阅读说明：本技术 一种化疗冰敷袋 (Ice pack for chemotherapy ) 是由 邱锡波 刘平 于 2019-08-26 设计创作，主要内容包括：本发明提供了一种化疗冰敷袋,所述化疗冰敷袋的芯层凝胶的制备方法包括以下步骤：将30～60重量份的水、5～15重量份的氯化钠、24～50重量份的丙烯酸类单体、1～10重量份的交联剂、0.1～5重量份的引发剂,混合均匀后触发交联反应至完全反应形成块状凝胶；所述丙烯酸类单体为丙烯酸、丙烯酸酯、丙烯酰胺及其衍生物中的一种或几种；所述交联剂为包含碳碳双键官能团的化合物。本发明的化疗冰敷袋在冷冻过程中不会结成硬块,所以冰敷时能够很好的贴合患者体表轮廓,提高冰敷效果；能够利用凝胶的多孔结构锁住冷量,使冷量能够缓慢而持久的释放,患者使用时可以直到症状缓解时再取下来,而不需频繁的为了避免冷量集中释放而间歇性使用,提升了患者的治疗体验。(the invention provides a chemotherapy ice bag, and a preparation method of a core layer gel of the chemotherapy ice bag comprises the following steps: uniformly mixing 30-60 parts by weight of water, 5-15 parts by weight of sodium chloride, 24-50 parts by weight of acrylic monomers, 1-10 parts by weight of cross-linking agent and 0.1-5 parts by weight of initiator, and triggering a cross-linking reaction until the cross-linking reaction is completely performed to form blocky gel; the acrylic monomer is one or more of acrylic acid, acrylate, acrylamide and derivatives thereof; the cross-linking agent is a compound containing a carbon-carbon double bond functional group. The chemotherapy ice bag disclosed by the invention cannot be hard in a freezing process, so that the chemotherapy ice bag can be well attached to the body surface contour of a patient during ice compress, and the ice compress effect is improved; can utilize the porous structure of gel to pin cold volume, make cold volume can slowly and lasting release, the patient can take off again when the symptom is alleviated during the use, and need not frequent in order to avoid cold volume concentrated release and intermittent type nature use, has promoted patient's treatment experience.)

1. The chemotherapy ice bag is characterized by comprising an outer layer package made of waterproof fabric and a core layer gel, wherein the preparation method of the core layer gel comprises the following steps:

Uniformly mixing 30-60 parts by weight of water, 5-15 parts by weight of sodium chloride, 24-50 parts by weight of acrylic monomers, 1-10 parts by weight of cross-linking agent and 0.1-5 parts by weight of initiator, and triggering a cross-linking reaction until the cross-linking reaction is completely performed to form blocky gel;

Wherein the acrylic monomer is one or more of acrylic acid, acrylate, acrylamide and acrylamide derivatives;

the cross-linking agent is a compound containing a carbon-carbon double bond functional group;

The initiator is a thermal initiator or a photoinitiator.

2. The chemotherapy ice pack of claim 1, wherein the cross-linking agent is 1, 6-hexanediol diacrylate, polyethylene glycol diacrylate or pentaerythritol triacrylate.

3. The chemotherapy ice pack of claim 1, wherein the thermal initiator is ammonium persulfate and the cross-linking reaction is triggered by heating to 70 ℃.

4. The chemotherapy ice pack of claim 1, wherein the photoinitiator is 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone and the means for triggering the crosslinking reaction is ultraviolet irradiation.

5. The chemotherapy ice pack according to claim 1, wherein the preparation method of the core layer gel comprises the following steps:

uniformly mixing 30 parts by weight of water, 5 parts by weight of sodium chloride, 50 parts by weight of acrylic acid monomer, 10 parts by weight of cross-linking agent polyethylene glycol diacrylate and 5 parts by weight of initiator ammonium persulfate, heating to 70 ℃, and keeping the temperature for 2 hours until the mixture completely reacts to form blocky gel.

6. the chemotherapy ice pack according to claim 1, wherein the preparation method of the core layer gel comprises the following steps:

uniformly mixing 50 parts by weight of water, 10 parts by weight of sodium chloride, 15 parts by weight of acrylic acid monomer, 15 parts by weight of hydroxyethyl methacrylate monomer, 8 parts by weight of cross-linking agent pentaerythritol triacrylate and 2 parts by weight of initiator ammonium persulfate, heating to 70 ℃, and keeping the temperature for 2 hours until complete reaction to form blocky gel.

7. The chemotherapy ice pack according to claim 1, wherein the preparation method of the core layer gel comprises the following steps:

uniformly mixing 60 parts by weight of water, 15 parts by weight of sodium chloride, 15 parts by weight of acrylic acid monomer, 9 parts by weight of hydroxyethyl acrylamide monomer, 1 part by weight of cross-linking agent 1, 6-hexanediol diacrylate and 0.1 part by weight of photoinitiator 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone, and irradiating by ultraviolet rays for half an hour until complete reaction is achieved to form blocky gel.

8. The chemotherapy ice pack of claim 1, further comprising straps for securing the chemotherapy ice pack to a user.

9. a method of preparing a chemotherapy ice pack according to any of claims 1 to 8, comprising the steps of:

(1) Uniformly mixing 30-60 parts by weight of water, 5-15 parts by weight of sodium chloride, 24-50 parts by weight of acrylic monomers, 1-10 parts by weight of cross-linking agent and 0.1-5 parts by weight of initiator, and triggering a cross-linking reaction until the cross-linking reaction is completely performed to form blocky gel; wherein the acrylic monomer is one or more of acrylic acid, acrylate, acrylamide and acrylamide derivatives; the cross-linking agent is a compound containing a carbon-carbon double bond functional group; the initiator is a thermal initiator or a photoinitiator

(2) and (3) packaging and sealing the block-shaped gel obtained in the step (1) by using a waterproof fabric bag.

Technical Field

The invention relates to the technical field of medical supplies, in particular to a chemotherapy ice bag.

Background

Chemotherapy is one of the three major methods for treating cancer, and about 70% of malignant tumor patients worldwide need to receive chemotherapy, which occupies a very important position in cancer treatment. The common means of chemotherapy is intravenous injection, however, drug extravasation easily occurs during intravenous injection, exuded drugs can cause edema around damaged venous skin, phlebitis, tissue necrosis and the like are caused, and serious patients even have lifelong disability.

Clinically, the ice bag ice compress is generally used for causing the local vasoconstriction of a patient to reduce the permeability of a blood vessel wall so as to reduce the damage of the extravasation of chemotherapeutic drugs to the patient, but at present, the ice bag ice compress is usually used for directly freezing water into ice to the patient. The disadvantage of this method is that the ice is hard and hard to fit the patient's body surface, resulting in poor cold compress effect in some cases; secondly, the ice block has large cold storage capacity, cold quantity is released in a centralized manner, and a patient is easily frostbitten, so that the ice bag is required to be removed after 15-30 minutes in the using process, the ice bag is iced again after several minutes, the repeated operation is carried out until the symptoms are relieved, and the process is relatively complicated.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a chemotherapy ice bag.

In order to achieve the purpose, the invention adopts the technical scheme that: a chemotherapy ice bag comprises an outer package of waterproof fabric and a core layer gel, and the preparation method of the core layer gel comprises the following steps:

Uniformly mixing 30-60 parts by weight of water, 5-15 parts by weight of sodium chloride, 24-50 parts by weight of acrylic monomers, 1-10 parts by weight of cross-linking agent and 0.1-5 parts by weight of initiator, and triggering a cross-linking reaction until the cross-linking reaction is completely performed to form blocky gel;

Wherein the acrylic monomer is one or more of acrylic acid, acrylate, acrylamide and acrylamide derivatives;

The cross-linking agent is a compound containing a carbon-carbon double bond functional group;

the initiator is a thermal initiator or a photoinitiator.

the chemotherapy ice bag disclosed by the invention cannot be hard in a freezing process, so that the chemotherapy ice bag can be well attached to the body surface contour of a patient during ice compress, and the ice compress effect is improved; the chemotherapy ice bag utilizes the porous structure of the gel to lock the cold quantity, so that the cold quantity can be slowly and durably released, and can be taken down by a patient until the symptom is relieved when the chemotherapy ice bag is used by the patient, the chemotherapy ice bag does not need to be frequently used intermittently to avoid frostbite caused by concentrated release of the cold quantity, and the treatment experience of the patient is improved.

preferably, the crosslinking agent is 1, 6-hexanediol diacrylate, polyethylene glycol diacrylate or pentaerythritol triacrylate.

Preferably, the thermal initiator is ammonium persulfate and the crosslinking reaction is triggered by heating to 70 ℃.

Preferably, the photoinitiator is 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone (I2959), and the mode for triggering the crosslinking reaction is ultraviolet irradiation.

Preferably, the preparation method of the core layer gel comprises the following steps:

Uniformly mixing 30 parts by weight of water, 5 parts by weight of sodium chloride, 50 parts by weight of acrylic acid monomer, 10 parts by weight of cross-linking agent polyethylene glycol diacrylate and 5 parts by weight of initiator ammonium persulfate, heating to 70 ℃, and keeping the temperature for 2 hours until the mixture completely reacts to form blocky gel.

preferably, the preparation method of the core layer gel comprises the following steps:

Uniformly mixing 50 parts by weight of water, 10 parts by weight of sodium chloride, 15 parts by weight of acrylic acid monomer, 15 parts by weight of hydroxyethyl methacrylate monomer, 8 parts by weight of cross-linking agent pentaerythritol triacrylate and 2 parts by weight of initiator ammonium persulfate, heating to 70 ℃, and keeping the temperature for 2 hours until complete reaction to form blocky gel.

Preferably, the preparation method of the core layer gel comprises the following steps:

Uniformly mixing 60 parts by weight of water, 15 parts by weight of sodium chloride, 15 parts by weight of acrylic acid monomer, 9 parts by weight of hydroxyethyl acrylamide monomer, 1 part by weight of cross-linking agent 1, 6-hexanediol diacrylate and 0.1 part by weight of photoinitiator 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone, and irradiating by ultraviolet rays for half an hour until complete reaction is achieved to form blocky gel.

Preferably, the chemotherapy ice bag further comprises a strap for securing the chemotherapy ice bag to a user.

The invention also provides a preparation method of any one of the chemotherapy ice bags, which comprises the following steps:

(1) uniformly mixing 30-60 parts by weight of water, 5-15 parts by weight of sodium chloride, 24-50 parts by weight of acrylic monomers, 1-10 parts by weight of cross-linking agent and 0.1-5 parts by weight of initiator, and triggering a cross-linking reaction until the cross-linking reaction is completely performed to form blocky gel; wherein the acrylic monomer is one or more of acrylic acid, acrylate, acrylamide and acrylamide derivatives; the cross-linking agent is a compound containing a carbon-carbon double bond functional group; the initiator is a thermal initiator or a photoinitiator

(2) And (3) packaging and sealing the block-shaped gel obtained in the step (1) by using a waterproof fabric bag.

The invention has the beneficial effects that: the chemotherapy ice bag provided by the invention does not become hard blocks in the freezing process, so that the chemotherapy ice bag can well fit the body surface contour of a patient during ice compress, and the ice compress effect is improved; the chemotherapy ice bag utilizes the porous structure of the gel to lock the cold quantity, so that the cold quantity can be slowly and durably released, and can be taken down by a patient until the symptom is relieved when the chemotherapy ice bag is used by the patient, the chemotherapy ice bag does not need to be frequently used intermittently to avoid the concentrated release of the cold quantity, and the treatment experience of the patient is improved.

Drawings

FIG. 1 is a graph showing the heat change during warming of a chemotherapy ice pack according to an embodiment of the present invention.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.