.

background

blood vessels are an important part of the circulatory system, and the research on the performance of blood vessels is of great significance in the screening and diagnosis of many diseases. The blood vessel has a multilayer tubular composite structure and bears the pressure of the blood vessel and the constraint of tissues outside the blood vessel, so that more parameters influencing the characteristics of the blood vessel are provided. At present, the research on the characteristics of blood vessels in clinical medicine mainly comprises the change of blood pressure, the mechanical property of blood vessels and the like; traditional blood vessel parameter measurement includes blood pressure measurement and blood vessel mechanical property measurement; but the measurements of the two parameters are independent of each other. This presents a fundamental problem on the one hand: the blood pressure and the physiological state of the blood vessels are not independent but affect each other; on the other hand, an operator needs to adopt different devices and steps to finish the measurement, so that the generation time of each parameter is different, the separate measurement process is complicated, the workload of measurement personnel is increased, and the measurement efficiency is low; the two measured partial quantities correspond to different cardiac cycles, and the value of the measured data is limited to a certain extent.

disclosure of Invention

in view of the above, it is necessary to provide a method and a device capable of measuring blood pressure and vascular mechanical parameters simultaneously.

a method of measuring a vascular physiological parameter, the method comprising:

Acquiring a first reference ultrasonic image sequence of a vessel to be measured when the vessel to be measured is not loaded and at least one group of ultrasonic image sequences of the vessel to be measured when the vessel to be measured is loaded in a preset manner, wherein each ultrasonic image sequence corresponds to a preset load;

sequencing the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences respectively to obtain a target first reference ultrasonic image sequence and at least one group of target ultrasonic image sequences in a cardiac cycle;

obtaining a displacement field sequence group according to the target first reference ultrasonic image sequence and the at least one group of target ultrasonic image sequences;

inputting the preset load into a preset finite element model of the blood vessel to be measured for simulation to obtain a blood vessel deformation under the preset load, and matching the blood vessel deformation with the displacement field sequence group to obtain a cardiac cycle blood pressure change waveform and a relationship between a blood vessel elastic modulus and a cardiac cycle blood pressure.

In one embodiment, inputting the preset load into a preset finite element model of the blood vessel to be measured for simulation, and obtaining the deformation of the blood vessel under the preset load;

Acquiring a second reference ultrasonic image sequence when the vessel to be measured is subjected to initial loading;

acquiring the pressing depth according to the first reference ultrasonic image sequence and the second reference ultrasonic image sequence;

inputting the pressing depth and the initial load into a preset contact mechanical model to obtain the elastic modulus of the surrounding tissue of the blood vessel to be measured;

and establishing the finite element model of the preset blood vessel to be measured according to the elastic modulus of the surrounding tissue and the target first reference ultrasonic image sequence.

In one embodiment, the establishing the finite element model of the preset vessel to be measured according to the elastic modulus of the surrounding tissue and the target first reference ultrasound image sequence comprises:

identifying the distance from a blood vessel to the skin surface, the blood vessel thickness and the blood vessel outer diameter according to one frame of image of the target first reference ultrasonic image sequence;

establishing a circumferential finite element model according to the distance between the blood vessel and the skin surface, the blood vessel thickness, the blood vessel outer diameter, the elastic modulus of the surrounding tissues and a preset circumferential simplified model; establishing an axial finite element model according to the distance between the blood vessel and the skin surface, the thickness of the blood vessel, the outer diameter of the blood vessel, the elastic modulus of the surrounding tissues and a preset axial simplified model;

and integrating to obtain the preset blood vessel finite element model to be measured according to the annular finite element model and the axial finite element model.

in one embodiment, acquiring the first reference ultrasound image sequence of the vessel to be measured when the vessel to be measured is not under a load, and acquiring the at least one group of ultrasound image sequences of the vessel to be measured when the vessel to be measured is under a preset load further includes:

Identifying a vessel diameter in the first reference ultrasound image sequence and the at least one set of ultrasound image sequences;

And judging whether the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences contain a complete cardiac cycle or not according to the vessel diameter, and if not, re-acquiring the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences.

In one embodiment, the sorting the first reference ultrasound image sequence and the at least one group of ultrasound image sequences respectively to obtain a target first reference ultrasound image sequence and at least one group of target ultrasound image sequences in a cardiac cycle includes:

respectively taking images corresponding to the blood vessel diameter reaching the local maximum for the first time in the first reference ultrasonic image sequence and each ultrasonic image sequence as first frames of the target first reference ultrasonic image sequence and each target ultrasonic image sequence;

Respectively taking the previous frame image of the first reference ultrasonic image sequence and each ultrasonic image sequence when the blood vessel diameter reaches the local maximum for the second time as the last frame of the target first reference ultrasonic image sequence and each target ultrasonic image sequence;

And adjusting the frame number of each target ultrasonic image sequence to be the same as the frame number of the target first reference ultrasonic image sequence according to the first frame and the last frame.

In one embodiment, a set of displacement field sequences is obtained according to the target first reference ultrasound image sequence and the at least one set of target ultrasound image sequences:

Calculating pixel point displacement of frames corresponding to each target ultrasonic image sequence and the target first reference ultrasonic image sequence to obtain a first displacement field sequence corresponding to each target ultrasonic image sequence;

Calculating pixel point displacement of each frame of image and the first frame of image in each target ultrasonic image sequence to obtain a second displacement field sequence corresponding to each target ultrasonic image sequence;

and combining the first displacement field sequence and the second displacement field sequence to obtain the displacement field sequence group.

in one embodiment, inputting the preset load into a preset finite element model of a blood vessel to be measured for simulation to obtain a blood vessel deformation under the preset load, matching the blood vessel deformation with the displacement field sequence group to obtain a cardiac cycle blood pressure variation waveform, and obtaining a relationship between a blood vessel elastic modulus and a cardiac cycle blood pressure, includes:

Obtaining a high pressure value and a low pressure value of the blood vessel to be measured by adopting an oscillometric method;

Determining high-pressure vessel deformation according to a first frame of each first displacement field sequence, and simulating the high-pressure vessel deformation by using the preset vessel finite element model to be measured to obtain the high-pressure vessel elastic modulus corresponding to each first displacement field sequence;

Determining the deformation of a low-pressure blood vessel according to the last frame of each first displacement field sequence, and simulating the deformation of the low-pressure blood vessel by using the preset finite element model of the blood vessel to be measured to obtain the elastic modulus of the low-pressure blood vessel corresponding to each first displacement field sequence;

And substituting the high pressure value, the low pressure value, the high pressure vessel elastic modulus corresponding to each first displacement field sequence and the low pressure vessel elastic modulus corresponding to each first displacement field sequence into a nonlinear constitutive model to perform fitting to obtain a fitting result, determining a vessel material parameter according to the fitting result, and obtaining the relationship between the vessel elastic modulus corresponding to each preset load and the cardiac cycle blood pressure by using the vessel material parameter.

In one embodiment, the method further comprises the following steps: determining the blood vessel deformation of each frame of image according to each second displacement field sequence;

Simulating the blood vessel deformation of each frame of image by using the blood vessel material parameters and the preset blood vessel finite element model to be measured to obtain the blood pressure change waveform of each second displacement field sequence;

and taking the weighted average value of the blood pressure change waveform of each second displacement field sequence as the heart cycle blood pressure change waveform of the blood vessel to be measured.

In one embodiment, inputting the preset load into a preset finite element model of a blood vessel to be measured for simulation to obtain a blood vessel deformation under the preset load, matching the blood vessel deformation with the displacement field sequence group to obtain a cardiac cycle blood pressure change waveform, and obtaining a relationship between a blood vessel elastic modulus and a cardiac cycle blood pressure;

obtaining the blood vessel deformation amount of the same blood pressure under the corresponding preset load according to the images of the same frame in each first displacement field sequence;

And simulating the blood vessel deformation of the same blood pressure by using the preset blood vessel finite element model to be measured, and obtaining the variation waveform of the blood pressure in the cardiac cycle and the relationship between the elastic modulus of the blood vessel and the blood pressure in the cardiac cycle by adopting an optimal approximation method.

a vascular physiological parameter measurement device, the device comprising:

The device comprises an image sequence acquisition module, a load detection module and a load detection module, wherein the image sequence acquisition module is used for acquiring a first reference ultrasonic image sequence of a vessel to be measured when the vessel to be measured is not loaded and at least one group of ultrasonic image sequences of the vessel to be measured when the vessel to be measured is loaded in a preset mode, and each ultrasonic image sequence corresponds to a preset load;

An image sequence processing module, configured to sort the first reference ultrasound image sequence and the at least one group of ultrasound image sequences, respectively, to obtain a target first reference ultrasound image sequence and at least one group of target ultrasound image sequences in a cardiac cycle;

A displacement field determination module, configured to obtain a displacement field sequence group according to the target first reference ultrasound image sequence and the at least one group of target ultrasound image sequences;

and the vessel physiological parameter determining unit is used for inputting the preset load into a preset finite element model of the vessel to be measured for simulation to obtain a vessel deformation under the preset load, and is also used for matching the vessel deformation with the displacement field sequence group to obtain a cardiac cycle blood pressure change waveform of the vessel to be measured and a relationship between a vessel elastic modulus and a cardiac cycle blood pressure.

A computer device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the processor when executing the computer program implements the steps of:

acquiring a first reference ultrasonic image sequence of a vessel to be measured when the vessel to be measured is not loaded and at least one group of ultrasonic image sequences of the vessel to be measured when the vessel to be measured is loaded in a preset manner, wherein each ultrasonic image sequence corresponds to a preset load;

Sequencing the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences respectively to obtain a target first reference ultrasonic image sequence and at least one group of target ultrasonic image sequences in a cardiac cycle;

obtaining a displacement field sequence group according to the target first reference ultrasonic image sequence and the at least one group of target ultrasonic image sequences;

inputting the preset load into a preset finite element model of the blood vessel to be measured for simulation to obtain a blood vessel deformation under the preset load, and matching the blood vessel deformation with the displacement field sequence group to obtain a cardiac cycle blood pressure change waveform and a relationship between a blood vessel elastic modulus and a cardiac cycle blood pressure.

a computer-readable storage medium, on which a computer program is stored, which, when being executed by a processor, carries out the steps of:

Acquiring a first reference ultrasonic image sequence of a vessel to be measured when the vessel to be measured is not loaded and at least one group of ultrasonic image sequences of the vessel to be measured when the vessel to be measured is loaded in a preset manner, wherein each ultrasonic image sequence corresponds to a preset load;

Sequencing the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences respectively to obtain a target first reference ultrasonic image sequence and at least one group of target ultrasonic image sequences in a cardiac cycle;

Obtaining a displacement field sequence group according to the target first reference ultrasonic image sequence and the at least one group of target ultrasonic image sequences;

inputting the preset load into a preset finite element model of the blood vessel to be measured for simulation to obtain a blood vessel deformation under the preset load, and matching the blood vessel deformation with the displacement field sequence group to obtain a cardiac cycle blood pressure change waveform and a relationship between a blood vessel elastic modulus and a cardiac cycle blood pressure.

a vascular physiological parameter measurement device, the device comprising: the device comprises a force sensor, an ultrasonic probe and a loading head;

The force sensor is arranged on the ultrasonic probe, and the loading head is detachably connected with the ultrasonic probe;

the loading head is used for applying load to the skin surface of a measured person during measurement, and the force sensor is used for measuring the load value applied to the skin surface of the measured person.

In one embodiment, the apparatus further includes a connection assembly, through which the loading head is detachably connected to the ultrasonic probe, the connection assembly including: a clamping groove and a connecting rod;

The clamping groove is of a hollow structure and is arranged at the measuring end of the ultrasonic probe, one end of the connecting rod is fixedly connected with the clamping groove, and the other end of the connecting rod is connected with the loading head.

In one embodiment, the loading head is in the shape of one of a cuboid, a sphere, a hemisphere, and a cylinder.

a data acquisition method based on the vascular physiological parameter measurement device, the data acquisition method comprising:

selecting the skin surface of a measured person as a measuring area, placing a loading head in the measuring area, and measuring an ultrasonic image sequence when the ultrasonic probe is not loaded;

Applying a load to the measurement region by the ultrasonic probe, and acquiring an ultrasonic image sequence of the measurement region again by the ultrasonic probe;

Adjusting the size of the applied load, and collecting an ultrasonic image sequence under the current load for multiple times;

And taking the ultrasonic image sequence when the ultrasonic probe is not loaded and the ultrasonic image sequence when the ultrasonic probe is loaded differently as acquisition data.

In one embodiment, the applying a load to the measurement region by the ultrasound probe and acquiring again an ultrasound image sequence of the measurement region by the ultrasound probe includes:

removing the loading head, placing the ultrasonic probe on the measurement region, contacting the ultrasonic probe with the skin surface of the measurement region, and acquiring an ultrasonic image sequence of the measurement region through the ultrasonic probe.

in one embodiment, the applying a load to the measurement region by the ultrasound probe and acquiring again an ultrasound image sequence of the measurement region by the ultrasound probe includes:

and replacing the loading head, placing the replaced loading head in the measurement area, and applying the load to the measurement area through the replaced loading head, wherein the surface area of the replaced loading head is larger than that of the loading head.

the method, the device, the computer device and the storage medium for measuring the physiological parameters of the blood vessel acquire the ultrasonic image sequences of the blood vessel to be measured when the blood vessel is loaded or unloaded through the ultrasonic probe, obtain the displacement field sequences corresponding to different loads and the displacement field sequences corresponding to different blood pressures, simulate each displacement field sequence by using a preset finite element model, can simultaneously obtain the blood pressure change waveform and the elastic modulus of the blood vessel in the cardiac cycle, and improve the efficiency of measuring the physiological parameters of the blood vessel.

drawings

FIG. 1 is a schematic diagram of a device for measuring physiological parameters of blood vessels;

FIG. 2a is an elevation view of a connection assembly in one implementation;

FIG. 2b is a left side view of the connecting assembly in one implementation;

FIG. 3 is a schematic flow chart diagram illustrating a data collection method according to one embodiment;

FIG. 4a is a schematic diagram of a measurement device for measuring a physiological parameter of a blood vessel on a common carotid artery in one embodiment;

FIG. 4b is a schematic diagram illustrating an image-side measurement of a circumferential blood vessel in one embodiment;

FIG. 4c is a schematic axial vessel image-side measurement in accordance with another embodiment;

FIG. 5a is a schematic view of a blood vessel and surrounding tissue in an unloaded state, according to an embodiment;

FIG. 5b is a schematic view of a blood vessel and surrounding tissue under load in another embodiment;

FIG. 6 is a flow chart illustrating a method for measuring a physiological parameter of a blood vessel according to an embodiment;

FIG. 7a is a diagram of a circumferential vessel identified by an ultrasound image in one embodiment;

FIG. 7b is a diagram of a circumferential vessel identified by ultrasound images in another embodiment;

FIG. 7c is a diagram of a circumferential vessel identified by ultrasound images in yet another embodiment;

FIG. 7d is an axial vessel identified by the ultrasound image in one embodiment;

FIG. 7e is an axial vessel identified by the ultrasound image in another embodiment;

FIG. 7f is an axial vessel identified by an ultrasound image in accordance with yet another embodiment;

FIG. 8 is a schematic flow chart illustrating a process of creating a finite element model of a predetermined vessel to be measured according to an embodiment;

FIG. 9 is a diagram of a toroidal finite element model in one embodiment;

FIG. 10 is a diagram of generating a UIC in one embodiment_nAnd UPC_na schematic diagram of (a);

FIG. 11 is a schematic structural diagram of a device for measuring physiological parameters of blood vessels in an embodiment;

FIG. 12 is a diagram illustrating an internal structure of a computer device according to an embodiment.

Detailed Description

In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.

In one embodiment, referring to fig. 1, a device 10 for measuring a physiological parameter of a blood vessel is provided, which includes: the device comprises a force sensor 1, an ultrasonic probe 2 and a loading head 3;

the force sensor 1 is connected with the ultrasonic probe 2, and the loading head 3 is detachably connected with the ultrasonic probe 2; the loading head 3 is used for applying load to the skin surface of the measured person during measurement, and the force sensor 2 is used for measuring the load value applied to the skin surface of the measured person.

for example, the force sensor 1 is a pressure sensor, measuring in the range between 0-30N and capable of measuring a force of 1N; the ultrasonic probe 2 can transmit ultrasonic signals and receive echo signals returned by tissues, and the ultrasonic probe 2 can be any existing ultrasonic probe such as a linear array probe, a convex array probe, a phased array probe and the like without limitation; the loading head 3 and the ultrasonic probe 2 can be in a thread mode, a buckle mode, a clamping groove mode and the like. The loading head 3 is made of rigid material, such as stainless steel, and the loading head 3 may be hollow or solid, and the outer contour thereof is regular shape, such as rectangular parallelepiped, sphere, hemisphere, ellipsoid, cylinder, etc.

In one embodiment, referring to fig. 2a and 2b, the loading head 3 is detachably connected to the ultrasonic probe 2 through a connection assembly 4, and the connection assembly 4 includes: a card slot 41 and a connecting rod 42; the clamping groove 41 is of a hollow structure, the clamping groove 41 is arranged at the measuring end of the ultrasonic probe 2, one end of the connecting rod 42 is fixedly connected with the clamping groove 41, and the other end of the connecting rod 42 is connected with the loading head 3.

in this embodiment, the shape of the slot 41 is matched with the measuring end of the ultrasonic probe 2, the slot 41 may be made of plastic, and the slot 41 has a hollow structure so that the ultrasonic probe 2 can pass through; the connecting rod 42 is made of rigid material, such as a stud, and the loading head 3 is provided with threads to match with the stud.

in one embodiment, referring to fig. 3, a data acquisition method is provided based on the vascular physiological parameter measurement device 10, and specifically the method includes the following steps:

s120, selecting the skin surface of the measured person as a measuring area, placing the loading head 3 in the measuring area, and measuring the ultrasonic image sequence when the ultrasonic probe 2 is not loaded.

the blood vessel physiological parameter measuring device 10 can measure the physiological parameters of arteries of various parts, wherein the human body arteries comprise common carotid arteries, thoracic aorta, abdomen and the like; referring to fig. 4a, in the present embodiment, the common carotid artery is taken as an example, the measurement region is a region formed on the surface of the skin above the artery, the loading head 3 is contacted with the skin above the common carotid artery, and the ultrasound coupling agent is filled between the probe 2 and the skin. The acquired ultrasonic image comprises images of blood vessels and surrounding tissues, and the blood vessel image in the ultrasonic image is adjusted by rotating the ultrasonic probe 2; the blood vessel image comprises a circumferential image and an axial image; the circumferential direction is along the cross section of the blood vessel as shown in fig. 4b, and the axial image is along the length of the blood vessel as shown in fig. 4 c; it is understood that other directions of the blood vessel image can be obtained by rotating the ultrasonic probe in the implementation process, and this embodiment is only used for illustration.

s140, a load is applied to the measurement region by the ultrasonic probe 2, and the ultrasonic probe 2 acquires the ultrasonic image sequence of the measurement region again.

referring to fig. 5a and 5b, the operator applies pressure to the ultrasound probe 2, and ultrasound images of the tissue under pressure are acquired by the ultrasound probe. As an example, when measuring the ultrasound image sequence when applying the load, the ultrasound image sequence may be acquired by replacing the loading head or by using the ultrasound probe to directly acquire the ultrasound image sequence, for example, the spherical loading head may be removed and replaced by a rectangular loading head of 8mm × 20 mm.

S160, adjusting the size of the applied load, and collecting the ultrasonic image sequence under the current load for multiple times;

and S180, taking the ultrasonic image sequence when the ultrasonic probe is not loaded and the ultrasonic image sequence when the ultrasonic probe is loaded differently as acquisition data.

For example, the operator measures the circumferential ultrasound image sequence C of the common carotid artery without load by using a spherical loading head with the diameter of 5mm, and rotates the ultrasoundthe wave probe measures an axial ultrasonic image sequence A; measuring an annular ultrasonic image sequence C 'when 1N of pressure is applied to a 5mm spherical loading head, and rotating an ultrasonic probe to measure an axial ultrasonic image sequence A'; an operator removes the spherical loading head, applies 5N, 10N and 15N of pressure to the ultrasonic probe respectively, and acquires three groups of corresponding annular ultrasonic image sequences C under the three groups of pressure₁、C₂and, C₃and three sets of axial ultrasound image sequences A₁、A₂and, A₃。

in one embodiment, please refer to fig. 6, a method for measuring a vascular physiological parameter is provided, which includes the following steps:

S200, acquiring a first reference ultrasonic image sequence of the vessel to be measured when the vessel to be measured is not loaded and at least one group of ultrasonic image sequences of the vessel to be measured when the vessel to be measured is loaded in a preset mode, wherein each ultrasonic image sequence corresponds to one preset load.

The preset load of the blood vessel to be measured means that pressure is applied to the surface of the skin and indirectly acts on the blood vessel to be measured, and the preset load value is more than or equal to 1N; the first reference ultrasonic image and at least one group of ultrasonic image sequences are all collected to be the same measurement region blood vessel ultrasonic images, each ultrasonic image sequence is composed of ultrasonic images of a plurality of blood vessels, and the blood vessels in the ultrasonic images can be annular or axial.

s400, sequencing the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences respectively to obtain a target first reference ultrasonic image sequence and at least one group of target ultrasonic image sequences in the cardiac cycle.

the sequencing means that a plurality of images of the first reference ultrasound image sequence and each group of ultrasound image sequences are aligned, and in a specific implementation process, the images of each sequence can be intercepted according to the diameter of a blood vessel in the images, so that the obtained first reference ultrasound image sequence of the target and each image of each group of target ultrasound image sequences correspond to the same blood pressure; for example, the first frame of each of the first reference ultrasound image and each of the group of ultrasound images corresponds to an image at hypertension or an image at hypotension, and the last frame of each of the first reference ultrasound image and each of the group of ultrasound images corresponds to an image at hypertension or an image at hypotension.

S600, obtaining a displacement field sequence group according to the target first reference ultrasonic image sequence and at least one group of target ultrasonic image sequences.

The displacement field sequence is to calculate the displacement of pixels in two ultrasonic images by adopting image processing methods such as image correlation, spot tracking and the like; for example, calculating the displacement of pixel points in any two images in a target first reference ultrasonic image sequence and a target ultrasonic image sequence, or calculating the displacement of pixel points in any two images in the target ultrasonic image sequence; and then obtaining a plurality of displacement field sequences under the same load and different blood pressures and a plurality of displacement field sequences under the same blood pressure and different loads, wherein the displacement field sequence group consists of a plurality of displacement field sequences.

s800, inputting a preset load into a preset blood vessel finite element model to be measured for simulation, obtaining a blood vessel deformation amount under the preset load, and matching the blood vessel deformation amount with a displacement field sequence group to obtain physiological parameters of the blood vessel to be measured, wherein the physiological parameters comprise a cardiac cycle blood pressure change waveform and a relationship between a blood vessel elastic modulus and a cardiac cycle blood pressure.

in this embodiment, the preset finite element model of the blood vessel to be measured may be stored in advance, or may be established according to the acquired data after the data is acquired. The method comprises the steps of acquiring ultrasonic image sequences of a to-be-measured blood vessel under load and under no load through an ultrasonic probe, obtaining displacement field sequences corresponding to different loads and displacement field sequences corresponding to different blood pressures, simulating each displacement field sequence by using a preset finite element model, and simultaneously obtaining a blood pressure change waveform and a blood vessel elastic modulus of a cardiac cycle, thereby improving the efficiency of measuring the physiological parameters of the blood vessel.

in one embodiment, the method further includes, after step S200, the steps of:

Identifying the diameter of a blood vessel in the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences, and identifying the diameter of the blood vessel according to the direction of the blood vessel in the obtained ultrasonic image sequences; referring to fig. 7a to 7c, when the direction of the blood vessel in the image is circumferential, hough transform, kalman filter, etc. may be used to identify the circle and ellipse in the image, and obtain the corresponding diameter of the section of the blood vessel; referring to fig. 7d to 7f, when the direction of the blood vessel in the image is the axis, the straight line where the blood vessel is located in the image can be identified by using hough transform, radon transform, and the like, and the longitudinal diameter of the corresponding blood vessel can be obtained.

Judging whether the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences contain a complete cardiac cycle or not according to the diameter of the blood vessel, and if not, re-acquiring the first reference ultrasonic image sequence and the at least one group of ultrasonic image sequences; specifically, for example, an ultrasound image sequence is considered to contain a complete cardiac cycle if the vessel cross-sectional diameter or the vessel longitudinal diameter in the ultrasound sequence reaches a local maximum or a local minimum twice. For example, when a local maximum in vessel diameter has been detected only once in a sequence of ultrasound images, the sequence is considered to contain no complete cardiac cycle and data needs to be reacquired.

In an embodiment, referring to fig. 8, step S800 further includes a step of establishing a finite element model of a preset blood vessel to be measured:

and S710, acquiring a second reference ultrasonic image sequence when the blood vessel to be measured is subjected to initial loading.

S720, obtaining the pressing depth according to the first reference ultrasonic image sequence and the second reference ultrasonic image sequence.

The initial load is the load when the pressure applied to the blood vessel to be measured is equal to 1N; the pressing depth refers to the displacement of the blood vessel to be measured when the blood vessel is subjected to initial load relative to the loading head when the blood vessel is not subjected to the load; the second reference ultrasound image is measured by the loading head squeezing the measurement area. And obtaining a deformation field by using the first reference ultrasonic image sequence and the second reference ultrasonic image sequence through image processing methods such as image correlation, speckle tracking and the like, and further obtaining the indentation depth according to the deformation field at the moment. In this embodiment, the second reference ultrasound image sequence may be an ultrasound image sequence C ' and an ultrasound image sequence A ' of the axial direction measured with a 5mm spherical loading head and 1N applied '

S730, pressing depth and initial loadinputting a preset contact mechanics model to obtain the elastic modulus E of the peripheral tissue of the blood vessel to be measured_B。

S740, modulus of elasticity E according to surrounding tissue_BAnd establishing a preset finite element model of the blood vessel to be measured by the target first reference ultrasonic image sequence.

referring to FIG. 9, the blood vessel density and the surrounding tissue density were 1000kg/m during modeling³(ii) a And fitting the initial load and the pressing depth by methods such as a Hertz contact formula or a finite element example to obtain the elastic modulus E of the surrounding tissue_BAnd obtaining the toroidal finite element model shown in fig. 9 by using the toroidal finite element model, specifically in an embodiment, the step S730 further includes the following steps:

step one, according to a frame of image of the target first reference ultrasonic image sequence, the distance between a blood vessel and the surface of the skin, the thickness of the blood vessel and the outer diameter of the blood vessel are identified. In practice, the distance of the blood vessel from the skin surface, the thickness of the blood vessel, and the outer diameter of the blood vessel are obtained from the first reference ultrasound image of the target when no load is applied.

step two, establishing a circular finite element model according to the distance between the blood vessel and the skin surface, the blood vessel thickness, the blood vessel outer diameter, the elastic modulus of surrounding tissues and a preset circular simplified model; and establishing an axial finite element model according to the distance between the blood vessel and the skin surface, the thickness of the blood vessel, the outer diameter of the blood vessel, the elastic modulus of surrounding tissues and a preset axial simplified model.

In the present embodiment, the distribution pressure is set according to the magnitude of the initial load, and the sum of the pressures is equal to the pressure applied by the probe. It is understood that the axial finite element model is established in the same principle as the circumferential finite element model, and the preset axial simplified model may be a two-dimensional model which ignores the curvature of the blood vessel or a three-dimensional model which considers the curvature of the blood vessel.

In one embodiment, S400 in the method for measuring a vascular physiological parameter specifically includes:

step one, images corresponding to the first time when the blood vessel diameter reaches the local maximum in the first reference ultrasonic image sequence and each ultrasonic image sequence are respectively used as first frames of the target first reference ultrasonic image sequence and each target ultrasonic image sequence. Respectively taking the previous frame image when the blood vessel diameter in the first reference ultrasonic image sequence and each ultrasonic image sequence reaches the local maximum for the second time as the last frame of the target first reference ultrasonic image sequence and each target ultrasonic image sequence;

in the implementation process, when the ultrasound image sequence is sequenced, the first frame and the last frame are not limited to be selected in the above manner, and only the first frame and the last frame of the sequenced ultrasound image sequence need to correspond to the same blood pressure, and it can be understood that a complete cardiac cycle is included between the first frame and the last frame, or more than one cardiac cycle is also included.

And step two, adjusting the frame number of each target ultrasonic image sequence to be the same as the frame number of the target first reference ultrasonic image sequence according to the first frame and the last frame.

in the implementation process, if the number of image frames in the target ultrasound image sequence obtained after sequencing is different from the number of frames of the target first reference ultrasound image sequence, the missing images can be complemented by deleting images of redundant frames or adopting a least square mode when the number of image frames is insufficient, so that the number of frames of the target first reference ultrasound image sequence of each group of the target ultrasound image sequences obtained finally is the same.

in one embodiment, the obtaining of the displacement field sequence set in step 600 specifically includes the following steps:

Step one, calculating pixel point displacement of a frame corresponding to each target ultrasonic image sequence and the target first reference ultrasonic image sequence to obtain a first displacement field sequence corresponding to each target ultrasonic image sequence. Referring to FIG. 10, for any set of circular target ultrasound image sequences C_nFirst reference ultrasound image sequences C and C in the circumferential direction_nk frames are kept, wherein k is a positive integer greater than or equal to 2, C and C are calculated_npixel point displacement of first frame image of sequence obtains data as annular first displacement field sequence UIC_nTraversing k frame images to obtain a circumferential first displacement field sequence UIC_n。

Step two, calculating each frame image in each target ultrasonic image sequenceShifting pixel points of the image and the first frame image to obtain a second shift field sequence corresponding to each target ultrasonic image sequence; please continue to refer to fig. 10, sequentially calculate C_nEach frame image in the sequence and C_nPixel point displacement of the first frame image of the sequence, and using the obtained k frames of data as a second circumferential displacement field sequence UPC_n。

The displacement field sequence generated when the blood vessel in the ultrasonic image is in the axial direction has the same principle as that when the blood vessel is in the annular direction, and the first reference ultrasonic image sequence A and the axial target ultrasonic image sequence A are correspondingly generated according to the axial target_nobtaining a first sequence of displacement fields UIA_nAnd axial second displacement field sequence UPA_n. In the implementation process, the obtained UIC_n、UPC_n、UIA_n、UPA_nThe combination is performed as a displacement field sequence group.

In one embodiment, the present implementation uses a circular vessel derived displacement field sequence UIC_nand UPC_nFor example, the specific step S800 includes:

step one, obtaining a high pressure value P of a blood vessel to be measured by adopting an oscillometric method_hAnd a low pressure value P_l(ii) a In the implementation process P_hAnd P_lThe value can be obtained by using the existing device for measuring blood pressure, and the embodiment is not limited to the method.

Determining high-pressure vessel deformation according to a first frame of each first displacement field sequence, and simulating the high-pressure vessel deformation by using a preset vessel finite element model to be measured to obtain the high-pressure vessel elastic modulus corresponding to each first displacement field sequence;

Determining the deformation of the low-pressure blood vessel according to the last frame of each first displacement field sequence, simulating the deformation of the low-pressure blood vessel by using a preset blood vessel finite element model to be measured, obtaining the elastic modulus of the low-pressure blood vessel corresponding to each first displacement field sequence, and obtaining P_lgroup of

Simulating P by using finite element model_hLower simulation result, willThe simulation result and each UIC_nThe last frame in the process is compared, the closest simulation result is taken as the transient elastic modulus under high pressure, and then P is obtained_hGroup ofFor P_lBy the same method, P is obtained_lgroup of

And step four, substituting the high pressure value, the low pressure value, the high pressure vessel elastic modulus corresponding to each first displacement field sequence and the low pressure vessel elastic modulus corresponding to each first displacement field sequence into the nonlinear constitutive model to perform fitting to obtain a fitting result, determining a vessel material parameter according to the fitting result, and obtaining the relationship between the vessel elastic modulus corresponding to each preset load and the cardiac cycle blood pressure by using the vessel material parameter.

In practice, the material of the finite-element model is configured as a nonlinear elastic material, for example, the material s is configured as a Fung-Demiray constitutive model material, and the material parameters are determined by corresponding parametersAndAnd (4) determining.

Fifthly, determining the blood vessel deformation of each frame of image according to each second displacement field sequence; simulating the blood vessel deformation of each frame of image by using the blood vessel material parameters and a preset blood vessel finite element model to be measured to obtain the blood pressure change waveform of each second displacement field sequence; and taking the weighted average value of the blood pressure change waveform of each second displacement field sequence as the heart cycle blood pressure change waveform of the blood vessel to be measured.

For example, given a given external load, the internal pressure of the pipeline is changed within a reasonable range, and an internal pressure simulation result under the external load is obtained; will UPC_nEach frame in (1) is compared with the simulation result to approximate the optimumThe simulated intravascular pressure is taken as the intravascular pressure of the image; and each group of UPC_nObtaining a blood pressure change waveform in the sequence, and taking all UPCs_nthe statistics (e.g., weighted average) of the corresponding blood pressure change waveform are used as the blood pressure change waveform for the cardiac cycle.

In one embodiment, the step S800 of obtaining the blood pressure variation waveform of the cardiac cycle, and the relationship between the elastic modulus of the blood vessel and the blood pressure of the cardiac cycle can be further obtained by the following steps:

step one, obtaining the same blood pressure vessel deformation under the corresponding preset load according to the images of the same frame in each first displacement field sequence;

And step two, simulating the deformation of the blood vessel with the same blood pressure by using a preset finite element model of the blood vessel to be measured, and obtaining the variation waveform of the blood pressure in the cardiac cycle and the relationship between the elastic modulus of the blood vessel and the blood pressure in the cardiac cycle by adopting an optimal approximation method.

in practice, each UIC will be_nAnd combining the ith frame (i is 1,2, … … k), when an external load and the elastic modulus of surrounding tissues are given in a reasonable range by using a finite element module, outputting the blood vessel deformation under the combination of the transient elastic modulus of the blood vessel and the blood pressure and the transient blood pressure when the data under each load are optimally approximated according to a finite element example, and simultaneously obtaining the blood pressure change waveform of the cardiac cycle and the relation between the elastic modulus of the blood vessel and the blood pressure of the cardiac cycle. The specific optimal approximation can adopt an iterative optimization method and a machine learning method.

the iterative optimization method begins by selecting an initial set of vascular elastic modulus and blood pressure, e.g. E_C150kPa (15kPa) and 15kPa (P), if this is the case according to UIC_nIf the obtained blood vessel has a large deformation, the adjustment E is performed_CAnd the value of P until the output of the model of vascular deformation and UIC_nand (5) the consistency is achieved.

the machine learning method is within a reasonable range of human body data, such as 100kPa<E_C(P)<300kPa, calculating a plurality of pairs of material data points (P, E)_C(P)) and using the deformation field or its characteristic quantity as the input of machine learning model (P, E)_C(P)) as an output of the machine learning model. It is composed ofThe machine learning model may be a decision tree, a random jungle, an artificial neural network, or the like. Saving the trained machine learning model and further obtaining UIC_nThe corresponding cardiac cycle blood pressure change waveform and the elastic modulus E of the blood vessel are obtained through a trained machine learning model_C(P) is related to the cardiac cycle blood pressure.

in particular, the first displacement field sequence UIA is described for an axial vessel image_nAnd axial second displacement field sequence UPA_nthe blood pressure change waveform of the cardiac cycle and the elastic modulus E of the blood vessel can be obtained in the same way_A(P) is related to the cardiac cycle blood pressure. Furthermore, the hardening coefficient of the blood vessel to be measured and the intrinsic elastic modulus E of the anisotropic parameter when the blood vessel internal pressure is zero can be obtained according to the obtained relationship between the elastic modulus of the blood vessel and the blood pressure of the cardiac cycle_C(0) And E_A(0)。

It should be understood that, although the steps in the flowcharts of fig. 3, 6 and 8 are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and described, and may be performed in other orders, unless explicitly stated otherwise. Moreover, at least some of the steps in fig. 3, 6, and 8 may include multiple sub-steps or multiple stages that are not necessarily performed at the same time, but may be performed at different times, and the order of performing the sub-steps or stages is not necessarily sequential, but may be performed alternately or alternatingly with other steps or at least some of the sub-steps or stages of other steps.

in one embodiment, referring to fig. 11, the present embodiment provides a vascular physiological parameter measurement apparatus 900, including:

An image sequence acquiring module 901, configured to acquire a first reference ultrasound image sequence of a vessel to be measured when the vessel to be measured is not under a load, and at least one group of ultrasound image sequences of the vessel to be measured when the vessel to be measured is under a preset load, where each ultrasound image sequence corresponds to a preset load;

an image sequence processing module 902, configured to sort the first reference ultrasound image sequence and the at least one group of ultrasound image sequences respectively to obtain a target first reference ultrasound image sequence and at least one group of target ultrasound image sequences in a cardiac cycle;

A displacement field determining module 903, configured to obtain a displacement field sequence group according to the target first reference ultrasound image sequence and the at least one group of target ultrasound image sequences;

The vessel physiological parameter determining unit 904 is configured to input a preset load into a preset finite element model of the vessel to be measured to perform simulation, so as to obtain a vessel deformation amount under the preset load, and is further configured to match the vessel deformation amount with the displacement field sequence group, so as to obtain a cardiac cycle blood pressure variation waveform of the vessel to be measured, and a relationship between a vessel elastic modulus and a cardiac cycle blood pressure.

For specific definition of the vascular physiological parameter measurement device, reference may be made to the above definition of the vascular physiological parameter measurement method, which is not described herein again. The modules in the vascular physiological parameter measurement device can be wholly or partially realized by software, hardware and a combination thereof. The modules can be embedded in a hardware form or independent from a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules.

in one embodiment, a computer device, as shown in fig. 12, includes a memory and a processor, the memory stores a computer program that can be executed on the processor, and the processor implements the steps of the vascular physiological parameter measurement method according to any one of the above methods when executing the computer program.

In an embodiment, a computer-readable storage medium has stored thereon a computer program which, when being executed by a processor, carries out the steps of the vascular physiological parameter testing method of any of the above.

it will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above can be implemented by hardware related to instructions of a computer program, which can be stored in a non-volatile computer-readable storage medium, and when executed, can include the processes of the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), Programmable ROM (PROM), Electrically Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM (SDRAM), Double Data Rate SDRAM (DDRSDRAM), Enhanced SDRAM (ESDRAM), Synchronous Link DRAM (SLDRAM), Rambus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).

The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.