阅读说明：本技术 一种数字病理全景切片图像自动分析方法和系统 (Automatic analysis method and system for digital pathology panoramic slice image ) 是由 曹小伍 雷铭轩 于 2019-09-09 设计创作，主要内容包括：本发明公开了一种数字病理全景切片图像自动分析方法,具体包括以下步骤：S1、通过病理图像获取模块可接收需要进行检测分析的病理图像,并发送至病理图像处理系统内部,通过病理图像处理系统内部的图像颜色增强模块以及标准化处理模块可对病理图像的颜色以及规格进行统一标准化处理；S2、将S1中标准化处理的病理图像发送至特征提取模块内,本发明涉及医学图像处理技术领域。该数字病理全景切片图像自动分析方法和系统,可实现对病理图像的特征点进行提取以及颜色增强等统一标准化处理,对提取的特征图像进行分析检测,检测结果可发送至图像显示中心供医护人员进行辅助诊断,快速且精确的对病理全景切片图像进行自动分析。(the invention discloses an automatic analysis method for a digital pathological panoramic slice image, which specifically comprises the following steps: s1, the pathological image acquisition module can receive the pathological image to be detected and analyzed and send the pathological image to the interior of the pathological image processing system, and the image color enhancement module and the standardization processing module in the pathological image processing system can carry out unified standardization processing on the color and specification of the pathological image; s2, sending the pathological image subjected to standardization processing in the S1 to a feature extraction module, and the invention relates to the technical field of medical image processing. The automatic analysis method and the system for the digital pathology panoramic slice image can realize uniform standardized processing such as extraction, color enhancement and the like of the characteristic points of the pathology image, analyze and detect the extracted characteristic image, send the detection result to an image display center for medical staff to perform auxiliary diagnosis, and quickly and accurately perform automatic analysis on the pathology panoramic slice image.)

1. A digital pathology panoramic slice image automatic analysis method is characterized in that: the method specifically comprises the following steps:

S1, the pathological image which needs to be detected and analyzed can be received through the pathological image acquisition module (4) and sent to the interior of the pathological image processing system (3), and the color and specification of the pathological image can be uniformly standardized through the image color enhancement module (31) and the standardization processing module (32) in the pathological image processing system (3);

S2, the pathological images standardized in the S1 are sent to a feature extraction module (33), feature points on the pathological images can be extracted through the feature extraction module (33), meanwhile, the color, morphology, texture and spatial distribution features of the feature point images can be detected and analyzed through a feature analysis detection module (34), then, analysis results are sent to a classification calculation module (35), the pathological images can be calculated and classified, and the classified pathological images are sent to a storage unit (7) to be stored;

S3, when medical staff want to diagnose and analyze the pathological images in the storage unit (7), the image retrieval and extraction module (9) can retrieve and extract the pathological images in the storage unit (7) and send the pathological images to the image display center (11) through the wireless transmission module (10);

S4, the pathological image displayed in the image display center (11) can be consulted through the pathological image query module (51) in the pathological image diagnosis system (5), the pathological image can be diagnosed and analyzed through the diagnosis and analysis module (52), the data result after diagnosis and analysis can be sent to the inside of the integration processing module (53) for sorting, and finally the diagnosis result is sent to the storage unit (7) for storage, so that subsequent search and sending are facilitated, and the whole work is completed.

2. The utility model provides a digital pathology panorama section image automatic analysis system, includes central processing unit (1), the input of central processing unit (1) passes through the output electric connection of wire and feedback module (2), its characterized in that: the input end of the feedback module (2) is electrically connected with the output end of the pathological image processing system (3) through a lead, the input end of the pathological image processing system (3) is electrically connected with the output end of the pathological image acquisition module (4), the pathological image processing system (3) comprises an image color enhancement module (31), the output end of the image color enhancement module (31) is electrically connected with the input end of the standardization processing module (32) through a lead, and the output end of the standardization processing module (32) is electrically connected with the input end of the characteristic extraction module (33) through a lead, the output end of the characteristic extraction module (33) is electrically connected with the input end of the characteristic analysis detection module (34) through a lead, and the output end of the characteristic analysis detection module (34) is electrically connected with the input end of the classification calculation module (35) through a lead.

3. The automatic analysis system for digital pathology panoramic section images according to claim 2, characterized in that: the input end of the central processing unit (1) is electrically connected with the output end of the pathological image diagnosis system (5) through a lead, the output end of the pathological image diagnosis system (5) is electrically connected with the input end of the sending module (6) through a lead, and the output end of the sending module (6) is electrically connected with the input end of the central processing unit (1) through a lead.

4. The automatic analysis system for digital pathology panoramic section images according to claim 2, characterized in that: the output end of the central processing unit (1) is electrically connected with the input end of the storage unit (7) through a wire, and the storage unit (7) is in bidirectional connection with the backup unit (8) through wireless.

5. The automatic analysis system for digital pathology panoramic section images of claim 4, characterized in that: the storage unit (7) is in bidirectional connection with the image retrieval and extraction module (9) through wireless, and the output end of the image retrieval and extraction module (9) is electrically connected with the input end of the wireless transmission module (10) through a wire.

6. The automatic analysis system for digital pathology panoramic section images of claim 5, characterized in that: the wireless transmission module (10) is in bidirectional connection with the image display center (11) through wireless.

7. the automatic analysis system for digital pathology panoramic section images according to claim 3, characterized in that: the pathological image diagnosis system (5) comprises a pathological image query module (51), and the output end of the pathological image query module (51) is electrically connected with the input end of the diagnosis analysis module (52) through a lead.

8. The automatic analysis system for digital pathology panoramic section images according to claim 7, characterized in that: the output end of the diagnosis and analysis module (52) is electrically connected with the input end of the integrated processing module (53) through a lead.

Technical Field

The invention relates to the technical field of medical image processing, in particular to a method and a system for automatically analyzing a digital pathological panoramic slice image.

Background

The digital pathology system is a technology of organically combining a modern digital system and a traditional optical amplification device, a high-resolution digital image is obtained by scanning and collecting a full-automatic microscope or an optical amplification system, then high-precision multi-view seamless splicing and processing are automatically carried out on the obtained image by using a computer, high-quality visual data are obtained to be applied to various fields of pathology, and the digital pathology system is mainly composed of a digital section scanning device and data processing software. Firstly, a digital microscope or an amplifying system is utilized to carry out scanning acquisition imaging on glass slices one by one under a low-power objective lens, a microscopic scanning platform automatically scans and moves along the XY axis direction of the slices and automatically focuses along the Z axis direction, then the scanning control software collects high-resolution digital images by using a program control scanning mode on the basis of effective amplification of the optical amplification device, image compression and storage software automatically carries out seamless splicing processing on the images to produce and generate a Whole full-field digital slice (WSI), the data are stored in a certain medium to establish a digital pathological slice library, and then a corresponding digital pathological slice browsing system can be utilized, a series of visual data is processed by any scale up or down and any direction of movement for browsing and analyzing, as if a real optical microscope is operated.

With the development of computer-aided diagnosis medical technology, computer-aided therapy has the characteristics of high efficiency and high accuracy compared with manual film reading diagnosis, but because of the diversity and complexity of pathological images and the fact that each image has tens of millions and hundreds of millions of pixel points, the pathological image analysis work is very difficult, and therefore how to analyze the images quickly and accurately is the problem to be solved by the invention.

Disclosure of Invention

technical problem to be solved

Aiming at the defects of the prior art, the invention provides a method and a system for automatically analyzing a digital pathological panoramic section image, which solve the problems that pathological image analysis is very difficult and how to quickly and accurately analyze the image due to diversity and complexity of the pathological image and tens of millions and hundreds of millions of pixel points of each image.

(II) technical scheme

In order to achieve the purpose, the invention is realized by the following technical scheme: a digital pathology panoramic slice image automatic analysis method specifically comprises the following steps:

S1, the pathological image acquisition module can receive the pathological image to be detected and analyzed and send the pathological image to the interior of the pathological image processing system, and the image color enhancement module and the standardization processing module in the pathological image processing system can carry out unified standardization processing on the color and specification of the pathological image;

s2, sending the pathological images subjected to standardized processing in S1 to a feature extraction module, extracting feature points on the pathological images through the feature extraction module, simultaneously detecting and analyzing the color, morphology, texture and spatial distribution features of the feature point images through a feature analysis detection module, sending analysis results to a classification calculation module, calculating and classifying the pathological images, and sending the classified pathological images to a storage unit for storage;

S3, when medical staff need to diagnose and analyze the pathological images in the storage unit, the image retrieval and extraction module can retrieve and extract the pathological images in the storage unit and send the pathological images to the interior of the image display center through the wireless transmission module;

S4, the pathological image displayed in the image display center can be looked up through the pathological image query module in the pathological image diagnosis system, the pathological image is diagnosed and analyzed through the diagnosis and analysis module, the data result after diagnosis and analysis can be sent to the integration processing module for sorting, and finally the diagnosis result is sent to the storage unit for storage, so that subsequent search and sending are facilitated, and the whole work is completed.

The invention also discloses a digital pathological panoramic section image automatic analysis system, which comprises a central processing unit, the input end of the central processing unit is electrically connected with the output end of the feedback module through a lead, the input end of the feedback module is electrically connected with the output end of the pathological image processing system through a lead, the input end of the pathological image processing system is electrically connected with the output end of the pathological image acquisition module, the pathological image processing system comprises an image color enhancement module, the output end of the image color enhancement module is electrically connected with the input end of the standardization processing module through a lead, and the output end of the standardized processing module is electrically connected with the input end of the characteristic extraction module through a wire, the output end of the characteristic extraction module is electrically connected with the input end of the characteristic analysis detection module through a lead, and the output end of the characteristic analysis detection module is electrically connected with the input end of the classification calculation module through a lead.

Preferably, the input end of the central processing unit is electrically connected to the output end of the pathological image diagnosis system through a wire, the output end of the pathological image diagnosis system is electrically connected to the input end of the sending module through a wire, and the output end of the sending module is electrically connected to the input end of the central processing unit through a wire.

Preferably, the output end of the central processing unit is electrically connected with the input end of the storage unit through a wire, and the storage unit is in bidirectional connection with the backup unit through wireless.

Preferably, the storage unit is in bidirectional connection with the image retrieval and extraction module through wireless, and the output end of the image retrieval and extraction module is electrically connected with the input end of the wireless transmission module through a wire.

Preferably, the wireless transmission module is in bidirectional connection with the image display center through wireless.

preferably, the pathological image diagnosis system comprises a pathological image query module, and an output end of the pathological image query module is electrically connected with an input end of the diagnosis and analysis module through a lead.

preferably, the output end of the diagnostic and analytical module is electrically connected with the input end of the integrated processing module through a wire.

(III) advantageous effects

The invention provides a method and a system for automatically analyzing a digital pathological panoramic slice image. The method has the following beneficial effects:

(1) the input end of the central processing unit is electrically connected with the output end of the feedback module through a lead, the input end of the feedback module is electrically connected with the output end of the pathological image processing system through a lead, the input end of the pathological image processing system is electrically connected with the output end of the pathological image acquisition module, the pathological image processing system comprises an image color enhancement module, the output end of the image color enhancement module is electrically connected with the input end of the standardization processing module through a lead, the output end of the standardization processing module is electrically connected with the input end of the characteristic extraction module through a lead, the output end of the characteristic extraction module is electrically connected with the input end of the characteristic analysis detection module through a lead, and the output end of the characteristic analysis detection module is electrically connected with the input end of the classification calculation module through a lead, the input of central processing unit passes through wire and pathological image diagnostic system's output electric connection, and pathological image diagnostic system's output passes through wire and sending module's input electric connection, and sending module's output passes through wire and central processing unit's input electric connection, can realize extracting and unified standardized processing such as colour reinforcing to the characteristic point of pathological image, carry out analysis and detection to the characteristic image who draws again simultaneously, the testing result can be sent to image display center and supply medical personnel to carry out the auxiliary diagnosis, quick and accurate characteristics to pathological panoramic section image automatic analysis have been realized.

(2) According to the automatic analysis method and system for the digital pathology panoramic slice image, the output end of the central processing unit is electrically connected with the input end of the storage unit through the lead, the storage unit is in bidirectional connection with the backup unit through wireless, the characteristic image after classification calculation can be stored, meanwhile, the image data of the storage unit can be backed up through the setting of the backup unit, so that the image loss is avoided, and the diagnosis work of subsequent medical workers is influenced.

drawings

FIG. 1 is a schematic block diagram of the architecture of the system of the present invention;

FIG. 2 is a schematic block diagram of the pathological image processing system according to the present invention;

fig. 3 is a schematic block diagram of the structure of the pathological image diagnosis system of the present invention.

in the figure: 1-a central processing unit, 2-a feedback module, 3-a pathological image processing system, 31-an image color enhancement module, 32-a standardization processing module, 33-a feature extraction module, 34-a feature analysis detection module, 35-a classification calculation module, 4-a pathological image acquisition module, 5-a pathological image diagnosis system, 51-a pathological image query module, 52-a diagnosis analysis module, 53-an integration processing module, 6-a sending module, 7-a storage unit, 8-a backup unit, 9-an image retrieval extraction module, 10-a wireless transmission module and 11-an image display center.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-3, an embodiment of the present invention provides a technical solution: the utility model provides a digital pathology panorama section image automatic analysis method, can realize extracting the characteristic point of pathology image and unified standardized processing such as colour reinforcing, carries out analysis and detection to the characteristic image who extracts again simultaneously, and the testing result can be sent to image display center 11 and supply medical personnel to carry out the auxiliary diagnosis, has realized quick and accurate characteristics to pathology panorama section image automatic analysis, specifically includes following step:

s1, the pathological image acquisition module 4 can receive the pathological image to be detected and analyzed and send the pathological image to the inside of the pathological image processing system 3, and the image color enhancement module 31 and the standardization processing module 32 in the pathological image processing system 3 can carry out unified standardization processing on the color and specification of the pathological image;

S2, the pathological images standardized in the S1 are sent to a feature extraction module 33, feature points on the pathological images can be extracted through the feature extraction module 33, meanwhile, the color, morphology, texture and spatial distribution features of the feature point images can be detected and analyzed through a feature analysis detection module 34, then, the analysis results are sent to a classification calculation module 35, the pathological images can be calculated and classified, and the classified pathological images are sent to a storage unit 7 to be stored;

S3, when medical staff needs to diagnose and analyze the pathological images in the storage unit 7, the image retrieval and extraction module 9 can retrieve and extract the pathological images in the storage unit 7 and send the pathological images to the image display center 11 through the wireless transmission module 10;

s4, the pathological image query module 51 in the pathological image diagnosis system 5 can look up the pathological image displayed in the image display center 11, and the diagnosis and analysis module 52 can perform diagnosis and analysis on the pathological image, the data result after diagnosis and analysis can be sent to the integration module 53 for sorting, and finally the diagnosis result is sent to the storage unit 7 for storage, so as to facilitate subsequent search and sending, thereby completing the whole work.

The invention also discloses a digital pathological panoramic section image automatic analysis system, which comprises a central processing unit 1, wherein the input end of the central processing unit 1 is electrically connected with the output end of a feedback module 2 through a lead, the input end of the feedback module 2 is electrically connected with the output end of a pathological image processing system 3 through a lead, and the input end of the pathological image processing system 3 is electrically connected with the output end of the pathological image acquisition module 4, the pathological image processing system 3 comprises an image color enhancement module 31, the output terminal of the image color enhancement module 31 is electrically connected to the input terminal of the normalization processing module 32 through a wire, the output end of the standardization processing module 32 is electrically connected with the input end of the feature extraction module 33 through a wire, the output end of the feature extraction module 33 is electrically connected with the input end of the feature analysis detection module 34 through a wire, and the output end of the feature analysis detection module 34 is electrically connected to the input end of the classification calculation module 35 through a wire.

In the invention, the input end of the central processing unit 1 is electrically connected with the output end of the pathological image diagnosis system 5 through a lead, the output end of the pathological image diagnosis system 5 is electrically connected with the input end of the sending module 6 through a lead, the output end of the sending module 6 is electrically connected with the input end of the central processing unit 1 through a lead, the central processing unit 1 is used as the operation and control core of a computer system and is the final execution unit of information processing and program operation, the central processing unit has great development on the extension of logic structure, operation efficiency and function since the production, and the model of the central processing unit 1 is ARM 9.

In the invention, the output end of the central processing unit 1 is electrically connected with the input end of the storage unit 7 through a lead, the storage unit 7 is in bidirectional connection with the backup unit 8 through wireless, the storage of the characteristic images after classification calculation can be realized, and the backup processing can be carried out on the image data of the storage unit through the setting of the backup unit 8, so as to prevent the image loss from influencing the subsequent diagnosis work of medical personnel.

In the invention, the storage unit 7 is in bidirectional connection with the image retrieval and extraction module 9 through wireless, and the output end of the image retrieval and extraction module 9 is electrically connected with the input end of the wireless transmission module 10 through a lead.

In the invention, the wireless transmission module 10 is in bidirectional connection with the image display center 11 through wireless.

In the present invention, the pathological image diagnosis system 5 includes a pathological image query module 51, and an output terminal of the pathological image query module 51 is electrically connected to an input terminal of the diagnosis analysis module 52 through a conductive wire.

In the present invention, the output terminal of the diagnosis and analysis module 52 is electrically connected to the input terminal of the integrated processing module 53 through a wire.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.