阅读说明：本技术 用于改进的防水性的具有天然蜡的防晒组合物 (Sunscreen compositions with natural waxes for improved water repellency ) 是由 H-I·黄 A·纳兰霍 P·L·斯科特 于 2018-02-02 设计创作，主要内容包括：具有改进的防水性的防晒组合物,其包含(i)防晒活性剂；(ii)包含天然蜡的防水剂,所述天然蜡在体温下在线性粘弹性范围内具有小于1.0的阻尼因子；和(iii)能够使组分(i)～(iii)的乳液稳定的乳化剂或表面活性剂,其中所述防晒组合物在水浸渍4个小时之后保持其静态SPF至少75％,优选至少85％,且最优选至少99％。(A sunscreen composition having improved water resistance comprising (i) a sunscreen active; (ii) a water repellent comprising a natural wax having a damping factor of less than 1.0 at body temperature in the linear viscoelastic range; and (iii) an emulsifier or surfactant capable of stabilizing the emulsion of components (i) - (iii), wherein the sunscreen composition retains its static SPF after 4 hours of water immersion of at least 75%, preferably at least 85%, and most preferably at least 99%.)

1. A sunscreen composition comprising:

(i)0.1 wt.% to 45 wt.% of a sunscreen active;

(ii)0.1 wt.% to 10 wt.% of a water repellent comprising one or more natural waxes having a damping factor of less than 1.0 as calculated using amplitude sweep experiments at a constant angular frequency of 10Rad/sec and at a temperature of 37 ℃ at 0.01% to 100% strain, wherein the water repellent has a storage modulus higher than a loss modulus of the water repellent; and

(iii)0.1 wt.% to 10 wt.% of an emulsifier or surfactant,

Wherein the sunscreen composition retains at least 75% of its initial static SPF after 4 hours of water immersion.

2. The sunscreen composition of claim 1, wherein the sunscreen active agent comprises one or more of: dibenzoylmethane, p-xylylene dicamphor sulfonic acid, disodium phenyldibenzoimidazole tetrasulfonate, diethylamino-hydroxybenzoyl-hexyl benzoate, bis-diethylamino-hydroxybenzoyl benzoate, bis-benzoxazolyl-phenyl-ethylhexyl-aminotriazine, octocrylene, oselinyl, oxisal, homosalate, esomeprazole, ethylhexyl triazone, enzalene, amikacin, diethylhexyl-butyrylaminotriazine, benzylidene malonate polysiloxane, palisade-O, triethanolamine salicylate, cinoxate, p-aminobenzoic acid, oxybenzone, melandiester, titanium dioxide, zinc oxide, bis-oxtriazol, bestrozine, cresotrimazole trisiloxane, sulfisobenzone, dioxybenzone, encapsulated UV filters, Or a combination thereof.

3. A sunscreen composition according to any of the preceding claims, wherein the water repellent agent is present in an amount of 0.5 wt.% to 5 wt.%.

4. The sunscreen composition of any of the preceding claims, wherein the water repellant comprises natural vegetable wax, animal wax, and derivatives thereof.

5. The sunscreen composition of any preceding claim, wherein the water repellant comprises one or more of the following: waxberry wax, Chinese wax, beeswax, shellac wax, shea butter and cocoa butter.

6. The sunscreen composition of any preceding claim, wherein the waterproofing agent further comprises a triacylglycerol, a diacylglycerol, and/or an ester of a monoacylglycerol and palmitic acid.

7. the sunscreen composition of any preceding claim, wherein the waterproofing agent further comprises a triacylglycerol, diacylglycerol, and/or an ester of monoacylglycerol with myristic acid.

8. The sunscreen composition of any of the preceding claims, wherein the water repellant comprises one or more natural waxes having a pour point of 30 ℃ to 65 ℃.

9. The sunscreen composition according to any of the preceding claims, wherein the emulsifier is a water-in-oil emulsifier comprising sucrose distearate, sorbitan oleate, sorbitan dioleate, polyglyceryl-4 isostearate, polyglyceryl diisostearate, cetyl PEG/PPG-10/1 polydimethylsiloxane, lauryl PEG-8 polydimethylsiloxane, glyceryl stearate, or a combination thereof.

10. The sunscreen composition of any preceding claim, wherein the emulsifier is an oil-in-water emulsifier comprising sucrose stearate, lauric sorbitan ester, polyglyceryl-3 methyl glucose distearate, or a combination thereof.

11. The sunscreen composition of any of the preceding claims, wherein the surfactant is an ionic surfactant comprising dicetyl phosphate, ceteth-10 phosphate, beheneth-30 phosphate, diethanolamine cetyl phosphate, potassium cetyl phosphate, tris (laureth-4) phosphate, tris (ceteth-4) phosphate, distearyldimethylammonium chloride, polyquaternium-39, polyquaternium-7, or a combination thereof.

Background

Field of endeavor

The present disclosure relates to sunscreen compositions comprising biodegradable water repellents comprising naturally occurring waxes that provide enhanced water repellency, improved spreadability, and low eye irritation.

Background information

Natural waxes have been widely mentioned for use in cosmetic preparations such as creams or lotions, including over-the-counter dermatological preparations, e.g., sunscreen compositions or other topical compositions. Natural waxes also act as emollients or film formers. However, a review of the prior art by one of ordinary skill in the art reveals that a lack of viable examples exists.

Summary of The Invention

In a first embodiment, the present disclosure relates to a sunscreen composition comprising (i)0.1 wt.% to 45 wt.% of a sunscreen active; (ii)0.1 wt.% to 30 wt.% of a water repellent comprising one or more natural waxes having a damping factor of less than 1.0 as calculated using amplitude sweep tests at a constant angular frequency of 10Rad/sec and at a temperature of 37 ℃ at a strain of 0.01% to 100%, wherein the water repellent has a storage modulus higher than a loss modulus of the water repellent; and (iii)0.1 wt.% to 10 wt.% of an emulsifier or surfactant, wherein the sunscreen composition retains its static SPF of at least 75% after being soaked in water for 4 hours.

Preferably, the sunscreen active comprises one or more of the following: dibenzoylmethane, p-xylylene dicamphor sulfonic acid, disodium phenylbisbenzimidazole tetrasulfonate (bis-disulpholizer sodium), disodium phenylbisbenzimidazole tetrasulfonate, diethylaminohydroxybenzoyl hexyl benzoate, bis-diethylaminohydroxybenzoyl benzoate, bis-benzoxazolyl phenylethylhexyl aminotriazine, octocrylene, oxiranol, homosalate, esomeprazole, ethylhexyl triazone, enazalene, amikacin, diethylhexyl butamidotriazine, benzylidene malonate polysiloxane, palimidate-O, triethanolamine salicylate, cinoxate, p-aminobenzoic acid, oxybenzone, melandiol, titanium dioxide, zinc oxide, bis-oxtriazole, bengzinosine, trazodisiloxane, trimethosiloxane, bisbenzoxazole, sulfoisobenzone, dioxybenzone, encapsulated UV filters, and combinations thereof.

In any of the foregoing embodiments, the water repellant is present in an amount of 0.5 wt.% to 5 wt.%. In any of the foregoing embodiments, the waterproofing agent may further comprise an ester of triacylglycerol, diacylglycerol, and/or monoacylglycerol with a saturated or unsaturated fatty acid (e.g., palmitic acid and/or myristic acid). In any of the preceding embodiments, the water repellent comprises one or more natural waxes having a pour point of 30 ℃ to 65 ℃ selected from the group consisting of bayberry wax, chinese wax, beeswax, shellac wax, shea butter, cocoa butter; and combinations thereof.

In any of the foregoing embodiments, the emulsifier comprises a water-in-oil emulsifier having a hydrophilic-lipophilic balance of less than 6, preferably 4 to 6. The water-in-oil emulsifier is selected from sucrose distearate, sorbitan oleate, sorbitan dioleate, and sorbitan stearate; polyglyceryl-4 isostearate, polyglyceryl diisostearate, cetyl PEG/PPG-10/1 dimethicone, lauryl PEG-8 dimethicone, glyceryl stearate, and combinations thereof.

In any of the preceding embodiments, the emulsifier comprises an oil-in-water emulsifier having a hydrophilic-lipophilic balance of greater than 8, preferably 9 to 10. The oil-in-water emulsifier may be selected from the group consisting of sucrose stearate, sucrose laurate, sorbitan laurate, polyglyceryl-3 methyl glucose distearate, and combinations thereof.

In any of the preceding embodiments, the surfactant is an ionic surfactant comprising dicetyl phosphate, ceteth-10 phosphate, beheneth-30 phosphate, diethanolamine cetyl phosphate, potassium cetyl phosphate, tris (laureth-4) phosphate, tris (ceteth-4) phosphate, sodium stearyl glutamate, disodium stearyl glutamate, distearyldimethylammonium chloride, polyquaternium-39, polyquaternium-7, or a combination thereof.

Brief Description of Drawings

the features of the present disclosure are believed to be novel and the elements characteristic of the invention are set forth with particularity in the appended claims. The figures are for illustration purposes only and are not drawn to scale. The disclosure itself, however, both as to organization and method of operation, may best be understood by reference to the following description of the preferred embodiments when read in conjunction with the accompanying drawings in which:

Figure 1 is a graph showing rheological data for a mixture of 70 wt.% bayberry wax and 30 wt.% triglyceride, which illustrates the desirable elasticity of the waterproofing agent.

FIG. 2 is a graph showing flow curves for composition examples 1-3, which plot viscosity versus shear rate to illustrate the desired viscosity as it relates to the preferred dispensing profile.

Figure 3 is a photograph of examples 1 and 2 taken under uv light before and after water immersion.

FIG. 4 is a bar graph showing the average yield stress of three (3) samples from each of examples 1-3.

Detailed Description

Embodiments of the present disclosure may include, consist of, and consist essentially of: features and/or steps described herein, as well as any additional or optional ingredients, components, steps, or limitations described herein or otherwise understood by those of skill in the art. It is to be understood that all concentrations disclosed herein are in weight percent (wt%) based on the total weight of the composition, unless otherwise specified. The INCI (international designation for cosmetic ingredients) name of an ingredient/component is provided, where appropriate. Any numerical range recited herein is intended to include all sub-ranges subsumed therein and such ranges are understood to include every value and/or fraction between the lower and upper values of the stated range.

The present disclosure relates to sunscreen compositions having improved water resistance comprising (i) an effective amount of a sunscreen active; (ii) a water repellent comprising a natural wax; and (iii) an emulsifier or surfactant capable of maintaining an emulsion of sunscreen active and a water repellent comprising a natural wax. When using in vivo australian/new zealand standard 2604: 2012 and ISO2444 (2010) four hours water resistance test, the inventive compositions of the present disclosure provide water resistance for up to and possibly more than four (4) hours when evaluated. It increases spreadability and reduces stickiness while being safe for sensitive skin and causing no tearing.

(i) Sunscreen actives

One or more sunscreen actives useful in the present invention are capable of attenuating all or part of the harmful effects of ultraviolet ("UV") radiation. In addition, sunscreen actives must be non-toxic and non-irritating when applied to the skin. Sunscreen actives are generally classified into four groups as follows.

The first group of sunscreen actives includes ultraviolet a wavelength or "UVA" sunscreen actives. UVA sunscreen actives include, for example, members selected from the group consisting of: avobenzone, terephthalylidene dicamphor sulfonic acid, disodium phenyl dibenzoimidazole tetrasulfonate (bis-disullizer sodium), disodium phenyl dibenzoimidazole tetrasulfonate (sodium phenyl dibenzoxazole tetrasulfonate), diethylamino hydroxybenzoyl hexyl benzoate, bis-diethylamino hydroxybenzoyl benzoate, bis-benzoxazolyl phenyl ethyl hexyl aminotriazine, and combinations thereof.

The second group of sunscreen actives includes ultraviolet B shortwave or "UVB" sunscreen actives. UVB sunscreen actives include, for example, members selected from the group consisting of: octocrylene, oxcinolone, oteroxil, homosalate, esoxilazole, ethylhexyl triazone, enazalene, amikate, diethylhexyl butyrylaminotriazine, benzalmalonate polysiloxanes, palimyl-O, triethanolamine salicylate, cinoxate, p-aminobenzoic acid, derivatives thereof, and combinations thereof.

The third group of sunscreen actives includes sunscreen actives that absorb both UVA and UVB radiation. These full spectrum UV actives include members selected from the group consisting of: such as oxybenzone, meladil, titanium dioxide, zinc oxide, bis-oxtriazole, bestrophol, cresotrimazole trisiloxane, sulfisobenzone, dioxybenzone, and combinations thereof.

Further, useful sunscreen actives that reflect or scatter UV radiation include titanium dioxide, zinc oxide, surface treated titanium dioxide, surface treated zinc oxide, and combinations thereof. An example of a mineral-based sunscreen is the microorganism Dioxide MT^TM、UV-titan M262^TM、Parsol TX^TM、JTTO-MS7^TM、Z-Cote^TM、Zano^TM、Zano M^TM、Zano 10^TM、Zano 10 plus^TMAnd combinations thereof.

The fourth group of sunscreen actives includes encapsulated UV filters. The encapsulated UV filter comprises a member selected from the group consisting of: AVOCAP^TM(Avobenzone Encapsulated (60% payload) and 15% Octocriline), OMCCAP^TM(Octagon Encapsulated Methoxycinnamate (60% payload)), OXYCAP^TM(Encapsulated oxybenzone (47% payload) and octocrylene 20%), HOMCAP^TM(Encapsulated homosalate (60% payload)), OCTICAP^TM(encapsulated otisalate (60% payload)), ZINOCAP^TM(encapsulated ZnO (70% payload)), TITANCAP^TM(encapsulated TiO 2: 70% payload).

The choice of one or more sunscreen actives used in the sunscreen embodiments of the present invention is made in accordance with the desired objectives of the final product (i.e., Sun Protection Factor (SPF), broad spectrum protection, etc.). For example, consumers often desire full spectrum UV protection to reduce the risk of cancer from prolonged sun exposure and accelerated skin aging. Some consumers desire limited exposure to UV radiation to achieve some tanning effect from sun exposure while minimizing the risk of burns.

the sunscreen actives are present in the following amounts, individually or in combination, based on the total weight of the composition: from about 0.1 wt.% to about 45 wt.%, preferably from about 2 wt.% to about 40 wt.%, and most preferably from about 6.5 wt.% to about 30 wt.%.

(ii) Water-proofing agent

The water repellent of the composition of the present invention is preferably biodegradable, comprising a natural wax. The melting point of the water repellent is below 80 ℃, preferably below 70 ℃ and most preferably below 60 ℃. Combinations of water repellents may be used to lower the melting point of the mixture to the desired range. By way of example only, mixtures providing natural waxes having the following melting points may be used: below 80 c, preferably below 70 c and most preferably below 60 c. In addition, other synthetic waxes may be added to lower the melting point of the water repellent.

Preferably, the waterproofing agent has strong mechanical strength due to its elastic-like structure (as measured by an Anton Paar MCR 301 rheometer using the amplitude scan test method). Amplitude sweep tests were performed at a constant angular frequency of 10Rad/sec and at a constant temperature of 37 ℃ from 0.01% to 100% strain. The dynamic storage and loss moduli (G' and G ") are plotted against shear strain (y) in a rheological plot. The damping factor (tan δ) (ratio of loss modulus to storage modulus) can be expressed as follows:

Damping factor (tan delta) ═ G '/G'

If the storage modulus (G ') is higher than the loss modulus (G ") and the damping factor is less than 1.0, the structure of the waterproofing agent exhibits more elastic behavior, whereas if the storage modulus (G') is lower than the loss modulus (G") and the damping factor is greater than 1.0, the structure of the waterproofing agent exhibits more viscous behavior. By way of example only, the preferred water repellent (bayberry wax) has a damping factor of less than 1.0 in the linear viscoelastic range when the strain is less than 0.1%. Fig. 1 shows the rheological data for a mixture of 70 wt.% bayberry wax and 30 wt.% triglycerides. Triglycerides were added to aid in testing performance. The bayberry wax/triglyceride mixture exhibits desirable elasticity for use in the compositions of the present invention.

Examples of water repellents in sunscreen compositions are natural vegetable waxes, animal waxes, and derivatives thereof; such as waxberry wax (also known as waxberry wax), chinese wax, beeswax, shellac wax, shea butter, cocoa butter, or combinations thereof. The water repellent may further comprise esters of triacylglycerols, diacylglycerols and/or monoacylglycerols with saturated or unsaturated fatty acids, preferably palmitic acid and myristic acid. A single water repellant may provide a desired damping factor or multiple water repellents may be combined to form a desired elastic distribution.

The waterproofing agent is preferably present in an amount of 0.1 wt.% to 30 wt.%, more preferably 0.5 wt.% to 20 wt.%, and most preferably 0.5 wt.% to 5 wt.%. Any amount between the above ranges is also feasible to produce a satisfactory composition with the desired water repellency and skin feel.

(iii) Emulsifiers or surfactants

The compositions of the present invention further comprise an emulsifier or surfactant. Preferably, the emulsifier comprises at least a water-in-oil (W/O) emulsifier and an oil-in-water (O/W) emulsifier, a nonionic surfactant, or a combination thereof in an amount effective to stabilize the emulsion. Preferably, the emulsifier or surfactant may be present in an amount of from about 0.1 wt.% to about 10 wt.%, more preferably from about 1 wt.% to about 8 wt.%, and most preferably from about 2 wt.% to about 6 wt.%, based on the total weight of the composition.

W/O emulsifiers are used to stabilize emulsions in which the aqueous phase is dispersed in the continuous oil phase. Preferably, the W/O emulsifier has a hydrophilic-lipophilic balance (HLB) of less than 6, preferably 4-6. Examples of water-in-oil emulsifiers having an HLB of less than 6 include sucrose esters, such as sucrose distearate; sorbitan esters, such as sorbitan oleate, sorbitan dioleate, sorbitan stearate; polyglyceryl esters, such as polyglyceryl-4 isostearate, polyglyceryl diisostearate; cetyl polyethylene glycol (PEG)/polypropylene glycol (PPG)10/1 dimethicone; lauryl polyethylene glycol-8 (PEG-8) polydimethylsiloxane; glyceryl stearate; or a combination thereof.

The O/W emulsifier is used to stabilize emulsions in which the oil phase is dispersed in the continuous aqueous phase. The oil-in-water emulsifier preferably has an HLB of greater than 7, preferably 7-9 or 10. Examples of oil-in-water emulsifiers include other sucrose esters such as sucrose stearate, sucrose laurate; sorbitan esters, such as lauric sorbitan ester; polyglyceryl-3 methyl glucose distearate; or a combination thereof. Alternatively, ethoxylated fatty ethers and ethoxylated fatty esters may be used as oil-in-water emulsifiers having an HLB greater than 8.

The surfactant used to stabilize the emulsion may be an anionic surfactant or a cationic surfactant. Ionic surfactants have a better affinity for skin than nonionic surfactants. Examples of ionic surfactants are fatty phosphate esters, such as dicetyl phosphate, ceteth-10 phosphate, beheneth-30 phosphate, cetyl diethanolamine phosphate, potassium cetyl phosphate, tris (laureth-4) phosphate, tris (ceteth-4) phosphate, or combinations thereof. Other ionic surfactants may include fatty esters of carboxylic acids, such as sodium stearoyl glutamate, disodium stearoyl glutamate, distearyl dimethyl ammonium chloride, polyquaternium-39, polyquaternium-7, or combinations thereof.

Other ingredients

The sunscreen composition may further include one or more active or inactive cosmetic ingredients, such as, but not limited to, cosmetically acceptable carriers; an oil; a sterol; an amino acid; a humectant; powder; colorants (including pigments and/or dyes); a pH adjusting agent; a fragrance; essential oil; a cosmetic active ingredient; essential fatty acids; sphingolipids; self-tanning compounds such as Dihydroxyacetone (DHA) and erythrulose; a filler; an emulsifier; an antioxidant; a surfactant; an additional film-forming agent; a chelating agent; a gelling agent; a thickener; an emollient; a wetting agent; a humectant; a mineral; viscosity and/or rheology modifiers; a keratolytic agent; a retinoid; a hormone compound; an alpha-keto acid; anti-mycobacterial agents; an antifungal agent; an antimicrobial agent; an antiviral agent; an analgesic; an anti-allergen agent; h1 or H2 antihistamines; an anti-inflammatory agent; an anti-irritant; an anti-neoplastic agent; an immune system enhancer; an immune system suppressant; an anti-acne agent; an anesthetic; a preservative; an insect repellent; a skin cooling compound; a skin protectant; a skin permeation enhancer; removing keratan; a lubricant; a coloring agent; a decolorizer; a hypopigmenting agent; a preservative; a stabilizer; a medicament; a light stabilizer; spherical powder; one or more fragrances; a plant extract; an absorbent; salicylic acid; alpha and beta hydroxy acids; vitamins, including vitamins A, C and E; retinol and its derivatives; or any combination of the foregoing. One of ordinary skill in the art will recognize and appreciate that this list is non-limiting and that a variety of other active or inactive ingredients may be used in the compositions of the present invention.

The following formulations were prepared using the compositions of the present invention as shown in table I below.

TABLE I

Example 1 is a mixture of commercially available BANANAThe spray lotion has the similar formula of the spray lotion without tears and stinging. Example 2 is a composition of the present invention wherein the bayberry wax is a water repellant. Example 3 is a comparative example using a conventional film former (e.g., acrylate/methacrylate C)_12-22Alkyl ester copolymers) as water repellent.