阅读说明：本技术 一种抗敏舒缓保湿爽肤水及其制备方法 (Anti-allergy soothing moisturizing toner and preparation method thereof ) 是由 陈洁珍 于 2019-09-17 设计创作，主要内容包括：本发明公开了一种抗敏舒缓保湿爽肤水及其制备方法。所述的爽肤水包括以下组分：1,3-丙二醇、辛甘醇、丁二醇、甘油、小分子量透明质酸钠、尿囊素、棕榈酰甘氨酸、乙酰基四肽-40、乙酰基六肽-37、天然植物油、四氢甲基嘧啶羧酸、羟基磷灰石、C20-22醇磷酸酯(和)C20-22醇、辛基/癸基葡糖苷、防腐剂、EDTA-二钠,余量为去离子水。所述的爽肤水各成分配比科学、相互协调,具有显著的抗过敏、抗炎、镇静舒缓皮肤的功效,并且温和亲肤,性质稳定,安全无刺激,补水保湿效果佳,使肌肤水润光滑、有弹性。(The invention discloses an anti-allergy soothing moisturizing toner and a preparation method thereof. The toner comprises the following components: 1, 3-propanediol, caprylyl glycol, butanediol, glycerol, small molecular weight sodium hyaluronate, allantoin, palmitoyl glycine, acetyl tetrapeptide-40, acetyl hexapeptide-37, natural vegetable oil, tetrahydromethylpyrimidine carboxylic acid, hydroxyapatite, C20-22 alcohol phosphate (and) C20-22 alcohol, octyl/decyl glucoside, preservative, EDTA-disodium, and the balance deionized water. The toner has scientific and coordinated components, has obvious effects of resisting allergy, resisting inflammation, calming and relieving the skin, is mild and skin-friendly, has stable properties, is safe and non-irritant, has good moisturizing effect, and makes the skin moist, smooth and elastic.)

1. The anti-allergy, soothing and moisturizing toner is characterized by comprising the following components in percentage by weight: 2-5% of 1, 3-propylene glycol, 1-4% of caprylyl glycol, 2-5% of butanediol, 2-5% of glycerol, 0.2-1% of low molecular weight sodium hyaluronate, 0.1-1% of allantoin, 0.05-0.2% of palmitoyl glycine, 0. 400.05-0.2% of acetyl tetrapeptide-370.05-0.2%, 0.5-1.5% of natural vegetable oil, 0.5-2% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1-1% of hydroxyapatite, 1-2% of C20-22 alcohol phosphate (and) C20-22 alcohol, 0.1-0.5% of octyl/decyl glucoside, 0.1-0.2% of preservative, 0.01-0.03% of EDTA-disodium and the balance of deionized water.

2. The anti-allergy, soothing and moisturizing toner as claimed in claim 1, which is characterized by comprising the following components in percentage by weight: 5% of 1, 3-propylene glycol, 3% of caprylyl glycol, 4% of butanediol, 4% of glycerol, 0.6% of small molecular weight sodium hyaluronate, 0.6% of allantoin, 0.15% of palmitoyl glycine, 400.2% of acetyl tetrapeptide, 0-370.15% of acetyl hexapeptide, 1% of natural vegetable oil, 2% of tetrahydro-methyl pyrimidine carboxylic acid, 0.5% of hydroxyapatite, 2% of C20-22 alcohol phosphate (and) C20-22 alcohol, 0.2% of octyl/decyl glucoside, 0.1% of preservative, 0.02% of EDTA-disodium and the balance of deionized water.

3. The anti-allergy, soothing and moisturizing toner as claimed in claim 1 or 2, wherein the natural vegetable oil is echium oil and green tea seed oil in a mass ratio of 1: 0.5-1.

4. The anti-allergy, soothing and moisturizing toner as claimed in claim 3, wherein the natural vegetable oil is Echium oil and green tea seed oil in a mass ratio of 1: 1.

5. The anti-allergy soothing moisturizing toner as claimed in claim 1 or 2, wherein the preservative is German ShumeiK 350、K900 orK 940。

6. The anti-allergy, soothing and moisturizing toner as claimed in claim 1 or 2, wherein the molecular weight of the small molecular weight hyaluronic acid is 3000-10100 daltons.

7. A process for preparing the anti-allergy soothing moisturizing toner of claim 1, comprising the steps of:

s1: adding deionized water, 1, 3-propylene glycol, caprylyl glycol, butanediol, glycerol, small molecular weight sodium hyaluronate, allantoin, hydroxyapatite, C20-22 alcohol phosphate (and) C20-22 alcohol and octyl/decyl glucoside into a stirring pot, homogenizing for 8-10 min, heating to 75-85 ℃, and stirring until the materials are completely dissolved;

s2: continuously stirring and cooling to 40-50 ℃, adding palmitoyl glycine, acetyl tetrapeptide-40, acetyl hexapeptide-37, natural vegetable oil and tetrahydro-methyl pyrimidine carboxylic acid, and stirring until the system is uniform;

s3: finally, EDTA-disodium and a preservative are added and stirred evenly, and then the materials are discharged, so that the anti-allergy soothing moisturizing toner is obtained.

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to anti-allergy, soothing and moisturizing toner and a preparation method thereof.

Background

Sensitive skin is a special state of skin, is fragile and weak in resistance, is easy to have symptoms of red blood streak, edema, telangiectasia and the like after being stimulated by the outside, and is easy to have the feeling of pruritus, stabbing pain, burning heat, tightness and the like. Sensitive skin is characterized mainly by the following features: season change, temperature, humidity, wind, sunlight, radiation skin, easy redness, itching, stinging and burning sensation, and even small red rash. The use of skin care products (including cleansing, moisturizing, lotions, make-up, sunscreens, etc.) can cause flushing, itching, or stinging, burning, itching, desquamation, etc. After washing face, the skin is often reddish and tingling. Moderate exercise, mood swings, cutaneous vasodilation, hyperemia, redness. Improper diets such as spicy, alcoholic, and superheated diets can cause skin vasodilation, hyperemia, and redness. The epidermis of sensitive skin is thin, lacks the protection ability against ultraviolet rays, and is easy to age, the stratum corneum of the sensitive skin, which is shallow and thin, often cannot hold enough moisture, and people with the skin feel that the skin is lack of water and dry more sensitively than ordinary people in cold rooms in summer or dry climates in winter, so that it is very important to enhance moisture retention in daily care.

When using skin care products for people with sensitive skin, it is appropriate to use products with moderate or low concentration. Irritation of sensitive skin is also minimized. Once the skin is dry, desquamated or reddened, the skin is illuminated red for a healthy condition. To restore the skin as quickly as possible, the best approach is to reduce irritation without being excessively blown by wind and sun and eating irritating foods, and then to use low-sensitivity series products, after reducing the damage, the skin will recover to health by itself.

At present, most of the skin lotions on the market have the effects of moisturizing and whitening, but most of the skin lotions contain ingredients of perfume, alcohol and heavy preservative, so that the skin lotions easily cause burden to the skin with thin skin and the skin which is easily sensitive to external stimulation. Particularly alcoholic components, cause redness of sensitive skin after application. Therefore, the development of the toner which is mild in property, has anti-allergy, soothing and moisturizing effects and does not contain alcohol or spice is needed to meet the market demand.

Disclosure of Invention

The invention aims to provide anti-allergy, soothing and moisturizing toner and a preparation method thereof. The toner has scientific and coordinated components, has obvious effects of resisting allergy, resisting inflammation, calming and relieving the skin, is mild and skin-friendly, has stable properties, is safe and non-irritant, has good moisturizing effect, and makes the skin moist, smooth and elastic.

The invention is realized by the following technical scheme:

an anti-allergy, soothing and moisturizing toner comprises the following components in percentage by weight: 2-5% of 1, 3-propylene glycol, 1-4% of caprylyl glycol, 2-5% of butanediol, 2-5% of glycerol, 0.2-1% of low molecular weight sodium hyaluronate, 0.1-1% of allantoin, 0.05-0.2% of palmitoyl glycine, 0. 400.05-0.2% of acetyl tetrapeptide-370.05-0.2%, 0.5-1.5% of natural vegetable oil, 0.5-2% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1-1% of hydroxyapatite, 1-2% of C20-22 alcohol phosphate (and) C20-22 alcohol, 0.1-0.5% of octyl/decyl glucoside, 0.1-0.2% of preservative, 0.01-0.03% of EDTA-disodium and the balance of deionized water.

Preferably, the anti-allergy, soothing and moisturizing toner comprises the following components in percentage by weight: 5% of 1, 3-propylene glycol, 3% of caprylyl glycol, 4% of butanediol, 4% of glycerol, 0.6% of small molecular weight sodium hyaluronate, 0.6% of allantoin, 0.15% of palmitoyl glycine, 400.2% of acetyl tetrapeptide, 0-370.15% of acetyl hexapeptide, 1% of natural vegetable oil, 2% of tetrahydro-methyl pyrimidine carboxylic acid, 0.5% of hydroxyapatite, 2% of C20-22 alcohol phosphate (and) C20-22 alcohol, 0.2% of octyl/decyl glucoside, 0.1% of preservative, 0.02% of EDTA-disodium and the balance of deionized water.

The natural vegetable oil is prepared from echium oil and green tea seed oil in a mass ratio of 1: 0.5-1.

Preferably, the natural vegetable oil is echium oil and green tea seed oil which are prepared according to the mass ratio of 1: 1.

The preservative is German ShumeiK 350、K900 orK940. Wherein the content of the first and second substances,the INCI name of K350 is phenoxyethanol/methylparaben/ethylparaben/ethylhexylglycerin;the INCI name of K900 is benzyl alcohol/ethylhexyl glycerol/tocopherol;the INCI name for K940 is benzyl alcohol/ethylhexyl glycerol/phenoxyethanol.

The molecular weight of the low molecular weight hyaluronic acid is 3000-10100 daltons.

The anti-allergy soothing moisturizing toner is prepared by the following method, and the method comprises the following steps:

s1: adding deionized water, 1, 3-propylene glycol, caprylyl glycol, butanediol, glycerol, small molecular weight sodium hyaluronate, allantoin, hydroxyapatite, C20-22 alcohol phosphate (and) C20-22 alcohol and octyl/decyl glucoside into a stirring pot, homogenizing for 8-10 min, heating to 75-85 ℃, and stirring until the materials are completely dissolved;

s2: continuously stirring and cooling to 40-50 ℃, adding palmitoyl glycine, acetyl tetrapeptide-40, acetyl hexapeptide-37, natural vegetable oil and tetrahydro-methyl pyrimidine carboxylic acid, and stirring until the system is uniform;

s3: finally, EDTA-disodium and a preservative are added and stirred evenly, and then the materials are discharged, so that the anti-allergy soothing moisturizing toner is obtained.

The anti-allergy soothing moisturizing toner disclosed by the invention contains various anti-allergy soothing active factors including palmitoyl glycine, acetyl tetrapeptide-40, natural vegetable oil, tetrahydro-methyl pyrimidine carboxylic acid, hydroxyapatite and the like, and moisturizing factors including 1, 3-propylene glycol, caprylyl glycol, butanediol, glycerol, small molecular weight sodium hyaluronate, allantoin, acetyl hexapeptide-37 and the like, and the components interact to form a solution system which is stable in property, mild, skin-friendly and non-irritant, and can coordinately play remarkable anti-allergy, anti-inflammatory, soothing and soothing skin and moisturizing effects.

Palmitoyl glycine in the formula can reduce aging caused by chronic inflammation and restore skin balance; promoting the generation of micro-blood vessels and reproducing the luster of the skin; helps the synthesis and arrangement of the collagen fiber network structure, and leads the skin to recover compact. The acetyl tetrapeptide-40 is anti-erythrofilament peptide, and can relieve erythema and erythra symptoms by reducing the content of IL-6 and IL-8 induced by LL-37, remarkably inhibit collagenase activity, reduce collagen degradation, and improve skin roughness. The acetyl hexapeptide-37 is a water channel protein cell humectant, can effectively improve the expression level of AQP3 in a human body at the mRNA level, so that the content of AQP3 in the skin is improved, the acetyl hexapeptide-37 has good moisturizing activity, can promote the synthesis of type I collagen in dermal fibroblasts of the human body and the proliferation of keratinocytes, and has good effects of improving the skin elasticity and tightening the skin when being used together with palmitoyl glycine. The tetrahydro-methyl pyrimidine carboxylic acid protects the immune system of the skin, triggers and improves the reaction speed of heat shock protein, protects cell membranes and DNA, and stabilizes and repairs the skin inflammation and allergy symptoms. The hydroxyapatite can protect skin moisture and resist adverse factors of external environment, reduce skin sensitivity, maintain natural skin regeneration and skin repair process, and keep skin young. The Echium oil is derived from Echium seed, and has effects of relieving skin allergy, refreshing and comfortable feeling after use, promoting cell regeneration, and promoting skin compactness. The green tea seed oil is derived from green tea seeds, has remarkable anti-inflammatory and antioxidant effects, and has better anti-allergic and anti-inflammatory effects and skin calming effects when being used together with the echium oil. Allantoin is an anti-inflammatory humectant, and can dissolve keratin and promote cell regeneration. The small molecular weight sodium hyaluronate can effectively permeate skin, promote the synthesis of hyaluronic acid in the skin and the proliferation of keratinocytes and fibroblasts, and play roles in moisturizing, resisting wrinkles and resisting aging. Octyl/decyl glucoside is a green solubilizer that increases the solubility of natural vegetable oils in solution. The C20-22 alkyl phosphate and the C20-22 fatty alcohol are multifunctional anionic emulsifiers and can bring unique texture like velvet to the skin. 1, 3-propylene glycol, caprylyl glycol and butanediol are auxiliary moisturizers, have certain anti-allergy and anti-inflammation effects, and are beneficial to improving the stability of palmitoyl glycine, acetyl tetrapeptide-40 and acetyl hexapeptide-37 in a solution.

The anti-allergy, soothing and moisturizing toner formula disclosed by the invention contains a certain amount of micromolecular active peptide, amino acid derivative components and inorganic matter components (hydroxyapatite), and the problem is how to ensure the stability of a solution system and avoid the phenomena of precipitation and delamination in the storage process. The present inventors have found through a number of experiments that the use of 1, 3-propanediol, octanediol, butanediol, C20-22 alcohol phosphate (and) C20-22 alcohol, octyl/decyl glucoside, and other auxiliary components allows the solution to form a stable system without precipitation during long-term storage.

Compared with the prior art, the invention has the following beneficial effects:

(1) the anti-allergy, soothing and moisturizing toner disclosed by the invention contains various functional components such as palmitoyl glycine, acetyl tetrapeptide-40, natural vegetable oil, tetrahydro-methyl pyrimidine carboxylic acid, hydroxyapatite, acetyl hexapeptide-37, allantoin and the like, and has the remarkable anti-allergy, anti-inflammatory, soothing and soothing skin, moisturizing and moisturizing effects, so that not only can the anaphylactic reaction caused by various cosmetics be eliminated, but also a skin defense system can be recovered, the adverse skin reaction caused by environmental pollution can be effectively resisted, and the skin sensitivity is reduced.

(2) The anti-allergy, soothing and moisturizing toner disclosed by the invention is mild, stable, safe and effective in property, free of skin irritation, easy to absorb by skin, fresh and cool in face without being sticky after being used, simple in preparation method, controllable in conditions and stable in process.

Detailed Description

The following examples are further illustrative of the present invention and are not intended to be limiting thereof.

The ingredients in the formulations of the following examples are all commercially available products unless otherwise specified. Wherein the CAS number of the allantoin is 97-59-6, and the allantoin is purchased from rain and dew chemical Co., Ltd, Guangzhou city; palmitoylglycine CAS number 2441-41-0, available from Shanghai Allantin Biotechnology Ltd; acetyl tetrapeptide-40 and acetyl hexapeptide-37 are purchased from Dourbisch chemical Co., Ltd; the small molecular weight sodium hyaluronate was purchased from Shandong Guanguang Biotech Co., Ltd; the CAS number of the tetrahydro-methylpyrimidine carboxylic acid is 96702-03-3, and is purchased from Wuhanxin Jiali biotechnology limited; echium oil was purchased from Waser science, Inc., Guangzhou; the green tea seed oil is purchased from Jiangxi Baolin natural spice Co.Ltd; the hydroxyapatite being produced by German MerckCalcium (132204) available from behabo ltd, guangzhou; c20-22 alcohol phosphate ester (and) C20-22 were obtained from Guangzhou Kanghua Kogyoka Co., Ltd; octyl/decyl glucoside (APG-0810) is available from Guangzhou Hao Wealto Co., Ltd; glyceryl stearate (and) PEG-100 stearate were purchased from Bisheng trade, Inc., Guangzhou.